• 한국임상약학회지
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• 제29권4호
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• pp.223-230
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• 2019

Background: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some serious adverse effects, including hepatotoxicity, have been documented in clinical trials and post-marketing surveillance. Although TKI-induced hepatotoxicity can cause severe clinical complications in patients, the underlying mechanism is still unclear. Methods: Studies on TKI-induced hepatotoxicity were identified by Pubmed search, and relevant articles were reviewed. Results: Immunoallergic reaction, cytochrome P (CYP) 450 polymorphisms, and formation of reactive metabolites are under consideration as mechanisms of TKI-induced hepatotoxicity. Host protein-drug metabolite conjugates are recognized as antigens by class II major histocompatibility complexes and are believed to cause liver injuries. Polymorphisms in CYP, which influences TKI metabolism, can slow TKI metabolism and may induce development of hepatotoxicity. The formation of reactive metabolites during drug metabolism can induce hepatotoxicity by directly causing cytotoxicity, leading to cell dysfunction, and indirect toxicity by mediating secondary immune reactions. Concurrent use of various medications with TKI can also cause hepatotoxicity by affecting drug transporter or enzyme activities. Conclusion: Periodic monitoring of patients taking TKIs and risk/benefit reassessments though post marketing surveillance are necessary to prevent hepatotoxicity.

• 한국조경학회지
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• 제27권5호
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• pp.38-47
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• 2000

Carbon dioxide is a major greenhouse gas causing climate change. This study quantified annual direct and indirect uptake of carbon by urban greenspace, and annual carbon release from vegetation maintenance and fossil fuel consumption. The study area was whole Chuncheon and Kangleung, and also two districts of Kangnam and Junglang in Seoul, cities located in middle Korea. Carbon uptake by urban greenspace played an important role through offsetting carbon release by 6-7% annually in Chuncheon and Kangleung. For Kangnam and Junglang, where the population density was relatively higher, urban greenspace annually offset carbon release by 1-2%. Future possible tree plantings could double annual carbon uptake by existing trees in urban lands (except natural and agricultural lands) of a study city. Based on study results, planning and management guidelines for urban greenspace were suggested to save energy and to reduce atmospheric $CO_2$ concentrations. They included selection of optimum tree species, proper planting location from buildings, design of multilayered planting, amendment of existing regulations for greenspace enlargement, avoidance f intensive vegetation maintenance, and conservation of natural vegetation.

• Journal of Preventive Medicine and Public Health
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• 제22권4호
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• pp.528-541
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• 1989

The purpose of this study was to identify and measure the economic costs and benefits due to smoking in Korea. Cigarette smoking is a major cause of morbidity and mortality. In addition to the health risks of smoking, there are important economic consequences. A complete assessment of the economics of smoking requires evaluation of various health, economic, and intangible parameters, including benefits as well as costs of both the production and consumption of tobacco. In this article we focus on costs resulting from the health effects of smoking (expenditures for medical care and the value of productive output lost to morbidity, and premature mortality among smokers), since economic benefits from tobacco industry is offset by expenditures for purchasing tobacco. Two distinct methodologies will be applied to measure the economic costs of smoking cigarette, the human capital and willingness-to-pay approaches. This article used the former method. In 1985, total economic losses due to smoking was estimated as 505.7 billion won, which was composed of morbidity losses 64.9 billion won mortality losses 429.1 billion won and indirect costs 11.7 billion won.

• 설비공학논문집
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• 제17권6호
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• pp.560-568
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• 2005

The cost accounting of electricity and heat produced from an energy system is important in evaluating the economical efficiency and deciding the reasonable sale price. The OECOPC method, suggested by the author, was applied to a 650 MW combined cycle cogeneration system having 4 operating modes, and each unit cost of electricity and heat products was calculated. In case that a fuel cost is ${\\}400/kg$ and there are no direct and indirect cost, they were calculated as follows; electricity cost of ${\\}23,700/GJ$ at gas-turbine mode, electricity cost of ${\\}15,890/GJ$ at combined cycle mode, electricity cost of ${\\}14,146/GJ$ and heat cost of ${\\}6,466/GJ$ at cogeneration mode, and electricity cost of ${\\}14,387/GJ$ and heat cost of ${\\}4,421/GJ$ at combined cycle cogeneration mode. Further, these unit costs are applied to account benefit on this system. Since the suggested OECOPC method can be applied to any energy system, it is expected to contribute to cost accounting of various energy systems.

• The Journal of Asian Finance, Economics and Business
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• 제8권12호
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• pp.169-181
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• 2021

The study aims to investigate the direct effects of business management practices in terms of financial, marketing, human resources, and logistics operations practices on sales revenue and profitability growth of freight forwarding businesses. A quantitative research design and partial least square-structural equation modeling were used to examine the direct effects of the exogenous and endogenous variables. The study reveals that financial, marketing, and human resources practices have a positive and significant effect on sales revenue growth. Furthermore, marketing and logistics operations have a positive and significant effect on profitability growth in the context of freight forwarding in the Philippines, particularly in its country's capital. As the current study only examines the direct effects of business management practices, other researchers may also want to consider identifying other variables as mediation and moderation to test other indirect effects on the financial performance of the business. The findings of the study can significantly benefit the freight industry to consider addressing other challenges or make use of the paper to further develop their strategies and practices to improve their financial performance.

• 해양환경안전학회지
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• 제25권3호
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• pp.381-394
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• 2019

The marine industry contributes a large proportion of the air pollutant emissions along coastal regions, and this air pollution has been strongly linked to cardiovascular diseases and other illnesses. To alleviate the problem, many ports have installed alternative maritime power (AMP) facilities that enable onboard marine auxiliary engines with generators (gensets) to be shut down while a ship is at berth. This study compared the emissions from conventional gensets with those from AMP facilities, focusing on four emission types: greenhouse gases (GHG), sulphur oxides (SOX), nitrogen oxides (NOX), and particulate matter (PM). Both direct (combustion / operation) and indirect (upstream) emissions were considered together for the emission comparison. The results showed that AMP has lower emissions than conventional onboard gensets, and this benefit is highly dependent on the electricity generation mix onshore. On average, GHG emissions could be reduced by about 18.3 %, while the other emissions (SOX, NOX, and PM) would decrease more dramatically (88.4 %, 90.1 %, and 91.5 %, respectively). Additionally, future benefits of the AMP would increase due to the expansion of renewable energies. Thus, this study supports the potential of AMP as a promising solution for environmental concerns at ports worldwide.

• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.249-255
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• 2011

Poor safety management in construction management may adversely affect cost, schedule and quality of a project. Heavy fines upon safety offence becomes a burden to the budget; losing working hours as a result of safety incident impacts on the schedule, and compromising quality is always an indirect consequence when workers perform duties in an unsafe site environment. Therefore, promotion of safety management becomes the top priority in any construction manager's agenda. Working safely will benefit construction project and lead to a "real" success. This paper is a case study, based upon "Geller's 10 principles for achieving a total safety culture", reviewing how a Hong Kong leading construction company fosters the safety culture and possesses a pleasant safety record over years. Its safety performance is not only well ahead the local industry, but also ranges top within the Asia Pacific region and comparable to those mature Western industries. The review concluded that safety culture is one of the major components in construction management and collaboration is the essence to realize this positive culture within an organization. Safety management is not merely a "top down" approach, but requires the positive "bottom up" actions from the other end. The successful story of this company can demonstrate the contribution of safety management in construction management.

• 유통과학연구
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• 제22권4호
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• pp.105-114
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• 2024

Purpose : Due to the uncertainty of the global trade environment and the trade downturn, the shipping industry continues to face challenges. This study aims to investigate in-depth analysis of crisis overcoming strategies through case study of a company that is leader in the shipping and logistics industry. Research Desigh and Methodology : In order to conduct an in-depth analysis, a single case analysis was selected as a qualitative study. For this purpose, various secondary sources were used, and indirect interview data were also used. In this study, Maersk was selected because it has grown from a traditional shipping logistics company to a digital platform company. Results: Maersk has transformed itself into a comprehensive, digital logistics platform with several key strategies to respond to the long-term slump in the shipping industry. First, it leveraged Maersk's diversification and portfolio optimization strategy. Second, Maersk is transforming its logistics and transport processes through digitalization and technological innovation. Conclusion: Maersk, which is responding to the long-term recession facing the shipping industry, looked at how it has leveraged its strengths and explored new opportunities through a number of strategies and changes. This study provides insight into a digital logistics platform that will benefit the other companies as well.

• 근관절건강학회지
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• 제7권1호
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• pp.102-130
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• 2000

The aims of this study were to understand and to predict the determinant factors affecting the exercise behaviors and physical fitness by testing the Ponder's health promotion model, and to help the patients with rheumatoid arthritis and osteoarthritis perform the continuous exercise program, and to help them maximize the physical effect such as muscle strength. endurance, and fuctional status and mental effects including self efficacy and quality of life, and improve the physical and mental wellbeing, and to provide a basis for the nursing intervention strategies. We analyzed the clinical records of 208 patients with rheumatoid arthritis and degenerative arthritis who visited the outpatient clinics at H university hospital in Seoul between October 5, 1999 and October 24, 1999. Data were composed of self reported questionnaire and good of fitness score which were obtained by pedalling the ergometer of bicycle for 9 minutes. SPSS Win 8.0 and Window LISREL 8.12a were used for statistical analysis. 24 Of 54 hypothetical paths were supported in modified model, which was considered as a proper model with improved fit index. The physical fitness was directly influenced by exercise participation behavior and education level, and indirectly by physical fitness, while fatigue, physical disability, pastexercise behavior, life-style, self-efficacy, which explained 20% of physical fitness. The exercise participation were directly influenced by perceived benefits and self-efficacy, and indirectly influenced by life-style, fatigue and physical disability, and directly and indirectly by past exercise behavior, which explained 53% of exercise participation. Exercise score were directly affected by perceived health status, perceived benefits, self efficacy, and past exercise behavior, and were indirectly affected by fatigue, physical disability, and life-style, which explained 50%. Perceived health status were directly influeced by level of education, depression, sleep disorder, and physical disability, which explained 34% of perceived health status. Perceived benefit was directly influenced by fatigue, sleep disorder, physical disability, and life-style, which explained 45%. Perceived barriers was directly influenced by fatigue, sleep disorder, and lifestyle, which explained 9%. Self- efficacy was directly influenced by fatigue, physical disability, past exercise behavior, and level of education, which explained 61%. In conclusion, important variables for physical fitness were exercise participation and level of education, and variables affecting exercise participation were perceived self-efficacy, benefits, and past exercise behavior. Perceived self-efficacy of exercise was a significant predictor of exercise participation. Life-style, fatigue, and physical disability showed direct effects on perceived benefit, perceived barriers, and self-efficacy, and indirect effects on exercise behavior. Therefore, disease related factor should be minimized for physical performance and well being in nursing intervention for patients with rheumatoid arthritis, and plans to promote and continue exercise should be soaked to reduce disability. In addition, Exercise program should be planned and performed by the exact evaluation of exercise according to the ability of the patients and the contents to improve the importance of exercise and self efficacy in self control program, dedicated educational program should be involved.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8993-9004
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• 2014

Background: The incidence rate and the treatment costs of hepatocellular carcinoma (HCC) are high, especially in Thailand. Previous studies indicated that early detection by a surveillance program could help by down-staging. This study aimed to compare the costs and health outcomes associated with the introduction of a HCC surveillance program with no program and to estimate the budget impact if the HCC surveillance program were implemented. Materials and Methods: A cost utility analysis using a decision tree and Markov models was used to compare costs and outcomes during the lifetime period based on a societal perspective between alternative HCC surveillance strategies with no program. Costs included direct medical, direct non-medical, and indirect costs. Health outcomes were measured as life years (LYs), and quality adjusted life years (QALYs). The results were presented in terms of the incremental cost-effectiveness ratio (ICER) in Thai THB per QALY gained. One-way and probabilistic sensitivity analyses were applied to investigate parameter uncertainties. Budget impact analysis (BIA) was performed based on the governmental perspective. Results: Semi-annual ultrasonography (US) and semi-annual ultrasonography plus alpha-fetoprotein (US plus AFP) as the first screening for HCC surveillance would be cost-effective options at the willingness to pay (WTP) threshold of 160,000 THB per QALY gained compared with no surveillance program (ICER=118,796 and ICER=123,451 THB/QALY), respectively. The semi-annual US plus AFP yielded more net monetary benefit, but caused a substantially higher budget (237 to 502 million THB) than semi-annual US (81 to 201 million THB) during the next ten fiscal years. Conclusions: Our results suggested that a semi-annual US program should be used as the first screening for HCC surveillance and included in the benefit package of Thai health insurance schemes for both chronic hepatitis B males and females aged between 40-50 years. In addition, policy makers considered the program could be feasible, but additional evidence is needed to support the whole prevention system before the implementation of a strategic plan.