• 정보처리학회논문지D
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• 제19D권1호
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• pp.21-28
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• 2012

모노머 단백질의 상호작용 사이트 예측은 기능을 알지 못하는 단백질에 대해서 이것과 상호작용하는 단백질로부터 기능을 예측하거나 단백질 도킹을 위한 검색 공간의 감소에 중요한 역할을 한다. 그러나 상호작용사이트 예측은 대부분 단백질 상호작용이 세포 내에서 순간적 반응에 일어나는 약한 상호작용으로 실험에 의한 3차원 결정 구조 식별의 어려움이 따르며 이로 인해 3차원의 복합체 데이터가 제한적으로 양산된다. 이 논문에서는 모노머 단백질의 3차원 패치 계산을 통하여 구조가 알려진 복합체의 상호작용사이트와 비상호작용사이트에 대한 패치 속성을 추출하고 이를 기반으로 Support Vector Machine (SVM) 분류기법을 이용한 예측 모델 개발을 제시한다. 타겟 클래스의 데이터 불균형 문제 해결을 위해 under-sampling 기법을 이용한다. 사용된 패치속성은 2차 구조 요소와 아미노산 구성으로부터 총 9개가 추출된다. 147개의 단백질 복합체에 대해서 10 fold cross validation을 통해서 다양한 분류모델의 성능 평가를 하였다. 평가한 분류 모델 중 SVM은 92.7%의 높은 정확성을 보이고 이를 이용하여 분류 모델을 개발하였다.

• 한국작물학회지
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• 제45권5호
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• pp.316-321
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• 2000

Blast severity data of 39 rice varieties at 11 sites in Korea from 1997 to 1999 were analyzed using AMMI model and pattern analysis. Genotype x Environment (G$\times$E) interaction sum of squares (SS) accounted for 12 % of the total SS. Eight genotype groups and seven location groups were identified based on blast reaction pattern. The data obtained from over 21 sites with 44 test varieties from 1981 to 1996 were also considered. These were compared with the 1997-1999 data using the G$\times$E analysis results. Majority of the variability in the Korean Rice Blast Nursery (KRBN) were attributable to variations due to genotypes. Variations of G$\times$E interaction were maintained though test sites were reduced from 21 to 11 sites. Broadly compatible biological discriminative varieties identified were Nagdongbyeo and Akibare while broadly incompatible biological discriminative varieties identified were Hangangchalbyeo and Seogwangbyeo. Key sites for future evaluation work could be selected from location groups. Each location group should be represented by the site with the strongest interaction pattern. Blast responses in Cheolwon, Gyehwa, Suwon, Iksan, and Icheon showed different patterns from other locations.

• Archives of Pharmacal Research
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• 제20권6호
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• pp.579-585
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• 1997

To gain further insight into the mechanism of action of antiestrogens, we examined the interaction of antiestrogen with the estrogen receptor system and with estrogen- noncompetable antiestrogen binding sites. In addition to binding directly to the estrogen receptor, antiestrogens can be found associated with binding sites that are distinct from the estrogen receptor. In contrast to the restriction of estrogen receptors to estrogen target cells, such as those of uterus and mammary glands, antiestrogen binding sites are present in equal amounts in estrogen receptor-positive and -negative human breast cancer cell lines, such as MCF-7, T47D, and MDA-MB-231 that differ markedly in their sensitivity to antiestrogens. In order to gain greater insight into the role of these antiestrogen binding sites in the action of antiestrogens, we have examined the biopotency of different antiestrogens for the antiestrogen binding sites and that is CI628 > tamoxifen > trans-hydroxy tamoxifen > CI628M > H1285 > LY117018. This order of affinities does not parallel the affinity of these compounds for the estrogen receptor nor the potency of these compounds as antiestrogens. Indeed, compounds with high affinity for the estrogen receptor and greatest antiestrogenic potency have low affinities for these antiestrogen binding sites. Antiestrogenic potency correlates best with estrogen receptor affinity and not with affinity for antiestrogen binding sites. In summary, our findings suggested that interaction with the estrogen receptor is most likely the mechanism through which antiestrogens evoke their growth inhibitory effects.

• Child Health Nursing Research
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• 제12권1호
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• pp.57-64
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• 2006

Purpose: This study was conducted to analyze web sites that provide child-care information and to provide a proper model for child-care web sites. Method: The evaluation tool with 23 items including purpose, contents, timeliness and reliability, interaction, and function was developed and modified. Quantitative analyses of 48 web sites, which were selected using popular search engines, were done. Result: 1) The aim of the web site was clearly shown for 24 sites (63.2%) and 17 sites (44.7%) provided the information for judging whether the informant was an expert. 2) Most web sites provided information on feeding, nutrition, and common health problems, and 11 sites provided information on care of problem behavior, but only 6 sites provided information on mother-infant interaction. 3) Timely information was provided on 21 sites, however none of the sites provided information sources. 4) Methods for contact the authors were found for 31 sites (81.6%) and 19 sites (50%) had active bulletin boards to receive opinions from users. 5) There were 32 sites where information could be found by clicking less than 3 times. Conclusion: We suggest that the evaluation criteria for child-care web sites used in this study is a tool that can be used to evaluate web sites with consistency, but there is a need for further study to develop standardization of the evaluating tool.

• 품질경영학회지
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• 제40권2호
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• pp.219-230
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• 2012

These days, getting a gob is emerging as a hot social issue, and specialized sites offering job information are rapidly increasing. On the contrary of quantitative increase, job information sites have lots of problems with respect to satisfying customer's needs. This study is designed to explore web-site service quality factors in job information site, and relationship among characteristic web service quality, customer satisfaction, relationship quality and reuse intention. In this study we found that customer satisfaction is prior to relationship quality, which decide long-term customer relationship. And also, Trust which is one of the relationship quality and customer satisfaction affect customers reuse intent respectively. This study also found that characteristic service quality in related to job information site can be composed of four factors such as delivery of information, customization, web design and interaction. Delivery of information, web design and interaction affect trust, and web design and interaction affect customer satisfaction. And also relationship quality is prior to reuse intention.

• Rapid Communication in Photoscience
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• 제5권1호
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• pp.8-10
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• 2016

The potential curves of OH bonds of liquid water are inhomogeneous because of a variety of interactions with other molecules and this leads to a wide distribution of vibrational frequency which hampers our understanding of the structure and dynamics of water molecules. Mixed quantum/classical (QM/CM) calculation methods are powerful theoretical techniques to help us analyze experimental data of various vibrational spectroscopies to study such inhomogeneous systems. In a type of those approaches, the interaction energy between OH bonds and other molecules is approximately represented by the interaction between the charges located at the appropriate interaction sites of water molecules. For this purpose, we re-calculated the values of charges by comparing the approximate interaction energies with quantum chemical interaction energies. We determined a set of charges at the TIP4P charge sites which better represents the quantum mechanical potential curve of OH bonds of liquid water.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.17-25
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• 2003

Determining the binding sites in protein-nucleic acid complexes is essential to the complete understanding of protein-nucleic acid interactions and to the development of new drugs. We have developed a set of algorithms for analyzing protein-nucleic acid interactions and for predicting potential binding sites in protein-nucleic acid complexes. The algorithms were used to analyze the hydrogen-bonding interactions in protein-RNA and protein-DNA complexes. The analysis was done both at the atomic and residue level, and discovered several interesting interaction patterns and differences between the two types of nucleic acids. The interaction patterns were used for predicting potential binding sites in new protein-RNA complexes.

• 디자인학연구
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• 제17권4호
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• pp.37-50
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• 2004

플래시의 액션 스크립트, 자바 스크립트, 자바 등 웹 기반 프로그래밍 툴의 발전과 사용잗ㄹ의 총체적 경험으로써의 인터랙티비티의 중요성이 대두되면서, 웹은 정보를 면 단위로 보여주는 웹진의 형태로부터 인터랙티브한 조작 인터페이스를 제시하고 조작에 따라 즉각적으로 사용자에게 피드백을 주는 인터랙션의 형태로 진화하게 하였다. 웹은 소프트웨어에 비해 다향한 계층의 사용자가 비교적 단순한 작업을 하기 위해 사용하므로 보다 인터랙티브하게 작업을 지원함으로써 사용자의 인지적 부담을 줄이며 사용의 재미를 줄 필요가 있다. 본 연구에서는 이러한 추세에 따라 등장하고 있는 웹사이트의 인터랙티비티의 개념과 사례를 통해 인터랙티브화하는 경향을 분석하고, 웹의 인터랙티브화를 위한 디자인 전략들이 어떤 것들이 있는지 도출하였으며, 이의 적용 예를 보일 수 있는 사이트 개발 사례 제시를 목적으로 진행되었다. 본 연구는 웹 상에 있어서 인터랙티비티를 부여할 수 있는 디자인 전략을 제시하였으며, e-book 사이트에서의 인터랙티브 북셀프 디자인에 있어 인터랙션 디자인 전략의 적용 사례를 통해 디자인 개발 프로세스에 활용할 수 있는 가능성을 제시하였다.

• International Journal of Advanced Culture Technology
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• 제9권3호
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• pp.259-264
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• 2021

In modern socity, online communication plays a vital role in social interaction of communicities. It is so common for online users to see display advertisements online while surting the Net. Specifically, most web banners diaplayed on portral sites consist of words, phrase, and sentences. Considering that the primary purpose of adversiting is persuation, the advertisement such as web banners is an examplary case to show the interaction among pragmatics, translation and advertising because the linguistic expressions employed in the banners represent its pragmatic use, leading to persuation and functioning as a communicative tool for the smooth communication between source text producers (adversisers) and target audience (online users). This can be part of the so-called translation process. In particular, we can easily witness the use of English words in web banners. Thus, this paper looks at web banners displayed on major four portal sites-Naver, Daum, Nate, and Zum, giving a special attention to the content contained in the web banners as well as the use of English words. As s result, we found that the frequencies of English words in each portal site were higher when the advertised products were targeting young online users, whereas the frequencies were lower when the users are older group than young people. The finding supports the prgramatic perspective that linguistic expressions are understood in social contexts and shows the so-called translation process which involves a shift from semantic meaning of words to their pragmatic use. Finally, we can conclude that the interaction is possible when we have the framework where translation, pragmatics, and advertising are all communitative components for social interaction within social contexts.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2005년도 제17회 워크샵 및 추계학술대회
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• pp.634-637
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• 2005

Hydrogen adsorption mechanism onto the porous metal-organic frameworks (MOFs) has been studied by density functional theory calculation. The selected functionals for the predict ion of interact ion energies between hydrogen and potential adsorption sites of MOF was utilized after the evaluation with the various functionals for interaction energy of $H_2C_6H_6$ model system the adsorption energy of hydrogen molecule into MOF was investigated with the consideration of the favorable adsorption sites and the orientations. We also calculated the second favorable adsorption sites by geometry optimization using every combination of two first absorbed hydrogen molecules. Based on the calculation of first and second adsorption sites and energies, the hydrogen adsorption into MOF follows a cooperative mechanism in which the initial metal sites initiate the propagation of the hydrogen adsorption on the whole frameworks. In addition, it was found that the interaction strength between the simple benzene ring with hydrogen is significantly reinforced when the benzene ring has been incorporated into the framework of MOFs.