• Title/Summary/Keyword: in-use stability

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Comparative Study on the Regulations about In-Use Stability, and Analysis the In-Use Stability Application on Approved Syrups - Focused on the Guidelines in US, Europe and Korea - (국내외 의약품 개봉 후 안정성 규정 비교와 국내 시럽제의 안정성 적용 현황 분석 - 미국, 유럽, 한국의 가이드라인을 중심으로 -)

  • Park, Onnuri;Jang, Kyoung won;Ha, Dong mun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.3
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    • pp.137-146
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    • 2020
  • Syrup agents are often used after opening, and therefore, there is a high possibility of decreased quality. The Ministry of Food and Drug Safety (MFDS) published guideline on stability testing for pharmaceuticals after opening in December, 2016. We compared guidelines related to the period of use after opening between the United States of America (USA), Europe (EU), and Korea, and we analyzed whether the period of use or storage conditions is stated based on the data of drug approval for 4 dry syrups and 3 large packing syrups before and after the introduction of the guideline. First, in USA and EU, the period of use and storage conditions after opening should be listed on the label on the packaging container (as well as the expiration date), while in Korea, those are included in the area of precautions for use. Second, all of the analyzed drugs were not changed by the guidelines for establishing the new post-opening period of use, and they were only presented for the existing expiration date prior to the establishment of the guideline. Medicines that are used for multiple uses after opening may need improved instructions to ensure that the period of use and storage conditions are listed on the packaging according to stability evaluation after opening.

Stability Determination of the Various Cosmetic Formulations containing Glycolic Acid

  • Yeo, Hye-yeon;Kim, Jeong-hee
    • Journal of Fashion Business
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    • v.22 no.3
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    • pp.30-38
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    • 2018
  • Glycolic acid(GA) is well known the most effective cosmetic ingredient on the epidermal remodeling, accelerated desquamation and inhibitory effect on melanin synthesis. The various cosmetic formulations containing GA have not been reported in terms of stability. This study was to investigate the stability of three formulations(gel, cream, and ointment). The stability of obtained formulations was tested chemical and physical characteristics including the composition stability, hot-cool cycling, the variation of pH and viscosity, and the observation of color and odor. The experimental results showed that the gel and cream containing 5% GA, both formulations have proper stability in the centrifugal test, hot-cool cycling test, viscosity, pH stability and the observation of color and odor. On the other hand, the 5% GA ointment did not have stability. We concluded that the formulations of gel and cream are more suitable than ointment to use GA ingredient for developing cosmetic in terms of stability.

CAUCHY-RASSIAS STABILITY OF DERIVATIONS ON QUASI-BANACH ALGEBRAS

  • An, Jong Su;Boo, Deok-Hoon;Park, Choonkil
    • Journal of the Chungcheong Mathematical Society
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    • v.20 no.2
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    • pp.173-182
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    • 2007
  • In this paper, we prove the Cauchy-Rassias stability of derivations on quasi-Banach algebras associated to the Cauchy functional equation and the Jensen functional equation. We use the Cauchy-Rassias inequality that was first introduced by Th. M. Rassias in the paper "On the stability of the linear mapping in Banach spaces, Proc. Amer. Math. Soc. 72 (1978), 297-300".

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Fall Risk Assessments Based on Postural and Dynamic Stability Using Inertial Measurement Unit

  • Liu, Jian;Zhang, Xiaoyue;Lockhart, Thurmon E.
    • Safety and Health at Work
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    • v.3 no.3
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    • pp.192-198
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    • 2012
  • Objectives: Slip and fall accidents in the workplace are one of the top causes of work related fatalities and injuries. Previous studies have indicated that fall risk was related to postural and dynamic stability. However, the usage of this theoretical relationship was limited by laboratory based measuring instruments. The current study proposed a new method for stability assessment by use of inertial measurement units (IMUs). Methods: Accelerations at different body parts were recorded by the IMUs. Postural and local dynamic stability was assessed from these measures and compared with that computed from the traditional method. Results: The results demonstrated: 1) significant differences between fall prone and healthy groups in IMU assessed dynamic stability; and 2) better power of discrimination with multi stability index assessed by IMUs. Conclusion: The findings can be utilized in the design of a portable screening or monitoring tool for fall risk assessment in various industrial settings.

An Analysis of the Effect of Opened-fence of Public Buildings on Users'Satisfaction (공공기관의 담장개방효과가 이용만족도에 미치는 영향분석 -서울특별시 구청을 중심으로-)

  • 서주환;이준근
    • Journal of the Korean Institute of Landscape Architecture
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    • v.29 no.6
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    • pp.21-26
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    • 2002
  • The propose of this study is to suggest objective data to be utilized for a plan and the improvement of open space through the analysis of people's behaviour and satisfaction after the introduction of an opened-fence around offices followed by a plan for wall-afforestation of public institution's. The sites examined are four offices; two of them have opened-walls and the others have traditional enclosure. Analysis of frequency is conducted to understand the actual use according to people's individual peculiarities. Pearson's correlation analysis, t-test, multiple regression analysis are carried out to find out relations of fluents. In the end, the satisfaction is high in public institution satisfaction, entrance, space perception. stability, Landscaped office with opened-fence rather than fence, and the increase in usage of fluent of public institution satisfaction, entrance, space perception. stability, confusion brings about rising of use-satisfaction. Satisfaction with the exterior of building is the most important variable that influences the whole urban open space. Furthermore the influences of the approach and stability having connection with open or not-open fence is major variable affecting satisfaction of use of open space. Whether open or not is important factor on satisfaction of open space of office building. Through this study, we can find that opened fence determines use satisfaction of resting space of outdoor-office. So factors affecting satisfaction must be regarded as important requisite on planning, design, development and management in plan for afforestation of fence at public institution.

STABILITY IN NONLINEAR NEUTRAL LEVIN-NOHEL INTEGRO-DIFFERENTIAL EQUATIONS

  • Khelil, Kamel Ali;Ardjouni, Abdelouaheb;Djoudi, Ahcene
    • Korean Journal of Mathematics
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    • v.25 no.3
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    • pp.303-321
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    • 2017
  • In this paper we use the Krasnoselskii-Burton's fixed point theorem to obtain asymptotic stability and stability results about the zero solution for the following nonlinear neutral Levin-Nohel integro-differential equation $$x^{\prime}(t)+{\displaystyle\smashmargin{2}{\int\nolimits_{t-{\tau}(t)}}^t}a(t,s)g(x(s))ds+c(t)x^{\prime}(t-{\tau}(t))=0$$. The results obtained here extend the work of Mesmouli, Ardjouni and Djoudi [20].

Effects of Immobilization of the Ankle and Knee Joints on Postural Stability in Standing (바로 선 자세에서 발목과 무릎관절의 고정이 자세안정성에 미치는 영향)

  • Hwang, Su-Jin;Woo, Young-Keun;Jeon, Hye-Seon
    • Physical Therapy Korea
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    • v.15 no.1
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    • pp.30-37
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    • 2008
  • This study was designed to examine the effects of temporary immobilization of the ankle and knee joints on standing in healthy young adults with the use of a postural control mechanism. The subjects were twenty-four college students (12 males and 12 females, aged between 20 and 28). A Biodex balance system SD 950-302 and its software were used to measure indirect balance parameters in standing. Each subject underwent postural stability tests in 4-different joint conditions: free joints, ankle immobilization only, knee immobilization only, and ankle and knee immobilization. In addition, the postural stability test was conducted once with the subject's eyes open and once with the eyes closed conditions. For data analysis of the postural stability tests, the overall stability index, antero-posterior stability index, and medio-lateral stability index were recorded. The overall stability index (p=.000) and medial-lateral index (p=.003) were significantly greater different conditions with eyes closed in postural stability. Therefore, the eyes closed condition is expected to be used as an effective postural stability training for treatment planning in patients with unstable postures. In addition, training based on the dynamic multi-segment model can improve postural stability and is available to therapeutic programs, helping people with unstable balance to reduce their risk of falling.

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A Study on the Selection and Stability of Slings and Lugs of Mobile Cranes (이동식 크레인의 슬링.러그 선정 및 안정성 검토 연구)

  • Kim, Sun-Kuk;Seo, Jong-Min;Ho, Jong-Kwan
    • Korean Journal of Construction Engineering and Management
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    • v.9 no.6
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    • pp.164-174
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    • 2008
  • As buildings become larger, higher and more complex in most construction sites, construction projects have to deal with transportation of more materials, labor and equipment, necessitating more use of construction equipment. Notably, in the high-rise building and plant construction projects mobile cranes are adopted more frequently among different types of construction machinery, which also results in serious industrial accidents relating to the use of crane. To reduce serious industrial accidents involving cranes, researches on its stability is in need. The research herein aims to study how to select sling and lug of mobile crane and review its stability. The research outcomes herein will make considerable contributions to selecting mobile cranes efficiently and ensuring their stability.

Factors Affecting Use Satisfaction with Hospital Information System of Hospital Administrator (병원행정직원의 병원정보시스템 이용만족도에 영향을 미치는 요인)

  • Choi, Jun-Young;Ko, Min-Seok;Lee, Hyun-Suk
    • The Korean Journal of Health Service Management
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    • v.5 no.3
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    • pp.157-168
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    • 2011
  • This study was designed to identify satisfaction with Hospital Information System(HIS) and the factors affecting them in hospital administrators. The data was collected for 24 days from Mar. 02 to 25, 2011. Among a total of 82 cases of the questionnaires, only 76 cases were used. From the survey, it was made known that there was statistically significant difference in speed, preciseness and stability of environmental factors depending on the type of hospitals while significant difference was found in stability by number of beds. Among the factors of system operation, the administrational method affected speed, preciseness, stability and convenience statistically significantly whereas, however, preciseness, stability and convenience became significantly different depending on the number of staff members. As for the factors that could exercise influence upon satisfaction with administrative service of the HIS, it was revealed that statistically considerable impact could be caused under management of own EDPS expert as well as under comanagement by the medical institution and professional business entity in case of hospital.

Consideration to the Stability of FLC using The Circle Criterion (Circle Criterion을 이용한 FLC의 안정도에 대한 고찰)

  • Lee, Kyoung-Woong;Choi, Han-Soo
    • Journal of Institute of Control, Robotics and Systems
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    • v.15 no.5
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    • pp.525-529
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    • 2009
  • Most of FLC received input data from error e and change-of-error e' with no relation with system complexity. Basic scheme follows typical PD and PI or PID Controller and that has been developed through fixed ME In this paper, We studied the relationship between MF and system response and system response through changing Fuzzy variable of consequence MF and propose the simple FLC using this relationship. The response of FLC is changed according to the width of Fuzzy variable of consequence MF. As changing the Fuzzy variable of consequence MF shows various nonlinear characteristic, we studied the relation between response and MF using analytical method. We designed the effective FLC using three-variable MF and nine rules and took simulation for verification. In this study, we propose the method to design system with FLC in stability point which is an impotent characteristic of designing system. The circle criterion which is adapted to analysis the nonlinear system is put to use for proposed method. Since SISO FLC has a time-invariant and odd characteristic we can use the critical point not disk which is generally used to determine the stability in the circle criterion, to determine the stability. Using this, we can get the maximum critical point plot of SISO FLC with changing the consequence fuzzy variables. The predetermined critical point plot of FLC can be used to decide the region of the system to be stable. This method is effectively used to design the SISO FLC.