• Analytical Science and Technology
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• v.35 no.3
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• pp.93-115
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• 2022

Potential impurities in pharmaceuticals could be produced during manufacture, distribution, and storage and affect quality and safety of pharmaceuticals. In particular, highly reactive impurities could result in carcinogenic (mutagenic) effects on human body. International Conference on Harmonisation (ICH) has provided M7(R1) guideline for "Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk" and recommended an adoption of this guideline to the authorities. ICH M7(R1) guideline provides classification, accepted intakes, and controls of potential impurities in pharmaceuticals. However, since appropriate and unified analytical methods for impurities in pharmaceuticals have not been provided in this guideline, most potential impurities in pharmaceuticals are still difficult to manage and supervise by pharmaceutical companies and regulatory authorities, respectively. In this review, we briefly described definition of unintended mutagenic impurities, basic information in ICH M7(R1) guideline, and analytical methods to determine potential impurities. This review would be helpful to manage and supervise potential impurities in pharmaceuticals by pharmaceutical companies and regulatory authorities.

• Smart Media Journal
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• v.11 no.3
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• pp.39-53
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• 2022

Cloud of Things (CoT) can provide IoT applications with unlimited storage functions and processing power supported by cloud services. However, in a centralized cloud of things, it can create a single point of failure that can lead to bottleneck problems, outages of the CoT network. In this paper, to solve the problem of centralized cloud of things and interoperate between different service domains, we propose an IoT service interoperability system using distributed fog computing and blockchain technology. Distributed fog is used to provide real-time data processing and services in fog systems located at a geographically close distance to IoT devices, and to enable service interoperability between each fog using smart contracts and distributed ledgers of the blockchain. The proposed system provides services within a region close to the distributed fog entrusted with the service from the cloud, and it is possible to access the services of other fogs without going through the cloud even between fogs. In addition, by sharing a service right token issuance information between the cloud and fog nodes using a blockchain network, the integrity of the token can be guaranteed and reliable service interoperability between fog nodes can be performed.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.36-41
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• 2021

Although the technology for prediction or analysis using artificial intelligence is constantly developing, a black-box problem does not interpret the decision-making process. Therefore, the decision process of the AI model can not be interpreted from the user's point of view, which leads to unreliable results. We investigated the problems of artificial intelligence and explainable artificial intelligence using Blockchain to solve them. Data from the decision-making process of artificial intelligence models, which can be explained with Blockchain, are stored in Blockchain with time stamps, among other things. Blockchain provides anti-counterfeiting of the stored data, and due to the nature of Blockchain, it allows free access to data such as decision processes stored in blocks. The difficulty of creating explainable artificial intelligence models is a large part of the complexity of existing models. Therefore, using the point cloud to increase the efficiency of 3D data processing and the processing procedures will shorten the decision-making process to facilitate an explainable artificial intelligence model. To solve the oracle problem, which may lead to data falsification or corruption when storing data in the Blockchain, a blockchain artificial intelligence problem was solved by proposing a blockchain-based explainable artificial intelligence model that passes through an intermediary in the storage process.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.84-91
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• 2021

In the 21st century, a number of storm and flood disasters caused by rapidly changing climate change is increasing, and the number of flood accidents at construction sites is also increasing. However, no specific reduction measures have been presented and thereby safety management to prevent flood accident need to be improved. Therefore, in this study, the inundation pattern by downpour at the excavation site was interpreted and the inundation risk quantification method was used to classify the risk magnitude. Finally, using the fish-bone diagram, we derived the major reasons of inundation accident at construction site systematically. The simulation results showed that the inundation depths of small-scale excavation sites and excavation sites exceeded 3 m due to the fluid flowing through the excavation surface. In addition, depending on the excavation site, a high velocity temporarily observed and decreased due to the storage effect, or high velocity surpassing 10 m/s continued. Since this type of flooding can pose a risk to most or all workers, if proper management measures are insufficient, fatal damage to life and property could occur. Consideration of the roots of these disasters is judged to be helpful in understanding the causes of inundation accidents that result in casualties and presenting accident reduction measures.

• Journal of Korea Water Resources Association
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• v.54 no.7
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• pp.495-507
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• 2021

With the recent industrial development, accidental pollution in riverine environments has frequently occurred. It is thus necessary to simulate pollutant transport and dispersion using water quality models for predicting pollutant residence times. In this study, we conducted a field experiment in a meandering reach of the Sum River, South Korea, to validate the field applicability and prediction accuracy of RAMS+ (River Analysis and Modeling System+), which is a two-dimensional (2D) stream flow/water quality analysis program. As a result of the simulation, the flow analysis model HDM-2Di and the water quality analysis model CTM-2D-TX accurately simulated the 2D flow characteristics, and transport and mixing behaviors of the pollutant tracer, respectively. In particular, CTM-2D-TX adequately reproduced the elongation of the pollutant cloud, caused by the storage effect associated with local low-velocity zones. Furthermore, the transport model effectively simulated the secondary flow-driven lateral mixing at the meander bend via 2D dispersion coefficients. We calculated the residence time for the critical concentration, and it was elucidated that the calculated residence times are spatially heterogeneous, even in the channel-width direction. The findings of this study suggest that the 2D water quality model could be the accidental pollution analysis tool more efficient and accurate than one-dimensional models, which cannot produce the 2D information such as the 2D residence time distribution.

• Journal of the Korean Geosynthetics Society
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• v.21 no.4
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• pp.1-12
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• 2022

Generally, the plate load test and the field density test are conducted for compaction quality control in earthwork, and then additional analysis. Recently developed that the DCPT (Dynamic Cone Penetration Test) equipment for smart compaction quality control its the system are able to get location and real-time information about worker history management. The IoT-based the DCPT system improved the time-cost in the field compared traditional test, and the functions recording and storage of the DPI (Dynamic Cone Penetration Index) were automated. This paper describes using these DCPT equipment on in-situ and compared to the standards of the DCPT, and the compaction trend had be confirmed with DPI as the field test data. As a result, the DPI of the final compaction decreased by 1.4 times compared to the initial compaction, confirming the increase in the compaction strength of the subgrade compaction layer 10 to 14 cm deep from the surface. A trend of increasing compaction strength was observed. This showed a tendency to increase the compaction strength of the target DPI proposed by MnDOT and the results of the existing plate load test, but there was a difference in the increase rate. Therefore, additional studies are needed on domestic compaction materials and laboratory conditions for target DPI and correlation studies with the plate load tests. If this is reflected, it is suggested that DCPT will be widely used as smart construction equipment in earthworks.

• Journal of Internet Computing and Services
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• v.23 no.1
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• pp.135-145
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• 2022

This paper presented a method to build a predictable smart ammunition logistics system using the 4th industrial technology for ammunition logistics, which is the core functions in the field of defense and logistics. We have analyzed the current level of ammunition logistics with various perspectives such as domestic and overseas logistics policies, technology trends, ammunition logistics characteristics, the smart logistics certification measures by Ministry of Land, Infrastructure and Transport. As a result it is considered that the current ammunition logistics needs needs improvement. To improve this, we presented a direction based on the implications derived after analyzing various ongoing programs such as wired/wireless-based automation, smart ammunition depots, and logistics innovation of the army, navy, and air force that can be applied to the ammunition logistics. In order to implement a data-based smart ammunition logistics management system that can achieve innovation and efficiency of total life cycle while meeting changes in the battlefield environment, we presented 4 objectives such as "automation and modernization of field work", "3D-based storage management & improvement of issuing at war," and "data management for prediction-oriented ammunition management". it is expected that there will be benefits such as improvement of operational continuity, guarantee of ammunition reliability, budget reduction, improvement of inefficiencies such as delay, waiting, and double work, and reduction of accidents.

• The Journal of the Acoustical Society of Korea
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• v.42 no.5
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• pp.403-411
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• 2023

Functional ultrasound imaging, such as elasticity imaging and micro-blood flow Doppler imaging, enhances diagnostic capability by providing useful mechanical and functional information about tissues. However, the implementation of functional ultrasound imaging poses limitations such as the storage of vast amounts of data in Radio Frequency (RF) data acquisition and processing. In this paper, we propose a sub-Nyquist approach that reduces the amount of acquired axial samples for efficient shear-wave elasticity imaging. The proposed method acquires data at a sampling rate one-third lower than the conventional Nyquist sampling rate and tracks shear-wave signals through RF signals reconstructed using band-pass filtering-based interpolation. In this approach, the RF signal is assumed to have a fractional bandwidth of 67 %. To validate the approach, we reconstruct the shear-wave velocity images using shear-wave tracking data obtained by conventional and proposed approaches, and compare the group velocity, contrast-to-noise ratio, and structural similarity index measurement. We qualitatively and quantitatively demonstrate the potential of sub-Nyquist sampling-based shear-wave elasticity imaging, indicating that our approach could be practically useful in three-dimensional shear-wave elasticity imaging, where a massive amount of ultrasound data is required.

• Journal of the Korean Society of Radiology
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• v.17 no.4
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• pp.557-564
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• 2023

In this study, 3D printing technology was used to compensate for the shortcomings of the use of lead, which has proven to have excellent shielding performance, and to control unnecessary human exposure. 3D printers can implement three-dimensional shapes and can immediately apply individual ideas, which has great advantages in maintaining technology supplementation while reducing the cost and duration of prototyping. Among the various special 3D printers, the FDM method was adopted, and the filament used for output was manufactured using a research extruder by mixing two materials, PLA (Poly-Lactic-Acid) and tungsten. The purpose was to verify the validity through dose evaluation and to provide basic information on the production of chapezones of various materials. The mixed filament was implemented as a morphological shield. Filaments made of a research extruder by mixing PLA and tungsten were divided into 10 %, 20 %, 30 %, 40 %, and 50 % according to the tungsten content ratio. Through the process of 3D Modeling, STL File storage, G-code generation, and output, 10 cm × 10 cm × 0.5 cm was manufactured, respectively, and dose and shielding ability were evaluated under the conditions of tube voltages of 60 kVp, 80 kVp, 100 kVp, 120 kVp, and tube currents of 20 mAs and 40 mAs.

• Journal of the Korean Society of Radiology
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• v.17 no.6
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• pp.947-955
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• 2023

This study was conducted to investigate the awareness of spent nuclear fuel among residents in nuclear power plant areas and use it as basic data for establishing a disposal facility for high-level radioactive waste. 204 questionnaires collected online were analyzed using SPSS Window Ver 28.0. To verify differences between groups, t-test and one-way ANOVA were performed. And correlation analysis was conducted to confirm the relationship between variables. As a result, first, risk perception regarding nuclear-related accidents showed statistically significant differences depending on gender and educational level. The position on the construction of a permanent disposal facility for spent nuclear fuel showed a statistically significant difference depending on gender, education, and age, and the perception of the importance of each evaluation standard for establishing a spent nuclear fuel management plan showed a statistically significant difference depending on education and age. In terms of trust in information-providing institutions, trust in the National Assembly was found to be the lowest. Second, the results of the correlation analysis between variables showed that local residents are aware that an alternative to the current disposal of spent nuclear fuel is needed, and that financial support for the construction of a permanent disposal facility is needed. Therefore, in order to build a high-level radioactive waste disposal site, it is believed that it is necessary to increase trust in the government, collect opinions from local residents, and provide economic support.