• Journal of Ginseng Research
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• 제39권3호
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• pp.250-256
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• 2015

Background: It has been known that ginseng can be applied as a potential nutraceutical for memory impairment; however, experiments with animals of old age are few. Methods: To determine the memory enhancing effect of red ginseng, C57BL/6 mice (21 mo old) were given experimental diet pellets containing 0.12% red ginseng extract (approximately 200 mg/kg/d) for 3 mo. Young and old mice (4 mo and 21 mo old, respectively) were used as the control group. The effect of red ginseng, which ameliorated memory impairment in aged mice, was quantified using Y-maze test, novel objective test, and Morris water maze. Red ginseng ameliorated age-related declines in learning and memory in older mice. In addition, red ginseng's effect on the induction of inducible nitric oxide synthase and proinflammatory cytokines was investigated in the hippocampus of aged mice. Results: Red ginseng treatment suppressed the production of age-processed inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interleukin-$1{\beta}$ expressions. Moreover, it was observed that red ginseng had an antioxidative effect on aged mice. The suppressed glutathione level in aged mice was restored with red ginseng treatment. The antioxidative-related enzymes Nrf2 and HO-1 were increased with red ginseng treatment. Conclusion: The results revealed that when red ginseng is administered over long periods, age-related decline of learning and memory is ameliorated through anti-inflammatory activity.

• 자원리싸이클링
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• 제9권5호
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• pp.16-21
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• 2000

Generation of abnormally large grains in the microstructure of small grains has been investigated on some ferrites. Some fractions of large grains were observed in the microstructue of sintered ZnFe$_2$O$_4$, Mn-ZnFe$_2$O$_4$, Fe$_3$O$_4$(in $N_2$) and MnFe$_2$O$_4$(in air). On the other hand, the large grains were not observed in $NiFe_2$$O_4$ and $CoFe_2$$O_4$, independent of calcining and sintering conditions. The large grains seem to be generated in such ferrites that are easy to very their compositions or valencies at high temperatures. as the sintering proceeded, the number of large grains was increasing to from a continuous structure consisting of large grains, while the size of large grains did not increase remarkably. In addition, the growth of small grains was also very slow during the generation of the large grains. The large grains appeared be suddenly generated after some induction periods. Avrami equation could be applied to the relation between net volume of large grains and sintering time. Thus, the grain boundaries may be strongly stabilized when the large grains are generated. The large grain is generated y the local activation of the stabilized rain boundaries, which is caused by the variation of composition or valencies during sintering. It is concluded that the essence of the abnormal gain growth is not the generation of abnormally large grains, but the abnormal stabilization and the local activation of he grain boundaries.

• 한국임상수의학회지
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• 제10권2호
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• pp.215-220
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• 1993

The anesthetic effects by dosages of Tiletamlne-Zolazepam in the dogs were investigated and then the optimal dosages for the operation of patients were suggested. 1. In groups of T+Z 20, 10 and 5 mg/kg administration, anesthetic periods are 180~300, 33~47 and 40~50 minutes, respectively and complete recovery from anesthesia was shorted with taking 53~72 minutes in the group of 5 mg/kg administration. 2. Reflex responses to eyelids, cornea and pharyngolarynx were maintained but pedal reflexes became considerably sluggish 3. It showed tachycardias on ECG but there were no specific dysrhythmias. On EEG, it showed low voltage-fast waves before anesthesia, high voltage-fast waves in induction stage, low voltage-slow waves in anesthetic stage and high voltage-fast waves again in recovery stage. 4. Surgical procedures could be performed satisfactorily in 6 cases of the 10 mg/kg administration group, but in 3 of 5 cases of 5 mg/kg administration group it could be completed after additional administration. 5. In conclusion, it was considered desirable for anesthetizing dogs that for healthy cases T+Z at the level of 10 mg/kg B.W. was administered, and for poor risk patients, 5 mg/kg B.W., followed by an additional administration in unsatisfied cases.

• 한국식품영양과학회지
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• 제30권3호
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• pp.552-556
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• 2001

The purpose of this study was to investigate the antioxidant effect of aqueous green tea(AGT) on soybean oil. AGT was freeze-dried and 20% of the freeze-dried aqueous green tea powder (AGTP) was added to soybean oil in the quantities of 0.5%, 1% and 5%. Soybean oil without the addition of AGTP was used as a control. Soybean oil with 0.02% butylated hydroxytoluen(BHT) was used as another experimental sample. Each sample was stored at 6$0^{\circ}C$ for 15 days. The oxidation of these samples was determined by measuring the acid value (AV), peroxide value (POV), and thiobarbituric acid (TBA) value. The result showed that the acid values were lowest in 0.02% BHT, followed by the 0.5% AGTP, 1% AGTP, 5% AGTP and finally the control. When AGTP was added, the peroxide value was lower than both the control and 0.02% BHT. The lowest TBA values were in the 0.5% AGTP followed by 0.02% BHT, 1% AGTP, 5% AGTP and the control, respectively. The 5% AGTP (285 min), 1% AGTP (249 min) and 0.5% AGTP (238) demonstrated longer induction periods, compared to the control (204 min) and the BHT (229 min) by Rancimat method.

• 원예과학기술지
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• 제31권4호
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• pp.496-502
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• 2013

Grapes (Vitis vinifera) are one of the most important fruits worldwide and are eaten raw or after conversion to jelly, jam, juice and wine. Grape skins are a major source of resveratrol (3,5,4'-trihydroxystilbene), which has the ability to reduce blood sugar as well as anticancer, anti-inflammatory, and other beneficial cardiovascular effects. In this study, we investigated the increased accumulation of resveratrol in grape skin and leaves following ultrasonication treatment, which has been shown to induce resveratrol accumulation in several plants. Various ultrasonication treatment times and incubation periods were employed to identify the optimum conditions for the maximum accumulation of resveratrol. Treatment and further incubation led to increased resveratrol in both grape skins and leaves, with the highest increases of 7.7-fold and 1.9-fold occurring in response to 5 min ultrasonication treatment followed by 6 hour incubation and 15 min ultrasonication treatment followed by 3 hour incubation, respectively. The underlying mechanism for the increased amounts of resveratrol were studied by employing a semi-quantitative RT-PCR to monitor the expression levels of the resveratrol synthase (RS) gene in response to ultrasonication treatment. The RS gene increased the expression in response to ultrasonication treatment, suggesting that up-regulation of the RS gene by ultrasonication treatment triggers increased amounts of resveratrol. Taken together, these data indicate that this simple ultrasonication treatment of grapes can be an efficient post-harvest technology for increasing resveratrol in grape skins in addition to cleaning the fruits.

• Plant Biotechnology Reports
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• 제3권4호
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• pp.347-353
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• 2009

Procedures that induce microspore embryogenesis have been described for a range of Brassica species, but embryo yield remains low for a number of genotypes. We have carried out experiments with the microspores from a weakly responsive line of B. napus to determine the culture conditions that optimize their in vitro embryogenesis by treating them with effectors of ethylene synthesis and action. The results revealed that isolated microspores subjected to an initial heat stress in a medium supplemented with inhibitors of ethylene synthesis such as AVG and $CoCl_2$ exhibited significantly increased embryo yields. This suggested that regulatory effects are exerted by the ethylene produced by the isolated microspores on the early processes of gametogenesis. As a consequence, treatment of microspores with SAM, an ethylene synthesis precursor, or with the ethylene-releasing agent ethephon, led to decreases in embryo yield. A special response to ethylene during the early stages of microspore development was finally shown to occur through experiments where isolated microspores were treated for increasing periods of time with $CoCl_2$. Collectively, our data demonstrated that the induction of embryogenesis induced by heat stress can be enhanced by inhibitors of ethylene biosynthesis.

• 생명과학회지
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• 제6권2호
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• pp.111-119
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• 1996

The production of interleukin-1(IL-1)and nitric oxide(NO) by cultured fibroblast cells of human nasal turbinate was revealed by biological assay respectively. The cells were incubated for various periods of time in the presence of staphyloccocal toxic shock syndrome toxin-1(TSST-1) and house dust mite(Dermatophagoides farinae, HDM), and the culture supernatants were harvested. There was a little difference in the activities of IL-1beta and the amount of NO produced by the cells when stimulated with 0.002-0.1$\mu$g/ml of TSSTO-1 and 0.02-1$\mu$g/ml of HDM. The shapes of the time course curves for the production of IL-1beta and NO by the cells were different. Groups stimulated with TSST-1 or HDM produced more IL-beta in 2 h than no exposure group(Control). A certain mixed group(TSST-1, 10ng+mite, 100 ng) continued to produce IL-1beta highly throughout the entire incubation period. The cells stimulated with TSST-1 or HDM produced more NO in 2 h and 6 h than that produced in the end of incubation(48 h). Also, the mixed groups were generally similar. There results suggest that induction of IL-1beta by a certain mixed condition(TSST-1+mite) in fibroblast cell in vivo may play a role in inflammation.

• 한국식품과학회지
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• 제30권1호
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• pp.241-243
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• 1998

쌀 도정시 분리되는 쌀눈은 영양학적 가치로보아 식품자원으로 활용할 수 있어 이에 필요한 기초 자료로 쌀눈의 일반성분과 함께 저장 중 문제가 될 수 있는 유지의 변화를 처리방법별, 저장온도별로 관찰 하였다. 쌀눈의 주성분은 당질 36.5%, 조지방 21.6%, 조단백질 18.7%였고 열풍$(80^{\circ}C)$으로 6 시간 건조한 쌀눈과 처리하지 않은 (비처리) 쌀눈을 $60^{\circ}C$에 저장하면서 산가를 비교한 결과, 비처리 쌀눈 중 유지의 산가가 2배 상승하는데 소요되는 기간이 약 2일 이었으나, 건조쌀눈의 겨우 31 일 경과 후에도 1.15배에 그쳐 안정화 되었고, 이때 추출된 유지의 산패유도기간은 처리별로 큰 차이를 보이지 않았다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1994년도 하계학술대회 논문집 A
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• pp.189-191
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• 1994

YBCO bulks for levitation have fabricated using MPMG method. The superconducting properties and repulsive/attractive force against permanent magnet were investigated for the specimens annealed at various periods after MPMG. A linear induction motor type levitation - traveling vehicle using the pinning force of MPMG processed YBCO bulk has fabricated. The floating or hanging small vehicle mounted with two YBCO pellets was confirmed to travel stabley on the Nd-Fe-B permanent magnet track. The traveling speed of the vehicle was confirmed to depend on AC frequency linearly. At 200 Hz, the travel ins speed was found to be 110 cm/sec.

• 한국실내디자인학회논문집
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• 제15권6호
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• pp.238-246
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• 2006

Recent trends of interior design have a focus on creation of more various meanings rather than past ideology which sought after the compatibility to the function of modem design. These trends requires integral understanding of social and cultural ideologies with a sens of values for a certain periods. In addition, they also require creativity which able to read, find and solve consumer's diverse demand and desire. Considering the effort of trend forecasting in Korea is still heavily rely on the foreign trend shows, it is natural to attempt to study the analytical forecasting methodology based upon more systematic principles which lead to more objective outcome, when the understanding, forcasting and analysis of interior decoration trend are required. In this thesis, the analysis and forecasting of interior decoration trend are studied by means of verbal image code process which involves the induction of design concept through data extraction, classification and analysis, in order to understanding and satisfying the diversified consumer's demand and trend. The coding process of verbal image is understanding as general concept. by extracting common elements from abstract and individual image, and/or specific concept. Therefore, it is proposed that the database building and data mining process of verbal Image, and subsequent development of programming skill can be applied as more efficient tool for various verbal image process.