• Information and Communications Magazine
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• v.22 no.12
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• pp.105-119
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• 2005

광대역 유선통신망과 무선통신망이 통합되고, 통신과 방송이 융합되는 BcN 환경에서는 서비스 품질(QoS)이 보장되는 다양한 종류의 멀티미디어 서비스가 제공될 수 있어야하며, 다수의 통신방사업자가 제공하는 BcN들 간에 QoS 보장형 차별화서비스 제공을 위한 inter-domain 트래픽 엔지니어링 기능이 제공되어야한다. 특히, BcN 구축 초기 단계에서는 각 통신망 사업자가 개별적으로 구축 및 운영하는 BcN의 NNI signaling과 망운용관리 기능에 많은 차이점이 존재할 것으로 예상되기 때문에, 이들을 효율적으로 연동시킬 수 있는 inter-domain networking 기능 구현방안이 상세히 연구되어야한다. 본 논문에서는 BcN 환경에서의 QoS 보장형 차별화서비스제공을 위한 inter-domain 네트워킹 기술에 대하여 각 영역별로 살펴보며, 상용 BcN간 연동에 적용될 수 있는 트래픽 엔지니어링 및 관련 구현 기술에 대하여 살펴본다. Inter-domain networking 기능 모델로는 유럽연합(EU)의 IP Premium 프로젝트의 일환으로 개발된 MESCAL (Management of End-to-End Quality of Service Across the Internet at Large)을 분석하며, 세부 기능 구현 방안으로 MPLS NNI signaling 기반의 제어정면 연동방안, Web service 구조와 XML 기반의 망운용관리 평면 연동기능 구현 방안에 대하며 살펴본다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11B
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• pp.945-952
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• 2006

In hierarchical mobile IPv6 networks, when an inter-domain handover occurs, mobile nodes suffer from excessive signaling traffic and long handover latency, resulting in possible disruption of ongoing connections. Further, the selection of MAP and its load status critically affect the overall system performance. Therefore, we propose a dynamic MAP selection scheme that seeks to distribute load among MAPs as well as reduces inter-domain handovers. Performance is evaluated from not only an analytic model of average signaling cost but also simulation. The analytical and simulation results show that our proposed scheme improves load distributedness and reduces inter-domain handovers and signaling cost compared to another existing IETF based approach.

• BMB Reports
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• v.32 no.3
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• pp.215-225
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• 1999

Phytochromes (with gene family members phyA, B, C, D, and E) are a wavelength-dependent light sensor or switch for gene regulation that underscore a number of photo responsive developmental and morphogenic processes in plants. Recently, phytochrome-like pigment proteins have also been discovered in prokaryotes, possibly functioning as an auto-phosphorylating/phosphate-relaying two-component signaling system (Yeh et al., 1997). Phytochromes are photochromically convertible between the light sensing Pr and regulatory active Pfr forms. Red light converts Pr to Pfr, the latter having a "switch-on" conformation. The Pfr form triggers signal transduction pathways to the downstream responses including the expression of photosynthetic and other growth-regulating genes. The components involved in and the molecular mechanisms of the light signal transduction pathways are largely unknown, although G-proteins, protein kinases, and secondary messengers such as $Ca^{2+}$ ions and cGMP are implicated. The 124-127 kDa phytochromes form homodimeric structures. The N-terminal half contains the tetrapyrrolic phytochromobilin for red/far-red light absorption. The C-terminal half includes both a dimerization motif and regulatory box where the red light signal perceived by the chromophore-domain is recognized and transduced to initiate the signal transduction cascade. A working model for the inter-domain signal communication within the phytochrome molecule is proposed in this Review.

• Journal of Photoscience
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• v.7 no.3
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• pp.79-86
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• 2000

Phytochromes are red and far-red light absorbing photoreceptors for photomorphogenesis in plants. The red/far wavelength reversible biliproteins are made up of two structural domains. The light-perceiving function of the photoreceptor resides in the N-terminal domain, whereas the signal transducing regulatory function is located within the C-terminal domain. The characteristic role of the phytochromes as phtosensory molecular switches is derived from the phototransformation between two distinct spectral forms, the red light absorbing Pr and the far-red light absorbing Pfr forms. The photoinduced Pr Pfr phototransformation accompanies subtle conformational changes throughout the phytochrome molecule. The conformational signals are subsequently transmitted to the C-terminal domain through various inter-domain crosstalks and induce the interaction of the activated C-terminal domain with phytochrome interacting factors. Thus the inter-domain crosstalks play critical roles in the photoactivation of the phytochromes. Posttranslational modifications, such as the phosphorylation of Ser-598, are also involved in this process through conformational changes and by modulating inter-domain signaling.

• International journal of advanced smart convergence
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• v.1 no.2
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• pp.1-11
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• 2012

IP-based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health care, home automation, environmental monitoring, industrial control, vehicle telematics, and agricultural monitoring. In all these applications, a fundamental issue is the mobility in the sensor network, particularly with regards to energy efficiency. Because of the energy inefficiency of network-based mobility management protocols, they can be supported via IP-WSNs. In this paper, we propose a network-based mobility-supported IP-WSN protocol called mSFP, or the mSFP: "Multicasting-supported Inter-Domain Mobility Management Scheme in Sensor-based Fast Proxy Mobile IPv6 Networks". Based on [8,20], we present its network architecture and evaluate its performance by considering the signaling and mobility cost. Our analysis shows that the proposed scheme reduces the signaling cost, total cost, and mobility cost. With respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 7% and the total cost by 3%. With respect to the number of hops, the proposed scheme reduces the signaling cost by 6.9%, the total cost by 2.5%, and the mobility cost by 1.5%. With respect to the number of IP-WSN nodes, the proposed scheme reduces the mobility cost by 1.6%.

• Proceedings of the Korean Magnetic Resonance Society Conference
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• 2002.08a
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• pp.90-90
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• 2002

Syndecans, transmembrane heparan sulfate proteoglycans, are coreceptors with integrin in cell adhesion process. It forms a ternary signaling complex with protein kinase C and phosphatidylinositol 4,5 bisphosphate (PIP2) for integrin signaling. NMR data indicates that cytoplasmic domain of syndecan-4 (4L) undergoes a conformational transition in the presence of PIP2, forming oligomeric conformation. The structure based on NMR data demonstrated that syndecan-4L itself forms a compact intertwined symmetric dimer with an unusual clamp shape for residues Leu$^{186}$ -Ala$^{195}$ . The molecular surface of the syndecan-4L dimer is highly positively charged. In addition, no inter-subunit NOEs in membrane proximal amino acid resides (Cl region) has been observed, demonstrating that the Cl region is mostly unstructured in syndecan-4L dimmer. However, the complex structure in the presence of PIP2 induced a high order multimeric conformation in solution. In addition, phosphorylation of cytoplasmic domain induces conformational change of syndecan-4, resulting inhibition of PKC signaling. The NMR structural data strongly suggest that PIP2 promotes oligomerization of syndecan-4 cytoplasmic domain for PKC activation and further induces structural reorganization of syndecan for mediating signaling network in cell adhesion procedure.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.12
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• pp.125-135
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• 2003

In this paper, we developmed and implemented router and bandwidth broker that provides end-to-end QoS in differentiated service IP networks. Our design goal is to provide end-to-end premium service using the EF PHB. The bandwidth broker and router were implemented in the FreeBSD 4.6 platform. For the DiffServ router, we implemented QoS daemon, rollback managment routine, monitoring, and COPS-PR client. Also, Ive implemented bandwith broker which has SLS and resource management function, and signaling protocols for interfacing intra-and inter-domain. On the testbed, we have validated and evaluated the performance of the implemented DiffServ router and bandwidth broker using the inter-domain signaling protocol client in MS Windows platform. The test results show that the end-to-end QoS can be guaranteed for the inter-domain diffServ by the implemented system.

• Journal of the Korean Magnetic Resonance Society
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• v.21 no.2
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• pp.72-77
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• 2017

${\beta}-catenin$ is a key signaling protein which regulates cell signaling and gene transcription. Abnormal activation of ${\beta}-catenin$ is linked to many cancers, particularly with colorectal cancers. Although many genetic and biological studies on $Wnt/{\beta}-catenin$ have been reported and structures of the complex between ${\beta}-catenin$ and its diverse binding partners have been published, many of them have focused on armadillo repeat domain of ${\beta}-catenin$. Both N- and C-terminal domains have been suggested to regulate interactions of ${\beta}-catenin$ with other molecules, but still little is known about the C-terminal unstructured domain. To investigate the structure of this domain, construct of C-terminus was designed and structural studies were performed using size exclusion chromatography (SEC), circular dichroism (CD), fluorescence and nuclear magnetic resonance (NMR) spectroscopy. We observed that not only the purified full-length construct but the purified C-terminal construct also dimerizes in solution by SEC, suggesting that this domain involves in dimerization of ${\beta}-catenin$. CD and fluorescence data indicate its flexibility and structural formation in the presence of membrane environments.

• KIPS Transactions on Computer and Communication Systems
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• v.1 no.2
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• pp.87-98
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• 2012

In recent years, there are many data and multimedia services that are supported by WiFi-enabled mobile devices. As a result, the demand for the ability to connect to the Internet anywhere is rapidly increasing and network infrastructure is becoming increasingly important. The design of cost-efficient network mobility (NEMO) protocol is intended to reduce the demand for limited wired/wireless network bandwidth at the signaling of mobility support and packet delivery operations. In this paper, we propose a cost-effective inter-LMA domain mobility management scheme which provides fast handover with multicasting support in NEMO environments. And our Fast PR-NEMO scheme is compared with N-PMIPv6, rNEMO, and PR-NEMO. In conclusion, our proposed scheme shows the best performance in terms of location updating cost, and packet tunneling cost.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.1
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• pp.15-26
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• 2013

IP-based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health-care, home automation, environmental monitoring, industrial control, vehicle telematics and agricultural monitoring. In all these applications, mobility in the sensor network with special attention to energy efficiency is a major issue to be addressed. Because of the energy inefficiency of networks-based mobility management protocols can be supported in IP-WSN. In this paper we propose a network based mobility supported IP-WSN protocol called Multicasting-based inter-Domain Mobility Management Scheme in Sensor-based Fast Proxy Mobile IPv6 Networks (mSFP). Based on [8,20], We present its network architecture and evaluate its performance by considering the signaling and mobility cost. Our analysis shows that the proposed scheme reduces the signaling cost, total cost, and mobility cost. With respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 7% and the total cost by 3%. With respect to the number of hops, the proposed scheme reduces the signaling cost by 6.9%, the total cost by 2.5%, and the mobility cost by 1.5%. With respect to the number of IP-WSN nodes, the proposed scheme reduces the mobility cost by 1.6%.