• 동의생리병리학회지
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• 제24권4호
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• pp.571-579
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• 2010

The advancement of medical technology has made it possible to treat various incurable diseases. Especially organ transplantation can give another life to the patients who have organ failure and could not find any other ways to treat their diseases. According to the development of medical technology and immunosuppressive drugs, the rate and extent of organ transplantation is increasing these days. New medical technologies like organ transplantation brought on critical issues and these have changed the way of thinking and morals that has been the fundamental rules in our society. Bioethics is already an important field of medicine and oriental medicine should investigate the problem caused by the development of medical technology and life science and should form a view of life in oriental medicine. Oriental medicine is East Asian traditional medicine based on "Huangdi-Neijing", constructed by the system of Jangfu and meridian. The traditional therapies of oriental medicine have completed a scientific system on the point of view that looks on human and nature equally. This process continued to form a new medical theory as the environment was changed and the new diseases were appeared since "Huangdi-Neijing" and "Shoganron" showed a new scope to investigate human and diseases. Therefore, it is important to develop the point of view of oriental medicine as the medical situation was changed. Oriental medicine has a holistic view that considers human as a little cosmos resonated by a big cosmos and regards the possibility to recover and to regulate the energy in our body. This theory is a basic idea of oriental philosophy. Oriental medicine focuses on the balance of yin and yang of the body and tries to harmonize the imbalance of yin and yang caused by the life style and environment. This can solve many problems that cannot be settled by modern medicine and this can accomplish the new paradigm of oriental medicine that is needed these days.

• 대한의료기공학회지
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• 제13권1호
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• pp.56-76
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• 2013

Objective : The aim of this study was to find the literature basis on SuGi-therapy(手氣療法) in Donguibogam. Methods : Anma(按摩), Doin(導引), Angyo(按蹻), Anap(按壓) and Chuna(推拿), the keyword of this study, were researched, analyzed and classified in Donguibogam. Results : 1) In Donguibogam, the keyword Anma(按摩) and Doin(導引) showed up 10 and 33 times, respectively and 7 and 20 times, respectively in the body except the table of contents. In considering the meaningful cases, in short, Anma(按摩) and Doin(導引) appeared 7 and 16 times, respectively. Furthermore we could know Anma(按摩) showed up 4 times with the highest frequency in Oehyeongpyeon(外形篇), and Doin(導引) showed up 11 times with the highest frequency in Naegyeongpyeon(內景篇). 2) Anma(按摩) was mostly used as a separate word and only 2 times was "Anmadoin(按摩導引)" used. In 16 meaningful cases, Doin(導引) was used as "Doinbeop(導引法)" 14 times and 2 times was "Anmadoin(按摩導引)" used in a linked form. Among 14 times when "Doinbeop(導引法)" was referred, it was stated as "Do Doinbeop(導引法)" without any detailed explanations 2 times and it was explained about how to pose when people do Doinbeop(導引法) for prevention and treatment 12 times. 3) Reviewed in Donguibogam, Anma(按摩) and Doin(導引) were the ChoGi-therapy(調氣療法) in all. Because they include both massaging by oneself and getting a massage from someone else, they all could be 'SuGi-therapy(手氣療法)' in a broad sense. 4) In Sikjeokbyeong(息積病), the 12th chapter of Jeokchwimun(積聚文) in Japbyeongpyeon(雜病篇), Doinbeop(導引法) was referred as the treatment of Jeok(積) which belongs to obstinate and incurable diseases. This means SuGi-therapy(手氣療法) could be the basis of using widely on several incurable diseases in modern society. 5) There is few paper about SuGi-therapy(手氣療法). SuGi-therapy (手氣療法) doesn't seem to form a large part in modern Korean medicine but it is a remedy that has been together with the history of Korean medicine so long and has great therapeutic effects and usefulness. From now on, the literature and clinical study on SuGi-therapy(手氣療法) should be conducted continuously and developed for the better.

• 한국의사학회지
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• 제24권1호
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• pp.9-15
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• 2011

Recently, the oriental medicine industry in Korea has faced much hardship, due to the decreasing number of patients. Therefore, it is essential to investigate the reasons why patients are avoiding oriental medicine, because the percentage of people consuming medical service is an important marker that assesses the value of medical service. The researcher(s), based on theories on factors that affect health, health behaviors, and diseases, sought to find reasons why oriental medicine clinics saw a decline in the number of patients. Also, by proposing the problems inside the oriental medicine, I came to the following conclusion. -Because Koreans have low expectations for oriental medicine, they do not consider it as full medical service. Also, when they get sick, they are reluctant to seek oriental medicine because of reasons such as the limits of oriental medicine and check-ups, expensive medical cost, negative perception of oriental medicine, not enough support from the media, the old image of the oriental medicine and the little power the industry has on the society. -Among the inner problems of the oriental medicine community was the limitations that the science face on incurable and chronic diseases in terms of treatment and management, little professionalism, lack of scientific evidence, the attitude of the oriental medicine society, lack of sophistication in research methodology, and limitations in responding to changes in public health and the surroundings. The purpose of medicine is to eliminate the possibility of shortened life and dangers by treatment of diseases and health maintenance. For this to happen, structural and developed medical theories and means of treatment are necessary. The researcher hypothesizes that the problems that the oriental medicine society is facing mainly come from the lack of efforts and ability to provide such necessities.

• 동의생리병리학회지
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• 제27권5호
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• pp.594-601
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• 2013

The aim of this study was to analyze the differences between Qigong and Daoyin as a therapeutic exercise of traditional Korean medicine. We searched Pubmed and Chinese Academic Journals(CAJ) over time periods from their inception to August 13th, 2013. We analyzed the systematic reviews of Qigong and clinical trials of Daoyin. Total 12 Qigong and 16 Daoyin(11 Baduanjin, 4 Wuqinxi, 1 unspecified type of Daoyin) articles were met our inclusion criteria. As the results of our analyzation, Qigong was dominant in chronic or incurable disease. On the other hand, Daoyin was dominant in internal diseases or functional improving of internal organs. As using "Qi" is in common between Qigong and Daoyin, they have not been differentiated in world of traditional Korean medicine. However, it could be better to use the Qigong and Daoyin according to their effectual difference.

• Journal of Microbiology and Biotechnology
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• 제25권9호
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• pp.1578-1582
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• 2015

Granzyme A (GzmA) was identified as a cytotoxic T lymphocyte protease protein expressed in the nucleus. A number of nuclear proteins are well known as GzmA substrates, and GzmA is related with caspase-independent apoptosis. Histones H1, H2B, and H3 were identified as GzmA substrates through in vitro experiment with purified nucleosome. Here, we demonstrated that histone H3 was cleaved by GzmA in vivo during staurosporine-induced cell death. Moreover, histone H3 cleavage was blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. Taken together, we verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin.

• 한국인공지능학회지
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• 제4권1호
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• pp.11-13
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• 2016

These days, medical technology has been developed rapidly to meet desire of living healthy life. Average lifespan was extended to let people see a doctor because of many reasons. This study has shown rate of leaving of hospitals to investigate the rate of not only department of surgery but also department of internal medicine. Linear model, tree, classification rule, association and algorithm of data mining were used. This study investigated by using J48 and AD tree of decision-making tree In this study, J48 and AD tree of decision-making tree of data mining were used to investigate based on result of both data. Both algorithms were found to have similar performance. Both algorithms were not equivalent to require detailed experiment. Collect more experimental data in the future to apply from various points of view. Development of medical technology gives dream, hope and pleasure. The ones who suffer from incurable diseases need developed medical technology. Environment being similar to the reality shall be made to experiment exactly to investigate data carefully and to let the ones of various ages visit hospital and to increase survival rate.

• Journal of Preventive Medicine and Public Health
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• 제7권2호
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• pp.285-292
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• 1974

It is well known fact that many tuberculosis patients have often experienced interuption of treatment while their treatment. Because most of cases were inproved subjective symptome by adequate treatment for 3-6 months and patients misunderstood to be heal completely by their own dicision, It become the cause of emergency of drug resistance and chronic incurable diseases. The author intended to clarify the duration of treatment and its outcome by some characteristics of tuberculosis patients. The results obtained were as follows: 1. The rate of treatment for tuberculosis patients by each duration with 1-6, 7-12, 13-13, 19-24 and 25 or more months were 16, 23, 20, 14 and 25 percents respectively. The duration of treatment increased in patients with advancing age, better educated and registered at health center between 7-12 months after diagnosis for tuberculosis. 2. The rate of complete treatment, defaulters, death and migration were 43, 13, 8, and 10 percents respectively. The rate of complete treatment were high in older, better educated and registered at health center between 7-12 months after diagnosis. The rate of defaulters were high in younger, no educated and registered within 1 month after diagnosis. The rate of death was high in older and migration was high in younger.

• 턱관절균형의학회지
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• 제2권1호
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• pp.8-12
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• 2012

Objectives: It has been reported to continue that temporomandibular joint balancing medicine (functional cerebrospinal therapy; FCST) is effective in treating incurable diseases in clinic recently. FCST is based on the results of restricted cervical rotation test, it means that the results of restricted cervical rotation test has a very high reliability on test results. Methods: This study has the aim to understand restricted cervical rotation test method and to use well with high technical skill. So manual muscle test method which was based on the upper limb lifting resistance test method are compared with restricted cervical rotation test method and had been discussed. Results: Results are that restricted cervical rotation test by using the passive motion of arrested persons (patients) have high the reliability and accuracy. Conclusions: It is concluded that restricted cervical rotation test is the new type of manual muscle tests and the results of test are very high the reliability and accuracy so that the acquirement of test method is helpful in clinic practically.

• 한국발생생물학회지:발생과생식
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• 제21권1호
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• pp.1-10
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• 2017

The use of human mesenchymal stem cells (hMSCs) in cell-based therapy has attracted extensive interest in the field of regenerative medicine, and it shows applications to numerous incurable diseases. hMSCs show several superior properties for therapeutic use compared to other types of stem cells. Different cell types are discussed in terms of their advantages and disadvantages, with focus on the characteristics of hMSCs. hMSCs can proliferate readily and produce differentiated cells that can substitute for the targeted affected tissue. To maximize the therapeutic effects of hMSCs, a substantial number of these cells are essential, requiring extensive ex vivo cell expansion. However, hMSCs have a limited lifespan in an in vitro culture condition. The senescence of hMSCs is a double-edged sword from the viewpoint of clinical applications. Although their limited cell proliferation potency protects them from malignant transformation after transplantation, senescence can alter various cell functions including proliferation, differentiation, and migration, that are essential for their therapeutic efficacy. Numerous trials to overcome the limited lifespan of mesenchymal stem cells are discussed.

• BMB Reports
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• 제50권3호
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• pp.117-125
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• 2017

Most of the cancers are still incurable human diseases. According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. Despite the numerous efforts to target CSCs, current anti-cancer therapies are still impeded by CSC-derived cancer malignancies; increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. One of the most forceful underlying reasons is a "cancer heterogeneity" due to "CSC plasticity". A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. Here, we introduce findings on mechanisms of CSC reprogramming and CSC plasticity, which give rise to phenotypically varied CSCs. Also, we suggest concepts to improve CSC-targeted therapy in order to overcome therapeutic resistance caused by CSC plasticity and heterogeneity.