• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7195-7200
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• 2014

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.

• The KIPS Transactions:PartD
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• v.19D no.1
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• pp.63-80
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• 2012

Mobile devices with Android OS and iOS have been emerged as mobile computing devices where various software applications are deployed. Furthermore, they are anticipated to be used not only for traditional personal computing but also for enterprise computing. However, such mobile devices have their intrinsic characteristics such as limited resources and flexible network capabilities, which are not revealed in traditional computers. Hence, there is high demand for methods to develop mobile applications with reflecting their intrinsic characteristics. Since those characteristics belong to non-functional requirements, they should be reflected in architecture design while designing mobile applications. To design architecture, the architecture drivers that are architecture non-functional requirements are decided from mobile application characteristics. Conventional architecture design methods do not consider those characteristics so that the methods cannot be straightforwardly applied to mobile applications. In this paper, to efficiently develop mobile applications reflecting those characteristics, we propose a set of architecture patterns and define a guideline to apply those patterns. First, we define the characteristics of mobile applications distinguished and derive architectural drivers from them. Then, we propose architecture patterns in terms of static and dynamic views and define an architectural guideline to apply the patterns to designing architecture for mobile application. And, we perform case studies to verify the applicability of proposed patterns. Finally, we assess the proposed architecture patterns by proving how the patterns can fulfill identified architecture drivers and by comparing our approach with previous works.

• Journal of Korea Entertainment Industry Association
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• v.13 no.8
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• pp.143-150
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• 2019

Playing musical instruments has long been a hobby enjoyed by many, whether amateur or professional. However, a lot of long and arduous practice is required if one wants to acquire the skills of musical artist and truly enjoy the pleasure of playing. This repetitive and tedious practice is often a hindrance to the process of learning a musical instrument, and numerous educators have put a lot of research and effort into making the process easier and more fun for students. In addition, various media practice tools are being developed to keep the students engaged and having fun. The core elements of this content primarily include controlling the speed of backing tracks in accordance with the skill level of students and providing a backing ensemble that enables them to enjoy the fun of playing. This paper studies and compares various MIDI playback techniques capable of controlling speed and pitch in smartphone applications. Modern applications of these techniques are seen in music educational contents, as well as entertainment contents. It also discusses the development and launching of Upbeat, a drum-loop metronome that automatically increases speed by applying different techniques to its respective smartphone operating systems, Android OS and iOS.

• Proceedings of the IEEK Conference
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• 1998.06a
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• pp.491-494
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• 1998

Due to the improvement of PC performance and windows-based OS, PC-based control system is gradually taking over industrial control in the industry site, replacing the closed proprietary syste. PC-based system gives the avantages of ease-of-use, cost-effectiveness, simplicity of maintenace and the flexibility to design I/O system using standard technology. While there are many real time software soltions, most of hardware solutions are closed, vendor-depednent, proprietary systems for large scale plants. In this paper, we suggest the method to configure PC-based I/O system based on standard technology which gives the avantages to use off-the-shelf products for system integration.

• 한국정보통신설비학회:학술대회논문집
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• 2006.08a
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• pp.77-81
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• 2006

Because of the rapid increasing of network user, there are some problems to tolerate the network overhead. Recently, the research and technology of the user-level for high performance and low latency than TCP/IP which relied upon the kernel for processing the messages. For example, there is an Infiniband technology. The Infiniband Trade Association (IBTA) has been proposed as an industry standard for both communication between processing node and I/O devices and for inter-processor communication. It replaces the traditional bus-based interconnect with a switch-based network for connecting processing node and I/O devices. Also Infiniband uses RDMA (Remote DMA) for low latency of CPU and OS to communicate between Remote nodes. In this paper, we develop the SRP (SCSI RDMA Protocol) which is Storage Access Protocol on Infiniband network. And will compare to FC (Fibre Channle) based I-SCSI (Internet SCSI) that it is used to access storage on Etherent Fabric.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.1473-1479
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• 2009

Recently, the high speed train was operated and then the train system's reliability requirements are growing more and more. The exact prediction simulation is necessary in the design of power feeding system by the increase of railway electrification. In order to develope the AC feeding system analysis technology, real-time power simulator was manufactured. It is composed to eight channels analog input, forty channels analog output and forty-eight channels digital I/O. The size of simulator rack is 19" and the two I/O boards are installed the PXI chassis built into the real time os. The signal I/O is possible through BNC connector. The test results of manufactured simulator are obtained that the error range of analog I/O signal is below 1 % and simulation condition is set to 1 ms and the simulation output of the analog output compares the results of the simulator.

• ETRI Journal
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• v.37 no.5
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• pp.906-916
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• 2015

High-speed I/O channels require adaptive techniques to optimize the settings for filter tap weights at decision feedback equalization (DFE) read channels to compensate for channel inter-symbol interference (ISI) and crosstalk from multiple adjacent channels. Both ISI and crosstalk tend to vary with channel length, process, and temperature variations. Individually optimizing parameters such as those just mentioned leads to suboptimal solutions. We propose a joint optimization technique for crosstalk cancellation (XTC) at DFE to compensate for both ISI and XTC in high-speed I/O channels. The technique is used to compensate for between 15.7 dB and 19.7 dB of channel loss combined with a variety of crosstalk strengths from $60mV_{p-p}$ to $180mV_{p-p}$ adaptively, where the transmit non-return-to-zero signal amplitude is a constant $500mV_{p-p}$.

• Journal of Korea Game Society
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• v.20 no.6
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• pp.31-42
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• 2020

To accept more than thousands of concurrent players, MMO Game servers should use high performance I/O APIs provided by the OS. Despite the continuous improvement of the I/O models, these new I/O APIs are not applied on the applications immediately. In this study, we proposed a new MMO game server architecture using io_uring, Linux's new I/O model. We implemented the proposed architecture and achieved performance improvements of the server on a stress test benchmark with high concurrent connections.

• The Journal of the Korea Contents Association
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• v.16 no.10
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• pp.636-644
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• 2016

The actress of the movie is an operating system called Samantha. She only has a voice in the movie. Theodore, the main actor writes letters for his clients. He got married Katherin after dating for years but they failed to maintain their relationship. It was hard for them to grow with distance. On the contrary, the learning OS doesn't have any fixed pattern and any limits, so it becomes the ideal partner for him. Since she was accessed by him, Samantha has expanded her ability rhizomatically. She could have sex with human and philosophical debates with a departed philosopher. While they have relationship, Theodore experiences the expansion of his conscience. Love cannot be confined in a small box. After realizing how to love people around him, he sends a love letter to Katherine with all his heart. The meaning of co-existing with A.I. and human is to have a chance to introspect our inner side of mind more deeply.

• KIPS Transactions on Computer and Communication Systems
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• v.6 no.10
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• pp.415-420
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• 2017

Virtualization technique of OS-level is a new paradigm for deploying applications, and is attracting attention as a technology to replace traditional virtualization technique, VM (Virtual Machine). Especially, docker containers are capable of distributing application images faster and more efficient than before by applying layered image structures and union mount point to existing linux container. These characteristics of containers can only be used in layered file systems that support snapshot functionality, so it is required to select appropriate layered file systems according to the characteristics of the containerized application. We examine the characteristics of representative layered file systems and conduct write performance evaluations of each layered file systems according to the operating principles of the layered file system, Allocate-on-Demand and Copy-up. We also suggest the method of determining a appropriate layered file system principle for unknown containerized application by learning block I/O usage history of each layered file system principles in artificial neural network. Finally we validate effectiveness of artificial neural network created from block I/O history of each layered file system principles.