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Determination of Tiapride in Human Plasma Using Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry

  • Moon, Ya;Paek, In-Bok;Kim, Hui-Hyun;Ji, Hye-Young;Lee, Hye-Won;Park, Hyoung-Geun;Lee, Hye-Suk
    • Archives of Pharmacal Research
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    • v.27 no.9
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    • pp.901-905
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    • 2004
  • A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric(HILIC-MS/MS) method for the determination of tiapride in human plasma was developed. Tiapride and internal standard, metoclopramide were extracted from human plasma with dichloromethane at basic pH and analyzed on an Atlantis HILIC silica column with the mobile phase of acetonitrile-ammonium formate (190 mM, pH 3.0) (94:6, v/v). The ana-Iytes were detected using an electrospray ionization tandem mass spectrometry in the multi-ple-reaction-monitoring mode. The standard curve was linear (r=0.999) over the concentration range of 1.00-200 ng/mL. The coefficient of variation and relative error for intra- and inter-assay at three QC levels were 6.4∼8.8% and -2.0∼3.6%, respectively. The recoveries of tiapride ranged from 96.3 to 97.4%, with that of metoclopramide (internal standard) being 94.2%. The lower limit of quantification for tiapride was 1.00 ng/mL using 1 00 $\mu$L of plasma sample.

Study on the Effect of Membrane Module Configuration on Pervaporative Performance through Model Simulation (모델모사를 이용한 막모듈 연결 및 배열이 투과증발 막성능에 끼치는 영향에 관한 연구)

  • Yeom, Choong-Kyun;Yoon, Seok-Bok;Park, You-In
    • Membrane Journal
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    • v.18 no.4
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    • pp.294-305
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    • 2008
  • This study was focused on the investigation of the effects of membrane module configuration and the temperature of feed retentate flowing along with module length on membrane performance through model simulation. A simulation model of pervaporative dehydration through membrane module assemble in which a number of unit modules are connected in parallel or in series has been established. In this study, ethanol/water mixture was used as model mixture. Some of permeation parameters in the model were quantified directly from the real dehydration pervaporation of ethanol through a lab-made membrane. By adopting the coefficients determined empirically the simulation model could be of more practical value. The simulation of pervaporation with two basic module configurations, that is, parallel connection and series connection, could present the importance of process parameters such as feed rate, module connection mode, number of stages, and inter-stage heating.

Lossless Compression for Hyperspectral Images based on Adaptive Band Selection and Adaptive Predictor Selection

  • Zhu, Fuquan;Wang, Huajun;Yang, Liping;Li, Changguo;Wang, Sen
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.14 no.8
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    • pp.3295-3311
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    • 2020
  • With the wide application of hyperspectral images, it becomes more and more important to compress hyperspectral images. Conventional recursive least squares (CRLS) algorithm has great potentiality in lossless compression for hyperspectral images. The prediction accuracy of CRLS is closely related to the correlations between the reference bands and the current band, and the similarity between pixels in prediction context. According to this characteristic, we present an improved CRLS with adaptive band selection and adaptive predictor selection (CRLS-ABS-APS). Firstly, a spectral vector correlation coefficient-based k-means clustering algorithm is employed to generate clustering map. Afterwards, an adaptive band selection strategy based on inter-spectral correlation coefficient is adopted to select the reference bands for each band. Then, an adaptive predictor selection strategy based on clustering map is adopted to select the optimal CRLS predictor for each pixel. In addition, a double snake scan mode is used to further improve the similarity of prediction context, and a recursive average estimation method is used to accelerate the local average calculation. Finally, the prediction residuals are entropy encoded by arithmetic encoder. Experiments on the Airborne Visible Infrared Imaging Spectrometer (AVIRIS) 2006 data set show that the CRLS-ABS-APS achieves average bit rates of 3.28 bpp, 5.55 bpp and 2.39 bpp on the three subsets, respectively. The results indicate that the CRLS-ABS-APS effectively improves the compression effect with lower computation complexity, and outperforms to the current state-of-the-art methods.

A 12.5-Gb/s Low Power Receiver with Equalizer Adaptation (이퀄라이저 적응기를 포함한 12.5-Gb/s 저전력 수신단 설계)

  • Kang, Jung-Myung;Jung, Woo-Chul;Kwon, Kee-Won;Chun, Jung-Hoon
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.12
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    • pp.71-79
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    • 2013
  • This paper describes a 12.5 Gb/s low-power receiver design with equalizer adaptation. The receiver adapts to channel and chip process variation by adaptation circuit using sampler and serializer. The adaptation principle is explained. It describes technique receiving ground referenced differential signal of voltage-mode transmitter for low-power. The CTLE(Continuous Time Linear Equalizer) having 17.6 dB peaking gain to remove long tail ISI caused channel with -21 dB attenuation. The voltage margin is 210 mV and the timing margin is 0.75 UI in eye diagram. The receiver consumes 0.87 mW/Gb/s low power in 45 nm CMOS technology.

A study on integrating and discovery of semantic based knowledge model (의미 기반의 지식모델 통합과 탐색에 관한 연구)

  • Chun, Seung-Su
    • Journal of Internet Computing and Services
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    • v.15 no.6
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    • pp.99-106
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    • 2014
  • Generation and analysis methods have been proposed in recent years, such as using a natural language and formal language processing, artificial intelligence algorithms based knowledge model is effective meaning. its semantic based knowledge model has been used effective decision making tree and problem solving about specific context. and it was based on static generation and regression analysis, trend analysis with behavioral model, simulation support for macroeconomic forecasting mode on especially in a variety of complex systems and social network analysis. In this study, in this sense, integrating knowledge-based models, This paper propose a text mining derived from the inter-Topic model Integrated formal methods and Algorithms. First, a method for converting automatically knowledge map is derived from text mining keyword map and integrate it into the semantic knowledge model for this purpose. This paper propose an algorithm to derive a method of projecting a significant topic map from the map and the keyword semantically equivalent model. Integrated semantic-based knowledge model is available.

The effect of sigma phases formation depending on Cr/Ni equivalent ratio in AISI 316L austenitic stainless steel weldments. (AISI 316L 용접부의 시그마상 형성에 영향을 미치는 크롬/니켈 당량비)

  • Kim, Y.H.;Jang, A.Y.;Choi, C.H.;Kang, D.H.;Jeon, J.H.;Byun, J.C.;Jung, G.H.;Lee, S.H.;Lee, H.W.
    • Proceedings of the KWS Conference
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    • 2010.05a
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    • pp.21-21
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    • 2010
  • AISI 316L 용접금속의 크롬/니켈 당량비에 따른 시그마상의 영향을 알아보기 위하여 응고모드가 다른 3종류의 플럭스 코어드 와이어를 제작하였다. AISI 316L 시편에 FCAW 프로세스를 적용한 용접재를 $650^{\circ}C$, $750^{\circ}C$, $850^{\circ}C$, $950^{\circ}C$에서 각 각 1H, 5H, 24H, 72H동안 열처리하였다. 크롬/니켈 당량비가 높을수록 즉, 크롬의 함량이 높아질수록 $\delta$-페라이트 함량은 증가하였으며, $\delta$-페라이트는 고온에서 시그마상으로 변태되었다. $\delta$-페라이트는 $650^{\circ}C$에서 가장 느리게 분해되었으며 $850^{\circ}C$에서 가장 활발히 분해되었다. 용접부의 특성상 크롬과 니켈 등의 합금원소에 의하여 응고온도범위가 넓어져 $950^{\circ}C$에서도 시그마상이 석출되었으며, 5시간 이상 유지 시 구형으로 존재하였다. 충격시험 시 시그마상에 의해 취약해진 inter-dendrite 를 따라 파면이 형성되었으며, $-100^{\circ}C$이하의 극저온에서는 시그마상의 양과 무관하게 충격흡수에너지는 0에 가까워졌다. 하지만 3%미만의 $\delta$-페라이트를 함유하는 AF모드에서 발생한 DDC와 미량의 시그마상은 충격흡수에너지에 결정적인 영향을 미치지 않았다.

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HPLC-tandem Mass Spectrometric Analysis of the Marker Compounds in Forsythiae Fructus and Multivariate Analysis

  • Cho, Hwang-Eui;Ahn, Su-Youn;Son, In-Seop;Hwang, Gyung-Hwa;Kim, Sun-Chun;Woo, Mi-Hee;Lee, Seung-Ho;Son, Jong-Keun;Hong, Jin-Tae;Moon, Dong-Cheul
    • Natural Product Sciences
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    • v.17 no.2
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    • pp.147-159
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    • 2011
  • A high-performance liquid chromatography-electrospray ionization-tandem mass spectrometric method was developed to determine simultaneously eight marker constituents of Forsythiae fructus, and subsequently applied it to classify its two botanical origins. The marker compounds of Forsythia suspensa were phillyrin, pinoresinol, phillygenin, lariciresinol and forsythiaside; those of F.viridissima were arctiin, arctigenin and matairesinol. Separation of the eight analytes was achieved on a phenyl-hexyl column (150${\times}$2.0 mm i.d., 3 ${\mu}M$) using gradient elution with the mobile phase: (A) 10% acetonitrile in 0.5% acetic acid, (B) 40% aqueous acetonitrile. A few fragment ions specific to the types of lignans, among the product ions generated by collisonally induced dissociation (CID) of molecular ion clusters, such as [M-H]$^-$ or [M+OAc]$^-$ were used not only for fingerprinting analysis but for the quantification of each epimer by using multiple-reaction monitoring mode. It was shown good linearity ($r^2{\geq}$ 0.9998) over the wide range of all analytes; intra- and inter-day precisions (RSD, %) were within 9.14% and the accuracy ranged from 84.3 to 115.1%. The analytical results of 40 drug samples, combined with multivariate statistical analyses - principal component analysis (PCA) and hierarchical cluster analysis (HCA) - clearly demonstrated the classification of the test samples according to their botanical origins. This method would provide a practical strategy for assessing the authenticity or quality of the herbal drug.

Exploring Fashion Trends Using Network Analysis (사회연결망 분석을 활용한 패션 트렌드 고찰)

  • Park, Jisoo;Lee, Yuri
    • Journal of the Korean Society of Clothing and Textiles
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    • v.38 no.5
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    • pp.611-626
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    • 2014
  • Reading and foreseeing fashion trends is crucial and difficult in the fashion industry due to accelerated and diversified changes in fashion trends. We use network analysis to investigate fashion trends from 2004 to 2013 in order to find the inter-relevance among fashion trends. We extracted words from fashion trend info for women's wear provided by Samsung Design Net, created a 2-mode network of seasons and trend languages, and visualized this network using NodeXl program. Fashion trends repeated a unique pattern during the period. In the first half (2004-2008), retro modern, feminine modern, and ecological modern were dominant trends in consecutive order. The years 2009-2013 witnessed distinctive fashion trends in S/S seasons and in F/W seasons. 11F/W, 12F/W and 13F/W seasons were characterized by artistic creative style. From 2010, natural style dominated S/S seasons. 10S/S and 12S/S seasons were distinguished as a calm natural style that reflected a peaceful and simple life. In 11S/S and 13S/S seasons, soft natural style emerged as a sign of increased importance of inner spirit and natural energy. A seasonal reappearance of trends was observed every two years in S/S seasons that enabled the prediction that 14S/S will see another version of natural style. A macroscopic trend for the last 10 years was represented by the keywords 'modern' and 'natural'. 'Modern' involved the past styles such as 60's, Baroque and the origin of human life. 'Natural' was connected with design elements such as material, silhouette and color. Managerial implications and future study directions are discussed based on the results.

An adaptive frequency-selective weighted prediction of residual signal for efficient RGB video compression coding (능률적 RGB 비디오 압축 부호화를 위한 잔여신호의 적응적 주파수-선택 가중 예측 기법)

  • Jeong, Jin-Woo;Choe, Yoon-Sik;Kim, Yong-Goo
    • Journal of Broadcast Engineering
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    • v.15 no.4
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    • pp.527-539
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    • 2010
  • Most video coding systems use YCbCr color space for their inputs, but RGB space is more preferred in the field of high fidelity video because the compression gain from YCbCr becomes disappeared in the high quality operation region. In order to improve the coding performance of RGB video signal, this paper presents an adaptive frequency-selective weighted prediction algorithm. Based on the sign agreement and the strength of frequency-domain correlation of residual color planes, the proposed scheme adaptively selects the frequency elements as well as the corresponding prediction weights for better utilization of inter-plane correlation of RGB signal. Experimental results showed that the proposed algorithm improves the coding gain of around 13% bitrate reduction, on average, compared to the common mode of 4:4:4 video coding in the state-of-the-art video compression standard, H.264/AVC.

Efficient Fast Multiple Reference Frame Selection Technique for H.264/AVC (H.264/AVC에서의 효율적인 고속 다중 참조 프레임 선택 기법)

  • Lee, Hyun-Woo;Ryu, Jong-Min;Jeong, Je-Chang
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.33 no.10C
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    • pp.820-828
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    • 2008
  • In order to achieve high coding efficiency, H.264/AVC video coding standard adopts the techniques such as variable block size coding, motion estimation with quarter-pel precision, multiple reference frames, rate-distortion optimization, and etc. However, these coding methods have a defect to greatly increase the complexity for motion estimation. Particularly, from multiple reference frame motion estimation, the computational burden increases in proportion to the number of the searched reference frames. Therefore, we propose the method to reduce the complexity by controlling the number of the searched reference frames in motion estimation. Proposed algorithm uses the optimal reference frame information in both $P16{\times}16$ mode and the adjacent blocks, thus omits unnecessary searching process in the rest of inter modes. Experimental results show the proposed method can save an average of 57.31% of the coding time with negligible quality and bit-rate difference. This method also can be adopted with any of the existing motion estimation algorithm. Therefore, additional performance improvement can be obtained.