Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Inclusion Complexation of a Family of Cyclsohoraoses with Indomethacin

  • Lee, Sang-Hoo (Department of Microbial Engineering, Konkuk University, Hwayang-dong) ;
  • Kwon, Chan-Ho (Department of Microbial Engineering, Konkuk University, Hwayang-dong) ;
  • Choi, Young-Jin (Department of Microbial Engineering, Konkuk University, Hwayang-dong) ;
  • Seo, Dong-Hyuk (Department of Microbial Engineering, Konkuk University, Hwayang-dong) ;
  • Kim, Hyun-Won (Department of Biochemistry and Institute of Basic medical Sciences and Medical Engineering Institute) ;
  • Jung, Seun-Ho (Department of Microbial Engineering, Konkuk University, Hwayang-dong)
  • Published : 2001.06.01
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Abstract

Cyclosophoraoses are a class of unbranced cyclic-(1longrightarrow2)-${\beta}$-D-glucans found in the Rhizobium species. Their unique cyclic structures and high solubility make them potent for inclusion complexation as a host for an insoluble guest molecule. A family of neutral cyclosophoraoses (DP 17-27) isolated from Rhizobium meliloti 2011 was used as a host for inclusion complexation with an insoluble guest drug, indomethacin. A high performance liquid chromatographic analysis indicated that the inclusion complexation of cyclosophoraoses greatly ehanced the solubility of indomethacin compared with ${\beta}$-cyclodextrin. The estimated value of the association constant of the complex in water for $\beta$-cyclodextrin and cyclosophoraoses was $523M^{-1} and 17,570M^{-1}$, respectively. NMR spectroscopy showed that the inclusion complex was characterized by the interaction of the indole ring moiety of indomethacin with the cavity of cyclosophoraoses.

Keywords

References

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