• Title/Summary/Keyword: idiopathic thrombocytopenia

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Eight Constitution Acupuncture Effect on Thrombocytopenia After Splenectomy at Idiopathic Thromobocytopenic Purpura as First Manifestation of Systemic Lupus Erythematosus Lupus (SLE환자에서 ITP 진단으로 비장적출술 후 혈소판감소를 팔체질침으로 호전시킨 치험례)

  • Seo, Yong-Won;Ko, Heung
    • Journal of Acupuncture Research
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    • v.23 no.4
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    • pp.219-224
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    • 2006
  • Idiopathic thrombocytopenic purpura(ITP) is characterized by the development of a specific anti-platelet autoantibody immune response mediating the development of thrombocytopenia. Systemic lupus erythematosus(SLE) is an autoimmune disease characterized by the production of a wide variety of autoantibodies. We experienced SLE patient whose initial symptoms were related to idiopathic thrombocytopenic purpura(ITP). She has a thrombocytopenia after Splenectomy and Steroid therapy on ITP and SLE. After she took Eight constitution Acupuncture treatment, thrombocytopenia has improved. We think Acupuncture will be effective treatment at autoimmune disease.

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A 22-month-old Boy with Acute Glomerulonephritis Coexistent with Hemolytic Anemia and Idiopathic Thrombocytopenia

  • Park, Hye Won;Seo, Bo Seon;Jung, Su Jin;Lee, Jun Ho
    • Childhood Kidney Diseases
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    • v.19 no.1
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    • pp.43-47
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    • 2015
  • Hemolytic anemia and thrombocytopenia are rare clinical manifestations of acute glomerulonephritis. Initially, in all such cases, a diagnosis of hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, systemic lupus erythematosus, and amyloidosis should be ruled out. The presence of hemolytic anemia and thrombocytopenia is rare, but possible, in a case of acute poststreptococcal glomerulonephritis, and may result in delayed diagnosis or misdiagnosis. Correct and timely diagnosis would ensure adequate treatment in such patients. We report of a 22-month-old boy with acute glomerulonephritis coexistent with hemolytic anemia and idiopathic thrombocytopenia.

Giant platelet syndrome (거대혈소판 증후군)

  • Kook, Hoon
    • Clinical and Experimental Pediatrics
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    • v.49 no.8
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    • pp.833-838
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    • 2006
  • Giant platelet syndrome is a group of unique disorders characterized by the presence of abnormally large platelets, and usually accompanied by thrombocytopenia. Most cases of giant platelets are encountered in idiopathic thrombocytopenic purpura(ITP). In contrast, inherited giant platelet disorders, a group of heterogeneous diseases, are rare. Bernard-Soulier syndrome and its variants, and MYH9 related diseases have been defined at the molecular level. Abnormalities in transcription factors are implicated in a couple of macrothrombocytopenia syndromes. However, the molecular defects are unknown in gray platelet syndrome. It is important to make a proper diagnosis of congenital macrothrombocytopenia to avoid unnecessary medications and potentially dangerous treatment for presumed ITP.

The Effect of Helicobacter pylori eradication in Patients with H. pylori(+) Idiopathic thrombocytopenic Purpura : Case study (위나선균양성 특발성혈소판감소성자반증에서 위나선균박멸요법의 효과: 증례 연구)

  • Park, Chi-Young;Moon, Hong-Seop
    • Korean Journal of Clinical Pharmacy
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    • v.21 no.1
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    • pp.39-42
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    • 2011
  • Idiopathic thrombocytopenic purpura is a potentially life-threatening condition characterised by thrombocytopenia and mediated by an autoimmune mechanism. Several recent studies have suggested that an association exists between H. pylori eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura. This study confirmed the efficacy of H. pylori eradication in increasing the platelet count in steroid refractory idiopathic thrombocytopenic purpura patients. Eradication therapy is simple and inexpensive, with limited toxicity and the advantage of avoiding long-term immunosuppressive treatment.

Life-threating outcomes after dental implantation in patient with idiopathic thrombocytopenic purpura: a case report and review of literature

  • Lee, Sung-Tak;Kim, Jin-Wook;Kwon, Tae-Geon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.40
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    • pp.39.1-39.7
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    • 2018
  • Background: Patients with chronic ITP (idiopathic thrombocytopenia) frequently do not require comprehensive medication for daily life. Usually, it had been regarded that postoperative bleeding after a simple or surgical extraction is easily controlled by simple local measures even in patients with ITP. This lack of regular medication usage can sometimes lead practitioners or patients to underestimate the potential life-threatening risk of ITP. There had been no report on postoperative hemorrhage in a patient with ITP related to dental implant surgery. Case presentation: This report presented a life-threatening postoperative hemorrhage after dental implant surgery in an adult with chronic ITP and subsequent emergency management after severe bleeding and airway compromise. Conclusion: The presented case emphasizes the thorough hematological evaluation of the patients even for patients who do not take any specific medications for asymptomatic, chronic ITP.

Advances in management of pediatric chronic immune thrombocytopenia: a narrative review

  • Jae Min Lee
    • Journal of Yeungnam Medical Science
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    • v.40 no.3
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    • pp.241-246
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    • 2023
  • Immune thrombocytopenia (ITP) is a disease in which thrombocytopenia occurs because of immune-mediated platelet destruction and decreased platelet production. Although many pediatric patients with ITP experience spontaneous remission or reach remission within 12 months of first-line therapy, approximately 20% progress to chronic ITP. Patients who do not respond to first-line treatment or experience frequent relapses are of great concern to physicians. This review summarizes recent treatments for second-line treatment of pediatric chronic ITP.

A case of idiopathic thrombocytopenia in a Yorkshire terrier dog (개 특발성 혈소판감소증 1례)

  • Kim, So-La;Cho, Chang-Seok;Kim, Min-Jae;Kang, Tae-Young;Lee, Joo-Myoung;Park, Hyun Jung;Cheong, Jongtae;Lee, Kyoung-kap;Yun, Young-min
    • Korean Journal of Veterinary Research
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    • v.47 no.4
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    • pp.475-478
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    • 2007
  • A 4-year-old spayed female, Yorkshire terrier dog with a history of petechial and ecchymotic hemorrhages on the face, trunk and hind limb was referred to Veterinary Medical Teaching Hospital, Cheju National University. The complete blood count revealed a marked thrombocytopenia ($96{\times}10^3/{\mu}l$). The biochemical profile showed only slightly increased glucose. The coagulation profile such as prothrombin time and activated partial thromboplastin time, was within the reference range. In Giemsa staining, there were no endoparasites like as Babesia spp. on the RBC. This case was diagnosed as a idiopathic thrombocytopenia in a Yorkshire terrier dog. She was treated with prednisone (1 mg/kg BW, IM q 12 h) and cephalosporin (10 mg/kg BW, IM, q 12 h). When rechecked on day 6, the platelet was within reference range ($507{\times}10^3/{\mu}l$) and also petechial and ecchymotic hemorrhages on the body were gradually improved without any complications. The dose of prednisone was decreased to 0.5 mg/kg BW, q 24 h. On day 17, we finished treatment because all the clinical signs, blood and serum chemistry were reference range and platelet count was dramatically increased.

A Case of Idiopathic Thrombocytopenic Purpura in Pregnancy (임신과 동반된 특발성 혈소판 감소성 자반증 1례)

  • Kim, Mi-Sook;HwangBo, Ho-Joon;Lee, Young-Gi;Park, Yoon-Kee;Lee, Sung-Ho
    • Journal of Yeungnam Medical Science
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    • v.10 no.2
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    • pp.512-517
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    • 1993
  • Idiopathic thrombocytopenic purpura is an uncommon illness but most common form of thrombocytopenia in pregnancy. Corticosteroids, splenectomy, immunosuppressive drugs, and immunoglobulin therapy have been recommended for management. The optimal method of delivery is controversial. We have experienced a case of idiopathic thrombocytopenic purpura diagnosed previously and managed with corticosteroid and vincristine, which was followed by pregnancy, vaginal delivery and postpartum splenectomy.

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Multiple Mandibular Idiopathic Bone Cavities in a Patient with Immune Thrombocytopenia : A Case Report (면역성혈소판감소증 환자의 하악골에 발생한 다발성 특발성골강 : 증례보고)

  • Baek, Young-Jae;Geum, Dong-Ho;Lee, Jung-Han;Kim, Sung-Hee;Ahn, Kyung-Yong;Kim, Uk-Kyu
    • The Journal of the Korean dental association
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    • v.51 no.1
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    • pp.25-32
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    • 2013
  • The immune thrombocytopenia(ITP) is defined as a platelet count of less than $100,000/{\mu}L$. It is gene rally known as characterized by the bleeding manifestations of skin and/or mucosa like ecchymosis due to low platelet count, but reports of the related intraosseous lesions are not common. The idiopathic bone cavity(IBC) is an empty space of the bone, which occurs mainly in the long bones. It is found predominantly in the mandible in case of the maxillofacial area. In general, it appears as an isolated unilocular lesion without the correlation of the teeth. Although the cause of the IBC is supposed to be associated with hemostatic problems, the etiology is unclear and it was not disclosed the relevance of specific systemic disease. In this present case, IBCs that occurred in mandible of patient who has IPT was treated by curettage with platelet transfusion.

Immune thrombocytopenic purpura(ITP) (면역 혈소판감소 자색반병)

  • Shin, Hee Young
    • Clinical and Experimental Pediatrics
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    • v.49 no.8
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    • pp.830-832
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    • 2006
  • Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than $20,000/{\mu}L$. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection or insidiously with progressive petechiae, bruising, or purpura. In most cases the disease is self-limited; approximately 80% of children recover by 6 months after diagnosis, with or without treatment. Children with thrombocytopenia persisting for more than 6 months are defined as having chronic ITP. Clinical manifestations, diagnosis, laboratory findings, differential diagnosis and various treatment modalities are reviewed.