• Management & Information Systems Review
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• v.33 no.1
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• pp.191-217
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• 2014

The Purpose of this study is to find the effect factors of R&D investment in SMEs which plays an important role in the national economy, and the differences of the effect factors by the type of SMEs. The subject of this study is about 3,400 SMEs mentioned in "The survey of technical statistics on SMEs in 2007" by Korea Federation of Small and Medium Business. The effect factors are related with the size of business, the infrastructure of R&D and the activities of R&D which have been studied by many researchers. The methods of analysis are regression analysis, moderating effect analysis and the software package used is SPSS 12.0. The results of the study are as fallow. First, it was found that unlike in previous studies which show the effect of the elements of business's size, research infrastructure, research activities on R&D investment, one element alone can't be considered for meaningful result but the various elements have effect on R&D investment at the same time. In other words, the number of employees and the sales as the elements of business's size, the ratio of researchers, the technical ability, the ratio of equipment possession and the intellectual properties as the elements of R&D infrastructure, the activity of ideas and joint research as the elements of R&D activities have positive(+) effect, whereas the participation of CEO in the activity of R&D as the elements of R&D activities activity has negative(-) one. The number of employees, the ratio of researchers, and the sales had relatively high influence whereas equipment possession, technical ability, intellectual properties, the participation of CEO in the research, the activity of idea, joint research had relatively low influence. Next, it was also found that there are differences of the effect factors over the types of SMEs. SMEs were classified into 19 types by eight criteria such as start-ups and existing business by business age; small business and medium business by size; manufacturing business and service business by product type;independent business and subcontractor business by dealing type; businesses in the entering, growing, maturing and restructuring stage by growth stage; businesses with low, medium and high technology by technological level; pioneering business and non-pioneering business by industrial type; and businesses with state-of-the-art technology and non-advanced business by the level of business activities. The meaning of this study lies in the fact that it found the various effect factors should be considered at the same time when conducting study on SMEs' R&D investment, and the differences by the type should be acknowledged. This study surpassed the limitations of the previous studies which focused on a couple of factors and types. This study result can also be considered for other studies on achievement, organization, marketing and others. Moreover, it shows that a differential policy by business type is needed when formulating SME policy.

• Journal of Life Science
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• v.19 no.5
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• pp.620-624
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• 2009

D-Ala2-Leu5-enkephalin (DADLE), a hibernation inducer, can induce hibernation-like state in vivo and in vitro. We treated U937 human leukemia cancer cells with DADLE and investigated its possible effect on transcription and proliferation. Treatment of U937 cells with DADLE resulted in growth inhibition and induction of apoptotic cell death on high-dose as measured by MTT assay and DNA flow cytometer analysis. Bcl-XL, c-IAP-2 and survivin genes especially showed decreases in mRNA levels. DADLE treatment also inhibited the levels of cyclooxygenase (COX)-2 mRNA without alteration of COX-1 expression. DNA flow cytometer analysis revealed that DADLE caused arrest of the cell cycle on low-dose, which was associated with a down-regulation of cyclin E at the transcriptional level. DADLE treatment induced a marked down-regulation of cyclin-dependent kinase (Cdk)-2, -4 and -6. In addition, treatment with DADLE decreased telomere associated genes such as, c-myc and TERT, and increased TEP-1 in U937 cells. These results suggest that DADLE can be an inhibition agent in the cell cycle of the human leukemia cancer U937 cell.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.9 no.1
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• pp.51-55
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• 2013

Lennox-Gastaut syndrome (LGS) is a severe form of childhood epilepsy that is defined by generalized multiple type seizures, slowness of intellectual growth, and a specific EEG disturbance. Children affected might previously have infantile spasms or underlying brain disorder but etiology can be idiopathic. LGS seizures are often treatment resistant and the long term prognosis is poor. A 14-year-3-month old, 20.5 kg girl with LGS was scheduled for dental treatment under general anesthesia. The patient presented with multiple caries and heavy calculus. General anesthesia was induced and maintained with inhalation agent, Sevoflurane. And caries treatment, scaling, subgingival curretage were performed. LGS patients usually have poor oral hygiene due to mental retardation and have high risk of seizure during dental treatment. In dental treatment under general anesthesia for LGS, it must be considered of seizure control during peri-operative period. Also periodic recall check, instruction of oral hygiene must be performed.

• Journal of the Korean Data and Information Science Society
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• v.26 no.4
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• pp.947-956
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• 2015

In the knowledge and information age, to discover and protect Intellectual Properties would be very important for their economic value as a major growth engine. This study evaluated the reliability of a Delphi survey conducted by experts to assess the value of agricultural resources knowledge obtained from literature reviews and field interviews. Delphi method is collecting the opinions of experts for several rounds repeatedly, in the next round the experts have chance to modify their opinion. Scores between two rounds are highly correlated and standard deviations are declined for second round to imply that some correction of their evaluations are made. To check reliability of Delphi survey of two rounds Cronbach's reliability coefficient and Generalizability coefficient are derived. The Cronbach alpha's supported the reliability of the method, but the Generalizability analysis revealed some unexpected results while checking the variance components of sources of measurement errors. Despite the increased reliability coefficients, the deviations between the raters are increased which means that additional rounds are required to get consensus, the goal of Delphi research.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.13 no.3
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• pp.85-98
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• 2018

This study aims to investigate the effects of venture & inno-biz companies' technological innovation competences on technological performances and economic competitive advantage, using VRIO framework. The empirical data for this study were based on the technology assessment results of Korea Technology Finance Corporation (KOTEC) on 3,462 venture & inno-biz companies and the following 2 years' financial data. Sample companies with technological innovation resources, such as technology management strategy(Value), differentiation of technology(Rarity), imitation difficulty of technology(Imitability) and technical organization capability(Organization), made efforts to expand their intellectual property rights, technological development and commercialization of new products, thereby ensuring technological competitive advantage. Furthermore, technological competitive advantage were proved to improve sales growth, increase in operating revenue, and financial soundness. Compared with four VRIO factors' influence on business performance, imitation difficulty of technology(Imitability) and organization technological capability(Organization) had much more influence than any other internal resources or capabilities respectively.

• Journal of Hospice and Palliative Care
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• v.14 no.3
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• pp.163-171
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• 2011

Purpose: This study tested a model of hospice volunteer's motivations and outcomes to encourage more volunteer workers to participate in hospice care. Methods: This included 200 volunteers who attended the Autumn Conference in 2007 and 132 volunteers from five hospice organizations. Results: Volunteers' existential well-being affected an endogenous variable of volunteers' participation in volunteer activities. The durability of volunteer activity was affected by value motivation, the level of participation in volunteer activities and the level of job satisfaction. For volunteers' job satisfaction level, valid endogenous variables included existential well-being, social motivation, understanding motivation and value motivation. The durability of volunteer activities was indirectly affected through three different paths. Volunteers' existential well-being determined the level of their participation in volunteer activities, which in turn affected the durability of such activities. Social motivation influenced volunteers' job satisfaction, and then the durability of volunteer activities. Volunteers' understanding of motivation also influenced their job satisfaction, and then the durability of volunteer activities. Conclusion: Based on these results, this study proposes that the durability of volunteers activities could be improved by developing a program to improve volunteers' well-being and by providing volunteers with education on altruistic values, encouraging them to seek intellectual growth, and advocating them to continue volunteer activities based on close relationships with other volunteers.

• Korean Journal of Cognitive Science
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• v.28 no.4
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• pp.267-297
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• 2017

The anatomical structure of the brain reflects a great amount of information about an individual's cognitive ability. The present study reviewed research on developmental changes in brain structure in relation to biological maturation and intellectual growth focusing on children and adolescents. The purpose of the present study was to achieve an understanding of how children and adolescents' brain matures with development and also to examine whether individual differences in intelligence influences the development of brain structure. The first section introduces methods of measurement and analysis of brain structure, such as voxel-based morphometry and structural covariance. The second section reviews studies on the biological maturation of the brain and variables that influence brain development such as sex, environmental factors, and mental disorders, etc. The third section introduces the Parieto-Frontal Integration Theory of intelligence and reviews studies on the association between intelligence and developmental changes of the brain, including changes in structural covariance and functional connectivity. We conclude with a discussion on educational/clinical implications of this work and directions for future studies.

• The Journal of the Korea Contents Association
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• v.17 no.3
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• pp.532-541
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• 2017

Design is an extremely critical and important for the prosperity and development of a corporation, and design for children's facilities can be said to be a critical factor not only from a commercial perspective but also one of the critical factors that can be beneficial to the physical, intellectual and emotional growth and development of children. To measure the economic value of publicly designed children's facilities established with the purpose of children's design education, this research study utilized the Contingent Valuation Method. This research study attempts to provide useful information for policy administrators on the usage of both publicly designed children's facilities with high use value and also high non-use value through economic value measurement. To achieve the objectives of this research, the Contingent Valuation Method that utilized both open-ended questions and also double-bounded dichotomous choice methodologies was used. The results of the pre-verification that used the open-ended questions results from 50 test subject participants and the double-bounded dichotomous choice methodology results from 530 test subject participants confirmed that the average annual per person expense was estimated to be KRW 12,463. The gross benefit amount figure estimated for all households in the nation was estimated to be about KRW 219 billion annually.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.593-604
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• 2011

This study examines potential growth and different perspectives on green-walls, which are being re-evaluated recently. The aim is to identify the viewer preferences concerning the walls by collecting a wide spectrum of information to create an interior design related comprehensive and intellectual database. Also based on this proposition, choosing a green surface of indoor wall as a specific example stimulus, identifying a relationship betweeationsviewer's preference factors. The relationship will formulate detailed and absolute qualities, which will reach potential areas that the green walls can be widely applied in. As a result of a factor analysis, the viewers classified into the 3 factors as is pleasant, gorgeous and rich about the stimulus. Preferred key factors, which are closely related to emotional image language, were; cool, tidy, comfortable and beautiful. The common factors in preferred design stimulus, in order of importance are color>elements>image/form/plants. Specific levels of design factors according to relevance are contrast>furniture> modern>central/creeper foliage plants. In the meantime, this study is leading the process of quantitative measurement of green-walls to a new design direction and it is critical to consistently experimenting to back up the theory with solid evidence.

• Journal of the Korean Data and Information Science Society
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• v.23 no.6
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• pp.1145-1154
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• 2012

Recent research has been mostly focused on the differences of prenatal sex hormone could affect the ratio of the lengths of the second to fourth digits (2D:4D) as well as the rate of several physiological characteristics. It has been suggested that digit ratios are thought to be associated with either higher prenatal testosterone levels or greater sensitivity to androgens, or both. However, a study of person with disabilities are rare in Korea. The purpose of this study was to compare patterns of the ratio (2D:4D) of the lengths of the second and fourth digits in persons with disabilities and students without disabilities. Also, we empirically analyze the characteristics of persons with disabilities. We found that finger length ratio (2D:4D) of men with disabilities and student without disabilities were lower than women with disabilities and student without disabilities. Therefore, it could be confirmed that finger length ratio (2D:4D) is sexually dimorphic trait. There were no correlations between finger length ratio (2D:4D) and age group in persons with disabilities. Therefore, as with person without disabilities, the 2D:4D ratio was negatively associated with a growth process of persons with disabilities. Finally, There was no difference correlations between finger length ratio (2D:4D) and level of disability in persons with intellectual disabilities. From this, one possible explanation for this is that if finger length ratio (2D:4D) is related to person with disability then current classification of the level of disability deserves further investigation.