• 대한산업공학회지
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• 제22권4호
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• pp.705-718
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• 1996

A similarity coefficient based algorithm is proposed to solve the machine cells and part families formation problem in group technology. Similarity coefficients are newly designed from the machine-part incidence matrix. Machine cells are formed using a recurrent neural network in which the similarity coefficients are used as connection weights between processing units. Then parts are assigned to complete the cell composition. The proposed algorithm is applied to 30 different kinds of problems appeared in the literature. The results are compared to those by the GRAFICS algorithm in terms of the grouping efficiency and efficacy.

• Journal of Microbiology and Biotechnology
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• 제33권1호
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• pp.15-27
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• 2023

The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously known endemic regions. Biofilms produced by BP have been associated with antimicrobial therapy limitation and relapse melioidosis, thus making it urgently necessary to understand the mechanisms of biofilm formation and their role in BP biology. Microbial cells aggregate and enclose within a self-produced matrix of extracellular polymeric substances (EPSs) to form biofilm. The transition mechanism of bacterial cells from planktonic state to initiate biofilm formation, which involves the formation of surface attachment microcolonies and the maturation of the biofilm matrix, is a dynamic and complex process. Despite the emerging findings on the biofilm formation process, systemic knowledge on the molecular mechanisms of biofilm formation in BP remains fractured. This review provides insights into the signaling systems, matrix composition, and the biosynthesis regulation of EPSs (exopolysaccharide, eDNA and proteins) that facilitate the formation of biofilms in order to present an overview of our current knowledge and the questions that remain regarding BP biofilms.

• 전자공학회논문지
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• 제50권8호
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• pp.196-202
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• 2013

기저 세포암은 가장 일반적인 피부암이고 그 발병이 급속도로 증가하고 있다. 본 연구에서는 피부 조직에서 측정한 라만 스펙트럼에서 기저 세포암 진단을 위해 NMF(non-negative matrix factorization) 알고리즘을 사용하는 방법을 제안하였다. 측정된 라만 스펙트럼은 영역 선택과 정규화 등의 몇 가지 전처리 과정을 거쳐 분류 실험에 사용한다. 전처리 과정을 수행한 라만 스펙트럼은 NMF 알고리즘을 이용하여 분해된 행렬의 열벡터를 기저로 사용한다. 이 기저들을 선형 결합하여 각 클래스의 평균 스펙트럼에 근사하기 위한 가중치는 행렬 연산으로 결정한다. 분류 실험은 스펙트럼과 NMF에 의한 기저와 가중치의 선형 결합 스펙트럼의 차에 대한 제곱평균제곱근을 최소로 하는 클래스를 선택하는 것으로 수행한다. 기저 세포암의 진단을 위한 분류 실험에서 제안한 방법을 사용하는 경우가 약 99.1%의 평균 분류율로 이전의 BCC 진단에 사용한 방법보다 약 2-3% 정도의 향상된 성능을 보였다.

• 한국광학회지
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• 제19권2호
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• pp.150-158
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• 2008

확장된 존스 행렬법을 응용하여 등방성 매질과 이방성 매질의 경계면에서 투과계수를 근사적인 방법을 사용하지 않고 정확히 계산하였다. 광학 이방성이 작은 경우($|n_e-n_o|\;{\ll}\;n_o,\;n_e$), 계산된 투과계수가 근사식에 의한 투과계수와 일치하는 것을 확인하였다. 정확한 투과계수 표현을 사용하여 임의의 편광상태로 입사한 빛이 단축이방성 a-판을 투과한 후의 편광상태를 임의의 입사각과 방위각에 대하여 계산하였다. 또한 광축이 수직으로 교차된 이상적인 두 o-타입 편광자에 편광되지 않은 빛이 투과한 경우 투과율을 임의의 입사각과 방위각에서 계산한 후, 기존의 근사식과 비교하였고, 완전하지 않은 두 편광자의 소광계수와 두께의 변화에 따른 투과율을 계산하여 실제의 편광자를 상정한 소광도를 평가하였다. 근사식이 적용되지 않는 이방성이 큰 이방성 매질을 통과한 후의 빛의 편광상태를 분석할 때 적용될 수 있도록 정확한 투과계수를 사용하는 방법을 제시함으로써 액정 디스플레이 분야 광소자의 편광 분석에 기여하고자 하였다.

• 대한두개안면성형외과학회지
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• 제20권3호
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• pp.176-180
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• 2019

Background: Parotidectomy is the treatment of choice in many parotid tumors. Due to the extensive nature of the procedure, unfavorable complications such as gustatory sweating, surgical site depression are common. Various techniques using fascia, muscle or AlloDerm have been developed but debate still remains regarding its availability and affordability. We applied a newly developed acellular dermal matrix (Insuregraf) to the parotidectomy field to act as a physical barrier and to provide adequate filling effect for prevention of functional and aesthetic complications. Methods: From March 2010 to March 2017, 30 patients with parotid tumors underwent superficial parotidectomy. Twenty patients underwent only superficial parotidectomy. Ten patients had Insuregraf applied to the surgical site after superficial parotidectomy. We evaluated the incidence of Frey's syndrome, surgical site depression, and patient satisfaction rate in both groups. Results: The incidence of Frey's syndrome was lower in the Insuregraf group (0 vs. 2). Surgical site depression was also lower in the Insuregraf group (2 vs. 20). Satisfaction score for facial contour in Insuregraf group was 9.2 out of 10, which was comparable to 6.2 out of 10 in the control group. Conclusion: Application of Insuregraf after superficial parotidectomy is an effective surgical procedure to prevent complications such as Frey's syndrome and surgical site depression. This technique is affordable and safe with no immune reactions. Above all this surgical method should be considered as an option for patients who are concerned about the contour of the face after surgery.

• 전자공학회논문지CI
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• 제48권4호
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• pp.27-34
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• 2011

본 논문에서는 멀티미디어 콘텐츠 보호에 대한 반공모 코드를 위한 동적 멀티미디어 핑거프린팅 코드를 설계하는 알고리즘을 제안한다. 기존의 반공모 코드(ACC: Anti-Collusion Code)를 위한 멀티미디어 핑거프린팅 코드는 BIBD(Balanced Incomplete Block Design)의 접속행렬을 보수행렬로 변환하여 k를 k+1로 증대시키는 수리적 방법으로 설계되었다. 그리고 보수행렬의 코드벡터를 사용자에게 핑거프린팅 코드로 부여하고, 콘텐츠에 삽입하였다. 제안된 알고리즘에서는 사용자가 구매하는 콘텐츠로부터 특징점을 추출하고, 이를 기반으로 동적으로 핑거프린팅 코드를 설계할 수 있도록 BIBD의 v와 k+1 조건을 만족하는 반공모 코드의 후보성 코드를 코드북(Codebook)에 구축하고 ${\lambda}+1$ 조건을 만족하는 행렬(이하, Rhee행렬이라 함.)을 생성한다. 실험을 통하여 콘텐츠의 특징점 기반으로 생성된 Rhee행렬의 코드벡터는 v비트의 유의수준 ($1-{\alpha}$)에서 신뢰구간에 k가 존재하며, Rhee행렬의 각 행과 행, 열과 열 사이의 유클리디안 거리가 BIBD 기반의 보수행렬과 그래프 기반의 보수행렬과 같은 k값이 산출되었다. 더욱이 Rhee행렬의 첫 행과 첫 열은 생성과정에서 초기 점화벡터로 콘텐츠 포렌식 마크 정보가 되며, 이와 관계가 있는 나머지 코드벡터들과의 관계성이 코드북에 기록되어 있기 때문에, 공모된 코드를 추적할 때 원 핑거프린팅 코드의 상관관계 계수를 구할 필요 없이 코드북의 탐색으로 공모자를 추적이 용이하다. 따라서 본 논문에서 생성된 Rhee행렬은 수리적으로 생성된 BIBD 기반의 행렬보다 ACC로서 강인성과 충실도가 우수하다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3331-3335
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• 2013

Background: The incidence of prostate cancer, one of the most common cancers in elderly men, is increasing annually in Thailand. Matrix metalloproteinase 11 (MMP-11) is a member of the extracellular matrix metalloproteases which has been associated with human tumor progression and clinical outcome. Aim: To quantify MMP-11 expression in prostatic adenocarcinoma tissues and to determine whether its overexpression correlates with survival outcome, and to assess its potential as a new prognostic marker. Materials and Methods: Expression of MMP-11 was analyzed using immunohistochemistry in 103 Thai patients with prostatic adenocarcinoma. Overall survival was analyzed using Kaplan-Meier methods and Cox regression models. Results: Immunoreactivity of MMP-11 was seen in the stroma of prostatic adenocarcinoma tissue samples, high expression being significantly correlated with poor differentiation in Gleason grading, pathologic tumor stage 4 (pT4), and positive-bone metastasis (p<0.05), but not age and prostatic-specific antigen (PSA) level. Patients with high levels of MMP-11 expression demonstrated significantly shorter survival (p<0.001) when compared to those with low levels. Multivariate analysis showed that MMP-11 expression and pT stage were related with survival in prostatic adenocarcinoma [hazard ratio (HR)=0.448, 95% confidence interval (95%CI)=0.212-0.946, HR=0.333, 95%CI=0.15-0.74, respectively]. Conclusions: Expression of MMP-11 is significantly associated with survival in prostatic adenocarcinoma. High levels may potentially be used for prediction of a poor prognosis.

• The Korean Journal of Physiology and Pharmacology
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• 제14권4호
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• pp.199-204
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• 2010

The potential therapeutic action of shikonin in an experimental model of rheumatoid arthritis (RA) was investigated. As a RA animal model, DBA/1J mice were immunized two times with type II collagen. After the second collagen immunization, mice were orally administered shikonin (2 mg/kg) once a day for 35 days, and the incidence, clinical score, bone mineral density (BMD), bone mineral content (BMC) and joint histopathology were evaluated. BMD in the proximal regions of the tibia largely increased in the shikonin treatment group compared with the control group. We also examined the effect of shikonin on inflammatory cytokines and cartilage protection. Shikonin treatment significantly reduced the incidence and severity of collagen-induced arthritis (CIA), markedly abrogating joint swelling and cartilage destruction. Shikonin also significantly inhibited the production of matrix metalloproteinase (MMP)-1 and up-regulated tissue inhibitors of metalloproteinase (TIMP)-1 in mice with CIA. In conclusion, shikonin exerted therapeutic effects through regulation of MMP/TIMP; these results suggest that shikonin is an outstanding candidate as a cartilage protective medicine for RA.

• Journal of the Optical Society of Korea
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• 제17권1호
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• pp.33-37
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• 2013

In this study a new design concept of the Fabry-Perot filter, constructed with an anisotropic space layer and a couple of isotropic mirrors, was proposed based on the Maxwell equations and the characteristic matrix method. The single- and double-cavity Fabry-Perot filters were designed, and their optical properties were investigated with a developed software package. In addition, the dependence of the transmittance and phase shift for two orthogonal polarization states on the column angle of the anisotropic space layer and the incidence angle were discussed. We demonstrated that the polarization state of electromagnetic waves and phase shifts can be modulated by exploiting an anisotropic space layer in a polarization F-P filter. Birefringence of the anisotropic space layer provided a sophisticated phase modulation with varied incidence angles over a broad range, resulting in a wide-angle phase shift. This new concept would be useful for designing optical components with isotropic and anisotropic materials.

• 대한인간공학회지
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• 제33권4호
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• pp.289-297
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• 2014

Objective: The purpose of this study is to identify the incidence risk of cardiovascular disease (CVD) in the workplace, and to suggest the prediction models for level of CVD incidence risk. Background: CVD can be caused by various factors related to personal habits such as diet and exercise, or genetics. However it can also be caused and aggravated by work, making the elimination of such risk factors at work crucial disease (KOSHA, 2013). Method: The distribution of CVD risk assessment levels of 162 workers was compared with the acquired medical examination data to discuss the necessity of assigning additional risk factors. Two alternative risk assessment models were given to enhance the accuracy of the evaluation; adjusting risk scores given in the KOSHA GUIDE H-1-2013 (alternative 1) and building a matrix of KOSHA GUIDE H-1-2013 and risk assessment results based on work condition levels (alternative 2). To verify the suggested models, medical examination results of 12 workers approved of convalescence were referred to. Results: The second alternative showed more relevance between the results and workers approved of convalescence in predicting the risk group when applied to actual heath examination data from the approved workers. The power of description of the new method for determining the risk of CVD incidence, 83.3%, is higher than that of KOSHA GUIDE H-1-2013, 25%. Conclusion: Results of this study imply that more approved workers had been from unmanaged normal groups than managed risk groups, raising the importance of CVD management. Application: The new prediction model considering working time and shift work developed in this study is expected to be a fundamental data for risk analysis and management of CVD in the workplace.