• Korean Management Science Review
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• v.15 no.1
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• pp.97-115
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• 1998

This study aims to develop the methodology based on the AHP(Analytic Hierarchy Process) of evaluation for commercial paper. commercial paper is the ma product of merchant banks. commercial paper evaluation is annually performed by the credit-evaluation agency. Credit evaluation is performed by the informal judgemental system, which has potential to induce serious inconsistencies in decision-making. We present an objective scoring model which does not suffer from the weakness of the subjective judgement system. The model used is illustrated by analyzing the commercial paper evaluation for the 3 motor-companies(H, K and S motors).

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.4
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• pp.321-327
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• 2021

Sevoflurane is familiar to anesthesiologists as an inhaled anesthetic to induce and maintain anesthesia; however, it has not been widely used for sedation. Recently, the use of sevoflurane for inhalational sedation has been increasing. Moreover, in Korea, the use of sevoflurane for conscious or deep sedation in dental care for children and the disabled is increasing, primarily by dental anesthesiologists. In this article, we reviewed a sedation method using sevoflurane.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.15-24
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• 2019

Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases and also have potential applications in regenerative medicine. Natural products have long been used as compounds to develop new drugs. In this review, natural products that control NSC fate and induce their differentiation into neurons or glia are discussed. These phytochemicals enable promising advances to be made in the treatment of neurodegenerative diseases.

• Health Policy and Management
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• v.31 no.3
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• pp.261-271
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• 2021

Background: In 2018, the government increased the fee for the magnetic resonance imaging (MRI) image deciphering services of the external hospital to discourage the redundant MRI scan and to induce appropriate use of the MRI services. It is important to evaluate the effect of the policy to provide the basis for establishing other MRI-related policies. Methods: The healthcare data of the patients who had brain MRI scans were organized by episode and analyzed using the panel study in order to find out the effect of the MRI-related policy on the substitution effect and the medical expenses. Results: As a result of the increase in the fee of deciphering the MRI image, there has been an uplift in deciphering the MRI scan of the external hospital. It implies that more hospitals chose to use the MRI scan taken by other clinics or hospitals, rather than the MRI scan taken at their own facilities. Conclusion: The research results imply that a policy that facilitates the exchange of the medical image data between the hospitals is needed in order to establish an efficient management system of the healthcare resources. Such improvement is expected to reduce the social cost and contribute to the stability in the finance of national health insurance.

• Molecules and Cells
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• v.38 no.6
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• pp.475-481
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• 2015

Programmable nucleases, which include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) repurposed from the type II clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system are now widely used for genome editing in higher eukaryotic cells and whole organisms, revolutionising almost every discipline in biological research, medicine, and biotechnology. All of these nucleases, however, induce off-target mutations at sites homologous in sequence with on-target sites, limiting their utility in many applications including gene or cell therapy. In this review, we compare methods for detecting nuclease off-target mutations. We also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid off-target mutations.

• Journal of Periodontal and Implant Science
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• v.43 no.1
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• pp.3-11
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• 2013

Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interaction of nonperiodontopathic versus periodontopathic bacteria with innate immune components encountered in the gingival sulcus will be described. In particular, we will describe the susceptibility of these microbes to antimicrobial peptides (AMPs) and phagocytosis by neutrophils, the induction of tissue-destructive mediators from neutrophils, the induction of AMPs and interleukin (IL)-8 from gingival epithelial cells, and the pattern recognition receptors that mediate the regulation of AMPs and IL-8 in gingival epithelial cells. This review indicates that true periodontal pathogens are poor activators/suppressors of a host immune response, and they evade host defense mechanisms.

• Toxicological Research
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• v.17
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• pp.211-216
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• 2001

Drugs can have various adverse effects on the immune system including unintended immun-osuppression, induction of both drug-specific immune responses (including drug allergies) and non-specific immunostimulation (including autoimmune reactions), and direct activation of effector mechanisms (such as histamine release). As a practical matter, the Center for Drug Evaluation (CDER) relies on standard non-clinical toxicology studies to detect unintended immunosuppression. Specific assays using guinea pigs and mice are available to identify drugs that can induce immune-mediated dermal hypersensitivity reactions. Respiratory and systemic hypersensitivity and autoimmune reactions are more difficult to model in non-clinical studies. Unintended nonspecific immunstimulation can be detected in animal studies. CDER is currently developing specific guidance for evaluating potential drug immunotoxicity.

• Journal of the Ergonomics Society of Korea
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• v.34 no.3
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• pp.217-222
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• 2015

Objective:The objective of this study is to review the exposure limits in the legislation, guidelines, and standards for human vibration in Korea. Background: There have been relatively less interests in vibration than other risk factors in Korea. However, the importance of vibration is increasing as industry and everyday life are more mechanized. Method: Various enforcements were examined including legislation, guidelines, and standards for whole-body vibration and localized vibration. Results: No exposure limits were found in legislation, guidelines, and standards for the human vibration in Korea. Conclusion: It is important to introduce new duties regarding vibration risks to the general duties. Further studies are expected on the vibration exposure limits appropriate for Korean people and job conditions. Application: The results from this study would be of help to induce more interests in human vibration to the occupational health and safety professionals of Korea.

• Genomics & Informatics
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• v.12 no.4
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• pp.136-144
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• 2014

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.

• Proceedings of the Korean Society of Computer Information Conference
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• 2019.07a
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• pp.343-344
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• 2019

본 논문에서는 교수자에게 큰 부담을 주지 않으면서 학습 효과를 높이기 위한 방법으로 문제풀이 기반의 자발적 복습을 지원하는 교수학습 모형을 제안하고 이를 수업 운영에 적용하였다. 학습자들에게 배포한 수업내용을 복습할 수 있는 문제들로 구성한 유인물은 단순히 해당 요일의 수업을 되풀이하여 익히는 소극적 의미에서의 복습이 아니라 이전 수업 내용들 간의 연관성을 이해할 수 있도록 문제를 구성하고 학습자들의 복습시 발생하는 어려움을 해결할 수 있도록 교수 전략을 수립한다.