• 제목/요약/키워드: in(non)human

검색결과 4,014건 처리시간 0.027초

Single Dose Toxicity Study of IFN-Rod in Cynomolgus Monkey

  • Kim, Choong-Yong;Heo, Jeong-Doo;Han, Su-Cheol;Seol, Eun-Young;Tarumoto, Yasuo;Kwon, Myung-Sang;Ha, Chang-Su
    • 한국환경성돌연변이발암원학회:학술대회논문집
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    • 한국환경성돌연변이발암원학회 2004년도 춘계학술대회
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    • pp.60-60
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    • 2004
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한국기업에서 비정규직의 인적자원관리전략에 관한 탐색적 연구 (An Exploratory Study on the Human Resource Management Strategy of Non-Standard Workers in the Korean Companies)

  • 박민생
    • 경영과정보연구
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    • 제24권
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    • pp.73-75
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    • 2008
  • The purpose of this study is to propose the human resource management strategies of non-standard workers that can contribute to accomplishing both corporate social responsibility and business purpose in efficient and effective ways. For the purpose, this researcher investigated circumstances under which Korean companies are using non-standard workers and systems related to those workers. In Korea, the Non-Standard Workers Protection Act was enacted and revised, and became effective on July 1, 2007. The main provisions of the act are as follows. First, the systems of discriminatory treatment prohibition was legally stipulated, Second, restrictions on overwork for fixed-term and part-time employees and the written statement of working conditions were compelled. Third, only 26 kinds of jobs were permitted for worker dispatch in accordance with positive list system. To achieve their business purpose, companies often use standard workers, but sometimes non-standard workers unavoidably in accordance with their business strategy. This study propose main human resource management strategies of non-standard workers such as determining the scope of jobs, strengthening legal and systematic human resource management, improving human relations, extending the grievance procedure and converting non-standard workers into standard ones.

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Effect of Transportation Stress on Blood Parameters in Cynomolgus Monkeys

  • Kim, Choong-Yong;Han, Su-Cheol;Heo, Jeong-Doo;Yasuo Tarumoto;Chung, Moon-Koo;Han, Sang-Seop
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 춘계학술대회 논문집
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    • pp.87-87
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    • 2003
  • Various parameters of blood may be fluctuated by environmental factors such as transportation stress including diet, temperature, and so on). Thirty five 3- to 5 years-old cynomolgus monkeys were imported from Japan to evaluate potential toxic effect of a new biopharmaceutical. (omitted)

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Non-Synteny Regions in the Human Genome

  • Lee, Ki-Chan;Kim, Sang-Soo
    • Genomics & Informatics
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    • 제8권2호
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    • pp.86-89
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    • 2010
  • Closely related species share large genomic segments called syntenic regions, where the genomic elements such as genes are arranged co-linearly among the species. While synteny is an important criteria in establishing orthologous regions between species, non-syntenic regions may display species-specific features. As the first step in cataloging human- or primate- specific genomic elements, we surveyed human genomic regions that are not syntenic with any other non-primate mammalian genomes sequenced so far. Based on the data compiled in Ensembl databases, we were able to identify 10 such regions located in eight different human chromosomes. Interestingly, most of these highly human- or primate- specific loci are concentrated in subtelomeric or pericentromeric regions. It has been reported that subtelomeric regions in human chromosomes are highly plastic and filled with recently shuffled genomic elements. Pericentromeric regions also show a great deal of segmental duplications. Such genomic rearrangements may have caused these large human- or primate- specific genome segments.

國內詞育 원숭이의 血淸 LDH의 總活性値와 isoenzyme에 관한 硏究 (Studies on the Serum Total Activities and Isoenzyme PAtterns of LDH in Non-Human Primates Reared in Korea)

  • 윤상보;김덕환;서지민;신남식;현병화;김명철;윤효인;박배근;송희종
    • 한국임상수의학회지
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    • 제18권4호
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    • pp.380-389
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    • 2001
  • Non-human primates have been increasing in demand as important experimental animals and companion animals, domestically and internationally. The number of non-human primates for these purposes will be much enhanced in the near future. Despite this trend, basic physiological data are scarcely available in these animal species, leading to the difficulty to diagnose diseases when necessary, due to the absence of reference values. Particularly, there is not any report on the total activity of LDH of non-human primates, let alone LDH isoenzyme patterns, in Korea. LDH isoenzymes have a high level of efficaciousness as diagnostic and prognostic aids in various diseases. In this study, total activities and isoenzyme patterns of LDH were measured to obtain their reference values in domestically reared common marmosets, crab-eating macaques and Japanese macaques. There were widespread different values of serum total LDH among the non-human primate species experimented in this study. Serum LDH values of common marmosets and crab-eating macaques were 597.5$\pm$243.1 IU/l and 605.3$\pm$312.6 IU/l, respectively, whereas those of Japanese macaque showed 1,209$\pm$473.8 IU/l. Five isoenzyme fractions of LDH were observed in all experimented non-human primates but their ranks and proportions represented different patterns one another. In common marmosets, the percent of fraction for serum LDH1, LDH$_2$, LDH$_3$, LDH$_4$, and LDH$_{5}$ was 13.7$\pm$6.4%, 23.3$\pm$3.6%, 29.2$\pm$5.0%, 9.4$\pm$1.4% and 24.4$\pm$7.5%, respectively. The rank of LDH isoenzymes was LDH$_3$>LDH$_{5}$>LDH$_2$>LDH$_1$>LDH$_4$, in the descending order. For crab-eating macaques, the fraction of serum LDH$_1$, LDH$_2$, LDH$_3$, LDH$_4$, and LDH$_{5}$ occupied 19.5$\pm$12.7%, 25.3$\pm$9.3%, 23.8$\pm$8.1%, 10.2$\pm$2.8% and 21.3$\pm$14.2%, respectively. The order of LDH isoenzymes was LDH$_2$>LDH$_3$>LDH$_{5}$>LDH$_1$>LDH$_4$, from top to down. On the while, in Japanese macaques, the fraction of serum LDH$_1$ to LDH$_{5}$ showed 23.4$\pm$11.8%, 30.5$\pm$4.1%, 17.4$\pm$3.9%, 11.3$\pm$3.7% and 13.8$\pm$5.6%, respectively. The decreasing order indicated LDH$_2$>LDH$_1$>LDH$_3$>LDH$_{5}$>LDH$_4$. In conclusion, values such as LDH and LDH isoenzyme patterns of investigated for the first time from non-human primates reaared in Korea, could be reference values for the optimal diagnosis and therapy of diseases of the corresponding animal species. Other parameters of hematology and blood biochemistry are urgently needed to study for the benefit of our intimate non-human primates.an primates.

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학습효과를 고려한 인간 기계 직렬체계 신뢰도와 모수추정 (Human Machine Serial Systems Reliability and Parameters Estimation Considering Human Learning Effect)

  • 김국
    • 한국경영공학회지
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    • 제23권4호
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    • pp.159-164
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    • 2018
  • Human-machine serial systems must be normal in both systems. Though the failure of machine is irreducible by itself, the human errors are of recurring type. When the human performance is described quantitatively, non-homogeneous Poisson Process model of human errors can be developed. And the model parameters can be estimated by maximum likelihood estimation and numerical analysis method. System reliability is obtained by multiplying machine reliability by human reliability.

기업의 인적자원관리와 경영성과의 관계에 대한 연구 : 말콤 볼드리지 평가 기준을 중심으로 (A Study on the Relation between the Human Resource Management and Management Performance in Enterprise : Focused on the Malcolm Baldrige's Evaluation Model)

  • 박형근;정영배
    • 산업경영시스템학회지
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    • 제33권4호
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    • pp.85-99
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    • 2010
  • This study is to identify the present condition and level of human resource administration in domestic profit and non-profit organizations, and to investigate on the relation between human resource management and management performance in enterprise. This study is to make items related to the human resource management of American Malcolm Baldrige Award's level and management performance researching questions, investigates seven patterns of organs surveyed positively. The results are as follows: Firstly, the profit organs like manufacturing companies shows more positive than non-profit in comparison with human resource management of each organs. And a local government and public enterprise which is non-profit show to recognize human resource management is insufficient on th whole. Secondly, perception level of a medical institution, educational institution and service industry about aromaticity of human resource management by global standard shows to be positive, but the local government negative. Thirdly, the profit organ in the recognition of human resource management about details practice too, shows to be positive, while non-profit negative. Fourth, the result which compares and analyzes management performance between the similar industry overall show to recognize positive, but public enterprise negative about product, service performance and human resource management. Fifthly, the details practice of human resource administration shows to influence meaningly to all management performance. Therefore, all organizations will positively confront human resource management, make the circumstance of organization through systematic program, and promote the management performance of the organization.

RADIATION DOSE TO HUMAN AND NON-HUMAN BIOTA IN THE REPUBLIC OF KOREA RESULTING FROM THE FUKUSHIMA NUCLEAR ACCIDENT

  • Keum, Dong-Kwon;Jun, In;Lim, Kwang-Muk;Choi, Yong-Ho
    • Nuclear Engineering and Technology
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    • 제45권1호
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    • pp.1-12
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    • 2013
  • This paper describes the radiation doses to human and non-human biota in the Republic of Korea, as a result of the Fukushima nuclear accident. By using the measured airborne activity and ground deposition, the effective and thyroid doses of five human age groups (infant, 5 years, 10 years, 15 years and adult) were estimated by the ECOSYS code, and the whole body absorbed dose rate of the eight Korean reference animals and plants (RAPs) was estimated by the K-BIOTA (the Korean computer code to assess the risk of radioactivity to wildlife). The first-year effective and thyroid human doses ranged from 5.7E-5 mSv in the infant group to 2.0E-4 mSv in the 5 years group, and from 5.0E-4 mSv in the infant group to 3.4E-3 mSv in the 5 years group, respectively. The life-time (70 years) effective and thyroid human doses ranged from 1.5E-4 mSv in the infant group to 3.0E-4 mSv in the 5 years group, and from 6.0E-4 mSv in the infant group to 3.5E-3 mSv in the 5 years group, respectively. The estimated maximum whole body absorbed dose rate to the Korean RAPs was 6.7E-7 mGy/d for a snake living in soil (terrestrial biota), and 2.0E-5 mGy/d for freshwater fish (aquatic biota), both of which were far less than the generic dose criteria to protect biota from ionizing radiation. Also, the screening level assessment for ERICA's (Environmental Risks from Ionizing Contaminants: Assessments and management) limiting organisms showed that the risk quotient (RQ) for the estimated maximum soil and water activity was significantly less than unity for both the terrestrial and freshwater organisms. Conclusively, the radiological risk of the radioactivity released into the environment by the Fukushima nuclear accident to the public and the non-human biota in the republic of Korea is considered negligible.