• Communications for Statistical Applications and Methods
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• v.29 no.4
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• pp.421-439
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• 2022

Phase I dose-finding trials are essential in drug development. By finding the maximum tolerated dose (MTD) of a new drug or treatment, a Phase I trial establishes the recommended doses for later-phase testing. The primary toxicity endpoint of interest is often a binary variable, which describes an event of a patient who experiences dose-limiting toxicity. However, there is a growing interest in dose-finding studies regarding non-binary outcomes, defined by either the weighted sum of rates of various toxicity grades or a continuous outcome. Although several novel methods have been proposed in the literature, accessible software is still lacking to implement these methods. This study introduces a newly developed R package, UnifiedDoseFinding, which implements three phase I dose-finding methods with non-binary outcomes (Quasi- and Robust Quasi-CRM designs by Yuan et al. (2007) and Pan et al. (2014), gBOIN design by Mu et al. (2019), and by a method by Ivanova and Kim (2009)). For each of the methods, UnifiedDoseFinding provides corresponding functions that begin with next that determines the dose for the next cohort of patients, select, which selects the MTD defined by the non-binary toxicity endpoint when the trial is completed, and get oc, which obtains the operating characteristics. Three real examples are provided to help practitioners use these methods. The R package UnifiedDoseFinding, which is accessible in R CRAN, provides a user-friendly tool to facilitate the implementation of innovative dose-finding studies with nonbinary outcomes.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.1
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• pp.45-56
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• 2022

Recently, bicycle sharing system is introduced and the usage of shared bicycles is increasing in Suwon city. Despite the need to expand the bicycle road infrastructure, this is not the case. Therefore, this research attempts to propose a method for bicycle lane installation in Suwon city. For this, this research conducted location analysis based on the shared bicycle usage data and trip inducing facility data. Using location analysis results, appropriate routes for bicycle lanes are selected. As a result, two routes are selected. These routes have advantages that it is easy to connect with the existing bicycle roads or traffic inducing facilities and to install using the existing bicycle roads. However, these routes also have disadvantage that traffic congestion may occur due to the occupancy of the existing road space. It is expected that this research may contribute to expansion and maintenance of bicycle lane infrastructure, the bicycle and PM sharing service usage, implementation of sustainable urban transportation systems in Suwon city.

• The Journal of the Convergence on Culture Technology
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• v.8 no.2
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• pp.59-67
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• 2022

The main purpose of this study is to quantitatively grasp the effectiveness of the gardening program by conducting a gardening program to induce active activities of the elderly and to induce healing functions and social activities, and then observing the results before and after implementation. In order to achieve the purpose of the study, as a result of conducting 30 gardening programs for 20 elderly people at two elderly care facilities, the measure of depression was found to have an improvement effect as a practice-oriented program, and it was found to revitalize the elderly. In addition, it was found that the quality of life was improved by the gardening program, and it was found to be helpful in activating the brain.

• Journal of Soil and Groundwater Environment
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• v.27 no.2
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• pp.24-35
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• 2022

This study was conducted to estimate groundwater demand and supply for agricultural activities in a frequent-drought area that requires implementation of optimal distribution plan utilizing the well-network system (WNS). The WNS has been considered as a viable strategic way of supplying groundwater to farmlands by connecting groundwater wells physically or virtually. The study area heavily relied on groundwater resources for irrigation up to 53% due to a lack of surface water resources. Two kinds of methods, HOMWRS software and FAO approach, were used for estimating irrigation water requirements for paddy and upland fields, respectively. During the latest 10 years (2010~2019), the water requirements was estimated to be 1,106 m³/day. The requirements notably increased to 1,121~4,004 m³/day during active farming season (May to September), which exceeded the total yield capacity of pre-existing groundwater wells (2,356 m³/day) in the area. Detailed and definite determination for groundwater demand and supply helped to determine optimal scale parameters of WNS. The WNS has achieved more balanced distribution of groundwater resources for irrigation over the study area.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.4
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• pp.53-62
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• 2022

Disposition Effect (DE) is one of the many investment biases, wherein the investors sell the profitable stocks rather quickly and they tend to hold on the loss making stocks. Various factors related to the DE are the character of investors applying risk management which is also influenced by the social media, Salient Shock (COVID-19), and in the specific case of Indonesia, the phenomenon of rumor stocks wherein the price can rise as much as up to 8500%. The study aims to provide empirical evidence regarding the DE with specific explanatory factors, namely investor behavior and rumors. Data was obtained through a questionnaire sent to 248 Indonesian Stock Exchange Investors (IDX) during the period October-November 2021 by using Ordinary Least Square (OLS) method. The results show: Generation Z, women, and investors with a low education has a greater DE, risk-takers tend to have lower DE, and professionals have negative DE. Implementation of risk management will reduce DE. Social Media and the COVID-19 situation positively affect DE. Especially on stock rumors, there is evidence that investors who own rumor stocks will have a low DE. The results indicate the need for: (i) risk management, especially for Z Generation, women and low education Investors, (ii) to provide positive information so that information on social media can be responded to positively.

• Journal of Industrial Convergence
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• v.20 no.1
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• pp.63-68
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• 2022

In schools and corporate buildings, public WiFi Access Points are installed on the ceilings of hallways. In the case of an architectural structure in which a WiFi signal enters through a steel door made of a material with high signal attenuation, Internet connection is frequently cut off or fails when the door is closed. To solve this problem, our research implements an economical and portable WiFi extender using a Raspberry Pi and an auxiliary battery. Commercially available WiFi extenders have limitations in the location where the power plug is located, and WiFi extension using the WiFi hotspot function of an Android smartphone is possible only in some high-end models. However, because the proposed device can be installed at the position where the Wi-Fi reception signal is the best inside the door, the WiFi range can be extended while minimizing the possibility of damage to the original signal. Experimental results show that it is possible to eliminate the shadows of radio waves and to provide Internet services in the office when the door is closed, to the extent that web browsing and real-time video streaming for 720p are possible.

• SUVANNABHUMI
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• v.13 no.2
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• pp.109-134
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• 2021

Indonesia has undergone the rapid deforestation largely as a result of practical consequences of human overexploitation of the forest. Between 1950 and 2015, around 43% of the forest area in Indonesia had been lost (68.0 million hectares). The process of deforestation has partly been a response to the rapidly intensifying 'global' and 'domestic' economic demands. Deforestation in Indonesia is also indirectly due to 'materialism-driven' value system and the corresponding weakening of Indonesian ethics. Therefore, given that socio-cultural expressions of modern Indonesian value systems have mostly taken place within a framework of Islam, the aim of the paper is to attempt to find Islamic ethics in general, which can provide the basis of ecological ethics to prevent rapid deforestation in Indonesia. The paper is composed of the followings. First, following the 'Introduction', it outlines the historical process of deforestation in Indonesia and also its corresponding socio-economic contexts. Then it moves on to talk about ecological ethics in general, thereby emphasizing that the phenomenological problem of deforestation needs to be conceived at a philosophical level beyond ecological phenomena. After discussing the ecological ethics, the paper proceeds to examine Islamic ethics as a canonical framework of ecological ethics in Indonesia. In doing so, it attempts to apply the Islamic ethics to the diverse Indonesian society and then considers 'Pancasila' as a potential framework for a pragmatic link between Islam ethics and Indonesian society. Having said that, in conclusion, the paper argues that there is a need for 'concrete' translation of 'Pancasila' into implementation in an Indonesian context, thereby various agents (government, policy-practitioners, concessionaires and also all the Indonesian) may agree in saying 'no' to overexploitation of the forest, to rapid depletion of the forest and to 'unsustainable' development practices.

• The Plant Pathology Journal
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• v.38 no.3
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• pp.194-202
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• 2022

Erwinia amylovora and Erwinia pyrifoliae cause fire blight and black-shoot blight, respectively, in apples and pears. E. pyrifoliae is less pathogenic and has a narrower host range than that of E. amylovora. Fire blight and black-shoot blight exhibit similar symptoms, making it difficult to distinguish one bacterial disease from the other. Molecular tools that differentiate fire blight from black-shoot blight could guide in the implementation of appropriate management strategies to control both diseases. In this study, a primer set was developed to detect and distinguish E. amylovora from E. pyrifoliae by conventional polymerase chain reaction (PCR). The primers produced amplicons of different sizes that were specific to each bacterial species. PCR products from E. amylovora and E. pyrifoliae cells at concentrations of 10⁴ cfu/ml and 10⁷ cfu/ml, respectively, were amplified, which demonstrated sufficient primer detection sensitivity. This primer set provides a simple molecular tool to distinguish between two types of bacterial diseases with similar symptoms.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.965-974
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• 2022

Platinum anodes are widely used for metal oxides reduction in LiCl-Li₂O, however high-cost and low-corrosion resistance hinder their implementation. NiO-Li₂O ceramics is an alternative corrosion resistant anode material. Anode processes on platinum and NiO-Li₂O ceramics were studied in (80 mol.%) LiCl-(20mol.%)KCl and (80 mol.%)LiCl-(20 mol.%)KCl-Li₂O melts by cyclic voltammetry, potentiostatic and galvanostatic electrolysis. Experiments performed in the LiCl-KCl melt without Li₂O illustrate that a Pt anode dissolution causes the Pt²⁺ ions formation at 3.14 V and 550℃ and at 3.04 V and 650℃. A two-stage Pt oxidation was observed in the melts with the Li₂O at 2.40 ÷ 2.43 V, which resulted in the Li₂PtO₃ formation. Oxygen current efficiency of the Pt anode at 2.8 V and 650℃ reached about 96%. The anode process on the NiO-Li₂O electrode in the LiCl-KCl melt without Li₂O proceeds at the potentials more positive than 3.1 V and results in the electrochemical decomposition of ceramic electrode to NiO and O₂. Oxygen current efficiency on NiO-Li₂O is close to 100%. The NiO-Li₂O ceramic anode demonstrated good electrochemical characteristics during the galvanostatic electrolysis at 0.25 A/cm² for 35 h and may be successfully used for pyrochemical treating of spent nuclear fuel.

• Journal of Preventive Medicine and Public Health
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• v.55 no.1
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• pp.80-87
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• 2022

Objectives: Dengue remains hyperendemic in Malaysia despite extensive vector control activities. With dynamic changes in land use, urbanisation and population movement, periodic updates on dengue transmission patterns are crucial to ensure the implementation of effective control strategies. We sought to assess shifts in the trends and spatial patterns of dengue in Kelantan, a north-eastern state of Malaysia (5°15'N 102°0'E). Methods: This study incorporated data from the national dengue monitoring system (eDengue system). Confirmed dengue cases registered in Kelantan with disease onset between January 1, 2016 and December 31, 2018 were included in the study. Yearly changes in dengue incidence were mapped by using ArcGIS. Hotspot analysis was performed using Getis-Ord Gi to track changes in the trends of dengue spatial clustering. Results: A total of 10 645 dengue cases were recorded in Kelantan between 2016 and 2018, with an average of 10 dengue cases reported daily (standard deviation, 11.02). Areas with persistently high dengue incidence were seen mainly in the coastal region for the 3-year period. However, the hotspots shifted over time with a gradual dispersion of hotspots to their adjacent districts. Conclusions: A notable shift in the spatial patterns of dengue was observed. We were able to glimpse the shift of dengue from an urban to peri-urban disease with the possible effect of a state-wide population movement that affects dengue transmission.