• Journal of Chest Surgery
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• 제29권7호
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• pp.777-779
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• 1996

미숙아에 동반된 동맥관 개존증에서 indomethacin에 의한 폐쇄치료법이 소개된후 비수술적 치료방법 으로 각광을 받아왔으나, 증상이 있는 동맥관 개존증의 수술적 폐쇄는 가장 확실하고 안전한 치료법으 로 다시 평가받고 있다. 저자들은 최근에 체중 540gm과 1395gm 미숙아에서 indomethacin에 반응하지 않는 개존동맥 관을 clip 결찰하였다. 540gm의 미숙아는 술후 28시간에 사망하였는데 심한 혈소판 감소증을 보이는 등 출혈성 소인으로 이한 출혈이 원인이 되었다. 두 번째 미숙아 역시 indomethacin치료에도 호전이 없었으며 입원 8일째 괴 사성 소장결장염 합병으로 인한 회장천공으로 수술받았다. 체중증가가 없고 인공호흡기 이탈이 불가능 하여 입원 34일에 개존동맥관을 결찰하고동시에 회장조루복원술을시행하였다. 술후 6일째 인공호흡 기를 제거할 수 있었고 술후 33일에 체중 2050gm에 달하여 양호한 상태로 퇴원하였다.

• Journal of Microbiology and Biotechnology
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• 제11권3호
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• pp.463-468
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• 2001

Cyclosophoraoses are a class of unbranced cyclic-(1longrightarrow2)-${\beta}$-D-glucans found in the Rhizobium species. Their unique cyclic structures and high solubility make them potent for inclusion complexation as a host for an insoluble guest molecule. A family of neutral cyclosophoraoses (DP 17-27) isolated from Rhizobium meliloti 2011 was used as a host for inclusion complexation with an insoluble guest drug, indomethacin. A high performance liquid chromatographic analysis indicated that the inclusion complexation of cyclosophoraoses greatly ehanced the solubility of indomethacin compared with ${\beta}$-cyclodextrin. The estimated value of the association constant of the complex in water for $\beta$-cyclodextrin and cyclosophoraoses was $523M^{-1} and 17,570M^{-1}$, respectively. NMR spectroscopy showed that the inclusion complex was characterized by the interaction of the indole ring moiety of indomethacin with the cavity of cyclosophoraoses.

• 대한한방내과학회지
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• 제25권3호
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• pp.497-507
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• 2004

This study was carried out to investigate the effects of Ikwitang extract on indomethacin-induced gastric mucosal lesions in mice. Experimental groups were classified into a non-treated group(NM group), a non-administered group(CON group), the Misoprostol-administered group(MI group) and the Ikwitang-extract-administered group(IW group). This study examined the morphological change, distribution of mast cells, mucous surface cells, acid mucose secreted cells, and apoptic cells, BrdU, COX-1, Hsp70, $NF-{\kappa}B\;p50$, PKC, COX-2 and IL-12B of gastric mucosa. Results : The results of this study were as follows: 1. In the Misoprostol-administered group and the Ikwitang-extract-administered group, the hemorrhagic erosion of gastric mucous and infiltrated mast cells decreased. 2. Mucous surface cells and acid mucose secreted cells abserved in the Misoprostol-administered group and the Ikwitang-extract administered group. 3. The distribution of apoptic cells, Hsp70, $NF-{\kappa}B\;p50$, PKC, COX-2, and IL-12B increased in the Control group, but decreased in the Misoprostol-administered group and Ikwitang-extract-administered group. 4. Cells proliferation of gastric mucosa and the COX-l positive cells decreased in the Control group, but increased in the Misoprostol-administered group and the Ikwitang-extract -administered group. The above results suggest the lkwitang extract had beneficial effects on indomethacin induced gastric mucosal lesions.

• 대한한의학회지
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• 제26권3호
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• pp.215-227
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• 2005

Objectives : This study was carried out to investigate the effects of Pyungjintang on indomethacin-induced gastric mucosal lesions of mire. Methods : Experimental mice were classified into not-treated group (NOR group), gastro-inflammation elicitated group (CON group), misoprostol-administered group after gastro-inflammation elicitation (MA group), and Pyungjintang-administered group after gastro-inflammation elicitation (PA group). This study examined the morphological change, distribution of mast cells, mucus surface cells, neutral mucus secreting cells, acid mucus secreting cells, PNA reaction, angiogenesis (MIP-2), COX-1, Hsp70, NF-kB p50, COX-2IL-12B, ICAM-1, BrdU and apoptotic cells of gastric mucosa. Results : 1. The scars of diapedesis, dilatation of right gastric artery and the hemorrhagic erosions of gastric mucosa were reduced in the MA and PA groups. 2. Gastric perforation was observed in the gastro-inflammation elicitated group, but not in the MA and PA groups. 3. The COX-1 positive cellsl, cell proliferation of gastric mucosa, neutral mucus secreting ce31s, acid mucus secreting cells and PNA positive reaction of surface mucus cells were increased in the MA and PA groups. 4. The distribution of apoptotic cells, mast cells, MIP-2, Hsp70, NF-kB p50, COX-2, IL-l2B and ICAM-1 were decreased in the MA and PA groups. Conclusions : Pyungjintang had excellent effects on indomethacin-induced gastric mucosal lesions in mice.

• 대한한의학회지
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• 제25권3호
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• pp.111-122
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• 2004

Objectives : This study was carried out to investigate the effects of Jaeumgeonbi-tang extract on indomethacin-induced gastric mucosal lesions of mice. Methods : Experimental groups were classified into non-treatment group (CON group), non-administered group (GE group), misoprostol administered group (MA group) and Jaeumgeonbi-tang extract administered group (JG group). This study examined the morphological change, distribution of mast cells, mucous secreted cells and apoptotic cells, BrdU, COX-1, Hsp70, NF-κB p50, PKC, COX-2 and TNF-α of gastric mucosa. Results : 1. The hemorrhagic erosion of gastric mucosa and infiltrated mast cells were reduced in the MA and JG groups. 2. PNA reaction and mucous secreted cells were increased in the MA and JG groups. 3. The distribution of apoptotic cells, Hsp70, NF-κB p50, PKC, COX-2 and TNF-α were increased in the gastro­inflammation elicitated group, but decreased in the MA and JG groups. 4. The MA and JG groups showed increase on COX-1, BrdU. Conclusions : Jaeumgeonbi-tang extract had excellent effects on indomethacin-induced gastric mucosal lesions.

• Clinical and Experimental Pediatrics
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• 제49권12호
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• pp.1315-1323
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• 2006

목 적 : 미숙아 동맥관 개존 치료시 기존 치료제인 indomethacin 사용시 소변량 감소등의 부작용이 있으나 ibuprofen은 비슷한 효능을 보이면서도 부작용의 빈도는 낮다는 외국의 보고가 있어 국내에서는 처음으로 ibuprofen의 효능과 안전성에 대하여 알아보고자 본 연구를 시행하였다. 방 법 : 2005년 4월부터 2005년 12월까지 고려대학교 의료원 안산병원에서 출생한 재태연령 25주 이상 34주 미만의 미숙아 중 임상적 증상이 있는 동맥관 개존으로 진단되어 ibuprofen을 투여한 환아 12명과 2003년 2월부터 2005년 3월까지 같은 진단으로 indomethacin을 투여한 미숙아 중 임의로 20명을 선택하여 두 군으로 나누어 동맥관 개존의 치료 효과 및 약물의 부작용 및 임상 경과 등을 비교하였다. 결 과 : Ibuprofen 투여군에서 12례 중 11례(92%)에서 동맥관이 폐쇄되었고 indomethacin 투여군에서는 20례 중 18례(90%)에서 동맥관이 폐쇄되어 두 군간의 차이는 없었다(P=1.000). 혈청 나트륨 농도는 두 군 모두 투여시기에 따라 유의하게 감소하였으며(P<0.0001) 투여 전에 비해 3차 용량 투여 48시간 이후에 의미있게 감소하였다(P=0.0011). 혈청 BUN 및 creatinine 농도는 두 군 모두 약물 투여 전후에 차이가 없었으며 군간에서도 차이가 없었다. 소변 배설량도 두 군간 차이는 없었고 각 군별 투여시기에 따른 비교에서도 통계적으로 유의한 차이는 없었다(P=0.0725). 임상적 경과 및 주산기 합병증의 빈도는 두 군간 차이는 없었다. 결 론 : 정주용 ibuprofen은 미숙아 동맥관 개존의 치료에 있어서 정주 indomethacin과 비교할 때 폐쇄율과 합병증 빈도에서 비슷한 효과를 나타내었으나 혈청 나트륨 농도의 변화도 유사한 변화를 보이는 사실로 보아 indomethacin의 대안적인 약물로 사용할 수 있다고 생각한다.

• 대한수의학회지
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• 제19권2호
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• pp.115-119
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• 1979

Prostaglandin이 배란에 미치는 영향을 관찰하기 위하여 정상군과 양쪽 자궁을 제거한 가토에 indomethacin(prostaglandin 합성억제제)을 투여한 후 HCG데 의해 유발된 배란부위를 조직학적으로 관찰하였던 바 아래와 같은 결과를 얻었다. 1. indomethacin (10 mg/kg bw) 투여로 배란은 억제되었으며 투여량에 비례하여 배란은 억제되었다(p<0.01). 2. 자궁적출 단독으로는 배란에 영향을 주지 못하였다(p>0.05). 3. indomethacin은 난포파열을 억제함으로써 배란을 억제한다. 4. 토끼에서는 자궁이 아닌 장기에서 유래된 prostaglandin이 난포파열과정에 작용함으로써 배란을 시키는 작용이 있는 것으로 추정된다.

• Journal of Pharmaceutical Investigation
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• 제17권1호
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• pp.31-37
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• 1987

The studies on concurrent administrations of herb preparations(Daesiho-tang, Daehwangmogdanpi-tang, Dohaegseunggi-tang, Baenongsangeub-tang and Jeoryeong-tang) with indomethacin and tetracycline were carried out to investigate the antiinflammatory, antimicrobial, liver-protective and antiulcer activities. The results showed that the concurrent administrations of herb preparations with indomethacin and tetracycline increased significantly the antiinflammatory activities and antimicrobial activities respectively, and also improved the liver-protective activities and antiulcer activities against indomethacin or tetracycline-induced liver defect and Shay ulcers in rats, respectively.

• Archives of Pharmacal Research
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• 제16권1호
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• pp.43-49
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• 1993

The polyvinyl alcohol (PVA) hydrogel containing 1-methy-2-pymolidinone (MP) and sorbitol was preapred by the freeze and thaw method. The release rate of indomethacin from PVA hydrogel was used as a criterion for deciding the optimum formula of hydrogel using the computer optimization technique. The hydrogel of optimum formula was composed of PVA (10 w/v%), MP (0 w/v%) and sorbitol (40 w/v%) and the release rate of indomethacin was 1.981$\mu$g/ml$\cdot{min}^{1/2}$.

• Asian-Australasian Journal of Animal Sciences
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• 제5권1호
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• pp.29-32
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• 1992

The effects of prostaglandins (PG) and indomethacin, a PG synthesis inhibitor, on ovulation in the perfused fowl ovary were studied. Laying hens were killed by cutting the jugular vein 18-19 h before expected ovulation of the second follicle of a clutch sequence. The cannulated ovary was dissected free and connected with a recycling perfusion apparatus. Agents to be studied for their effects on ovulation were added to the perfusion fluid. $PGF_{2{\alpha}}$ at 0.1 and 1 mg/l induced ovulation, with a success rate of 25% and 30%, respectively. The same doses of $PGE_2$ were effective at 60% and 63%, respectively. Indomethacin partially blocked gonadotrophin-induced ovulation. It is suggested that PGs may play a supportive role in the process of follicular rupture in the domestic fowl.