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http://dx.doi.org/10.3344/kjp.2020.33.2.121

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models  

Sato, Karina Laurenti (Department of Physical Therapy, Federal University of Sergipe)
Sanada, Luciana Sayuri (Department of Physical Therapy, Physiotherapy Postgraduate Program, Santa Catarina State University)
da Silva, Morgana Duarte (Department of Physical Therapy, Federal University of Pampa)
Okubo, Rodrigo (Department of Physical Therapy, Physiotherapy Postgraduate Program, Santa Catarina State University)
Sluka, Kathleen A. (Department of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa)
Publication Information
The Korean Journal of Pain / v.33, no.2, 2020 , pp. 121-130 More about this Journal
Abstract
Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory pain models. Methods: TENS 60 Hz, 200 ㎲, 90% motor threshold (MT), SCS was applied at 60 Hz, an intensity of 90% MT, and a 0.25 ms pulse width. MA was performed by inserting a stainless-steel needle to a depth of about 4-5 mm at the Sanyinjiao (SP6) and Zusanli (ST36) acupoints on a spared nerve injury (SNI), knee joint inflammation (3% carrageenan), and non-inflammatory muscle pain (intramuscular pH 4.0 injections) in rats. Mechanical withdrawal thresholds of the paw, muscle, and/or joint were assessed before and after induction of the pain model, and daily before and after treatment. Results: The reduced withdrawal thresholds were significantly reversed by application of either TENS or SCS (P < 0.05). MA, on the other hand, increased the withdrawal threshold in animals with SNI and joint inflammation, but not chronic muscle pain. Conclusions: TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models while MA is only effective in inflammatory and neuropathic pain models.
Keywords
Acupuncture Therapy; Inflammation; Knee Joint; Myalgia; Neuralgia; Pain; Spinal Cord Stimulation; Transcutaneous Electric Nerve Stimulation;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Sluka KA, Judge MA, McColley MM, Reveiz PM, Taylor BM. Low frequency TENS is less effective than high frequency TENS at reducing inflammation-induced hyperalgesia in morphine-tolerant rats. Eur J Pain 2000; 4: 185-93.   DOI
2 Ma YT, Sluka KA. Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetized rats. Exp Brain Res 2001; 137: 94-102.   DOI
3 Matsuo H, Uchida K, Nakajima H, Guerrero AR, Watanabe S, Takeura N, et al. Early transcutaneous electrical nerve stimulation reduces hyperalgesia and decreases activation of spinal glial cells in mice with neuropathic pain. Pain 2014; 155: 1888-901.   DOI
4 Gibson W, Wand BM, Meads C, Catley MJ, O'Connell NE. Transcutaneous electrical nerve stimulation (TENS) for chronic pain - an overview of Cochrane Reviews. Cochrane Database Syst Rev 2019; 4: CD011890.
5 Nnoaham KE, Kumbang J. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev 2008; 3: CD003222.
6 Sluka KA, Bjordal JM, Marchand S, Rakel BA. What makes transcutaneous electrical nerve stimulation work? Making sense of the mixed results in the clinical literature. Phys Ther 2013; 93: 1397-402.   DOI
7 Cheing GL, Tsui AY, Lo SK, Hui-Chan CW. Optimal stimulation duration of tens in the management of osteoarthritic knee pain. J Rehabil Med 2003; 35: 62-8.   DOI
8 Johnson MI, Mulvey MR, Bagnall AM. Transcutaneous electrical nerve stimulation (TENS) for phantom pain and stump pain following amputation in adults. Cochrane Database Syst Rev 2015; 8: CD007264.
9 Jin DM, Xu Y, Geng DF, Yan TB. Effect of transcutaneous electrical nerve stimulation on symptomatic diabetic peripheral neuropathy: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract 2010; 89: 10-5.   DOI
10 Tokuda M, Tabira K, Masuda T, Nishiwada T, Shomoto K. Effect of modulated-frequency and modulated-intensity transcutaneous electrical nerve stimulation after abdominal surgery: a randomized controlled trial. Clin J Pain 2014; 30: 565-70.   DOI
11 Celik EC, Erhan B, Gunduz B, Lakse E. The effect of lowfrequency TENS in the treatment of neuropathic pain in patients with spinal cord injury. Spinal Cord 2013; 51: 334-7.   DOI
12 Yameen F, Shahbaz NN, Hasan Y, Fauz R, Abdullah M. Efficacy of transcutaneous electrical nerve stimulation and its different modes in patients with trigeminal neuralgia. J Pak Med Assoc 2011; 61: 437-9.
13 Sluka KA, Kalra A, Moore SA. Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. Muscle Nerve 2001; 24: 37-46.   DOI
14 Orr PM, Shank BC, Black AC. The role of pain classification systems in pain management. Crit Care Nurs Clin North Am 2017; 29: 407-18.   DOI
15 Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 2000; 87: 149-58.   DOI
16 Radhakrishnan R, Moore SA, Sluka KA. Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain 2003; 104: 567-77.   DOI
17 Lee JB, Choi SS, Ahn EH, Hahm KD, Suh JH, Leem JG, et al. Effect of perioperative perineural injection of dexamethasone and bupivacaine on a rat spared nerve injury model. Korean J Pain 2010; 23: 166-71.   DOI
18 Radhakrishnan R, Bement MK, Skyba D, Sluka KA, Kehl LJ. Models of muscle pain: carrageenan model and acidic saline model. Curr Protoc Pharmacol 2004; 25: 5.35.1-28.
19 Dailey DL, Rakel BA, Vance CG, Liebano RE, Amrit AS, Bush HM, et al. Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain 2013; 154: 2554-62.   DOI
20 Vance CG, Rakel BA, Blodgett NP, DeSantana JM, Amendola A, Zimmerman MB, et al. Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial. Phys Ther 2012; 92: 898-910.   DOI
21 Johnson M, Martinson M. Efficacy of electrical nerve stimulation for chronic musculoskeletal pain: a meta-analysis of randomized controlled trials. Pain 2007; 130: 157-65.   DOI
22 Sdrulla AD, Guan Y, Raja SN. Spinal cord stimulation: clinical efficacy and potential mechanisms. Pain Pract 2018; 18: 1048-67.   DOI
23 Buonocore M, Bonezzi C, Barolat G. Neurophysiological evidence of antidromic activation of large myelinated fibres in lower limbs during spinal cord stimulation. Spine (Phila Pa 1976) 2008; 33: E90-3.   DOI
24 Vallejo R, Bradley K, Kapural L. Spinal cord stimulation in chronic pain: mode of action. Spine (Phila Pa 1976) 2017; 42 Suppl 14: S53-60.   DOI
25 Cha MH, Choi JS, Bai SJ, Shim I, Lee HJ, Choi SM, et al. Antiallodynic effects of acupuncture in neuropathic rats. Yonsei Med J 2006; 47: 359-66.   DOI
26 Sato KL, Johanek LM, Sanada LS, Sluka KA. Spinal cord stimulation (SCS) improves decreased physical activity induced by nerve injury. Behav Neurosci 2014; 128: 625-32.   DOI
27 Beyaz SG, Bal NS. Spinal cord stimulation for a patient with neuropathic pain related to congenital syringomyelia. Korean J Pain 2017; 30: 229-30.   DOI
28 Lee SJ, Yoo YM, You JA, Shin SW, Kim TK, Abdi S, et al. Successful removal of permanent spinal cord stimulators in patients with complex regional pain syndrome after complete relief of pain. Korean J Pain 2019; 32: 47-50.   DOI
29 Plaster R, Vieira WB, Alencar FA, Nakano EY, Liebano RE. Immediate effects of electroacupuncture and manual acupuncture on pain, mobility and muscle strength in patients with knee osteoarthritis: a randomised controlled trial. Acupunct Med 2014; 32: 236-41.   DOI
30 Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci 2010; 13: 883-8.   DOI
31 Ezzo J, Hadhazy V, Birch S, Lao L, Kaplan G, Hochberg M, et al. Acupuncture for osteoarthritis of the knee: a systematic review. Arthritis Rheum 2001; 44: 819-25.   DOI
32 Cidral-Filho FJ, da Silva MD, More AO, Cordova MM, Werner MF, Santos AR. Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats. Neuroscience 2011; 193: 370-6.   DOI
33 Kalra A, Urban MO, Sluka KA. Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exp Ther 2001; 298: 257-63.
34 Maeda Y, Lisi TL, Vance CG, Sluka KA. Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats. Brain Res 2007; 1136: 43-50.   DOI
35 Song Z, Ansah OB, Meyerson BA, Pertovaara A, Linderoth B. Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus. Neuroscience 2013; 253: 426-34.   DOI
36 Takeshige C, Sato T, Mera T, Hisamitsu T, Fang J. Descending pain inhibitory system involved in acupuncture analgesia. Brain Res Bull 1992; 29: 617-34.   DOI
37 Mayer DJ. Biological mechanisms of acupuncture. Prog Brain Res 2000; 122: 457-77.   DOI
38 Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, et al. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet 2005; 366: 136-43.   DOI
39 Norrbrink C, Lundeberg T. Acupuncture and massage therapy for neuropathic pain following spinal cord injury: an exploratory study. Acupunct Med 2011; 29: 108-15.   DOI
40 Berman BM, Singh BB, Lao L, Langenberg P, Li H, Hadhazy V, et al. A randomized trial of acupuncture as an adjunctive therapy in osteoarthritis of the knee. Rheumatology (Oxford) 1999; 38: 346-54.   DOI
41 Vas J, Modesto M, Aguilar I, Santos-Rey K, Benitez-Parejo N, Rivas-Ruiz F. Effects of acupuncture on patients with fibromyalgia: study protocol of a multicentre randomized controlled trial. Trials 2011; 12: 59.   DOI
42 Yu YC, Koo ST, Kim CH, Lyu Y, Grady JJ, Chung JM. Two variables that can be used as pain indices in experimental animal models of arthritis. J Neurosci Methods 2002; 115: 107-13.   DOI
43 Zhao ZQ. Neural mechanism underlying acupuncture analgesia. Prog Neurobiol 2008; 85: 355-75.   DOI
44 da Silva MD, Bobinski F, Sato KL, Kolker SJ, Sluka KA, Santos AR. IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain. Mol Neurobiol 2015; 51: 19-31.   DOI
45 Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.   DOI
46 Sluka KA. Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation. J Pharmacol Exp Ther 1998; 287: 232-7.
47 Gopalkrishnan P, Sluka KA. Effect of varying frequency, intensity, and pulse duration of transcutaneous electrical nerve stimulation on primary hyperalgesia in inflamed rats. Arch Phys Med Rehabil 2000; 81: 984-90.   DOI
48 Skyba DA, Radhakrishnan R, Sluka KA. Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. J Pain 2005; 6: 41-7.   DOI
49 Gong W, Johanek LM, Sluka KA. Spinal cord stimulation reduces mechanical hyperalgesia and restores physical activity levels in animals with noninflammatory muscle pain in a frequency-dependent manner. Anesth Analg 2014; 119: 186-95.   DOI
50 da Silva MD, Guginski G, Werner MF, Baggio CH, Marcon R, Santos AR. Involvement of interleukin-10 in the anti-inflammatory effect of Sanyinjiao (SP6) acupuncture in a mouse model of peritonitis. Evid Based Complement Alternat Med 2011; 2011: 217946.