• 제목/요약/키워드: ileum

검색결과 572건 처리시간 0.025초

대장 중복증과 동반된 회장 분절 확장증 1례 (Segmental Dilatation of the Ileum Combined with Colonic Duplication: - a Case Report -)

  • 한석주;김성민;손석우;김호근;김재억;황의호
    • Advances in pediatric surgery
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    • 제4권2호
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    • pp.166-171
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    • 1998
  • Segmental dilatation of the small intestine is a rare form of the congenital intestinal anomaly. Many other combined anomalies have been reported in, but the association with colonic duplication has not been reported in the literature. We report a case of segmental dilatation of the distal ileum associated with colonic duplication. The main clinical and pathogenic aspects are discussed, and the literatures are reviewed.

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유전자 재조합 B형 간염 바이러스 표면 항원, CJC-50100의 일반약리작용 (General Pharmacology of CJC-50100, a Recombinant Hepatitis B Virus Surface Antigen)

  • 정성학;최재묵;이남중;전형수;김연희;김재승;하석훈;김영훈;이나경
    • Biomolecules & Therapeutics
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    • 제9권1호
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    • pp.55-62
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    • 2001
  • CJC-50100 is a recombinant hepatitis B virus surface antigen (HBsAg) expressed in yeast. The general pharmacological properties of CJC-50100 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses were 0.33~33.3 $\mu$g/kg i.m. for mice and rats and 3.3~9.9 $\mu$g/kg i.v. for dogs. The concentrations of 0.002~0.02 $\mu$g/ml were used for the assay with guinea pig ileum. Intramuscular administration of CJC-50100 at the doses did not alter general behavior and the responses for central nervous system, smooth muscle, gastrointestinal system, cardiovascular and respiratory system, and water and electrolytes excretion. In summary, CJC-50100 had no pharmacological effect in these studies even up to the 100-fold of the expected clinical dose, 20 $\mu$g/man/60 kg.

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Antibradykinin Effects of the Non-peptide Antagonists of Mixture Libraries Prepared by Solution-phase Combinatorial Synthesis

  • KAM Yoo Lim;CHOO Hea-Young P.
    • Biomolecules & Therapeutics
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    • 제13권3호
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    • pp.181-184
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    • 2005
  • The solution-phase combinatorial synthesis of iminodiacetic acid triamide libraries linked to 1-(4-chlorobenzhydryl)piperazine has been reported. Ten mixture libraries, each containing 5 components, were synthesized in 4 steps from N-BOC-iminodiacetic acid anhydride. Antibradykinin effects of the mixture and individual libraries were compared using guinea-pig ileum smooth muscle. The changes in the inhibition were also observed by testing the combination of two different compounds from the same library. We found out the correlation between the inhibition of mixtures and that of individual libraries. It is possible to choose the mixtures with relatively high inhibitory effects to find out the most effective individual compound for further synthesis.

CJ-50001 (rG-CSF)의 일반약리작용 (Giniral pharmacology of CJ-50001 (rG-CSF))

  • 정성목;김영훈;신재규;최재목;고형곤;김제학;김현수
    • Biomolecules & Therapeutics
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    • 제5권3호
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    • pp.316-322
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    • 1997
  • CJ-50001 is a recombinant granulocyte-colony stimulating factor (rG-CSF) synthesized by recombi-nant DNA technology using E. coli as an expression system. The general pharmacological properties of CJ-50001 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses are 100, 300 and 1, 0007g/kg, i.v. for mice and rats, 1, 10 and 100$\mu$g/kg, 1.v. for dogs and 1 and 10$\mu$g/ml for isolated guinea pig ileum. Intravenous administration of CJ-50001 at this dose range did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electro-lytes excretion. In summary, CJ-50001 had no harmful pharmacological erect in these studies even up to the 200-fold expected clinical dose, 2507g/man.

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A Case of Taenia asiatica Infection Diagnosed by Colonoscopy

  • Kim, Heung Up;Chung, Young-Bae
    • Parasites, Hosts and Diseases
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    • 제55권1호
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    • pp.65-69
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    • 2017
  • A case of Taenia asiatica infection detected by small bowel series and colonoscopy is described. The patient was a 42-year-old Korean man accompanied by discharge of movable proglottids via anus. He used to eat raw pig liver but seldom ate beef. Small bowel series radiologic examinations showed flat tape-like filling defects on the ileum. By colonoscopy, a moving flat tapeworm was observed from the terminal ileum to the ascending colon. The tapeworm was identified as T. asiatica by mitochondrial DNA sequencing. The patient was prescribed with a single oral dose (16 mg/kg) of praziquantel.

Carbamate 화합물의 합성 및 위생학적 연구 (Synthesis and Biological Activities of Carbamate Derivative)

  • 강회양
    • 한국환경보건학회지
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    • 제22권2호
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    • pp.19-24
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    • 1996
  • Carbamates are generally used as insecticide, thus 5.7-dichloro-8~hydroxyquinolinyl- N-ethylcarbamate was newly synthesized. Its physical properties were determined and chemical structure was identified by means of I.R., nmr in addition to elemental analysis. The yield of addition, using triethylamine as catalyst, 5.7-dichloro-8-hydroxyquinoline and isocyanate was better than that of condensation of 5.7-dichloro-8-hydroxyquinoline with carbamoylchloride. The effct of the compound on rabbit's ileum, and antibacterial activity against Staphylococcus aureus, Salmonella typhi, Echerichia coli, and Pseudomonas aeruginosa were examined. The present organic synthesized compound showed the bacteriostatic action on salmonella typhi, escherichia coli, and pseudomonas aeruginosa, but no otherwise effect of contraction of rabbit's ileum in the concentration of $250 \mu g/ml$.

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鼻出血에 應用되는 艾柏飮의 效能에 關한 實驗的 硏究 (An Experimental Study on the Effects of Aebaegeum Applicable to the Treatment of Epistaxis)

  • 홍익표;채병윤
    • 한방안이비인후피부과학회지
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    • 제3권1호
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    • pp.1-15
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    • 1990
  • Aebaegeum has been widely used in the treatment of epistaxis, as based on Oriental Medical 1iteratures. In order to investigate experimentally the clinical effects of Aebaegeum, hemostatic time, plasma recalcification time and prothrombin time of hypoprothrombinemia induced by warfarin injection, action on isolated ileum, action on blood vessel, action on blood pressure and respiration and action on heart were observed. The result of the studies were obtained as follows: 1. Hemostatic time of vein ruptured mice was significantly shortened. 2. Plasma recalification time and prothrombin time of hypoprothrombinemic rats induced by warfarin injection were significantly shortened. 3. Spontaneous mobilities in the isolated ileum of mice were significantly suppressed, and contraction by acetylcholine chloride and barium chloride were inhibited. 4. Dilatation of blood vessel and downing of blood pressure of rabbit were noted. 5. Contraction of heart in the original position and isolated heart of frog were significantly shortened. According to the above result, it is expected that Aebaegeum can be widely applicable to the treatment of epistaxis.

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다람쥐 소화관의 내분비세포에 관한 전자현미경적 연구 (Electron Microscopic Observations of Endocrine Cells on the Squirrel's Gastrointestinal Tract)

  • 이형식;이재현
    • 대한수의학회지
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    • 제26권1호
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    • pp.19-30
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    • 1986
  • Endocrine cells were observed in the gastrointestinal tract of the squirrels by light microscopy using Grimelius and Masson-Hamperl silver impregnation, and in the stomach and duodenum by electron microscopy. Light microscopically, argyrophil cell decreased gradually in number in the pyloric region and ileum, stomach, duodenum and jejunum and rectum in the order listed. Argentaffin cells were moderately distributed in the stomach, pyloric region and duodenum, while absent in the jejunum, ileum and rectum. Five kinds of cell types, EC, ECL, D, $D_1$ and G cells were identified in the stomach and three kinds of cell types, S, $EC_1$ and $EC_2$ were also identified in the duodenum by electron microscopy. A cilium noted in the cytoplasm of $D_1$-type cell. The species differences in the distribution, size and structure of the secretory granules were discussed.

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5.7-Dichloro-8-hydroxyquinaldyl-N-ethylcarbamate의 합성 및 항균작용에 관한 연구 (Study on the Synthesis and Antimicrobial Activity of 5.7-Dichloro-8-HydroxyquinaldyI-N-Ethylcarbamate)

  • 강회양
    • 한국환경보건학회지
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    • 제24권1호
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    • pp.47-53
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    • 1998
  • 5.7-Dichloro-8-hydroxyquinaldyl-N-ethylcarbamate, one of the carbamate derivative which are generally used as insecticide, was newly synthesized. Its physical properities were determined and chemical structure was indentified by means of I.R., nmr in addition to elemental analysis. The yield of addition, using triethylamine as catalyst, 5.7-dichloro-8-hydroxyquinaldine and isocyanate was better than that of condensation of 5.7-dichloro-8- hydroxyquinaldine with carbamoylchloride. The effect of the cornpond on rabbit's ileum, and antibacterial activity against Staphylococcus aureus, Salmonella typhi, Escherichia coli, and Pseudomonas aeruginosa were examined. It was observed that the dosage over 100 $\mu$g/ml of the compound relaxed rabbit's ileum and the same dosage of the compound inhibited growth of the above strains of bactera.

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개방성 제장간막관 기형4예 보고 (Patent Omphalomesenteric Duct Remnants - Report of 4 Cases -)

  • 이우용;이석구;김현학
    • Advances in pediatric surgery
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    • 제3권2호
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    • pp.148-151
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    • 1997
  • The omphalomesenteric duct normally obliterates by the sixth week of intrauterine life. Incomplete obliteration results in various abnormalities which may be apparent in the newborn infant. These include fistula resembling ileum, a prolapsed loop of intestine through the umblicus and a fistula draining intestinal contents. The tract may contain ectopic tissue of stomach, colon or pancreas. Although this malformation should be recognizable at birth, 40 % of patients are not treated until after the first month of life. In the past 28 months since the Samsung Medical Center opened its doors to public, the authors have treated 4 cases of patent omphalomesenteric duct remnant including one case of T-shaped total prolapse of the duct and adjacent ileum. These cases will be discussed and the literature reviewed.

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