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Predictor of Liver Biochemistry Improvement in Patients with Cytomegalovirus Cholestasis after Ganciclovir Treatment

  • Puspita, Gina;Widowati, Titis;Triono, Agung
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.25 no.1
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    • pp.70-78
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    • 2022
  • Purpose: Cholestasis resulting from cytomegalovirus (CMV)-induced hepatitis manifests in 40% of patients with a CMV infection. Ganciclovir treatment in children with CMV infections has proven to be highly effective. Until now, there are very few studies have identified predictive factors for liver biochemistry improvement after ganciclovir therapy. This study aimed to identify the predictors of liver biochemistry improvement in patients with CMV cholestasis after ganciclovir treatment. Methods: A retrospective cohort study was conducted using medical records from Dr. Sardjito General Hospital Yogyakarta, Indonesia from 2013 to 2018. CMV cholestasis was confirmed based on serum CMV IgG and IgM positivity and/or blood and urine CMV antigenemia positivity. Incomplete medical records and other etiologies for cholestasis, such as biliary atresia, choledochal cyst, metabolic diseases, and Alagille syndrome, were excluded. Patient age at cholestasis diagnosis and ganciclovir treatment, duration of CMV cholestasis, history of prematurity, central nervous system involvement, and nutritional status were analyzed and presented as an odds ratio (OR) with a 95% confidence interval (95% CI). Results: CMV cholestasis with ganciclovir therapy was found in 41 of 54 patients. Multivariate analysis showed that a shorter duration of CMV cholestasis (OR: 4.6, 95% CI: 1.00-21.07, p=0.04) was statistically significant for liver biochemistry improvement after 1 month of ganciclovir treatment. The remaining factors that were analyzed were not significant predictors of liver biochemistry improvement in patients with CMV cholestasis after ganciclovir treatment. Conclusion: A shorter duration of CMV cholestasis is the predictor of liver biochemistry improvement after 1 month gancyclovir treatment.

An Overview to the History of Social Forestry in Overcoming Poverty and Forest Conservation in Java's Colonial Period

  • Hum, Warto M.
    • Journal of Forest and Environmental Science
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    • v.38 no.1
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    • pp.1-11
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    • 2022
  • The Dutch colonial government introduced social forestry at the end of the 19th century with a commitment to controlling forest resources in the Dutch East Indies. This program was a response to the rampant deforestation which had resulted in forest degradation and poverty of the population around the forest. This study examined the practice of social forestry in the late colonial period which had not been done much. From a historical perspective, social forestry practices in Indonesia before independence could be explained more comprehensively. This study uses a historical method which includes four stages: heuristic, source criticism, interpretation, and historiography (composing historical stories). Sources of information were explored through studies of archival documents and contemporary artefacts, especially official colonial government reports and contemporary newspapers/magazines. Data from various sources are then compared and tested for validity to obtain data validity. The next stage is to build facts based on data obtained and then interpreted using the social science theories. Finally, compiling a historical (historiographical) story about social forestry during the late colonial period. The results showed that colonial forestry during the colonial period was still limited in terms of area and method, namely in the area of teak forest and involving villagers through the intercropping system. Farmers involved in these activities are called pesanggem who earn income from forest land being rejuvenated. However, the relationship between pesanggem and the forestry service has not been well institutionalized, consequently the pesanggem is often disadvantaged. Including certainty of ownership and ownership of forest land never gained clarity and even became a source of conflict.

A retrospective institutional study of human age determination by evaluating the pulp length and width ratio of the maxillary lateral incisor on panoramic radiographs in Indonesian subjects

  • Herianti, Vanessa Rizka;Oscandar, Fahmi;Dardjan, Murnisari
    • Imaging Science in Dentistry
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    • v.51 no.4
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    • pp.421-427
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    • 2021
  • Purpose: The pulp length to width (PL/W) ratio of the maxillary lateral incisor can be used as an age determination method. This study aimed to investigate the correlation between the PL/W ratio of the maxillary lateral incisor on panoramic radiographs and human chronological age in Indonesian subjects. Materials and Methods: This study analyzed with 134 maxillary lateral incisors on 113 panoramic radiographs from patients who visited the Oral and Maxillofacial Radiology Unit of Dental Hospital Universitas Padjadjaran, Bandung, Jawa Barat, Indonesia, from 2013 to 2018 (age range: between 11 to 60 years). The pulp length was measured from the pulp chamber roof to the apical foramen, and the pulp width was measured on the cervical area of the cementoenamel junction in millimeters using Fiji ImageJ open-source software. Simple linear regression (in SPSS) was used to analyze the results. The reliability of the observers was evaluated. Results: The PL/W ratio of the maxillary lateral incisor was significantly correlated with chronological age (P<0.01). No statistically significant difference was found in the PL/W ratio between the left and right maxillary lateral incisors(P=0.333). There was a very strong correlation (r=0.939) between the PL/W ratio of the maxillary lateral incisor and human chronological age, with the following formula: age= -3.057+1.875×PL/W ratio (R2=0.882, standard error of estimate: 4.659). Conclusion: The PL/W ratio of the maxillary lateral incisor on panoramic radiograph can be used for age determination in Indonesian subjects.

Analysis of Application Cases of Living Lab for Urban Water Resources: Focusing on Sam-bang Water Living Lab (도시 수자원 리빙랩 적용사례 분석: 김해시 삼방워터 리빙랩을 중심으로)

  • Lee, Nam Jung;Lee, Jung Hoon;Kum, Ah Ro
    • Journal of Information Technology Services
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    • v.20 no.6
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    • pp.141-150
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    • 2021
  • With the recent spread of the concept of Smart Cities which is to solve urban problems with ICT technology, Living Lab, which identifies the demands of citizens who dwell in the city and verifies the acceptability of the services being introduced, has become an important topic. Living Lab is an open innovation platform introduced in consideration of the user's perspective in real life and is a new approach in that service developers use collective intelligence in the process of Co-creation with users. Living Lab is operated on topics which is close to citizens' daily lives such as energy, housing, transportation, and education. In particular, as energy and environmental-focused Living Lab emerges in accordance with the 'Korean New Deal Policy', interest and importance in the field are increasing. The paper derives the characteristics of water resource Living Lab through case analysis of several Living Lab practices. Water resource Living Lab in Daejeon and Chuncheon, which are located in Korea, and water resource Living Lab in Romania and Indonesia are covered in this paper as the reference. The paper finally analyzes the case of Sambang Water Living Lab in Gimhae, which is the city located in southern part of Korea. As a result of case analysis, the urban water resource Living Lab focuses on the raw water of urban water resource and should respond sensitively to the safety of citizens. And for the success of this urban water resource Living Lab, it is essential to ensure that citizens participating in the Living Lab clearly understand the concept of water resources, and citizens' opinions to be implemented as services.

Open Communication About Reproductive Health Is Associated With Comprehensive HIV Knowledge and a Non-stigmatising Attitude Among Indonesian Youth: A Cross-sectional Study

  • Wirawan, Gede Benny Setia;Gustina, Ni Luh Zallila;Januraga, Pande Putu
    • Journal of Preventive Medicine and Public Health
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    • v.55 no.4
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    • pp.342-350
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    • 2022
  • Objectives: Human immunodeficiency virus (HIV) prevention among youth seems under-prioritised compared to other key populations. HIV knowledge and stigma are important parts of HIV prevention. To inform HIV prevention among youths, this study quantitatively analysed the associations between open communication regarding sexuality and sexual health, comprehensive HIV knowledge, and non-stigmatising attitudes in Indonesia. Methods: This study used data from the Indonesian Demographic and Health Survey (IDHS) 2017. The analysis included unmarried men and women aged 15-25 years old. Comprehensive HIV knowledge and a stigmatising attitude were defined according to the IDHS 2017. Open communication about sexuality and sexual health was defined as the number of people with whom participants could openly discuss these topics in their direct network of friends, family, and service providers, with a scale ranging from 0 to a maximum of 7. Primary analysis used binomial logistic regression with weighting adjustments. Results: The final analysis included 22 864 respondents. Twenty-two percent of youth had no one in their direct network with whom to openly discuss sexual matters, only 14.1% had comprehensive HIV knowledge, and 85.9% showed stigmatising attitudes. Youth mostly discussed sex with their friends (55.2%), and were less likely to discuss it with family members, showing a predominant pattern of peer-to-peer communication. Multivariate analysis showed that having a larger network for communication about sexuality and sexual health was associated with more HIV knowledge and less stigmatising attitudes. Conclusions: Having more opportunities for open sex communication in one's direct social network is associated with more HIV knowledge and less stigmatising attitudes.

The development of EASI-based multi-path analysis code for nuclear security system with variability extension

  • Andiwijayakusuma, Dinan;Setiadipura, Topan;Purqon, Acep;Su'ud, Zaki
    • Nuclear Engineering and Technology
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    • v.54 no.10
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    • pp.3604-3613
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    • 2022
  • The Physical Protection System (PPS) plays an important role and must effectively deal with various adversary attacks in nuclear security. In specific single adversary path scenarios, we can calculate the PPS effectiveness by EASI (Estimated Adversary Sequence Interruption) through Probability of Interruption (PI) calculation. EASI uses a single value of the probability of detection (PD) and the probability of alarm communications (PC) in the PPS. In this study, we develop a multi-path analysis code based on EASI to evaluate the effectiveness of PPS. Our quantification method for PI considers the variability and uncertainty of PD and PC value by Monte Carlo simulation. We converted the 2-D scheme of the nuclear facility into an Adversary Sequence Diagram (ASD). We used ASD to find the adversary path with the lowest probability of interruption as the most vulnerable paths (MVP). We examined a hypothetical facility (Hypothetical National Nuclear Research Facility - HNNRF) to confirm our code compared with EASI. The results show that implementing the variability extension can estimate the PI value and its associated uncertainty. The multi-path analysis code allows the analyst to make it easier to assess PPS with more extensive facilities with more complex adversary paths. However, the variability of the PD value in each protection element allows a significant decrease in the PI value. The possibility of this decrease needs to be an important concern for PPS designers to determine the PD value correctly or set a higher standard for PPS performance that remains reliable.

Students' Knowledge, Awareness, and Pro-Environmental Behavior in Urban to Design Climate Change Book Serials

  • Sigit, Diana Vivanti;Azrai, Eka Putri;Suryanda, Ade;Epriani, Melisa;Ichsan, Ilmi Zajuli;Rahman, Md. Mehadi;Rogayan, Danilo V. Jr.
    • Journal of People, Plants, and Environment
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    • v.24 no.5
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    • pp.509-517
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    • 2021
  • Background and objective: Problems currently occurred in the environment are caused by a lack of environmental awareness of the community. Biology students learn the environment in ecological learning. Students must explore environmental knowledge (EK) and are expected to have high environmental awareness (EA) and then apply their knowledge in daily life with pro-environmental behavior (PEB). There is a need for designing climate-change book serials for university students (CCBS-US) towards contextualized learning. This study aimed to determine the relationship between EK and EA and the PEB of biology students as a baseline for designing CCBS-US. Methods: The study used a quantitative descriptive method with a correlational design. Total 136 biology students from a state university in Jakarta, Indonesia served as samples of the study. Results: Research results revealed a positive relationship between EK and PEB of biology students. There was a positive relationship between EA and PEB of biology students and between EK and EA and PEB of Biology students. Moreover, 77% of students reported their EK is very high, 55% of students reported their EA is medium, and 46% of students reported their PEB is medium. Ecological learning has a vital role in shaping the EK, EA, and PEB, thus CCBS-US needs to be developed. Conclusion: The study concluded that there was a relationship between EK, EA, and PEB. The study recommends the development of CCBS-US based on the survey results.

Developmental characteristics and genetic diversity of the two-spotted cricket Gryllus bimaculatus De Geer, 1773 (Orthoptera: Gryllidae) in South Korea

  • Gyu-Dong, Chang;Su Hyun, Yum;Jeong-Hun, Song
    • International Journal of Industrial Entomology and Biomaterials
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    • v.45 no.2
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    • pp.115-125
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    • 2022
  • In this study, we investigated the developmental characteristics and genetic diversity of seven populations of two-spotted crickets (Gryllus bimaculatus De Geer, 1773 (Orthoptera: Gryllidae)) raised in South Korea. Regarding the developmental characteristics of the species, we observed no statistically significant difference in the weight of the nymphs in the six populations we tested. After molting, although weight differences were observed between the populations in each stage of the developmental period, the average weight for each developmental stage was constant. We also analyzed mitochondrial COI gene sequences (DNA barcoding region) of the reared crickets collected from five insect farms and two national insect rearing facilities and the resultant sequences were analyzed together with the 12 sequences from foreign countries specimens obtained from public data. We detected six haplotypes from 111 specimens, indicating a low intraspecific genetic distance (~1.8%). The most dominant haplotype was overwhelmingly haplotype 1, which was found in all South Korean specimens and four specimens from China, Indonesia, and Germany. These findings indicate that the low genetic diversity of South Korean specimens can be explained by the fact that the G. bimaculatus population imported for feed from Japan in the early 2000s became a maternal group that spread throughout cricket farms in South Korea. In order to breed healthy cricket strains, it is necessary to increase genetic diversity by importing them from other countries through appropriate quarantine procedures.

The Scientific Name of Aquilariae Lignum based on distribution of Aquilaria spp. (Aquilaria 속 식물 분포도에 근거한 심향(沈香)의 학명)

  • Kim, In-Rak
    • The Korea Journal of Herbology
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    • v.28 no.5
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    • pp.13-19
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    • 2013
  • Objectives : The purpose of this study is correct the scientific name of Aquilariae Lignum in Korean Herbal Pharmacoepia. Methods : The production areas of Aquilariae Lignum and its trading status with China in Chinese history, Sanscrit-Chinese Translation Sutra, Naming year and the discovered district in main Aquilaria spp., Several nation's Pharmacoepia, The Plant List(TPL), Convention on International Trade in Endangered Species of Wild fauna and flora(CITES) and The International Union for Conservation of Nature(IUCN) were cross-checked. Results : The records in the Jiaozhouyiwuzhi written in the early 2nd century said that Aquilariae Lignum was produced in Vietnam. NanfangCaomuZhuang written in 304 said that Agarwood in Vietnam had white flowers. Vietnam had led production and trading of Aquilariae Lignum until Qing Dynasty. Aquilariae Lignum from Malaysia and Indonesia was not traded with China. In Sanscrit-Chinese Translation Sutra, India Aquilariae Lignum was translated as Vietnam Aquilariae Lignum. Aquilaria malaccensis was discovered from Malay-Peninsular in 1783, and has green or dirty yellow flowers. A. agallocha from North-Eastern India in 1814, white flowers. A. crasssna from Vietnam in 1914, white flowers. A. crassna is different from A. malaccensis in several ways, such as flower, fruit, seed and disribution. In several Nation's Pharmacoepia, A. crassna was a synonym of A. agallocha. But in TPL, CITES and IUCN, A. malaccensis was an accepted name, and A. agallocha was a synonym of A. malaccensis. Conclusions : These results show that the original species of Aquilariae Lignum in Korea Herbal Pharmacoepia should be reversed from A. agallocha to A. crassna Pierre ex Lacomte.

A Study on Supply Chain Analysis of Global Cod Industry - Focusing on COVID-19 pandemic and Intermediary Trade of South Korea - (세계 대구산업의 공급사슬 구조 분석 - 코로나19와 한국 중계무역을 중심으로 -)

  • Huang, Shan-Shan;Lee, Jung-Phil
    • The Journal of Fisheries Business Administration
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    • v.53 no.3
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    • pp.1-15
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    • 2022
  • The global cod market is supposed to have weak structure with a high dependence on the supply of Russia, the United States, Norway, and China. The COVID-19 pandemic has significantly disrupted the cod supply chain for the worse. Fish processing facilities in China stopped their operation, and cod demand declined due to shrinking consumption in Europe. The position of South Korea as an intermediary trade country between Russia and China strengthened due to the U.S.-China trade war and the Atlantic cod decrease in 2019. However, this global cod supply chain collapse has caused South Korea to export accumulated cod to Indonesia and Vietnam at a bargain price, showing that South Korea was unable to cope with this supply chain crisis. The primary purpose of this study is to investigate changes in the global cod supply chain and their impacts on the intermediary trade of South Korea caused by the COVID-19 pandemic. It also aims to provide implications by analyzing advanced cases in Denmark. As the cod supply chain crisis countermeasures, this study suggests that South Korea develop high value-added marine products, gain competitive advantages by solidifying the value chains of related countries, and activate export by discovering alternative markets in terms of the supply chain of the cod industry.