• 동의생리병리학회지
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• 제23권1호
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• pp.214-218
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• 2009

Platycodon grandiflorum is a long-lived herbaceous and one of the very important herbal medicine and foods. P. grandiflorum is called do-ra-ji in Korea. Inter-simple sequence repeats (ISSR) markers were performed in order to analyse the phenetic relationships of four accessions of P. grandiflorum. Wild groups had higher expected diversity, 0.164 for Korean and 0.157 for Chinese accessions than those of cultivated groups, 0.079 for Korea and 0.059 for China. The total genetic diversity in P. grandiflorum was 0.268 across species and the value was lower than average values for species with similar life history traits. The patchy distribution and domestication are proposed as possible factors contributing to low genetic diversity. An assessment of the proportion of diversity within species, HAccession/HSpecies, indicated that about 57.1% the total genetic diversity was among species. Thus, the majority of genetic variation (42.9%) resided within accessions. The estimated Nm (the number of migrants per generation) was very low among four accessions (mean Nm = 0.376). The low estimate of Nm indicated that gene flow was not extensive among four accessions. ISSR01-02 locus can be recognized as an unique locus of Korean groups (wild and cultivated accessions). Thus the locus can be used to distinguish Korean accessions from Chinese accessions. ISSR04-06 locus was found specific to Chinese groups (wild and cultivated accessions) and was not shown in Korean accessions. Although the size of sampling was not large enough for P. grandiflorum, the analyses of ISSRs will certainly provide an enhanced view on the phylogeny of accessions.

• 방송공학회논문지
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• 제16권6호
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• pp.962-968
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• 2011

기존의 무손실 압축은 일반적으로 채널간의 상관관계를 고려하지 않고 각각의 채널을 따로 압축하였다. 채널 간 상관관계를 이용하는 경우도 있으나 이들은 위성/항공 영상과 같은 경우에 제한된 것으로서 일반적인 이미지에 대해서는 만족할만한 성능을 얻지 못하였다. 본 논문에서는 컬러 이미지가 갖는 채널 간의 상관관계를 이용하여 무손실 압축의 성능을 향상시키는 방법을 제안하였다. 제안된 방법에서는 채널 간 상관관계를 표현할 수 있도록 하기 위하여, 비대칭 샘플링을 통해 주어진 영상의 모자이크 이미지를 구성하여 압축을 수행하였고, 압축된 모자이크 이미지의 정보를 이용해서 샘플링되지 않은 나머지 이미지를 예측하여 압축할 정보의 양을 감소시켰다. 제안된 방법은 압축 성능을 평가하는데 일반적으로 사용되는 데이터들에 대해서 채널 간 상관관계를 이용하지 않는 방법에 대해 35%, 채널 간 상관관계를 이용한 기존 방법에 대해 10%의 성능 개선을 보인다.

• 한국항행학회논문지
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• 제24권1호
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• pp.53-60
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• 2020

본 논문에서는 가변 데이터 전송 가능한 텔레메트리 송신기의 구조에 대해 연구하였다. 가변 데이터 전송을 위하여 가변 컷오프 특성을 가지는 VPMF (variable pre-modulation filter)와 가변입력 샘플레이트 변환기 (variable input sample rate converter)가 결합된 구조를 제안한다. VPMF는 일반적인 PMF (pre-modulation filter)와 동일하게 변조 전 신호의 고주파 성분을 억제하여 RF (radio frequency)신호의 대역을 제한하는 특성을 지니며, 추가적으로 입력 데이터율에 따라 가변 컷오프 특성을 갖는다. 가변입력 샘플레이트 변환기는 입력 데이터율 변경 시 추가적인 구조변경 없이 입력 데이터율과 무관하게 출력을 일정한 샘플링 속도로 변환하는 기능을 갖는다. 추가적으로 실시간 변화하는 데이터양에 대응하기 위해 VPMF와 가변입력 샘플레이트 변환기를 능동적으로 제어하는 소프트웨어 프로그램 기법을 제안한다. 제안 방법을 적용하여 시뮬레이션과 실제 제작을 통하여 입력 데이터율 390 kbps ~ 25 Mbps 범위에서 IRIG (inter-range instrumentation group) 표준의 99% 전력 대역폭, null-to-null 대역폭, 1st IMD (inter modulation distortion) 비교 결과 규격을 만족하는 데이터 전송이 가능함을 확인하였다.

• Archives of Pharmacal Research
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• 제28권10호
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• pp.1190-1195
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• 2005

The objective of this study was to develop an assay for mequitazine (MQZ) for the study of the bioavailability of the drug in human subjects. Using one mL of human plasma, the pH of the sample was adjusted and MQZ in the aqueous phase extracted with hexane; the organic layer was then evaporated to dryness, reconstituted and an aliquot introduced to a gas chromatograph/mass spectrometer (GC/MS) system with ion-trap detector. Inter- and intra-day precision of the assay were less than 15.1 and $17.7{\%}$, respectively; Inter- and intra-day accuracy were less than 8.91 and $18.6{\%}$, respectively. The limit of quantification for the current assay was set at 1 ng/mL. To determine whether the current assay is applicable in a pharmacokinetic study for MQZ in human, oral formulation containing 10 mg MQZ was administered to healthy male subjects and blood samples collected. The current assay was able to quantify MQZ levels in most of the samples. The maximum concentration ($C_{max}$ was 8.5 ng/mL, which was obtained at 10.1 h, with mean half-life of approximately 45.5 h. Under the current sampling protocol, the ratio of $AUC_{t{\rightarrow}last}$ to $AUC_{t{\rightarrow}{\infty}}$ was $934{\%}$, indicating that the blood collection time of 216 h is reasonable for MQZ. Therefore, these observations indicate that an assay for MQZ in human plasma is developed by using GC/MS with ion-trap detector and validated for the study of pharmacokinetics of single oral dose of 10 mg MQZ, and that the current study design for the bioavailability study is adequate for the drug.

• 대한간호학회지
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• 제11권1호
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• pp.29-44
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• 1981

Nursing role tends to be more complex then before because of the increased number of health professionals and of the health needs of patient. Accordingly, nursing role expectations are various and sometimes conflict by its role set. There are various literatures on role conflict of nurses and discussed how to eliminate the conflict in order to improve nursing service particularly in the hospital organization. This study was designed to determine if role conflict exist among nurses who work in a hospital and if so what resolution were most frequently selected by the nurses to the role conflict. The study population was fifty six registered nurses of K university hospital. The fifty six was defined and selected by nonproportional stratified sampling method to obtain subjects who are from uniform role set. A questionnaire, a list of role connect, stimulated by the literature review, knowledge based on several years' experience in nursing was formulated by the author and administered to the study population. The questionnaire included twenty nine closed question items of role conflict and classified according to the intra sender conflict, intersender conflict, person conflict and interperson conflict. The response choices to the questions range on a scale continuum with degrees of conflict from one to five: never - 0, seldom - 1, occasionally - 2, frequently - 3, and mostly -4. Per cent, means, standard deviation, and x² -test were used to analyze data. The findings of the study could be summarized as follows. 1. General characterstics of the study population: Most of the population were between the age of 22-27 and are not married. 2. Analysis of Role conflict Existence of Role conflict of nurses was found by the total mean conflict score, 2.06. Inter Sender Role conflict revealed the most high mean conflict score and the lowest one was inter person role conflict. Among the five role senders of nurses: Physician, patient and hi9 family, peer and superior, nursing students and hospital administrator, nurses showed the highest conflict mean score for physicians and the lowest score for Nursing student. 3. Analysis of role conflict resolution. Compromise through discussion with the role sender was the most frequently selected method by the respondents. The result also showed that the respondents tend to resolve the conflicting situation created by patient or his family by persuation. On the o thor hand, Avoidance and ignorance was frequently chosen for the conflicting role expectations from the hospital administrator.

• Korea-Australia Rheology Journal
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• 제21권2호
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• pp.127-133
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• 2009

Hemorheological results may be influenced by the time between blood sampling and measurement, and storage conditions (e.g., temperature, time) during sample delivery between laboratories may further affect the resulting data. This study examined possible hemorheological alterations subsequent to storage of rat and dog blood at room temperature ($22^{\circ}C$) or with cooling ($4{\sim}10^{\circ}C$) for 2, 4, 6, 24, 48 and 72 hours. Measured hemorheological parameters included hematological indices, RBC aggregation and RBC deformability. Our results indicate that marked changes of RBC deformability and of RBC aggregation in whole blood can occur during storage, especially for samples stored at room temperature. The patterns of deformability and aggregation changes at room temperature are complex and species specific, whereas those for storage at the lower temperature range are much less complicated. For room temperature storage, it thus seems logical to suggest measuring rat and dog cell deformability within 6 hours; aggregation should be measured immediately for rat blood or within 6 hours for dog blood. Storage at lower temperatures allows measuring EI up to 72 hours after sampling, while aggregation must be measured immediately, or if willing to accept a constant decrease, over 24~72 hours.

• 전자공학회논문지
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• 제51권10호
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• pp.87-95
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• 2014

본 논문에서는 이중 채널 CIS(CMOS Image Sensor) 인터페이스를 위한 수신기 설계에 대해서 기술한다. 두 채널은 각각 CTLE(Continuous-Time Linear Equalizer)를 포함하며 샘플러, 병렬 변환기 그리고 clocking 회로로 구성되어 있다. Clocking 회로는 PLL, PI, CDR을 포함한다. CDR은 PI 기반이며 OSPD(Over Sampling Phase Detector)와 FSM(Finite State Machine)을 추가하여 빠른 락 소요 시간과 지연 시간, 향상된 jitter tolerance를 갖도록 하였다. CTLE는 3 GHz에서 -6 dB 손실을 갖는 채널의 ISI(Inter Symbol Interference)를 제거하며 CDR은 8000 ppm 이하의 주파수 오프셋에 대해 1 baud period 이내의 빠른 락 소요 시간을 갖는다. 65 nm CMOS 공정을 이용하여 설계하였으며 eye diagram에서 최소 368 mV의 전압 마진과 0.93 UI의 시간 마진을 갖는다.

• 대한의생명과학회지
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• 제8권4호
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• pp.235-244
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• 2002

This study was carried out to determine the blood and milk progesterone by enzyme-linked immunosorbent assay (ELISA), and milk urea nitrogen (MUN) in cows. MUN and protein concentration were determined using automated infared procedures. The optimum conditions of ELISA system was investigated including the first and second antibody titres, bound percent, and enzyme conjugate and also the factors on MUN and protein concentration by sampling procedures and addition of preservatives. Progesterone antibodies did not react to pregnenlone, testosterone, estrone, estradiol-l7$\beta$, aldosterone, cortisol, corticosterone and 11$\alpha$-dehydroxycortisone (DOC), but reacted with only progesterone. The intra and inter-assay coefficient of variation 4.5%, 6.1~9.4% when used of bovine serum. The morning, MUN concentration (17.6$\pm$2.8 mg/100 ml) in the 13 herds was similar to that of evening MUN concentration of the lactating cows from the same herd. A significant relationship between morning and evening milk samples of upper parameters was found r=0.93. Difference in MUN concentration with sampling procedures and using of preservatives were investigated.

• 대한수의학회지
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• 제33권4호
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• pp.711-717
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• 1993

This study was performed to examine the charges of serum cortisol concentrations on the normal conditions in Korean native goats by enzyme-linked immunosorbent assay(ELISA). The Korean native goats were 4 to 30 months old and weighted 6.0 to 28kg. The goats were allowed ad libitum access to water and food. To minimize the stress with handing and blood sampling, animals were adapted for 2 weeks before the experiment. After adaptation, intravenouse catheter was inserted left intact a jugular vein of 6 goats and blood samples were done 2~3 days later. Experimental animals were divided into 2 groups which was non-catheterized and catheterized group in order to examine the effect for changes of serum concentration and circadian rhythm of cortisol. The results were obtained as follows ; The sensitivity of serum cortisol concentration was $20pg/m{\ell}$. The intra-assay and inter-assay coefficient of variation were below 2.5% and 5%, respectively. Serum concentration of cortisol was more higher in noo-catheterized group$(32.84{\pm}16.78ng/m{\ell})$ than catheterized group$(23.20{\pm}10.29ng/m{\ell})$. The difference according to months old in serum concentration of cortisol was the more higber on 4~6 than 7~12 and lowest over 12 months old. A circadian rhythm in the serum concentration of cortisol in Korean native goats was not found significantly with 2 hours sampling intervals.

• 생명과학회지
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• 제18권6호
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• pp.753-758
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• 2008

원추리속(Genus Hemerocallis) 식물은 초본이며 일부 종은 약용으로 매우 중요하다. 이 속내 8개 분류군에 대해 ISSR (inter simple sequence repeats) 마커로 계통학적 관계를 분석하였다. 조사한 식물은 원추리(Hemerocallis fulva), 왕원추리(H. fulva for. kwanso), 각시원추리(H. dumortieri), 골잎원추리(H. coreana), 홍도원추리(H. hongdoensis), 큰원추리(H. middendorffi), 노랑원추리(H. thunbergii), 애기원추리(H. minor)이다. 또한 이들 분류군에 대한 유전적 변이와 구조를 조사하였다. 종간 유전적 다양도는 $0.068{\sim}0.123$이며 평균 유전적 다양도는 0.098로 전반적으로 낮았다. 애기원추리가 가장 높은 값을 나타내었다. 세대 당 이주하는 개체수는 매우 적었다(Nm=0.128). 원추리속 종은 계통도에서 세 분지군으로 나누어졌다. 한 그룹은 H. fulva, H. fulva for. kwanso, H. middendorffi였다. 다른 그룹은 Hemerocallis, H. dumortieri, H. thunbergii, H. minor였다. 나머지는 H. coreana와 H. hongdoensis로 두 번째 그룹과 자매군을 형성하였다. 비록 종 내 적은 개체수로 분석하였지만 원추리속 식물종이 ISSR 마커로 잘 분리되었다.