• Clinical and Experimental Reproductive Medicine
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• v.16 no.2
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• pp.211-220
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• 1989

The aim of this study was to compare the response and their outcome of superovulation induction protocol in IVF-ET program. One hundued seventy seven infertile women were stimulated by FSH/hMG(group I, N=128), clomiphene citrate/hMG(group II, N=51), and hMG(group III, N=18) for the purpose of ovulation induction. The results were as follows; 1. The mean ages of patients were $31.9{\pm}3.8$ in group I, $30.6{\pm}3.3$ in group II, and $29.3{\pm}2.5$ in group III. 2. The day of hCG administration was $11.1{\pm}1.8$ in group I, $12.1{\pm}2.0$ in group II, and $13.7{\pm}6.8$ in group III. The hCG administration day of group III was significantly delayed compared with that of group I (p<0.001). 3. The terminal E2 pattern in group II was different from those of group I and III, but there was no significant difference. 4. The mean numbers of mature eggs aspirated were $5.5{\pm}3.8$ in group I, $5.0{\pm}3.3$ in group II, and $5.6{\pm}5.4$ in group III. There was no significant differences in the mean numbers of mature eggs retrieved among the three groups. 5. The fertilization rate of eggs was significantly higher in group II (67.9%) than that of group I (52.2%)(p<0.001). 6. The cleavage rate of group I (67.0%) was significantly lower than those of group II (93.2%) and group III (95.8%) (p<0.0001). 7. The mean numbers of embryos transfered were $3.3{\pm}1.4$ in group I, $3.1{\pm}1.3$ in group II, and $3.2{\pm}1.6$ in group III and the ET rate was 69.0% in group I, 77.3% in group II, and 100% in group III. There was significant difference in ET rate between group I and group III (p<0.005). 8. The pregnancy rates per OPU cycle or ET cycle were not significantly different among the three groups, but delivered and ongoing pregnancy rates were significantly different between group I (36.8%) and group II (p<88.8%) (p<0.05).

• Journal of the Korean Institute of Gas
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• v.12 no.4
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• pp.29-33
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• 2008

The focus of this study is to develop a virtual reality program for safe training and virtual reality of hydrogen station. This programme consists of 4 modules such as hydrogen and safety module, hydrogen station module, hypothetical experience module, and accident scenarios module for hydrogen experts. User can experience with principles and operation condition and collect the information of hydrogen station by this programme and can simultaneously study the probable scenarios, emergency response plan/standard operating procedure about hydrogen stations. It makes it possible to educate and safety publicity for the trainee. This virtual reality program will be expected to be helpful for hydrogen station's construction propagation and technology development which is essential for hydrogen energy induction.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.6743-6750
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• 2015

The purpose of this study was to examine the perceptions between teachers and parents on the role and operation of Sejong Special Self-Governing City Early Childhood Education and Development Institute (ECED). The conclusions were as follows: First, more than 96% of the teachers and parents perceived that it was necessary to establish ECED, and the major role of the institute should be providing experience-based educational program. Second, the program of the institute should be organized based on interest induction of children and their creativity development, and cultural art experience-based education was the most desirable program for the weekend. Third, for the teacher support programs, professional development and empathy ability improvement were the key of the program, whereas the parents perceived that communication skills with their children and understanding of child development were essential. As a result, it was obvious that the needs of ECED establishment from teachers and parents were high, and the perceptions of both sides were not different.

• Molecules and Cells
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• v.25 no.4
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• pp.559-565
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• 2008

Members of the TGA family of basic domain/leucine zipper transcription factors regulate defense genes through physical interaction with NON-EXPRESSOR OF PR1 (NPR1). Of the seven TGA family members, TGA4/octopine synthase (ocs)-element-binding factor 4 (OBF4) is the least understood. Here we present evidence for a novel function of OBF4 as a regulator of flowering. We identified CONSTANS (CO), a positive regulator of floral induction, as an OBF4-interacting protein, in a yeast two-hybrid library screen. OBF4 interacts with the B-box region of CO. The abundance of OBF4 mRNA cycles with a 24 h rhythm under both long-day (LD) and short-day (SD) conditions, with significantly higher levels during the night than during the day. Electrophoretic mobility shift assays revealed that OBF4 binds to the promoter of the FLOWERING LOCUS T (FT) gene, a direct target of CO. We also found that, like CO and FT, an OBF4:GUS construct was prominently expressed in the vascular tissues of leaf, indicating that OBF4 can regulate FT expression through the formation of a protein complex with CO. Taken together, our results suggest that OBF4 may act as a link between defense responses and flowering.

• The Mathematical Education
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• v.38 no.2
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• pp.129-144
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• 1999

The purpose of our work is to developing the program of math. camp to improve underachiever's mathematical disposition. To do this, the following research were taken; (1)Analysis of current status of programs for underachievers (2)Analysis of inclination to mathematics(We collected the data from 2 classes of middle schools) (3)Prepare and apply the program of math. camp for the students including underachievers, and then analysis the effect of the math. camp The results of this study is as follows; (1)Only 40% of investigated schools have their own programs for underachievers. But almost all general high schools do not have such programs because students do not want. More than half of the investigated teachers suggested that the most important thing for underachievers is the induction of motivation for mathematics. (2)Many students dislike mathematics from 5∼6 grade of elementary school, and more than 50% of students think that 'measure' and 'equations' items are difficult. (3) After attending the math. camp based on the games and activities in small groups, the students in the middle-ranking group showed more positive reactions against the items of mathematical disposition and attitude tests. The students in the row-ranking group were improved in the 'self-confidence' and 'will' items of mathematical disposition test and in the 'superiority' and 'interest' items of mathematical attitude test.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.3
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• pp.1-9
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• 2009

Processing mail objects in a mail processing center involves several steps and operations, in particular dispatching as well as sorting by destination. The purpose of this paper is to present a model for the part-time worker staffing and allocation problem as it arises at the parcel sorting area in a mail processing center. The problem is formulated as a mixed integer linear program model to minimize the variable part-time workforce related cost. Hot only the characteristics of the sorting operations but also the dispatching requirements of the vehicles are reflected into the model. Six example problems with three different daily amounts of arriving mail are solved with LINGO to demonstrate the effectiveness of the 7-level induction option for the parcel sorting machine over the current 3-level one. The results indicate that measurable savings can be achieved by departing from current practice.

• Genomics & Informatics
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• v.5 no.2
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• pp.68-76
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• 2007

Due to the increasing interest in SNPs and mutational hot spots for disease traits, it is becoming more important to define and understand the relationship between SNPs and their flanking sequences. To study the effects of flanking sequences on SNPs, statistical approaches are necessary to assess bias in SNP data. In this study we mainly applied Markov chains for SNP sequences, particularly those located in intronic regions, and for analysis of in-del data. All of the pertaining sequences showed a significant tendency to generate particular SNP types. Most sequences flanking SNPs had lower complexities than average sequences, and some of them were associated with microsatellites. Moreover, many Alu repeats were found in the flanking sequences. We observed an elevated frequency of single-base-pair repeat-like sequences, mirror repeats, and palindromes in the SNP flanking sequence data. Alu repeats are hypothesized to be associated with C-to-T transition mutations or A-to-I RNA editing. In particular, the in-del data revealed an association between particular changes such as palindromes or mirror repeats. Results indicate that the mechanism of induction of in-del transitions is probably very different from that which is responsible for other SNPs. From a statistical perspective, frequent DNA lesions in some regions probably have effects on the occurrence of SNPs.

• Journal of Microbiology and Biotechnology
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• v.18 no.12
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• pp.1997-2003
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• 2008

Cordyceps militaris is well known as a traditional medicinal mushroom and has been shown to exhibit immunostimulatory and anticancer activities. In this study, we investigated the apoptosis induced by an aqueous extract of C. militaris (AECM) via the activation of caspases and altered mitochondrial membrane permeability in human breast cancer MDA-MB-231 cells. Exposure to AECM induced apoptosis, as demonstrated by a quantitative analysis of nuclear morphological change and a flow cytometric analysis. AECM increased hyperpolarization of mitochondrial membrane potential and promoted the activation of caspases. Both the cytotoxic effect and apoptotic characteristics induced by AECM treatment were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor, which demonstrates the important role of caspase-3 in the observed cytotoxic effect. AECM-induced apoptosis was associated with the inhibition of Akt activation in a time-dependent manner, and pretreatment with LY294002, a PI3K/Akt inhibitor, significantly increased AECM-induced apoptosis. The results indicated that AECM-induced apoptosis may relate to the activation of caspase-3 and mitochondria dysfunctions that correlate with the inactivation of Akt.

• Journal of the Korean Magnetics Society
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• v.5 no.5
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• pp.892-899
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• 1995

A numerical simulation program based on the finite elerrent method is developed for calculating electromagnetic field of the cylindrical electromagnetic pump. The calculated results by the developed program show that Lorentz forces show maximum peak at an optimum length ($L_c$) of the induction coil. The value of $L_c$ depends on the radius of the molten metal when the skin depth is large. On the other hand, the value of $L_c$ depends on the skin depth when it is small.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.205-211
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• 2021

In order to test the functionality of Panax ginseng thioredoxin 1 (PgTRX1) isolated from fermented wild ginseng roots, a transient effect on physiological activity were performed over a short time frame using the Agrobacterium infiltration technique. The PgTRX1 gene isolated from fermented wild ginseng was confirmed to have a size of 579 bp, and the expression of PgTRX1 was the highest in the sample after 6 h of fermentation. As a result of constructing this gene and confirming the infiltration reaction mediated by Agrobacterium in tobacco leaves, it was found that the expression of the NbHSR203j gene was also induced as PgTRX1 expression increased. As a result of measuring the biological activity of the infiltration samples, the total phenol content increased by 35.45±1.84 to 49.01±1.84 ㎍ GAE/mL compared to the control, and the total flavonoid amount of 9.52±0.41 to 9.82±0.25 ㎍ QE/mL was slightly high. From these results, Agrobacterium-mediated PgTRX1 appears to be related to the hypersensitive response induction mechanism of plants and the production of secondary metabolites such as phenolic substances.