• Bulletin of the Korean Chemical Society
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• 제16권6호
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• pp.547-552
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• 1995

As an extension to the Kramers' restricted Hartree-Fock (KRHF) method [J. Comp. Chem., 13, 595 (1992)], we have implemented the Kramers' restricted configuration interaction (KRCI) program in order to calculate excited states as well as the ground state of polyatomic molecules containing heavy atoms. This KRCI is based on determinants composed of the two-component molecular spinors which are generated from KRHF calculations. The Hamiltonian employed in the KRHF and KRCI methods contains most of all the important relativistic effects including spin-orbit terms through the use of relativistic effective core potentials (REP). The present program which is limited to a small configuration space has been tested for a few atoms and molecules. Excitation energies of the group 14 and 16 elements calculated using the present KRCI program are in good accordance with the spectroscopic data. Calculated excitation energies for many Rydberg states of K and Cs indicate that spin-orbit terms in the REP, which are derived for the ground state, are also reliable for the description of highly excited states. The electronic states of the polyatomic molecule CH3I are probed from the molecular region to the dissociation limit. Test calculations demonstrate that the present KRCI is a useful method for the description of potential energy surface of polyatomic molecules containing heavy atoms.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.476-476
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• 2011

Introduction of CNTs into a metal matrix has been considered to improve the mechanical properties of the metal matrix. However, the binding energy between metals and pristine CNTs wall is known to be so small that the interfacial slip between CNTs and the matrix occurs at a relatively low external stress. The interfacial strength between CNT and metal matrix is thus one of the key factors for successful development of the CNT/metal composites. Defective or functionalized CNT has been considered to enhance the interfacial strength of nanocomposites. In the present work, we design the various realistic hybrid structures of the single wall CNT/Cu complexes and characterize the interaction between single wall CNTs and Cu nano-particle and Cu13 cluster using first principle calculations. The characteristics of functionalized CNTs with various surface functional groups, such as -COOH, -OH, and -O interacting with Cu are investigated. We found that the binding energy can be enhanced by the surface functional group including oxygen since the oxygen atom can mediate and reinforce the interaction between carbon and Cu. These results strongly support the recent experimental work which suggested the oxygen on the interface playing an important role in the excellent mechanical properties of the CNT/Cu composite.

• 대한수학교육학회지:수학교육학연구
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• 제15권1호
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• pp.75-105
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• 2005

본 연구는 엑셀을 활용한 소그룹 모델링의 흐름과 학생과 엑셀의 상호작용이 모델링에 미치는 영향에 대한 이해를 바탕으로 추후 엑셀을 활용한 소그룹 모델링을 통한 수학 교수ㆍ 학습을 위한 기초적인 정보를 제공하는데 목적이 있다. 엑셀을 활용한 소그룹 모델링의 흐름을 알아보기 위해 학생들이 고려하는 양, 양들간 관계, 구성하는 모델을 바탕으로 모델링 주기를 살펴보았다 또한 학생과 엑셀의 상호작용이 모델링에 미치는 영향을 이해하기 위해 학생과 엑셀의 상호작용을 모델 형성, 모델 정교화, 모델을 통한 상황 해석ㆍ예측ㆍ통제 측면에서 분석하였다. 본 연구로부터 엑셀을 활용한 소그룹 모델링이 어떻게 이루어지는가와 학생-엑셀 상호작용 패턴에 대한 이해를 바탕으로 모델링 도구로서의 엑셀의 잠재력을 확인하고 학생들의 모델링 활동에 있어서의 강점과 취약점을 확인할 수 있었다. 또한 엑셀을 활용한 소그룹 모델링이 보다 효과적으로 이루어지기 위해 요구되는 교사 역할에 관한 시사점을 얻을 수 있었다.

• Tuberculosis and Respiratory Diseases
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• 제85권2호
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• pp.147-154
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• 2022

Background: The expression of calcium signaling pathway molecules is altered in various carcinomas, which are related to the proliferation and altered characteristics of cancer cells. However, changes in calcium signaling in anti-cancer drug-resistant cells (bearing a T790M mutation in epidermal growth factor receptor [EGFR]) remain unclear. Methods: Afatinib-mediated changes in the level of store-operated Ca²⁺ entry (SOCE)-related proteins and intracellular Ca²⁺ level in non-small cell lung cancer cells with T790M mutation in the EGFR gene were analyzed using western blot and ratiometric assays, respectively. Afatinib-mediated autophagic flux was evaluated by measuring the cleavage of LC3B-II. Flow cytometry and cell proliferation assays were conducted to assess cell apoptosis and proliferation. Results: The levels of SOCE-mediating proteins (ORAI calcium release-activated calcium modulator 1 [ORAI1], stromal interaction molecule 1 [STIM1], and sarco/endoplasmic reticulum Ca²⁺ ATPase [SERCA2]) decreased after afatinib treatment in non-small cell lung cancer cells, whereas the levels of SOCE-related proteins did not change in gefitinib-resistant non-small cell lung cancer cells (PC-9/GR; bearing a T790M mutation in EGFR). Notably, the expression level of SOCE-related proteins in PC-9/GR cells was reduced also responding to afatinib in the absence of extracellular Ca²⁺. Moreover, extracellular Ca²⁺ influx through the SOCE was significantly reduced in PC-9 cells pre-treated with afatinib than in the control group. Additionally, afatinib was found to decrease the level of SOCE-related proteins through autophagic degradation, and the proliferation of PC-9GR cells was significantly inhibited by a lack of extracellular Ca²⁺. Conclusion: Extracellular Ca²⁺ plays important role in afatinib-mediated autophagic degradation of SOCE-related proteins in cells with T790M mutation in the EGFR gene and extracellular Ca²⁺ is essential for determining anti-cancer drug efficacy.

• 디지털융복합연구
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• 제13권5호
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• pp.393-400
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• 2015

본 연구는 중년여성을 대상으로 12주간의 간헐적 단식과 저항운동이 성호르몬과 당대사 변인에 어떤 영향을 주는지 알아보고자 하였다. 이에 두 그룹을 선정하여 EG에는 간헐적 단식과 저항운동을 적용하였으며, CG는 통제군으로서 EG의 효과를 검증할 수 있는 군으로 설정하였다. EG에 적용된 간헐적 단식은 주당 1회 24시간의 단식을 실시하였으며, 저항운동은 주 당 3회 60분간 1RM을 기준으로 60% 강도로 실시하였다. 각 측정변인은 12주간의 처치전후 측정하여 처치효과를 검증하였다. 이와 같은 절차를 통해 다음과 같은 결론을 얻었다. 첫째, 간헐적 단식과 저항운동을 적용한 그룹에서 성호르몬(에스트라디올, 테스토스테론)의 변화에 유의한 상호작용효과를 나타냈다. 둘째, 간헐적 단식과 저항운동을 적용한 그룹에서 당대사변인(글루코스, 인슐린, HOMA-IR)의 변화에 유의한 상호작용효과를 나타냈다. 본 연구는 간헐적 단식과 저항운동을 동시에 적용하여 진행하여 긍정적인 결과를 얻었다. 하지만 간헐적 단식과 저항운동 각각의 효과를 검증하는 데는 한계가 있는 것으로 판단된다.

• 디지털융복합연구
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• 제14권3호
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• pp.489-497
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• 2016

본 연구는 8주간 고령여성을 대상으로 유단백 섭취와 탄성밴드운동을 통해 고령여성의 활동체력 및 대사성 위험인자의 변화를 살펴보고자 하였다. 이를 위해 처치군(TG)과 통제군(CG)으로 구분하여 두 그룹을 선정하였다. TG에서는 유단백 섭취와 탄성밴드운동을 8주간 적용하였으며, CG는 통제군으로서 본 프로그램에 참여하지 않고 일반적 생활을 영위하도록 하였다. TG에 적용된 유단백 섭취는 하루 3회 총 900ml가 제공되었으며, 이와 함께 탄성밴드운동을 주 당 4회 준비운동과 정리운동을 포함해 60분간 실시되었다(RPE<17). 자료분석은 8주간 프로그램 적용 전과 후에 측정하여 프로그램의 상호작용효과를 검증하고자 하였다. 이와 같은 절차를 통해 다음과 같은 결론을 얻었다. 첫째, 8주간의 유단백 섭취와 탄성밴드운동은 고령여성의 활동체력(근력, 근지구력, 평형성) 변화에 유의한 상호작용효과를 나타냈다(p<.05). 둘째, 8주간의 유단백 섭취와 탄성밴드운동은 고령여성의 대사성위험인자(TC, HDL-C, LDL-C) 변화에 유의한 상호작용효과를 나타냈다(p<.05). 본 연구는 유단백 섭취와 탄성밴드운동을 통해 고령여성의 활동체력 및 대사성위험인자의 긍정적 변화를 나타냈다. 하지만 모든 요인에서 유의한 변화를 나타내지 않아 후속연구에서는 구체화된 연구가 필요할 것으로 사료된다.

• 한국보육지원학회지
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• 제5권2호
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• pp.91-112
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• 2009

본 연구는 유아교육기관 교육활동에서의 집단형태에 따른 유아의 참여행동과 교사의 언어를 관찰하였다. 연구대상은 대전시 소재 유치원의 만 5세 2학급 유아 45명과 각 학급 담임이었고, 4주 동안 시간표집법에 의한 16회 관찰을 통해, 활동 집단 형태와 유아의 참여행동 및 교사의 언어를 분석하였다. 분석 결과, 교사주도 대집단 활동과 구조화된 활동내용이 많았다. 유아 참여는 대집단활동에서 일방적 응시행동이 많았고 교사의 설명하기가 높게 나타났다. 자유선택활동 또래 간 소집단에서의 유아의 참여는 적극적 반응행동이 높게 나타났으며, 교사의 언어는 칭찬과 인정하기의 빈도가 많은 것으로 나타났다. 이와 같은 결과를 중심으로 일과 구성에 나타난 교육활동의 집단형태 운영와 유아의 참여행동 및 교사의 언어 사용에 대해 논의하였다.

• 천문학회보
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• 제40권1호
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• pp.77.3-78
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• 2015

It is known that the galaxy evolution by direct interaction between galaxies is most active in a galaxy group. As a result, the satellite galaxies are closely related to their central galaxy in properties such as morphology, color and star formation rate (so-called 'galactic conformity'). However, it is not clear yet whether such conformity between galaxies is found in a galaxy cluster. Recently, Lee et al. (2014) have found a measurable correlation between the colors of bright galaxies and the mean colors of their faint companions in a cluster WHL J085910.0+294957 at z = 0.3, using the photometrically-selected cluster members. They suggest that such correlation may be the vestige of infallen groups in the cluster as one possibility. In order to confirm the small-scale conformity in galaxy clusters with higher reliability, we study the Virgo cluster using the Extended Virgo Cluster Catalog (EVCC). The cluster members are selected spectroscopically unlike in WHL J085910.0+294957. We examine the galactic conformity in two distinct areas of the Virgo cluster: the inner X-ray emission region and its outer region. We find a marginal conformity in color (> $2{\sigma}$ significance to bootstrap uncertainty) in the outer region, while no meaningful signal of small-scale conformity is detected in the X-ray emission region. We discuss the implication of this result, focusing on cluster mass assembly and cluster environmental effects on galaxy evolution.

• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.459-473
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• 2000

Dental caries is the most common disease in the maxillofacial area. There are many factors contributing to its development, but complete understanding and prevention is not fully known. Since the structure of the coronal and root portion of the tooth is different, the remineralization and demineralization process is also known to be different. In this study, by using a partially saturated buffer solution, we created artificial enamel and dentin caries and evaluated mineral loss. A remineralization solution with four different degrees of saturation (degree of saturation ; group 1, 0.268, group 2, 0.309, group 3, 0.339, group 4, 0.390, PH 4.3, F-2ppm) was used on a demineralized specimen. The mineral precipitating quantity and depth was evaluated by using microradiography. Using an atomic force microscope (AFM), hydroxyapatite crystals of normal, demineralized, and remineralized enamel and dentin were evaluated. The results were as follows: 1. As the degree of saturation of the remineralizing solution increased, the mineral precipitation in the enamel was increased. In group 4, mineral precipitation was limited near the surface. 2. As the degree of saturation of the remineralizing solution increased, the mineral precipitation in the dentin was decreased and it occurred in a deeper portion. In group 4, however, mineral precipitation occurred on the surface and its quantity increased. 3. There was a statistically significant interaction between enamel and dentin mineral content changes on specimens treated with remineralization and demineralization solution (demineralization r=0.44, remineralization r=0.44, p<0.05). 4. Demineralized hydroxyapatite crystals showed central and peripheral dissolving and widening of intercrystal spaces under the AFM. 5. In dentin remineralization small crystal precipitation occurred between the large crystals. We conclude that by adjusting acidulated buffer solution's degree of saturation, we can control enamel and dentin remineralization. In addition, the AFM is highly useful in evaluating changes in remineralized and demineralized hydroxyapatite crystals.

• Asian-Australasian Journal of Animal Sciences
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• 제15권4호
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• pp.555-564
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• 2002

Twenty Landrace and twenty Min piglets, with an average initial body weight of 22.4 kg, were randomly divided into 5 groups with 4 animals per group, within each of the breeds. The piglets were housed in individual concrete pens. Each group of the piglets was fed one of 5 diets. The diets contained either 20% raw Argentine soybeans, 20% processed Argentine soybeans ($118^{\circ}C$ for 7.5 min.), 20% raw Chinese soybeans, 20% processed Chinese soybeans ($118^{\circ}C$ for 7.5 min.) or no soybean products (control diet). Faecal samples were collected on days 6, 7 and 8 of the treatment period. Digestibilities of dietary nutrients were determined with AIA (acid insoluble ash) as a marker. After a 17 day treatment, three piglets were killed from each of the groups. Tissue samples of small and large intestine for light and electron microscopy examination were taken immediately after the opening of abdomen. Then, the weight or size of relevant organs was measured. The results show that the digestibilities of dry matter (DM), crude protein (CP) and fat were higher in Min piglets than in Landrace piglets (p<0.05). The diets containing processed soybeans had a significant higher CP digestibility than the control diet and the diets containing raw soybeans (p<0.05). Landrace piglets had heavier and longer small intestines, heavier kidneys and a lighter spleen than Min piglets (p<0.05). The pancreas of the animals fed the diets containing processed soybeans was heavier than that of the animals fed control diet (p<0.05) and the diets containing raw soybeans. But, the differences between raw and processed soybean diets were not significant. A significant interaction (p<0.05) between diet and pig breed was observed in weight of the small intestine. The Landrace piglets increased the weight in their small intestine when they were fed the diets containing soybeans. In the light micrographs and electron scanning micrographs, it was found that the villi of small intestinal epithelium of animals (especially Landrace piglets) fed the diets containing raw Chinese soybeans were seriously damaged. The transmission electron micrograph showed that a lot of vesicles were located between the small intestinal microvilli of these piglets. The histological examination also indicated that the proportion of goblet cells in villi and crypts in the piglets consuming the control diet was significantly lower (p<0.01 and p<0.02, respectively) than those of the animals consuming the diets containing raw or processed soybeans.