• Journal of Power System Engineering
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• v.17 no.4
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• pp.139-146
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• 2013

Because the magnetic bearing supports levitating body without contact, wear, noise and vibration, it is very useful to high revolution machinery. In this paper we selected ATmega 128, a less expensive and widely used micro controller, for control the magnetic bearing system. And we selected the sampling time and the control gain of PID controller through trial-and-error. The control program of the one board controller utilized lookup table to reduce calculation time, and bit shifting for the integer calculation in instead of floating point calculation. As the results, the controller carried out relatively high speed PID control on sampling time 0.25 ms. At last the rotation test for the magnetic bearing system was carried out by 3 phase induction motor and air turbine.

• BMB Reports
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• v.52 no.1
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• The Korean Journal of Pain
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• v.33 no.2
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• pp.121-130
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• 2020

Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory pain models. Methods: TENS 60 Hz, 200 ㎲, 90% motor threshold (MT), SCS was applied at 60 Hz, an intensity of 90% MT, and a 0.25 ms pulse width. MA was performed by inserting a stainless-steel needle to a depth of about 4-5 mm at the Sanyinjiao (SP6) and Zusanli (ST36) acupoints on a spared nerve injury (SNI), knee joint inflammation (3% carrageenan), and non-inflammatory muscle pain (intramuscular pH 4.0 injections) in rats. Mechanical withdrawal thresholds of the paw, muscle, and/or joint were assessed before and after induction of the pain model, and daily before and after treatment. Results: The reduced withdrawal thresholds were significantly reversed by application of either TENS or SCS (P < 0.05). MA, on the other hand, increased the withdrawal threshold in animals with SNI and joint inflammation, but not chronic muscle pain. Conclusions: TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models while MA is only effective in inflammatory and neuropathic pain models.

• IMMUNE NETWORK
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• v.13 no.4
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• pp.157-162
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• 2013

Application of vaccine materials through oral mucosal route confers great economical advantage in animal farming industry due to much less vaccination cost compared with that of injection-based vaccination. In particular, oral administration of recombinant protein antigen against foot-and- mouth disease virus (FMDV) is an ideal strategy because it is safe from FMDV transmission during vaccine production and can induce antigen-specific immune response in mucosal compartments, where FMDV infection has been initiated, which is hardly achievable through parenteral immunization. Given that effective delivery of vaccine materials into immune inductive sites is prerequisite for effective oral mucosal vaccination, M cell-targeting strategy is crucial in successful vaccination since M cells are main gateway for luminal antigen influx into mucosal lymphoid tissue. Here, we applied previously identified M cell-targeting ligand Co1 to VP1 of FMDV in order to test the possible oral mucosal vaccination against FMDV infection. M cell-targeting ligand Co1-conjugated VP1 interacted efficiently with M cells of Peyer's patch. In addition, oral administration of ligand-conjugated VP1 enhanced the induction of VP1-specific IgG and IgA responses in systemic and mucosal compartments, respectively, in comparison with those from oral administration of VP1 alone. In addition, the enhanced VP1-specific immune response was found to be due to antigen-specific Th2-type cytokine production. Collectively, it is suggested that the M cell-targeting strategy could be applied to develop efficient oral mucosal vaccine against FMDV infection.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.7
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• pp.1020-1025
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• 2002

Government R＆D Programs' success and failures depend on the choice of the excellent project from diverse proposal. Therefore project evaluation process should be transparency, objectivity and confidence. Institute of Information Technology and Assessment(IITA) working for the Ministry of Information and Communication(MIC). IITA management the informatization fund and government R & D program. IITA have execute choice of R & D project and assessment proposals and reformed the system of evaluation. This advanced evaluation system made in the end of the 90's and adapted it to the college basic R & D program in 1999. Advanced evaluation system is electronic and remote system. This advantage is very shift and correct to process. So the system save the task and money from 46% to 78%. But it is some Problem, security and technical experts for the choice of the Government R & D project in remote evaluation system.

• The Journal of Korean Institute for Practical Engineering Education
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• v.4 no.1
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• pp.80-85
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• 2012

The importance of warehouse is increasing since the role of warehouse in modern industry is changing from concept of storage to concept of circulation which facilitates purchasing, production, storage and distribution activities by induction of information system. In this study, a program is developed using C# for evaluating efficiency of automated storage and retrieval system(AS/RS). A simulation work is done for eight operating schemes under the combination of three conditions, which are storing method, the shape of automatic warehouse and the sequence of command performs, and the moving distance of stacker crane is calculated using the same gateway data. Using this program, the optimal operating scheme can be proposed based on the analyzed results of simulation. This progrm shows the effectiveness and applicability through the simulation work and can be utilized for courses which are related to factory facilities.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.640-645
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• 2020

To produce an input device stably using the transparent electromagnetic pattern of an electromagnetic induction method, pattern inspection is required in advance in the production process. Various methods of inspecting the capacitive pattern for hand-touch have been proposed, but it is difficult to find the related technical data for the pattern inspection method of the transparent electromagnetic induction method. In this study, to develop an inspection system for a fused electromagnetic resonance pen sensor with a copper-etched metal mesh pattern, an inspection algorithm and method for measuring the antenna impedance inside the sensor was proposed by measuring only the exposed FPCB connector. The proposed method was configured as a control board consisting of a microprocessor that forms a loop between specific channels according to the command of a computer, a computer-controlled by the Windows program, an LCR meter measuring the impedance between specific channels, and transmitting the measurement results back to the computer. An evaluation of the proposed system and measurements of nine specimens showed that it could detect the defects of the sensor used in the actual product.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.414-420
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• 2005

The ShortStack Micro Server enables any product that contains a microcontroller or microprocessor to quickly and inexpensively become a networked, Internet-accessible device. The ShortStack Micro Server provides a simple way to add LonWorks networking to new or existing smart devices. . It implements the LonTalk protocol and provides the physical interface with the LonWorks communication. The ShortStack host processor can be an 8, 16, or 32-bit microprocessor or microcontrollers. The ShortStack API and driver typically require about 4kbytes of program memory on the host processor and less than 200 bytes of RAM. The interface between host processor and the ShortStack Micro Server may be a Serial Communication Interface (SCI). The LonWorks control module with a high performance is developed, which is composed of the 8 bit PIC Microprocessor for host processor and the smart neuron chip for the ShortStack Micro Server. This intelligent control board is verified as proceeding the various function tests from experimental system with an boost pump and inverter driving systems. It is also confirmed that the developed control module provides stably 0-10VDC linear signal to the input signal of inverter driving system for varying the induction motor speed. Thus, the experimental results show that the fabricating intelligent board carried out very well the various functions in the wide operating ranges of boost pump system. This developed control module expect to apply to industrial fields to require the comparatively exact control and monitoring such as multi-motor driving system with inverter, variable air volume system and the boost pump water supply systems.

• Clinical and Experimental Reproductive Medicine
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• v.20 no.1
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• pp.37-43
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• 1993

In 27 patients with the past history of poor response to the gonadotropin superovulation induction due to poor follicular growth or permature surge of endogenous luteinizing hormone, the effectiveness of pituitary supperssion with the gonadotropin releasing hormone agonist(GnRH-a) in in vitro fertilization(IVF) program was evaluated in 43 cycles using a combination regimen of D-Trp-6 LHRH(Decapeptyl, Ferring)and FSH/hMG from June, 1989 to August, 1990 at Korea University Hospital IVF Clinic. At midluteal phase of menstrual cycle, Decapeptyl-CR was administered by long-term protocol to minimize initial agonistic effect of endogenous gonadotropins. After the confirmation of pituitary suppression, about 2-3 weeks after GNRH-a administration, ovarian follicle growth was stimulated with FSH/hMG and followed by transvaginal ultrasonic measurement of follicle size and by monitoring of serm E2 and LH if necessary. When compared with the control group stimulated with gonadotropin regimen only, the cancellation rate and occurrence rate of premature LH surge during gonadotropin treatment were significantly lower in study group(11.6% and 2.4%, respectively). There is no significant differences in the mean number of aspirated oocytes, fertilization/cleavage rate, embryo transfer(ET) rate, and mean number of embryos transferred between the two groups. The pregnancy rate per treatment cycle, 16.3%, and per ET cycle, 23.3%, were significantly higher in the study group compared with those of control group. These data suggest that GnRH-a therapy is effective for previous poor responder In gonadotropin superovulation induction for IVF.

• Journal of Plant Biotechnology
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• v.37 no.4
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• pp.343-356
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• 2010

Plant micropropagation techniques include bud cultures using apical or axillary buds, organogenesis through callus culture or adventitious bud induction, and somatic embryogenesis. In Korea Forest Research Institute (KFRI), the first tissue culture trial in woody plant was initiated from the bud culture of hybrid poplars (Populus alba x P. glandulosa) in 1978. Since then several mass propagation techniques have developed from conifer and hardwood species, resulting in allowing practical application to Poplars, Birches and some oak species. In addition, useful micropropagation and genetic resources conservation techniques were established in some rare and endangered tree species including Abeliophyllum distichum. Among various in vitro propagation techniques, somatic embryogenesis is known to be the most efficient plant regeneration system. Since the first somatic embryo induction was reported in Tilia amurensis by KFRI in 1986, various protocols for direct or indirect somatic embryogenesis systems have developed in conifer and hardwood species including Larix leptolepis, Pinus rigida x P. taeda F1, Kalopanax septemlobus and Liliodendron tulipifera, etc. However, most of these technologies have been developed using juvenile tissues, i.e. immature zygotic embryos or mature embryos. Therefore it has been difficult to directly application to tree breeding program due to their unproven genetic background. Recently remarkable progresses and new approaches have been achieved in mature tree somatic embryogenesis. In this article we reviewed several micropropagation techniques, which have been mainly developed by KFRI and recent international progresses.