• Proceedings of the PSK Conference
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• 2002.10a
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• pp.423.2-424
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• 2002

The present study evaluates the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. PCR analysis after i.v. injection in mice showed that plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min post-injection. Plasmid DNA concentration also rapidly declined at the injection site after i.m. injection. with less than 1 % of the initial concentration remaining at 90 min post-injection. (omitted)

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.12
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• pp.3179-3186
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• 1993

The study on the spray characteristics of TBI(Throttle Body Injection) injector has been carried out in this paper. The objective of this study is to improve the performance of TBI injector. The increase in the injection pressure and the utilization of assisted air are considered. The spray patten of TBI injector take the hollow-cone shape with $60^{\circ}~70^{\circ}$ spray angle regardless of injection pressure and injection pulse width. SAMD(Sauter Mean Diameter) of water in TBI injector are 510-$550{\mu}m$ and 310-$370{\mu}m$ respectively when injection pressures are $0.75 kgf/cm^{2}$ and $2.8 kgf/cm^{2}$. Then SMD of gasoline is estimated 380~$410{\mu}m$ and 230~$280{\mu}m$ respectively. The improvement of spray characteristics in TBI injector can be obtained with assisted air. If $W_{A}/W_{L}$ was over 0.2, SMD of water can be made under $50{\mu}m$.

• Journal of Embryo Transfer
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• v.9 no.2
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• pp.167-172
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• 1994

This experiment was arried out to investigate the development of ea4y rabbit embryos in vivo. Twenty-six New Zealand White does were superovulated by treatment with PMSG(Intervet Co; I. M single injection, 150. U./rabbit) followed 3 day later by simultaneous I.V injection of 100 I.U HCG (Intervet Co, )and natural service with fertile male. All of does was killed at the specific times (24, 27, 30, 36, 42, 50 and 93 h post-hCG) to find out the early embryonic development in vivo respectively. Embryos at the specified stages of development were obtained at the following times after injection of hCG; one-ceH at 24 h, two-cell at 24~27h, four-cell at 27~36 h, morulae at 50 h and early blasto-cyst at 93 h and expanded or hatching blastocyst at 144 h. Number of embryos recovered per rabbit superovulated was 26.1 and average of recovery rate was 83.7%. The results suggest that superovulation was efficient for the increase of embryo number in rabbits, and as shown in results, asynchronous cleavage was prevalent among the recovered embryos.

• Journal of ILASS-Korea
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• v.7 no.3
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• pp.31-37
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• 2002

In previous study, diesel-methanol stratified injection system is manufactured and applied to a D.I. diesel engine in order to realize combustion improvement using methanol, which is oxygenated fuel with large latent heat. We know that NOx and soot is reduced by stratified injection of diesel fuel-methanol. Therefore, in the present study, combustion diagnosis using optical measurement is tried to make clear effect of methanol on simultaneous reduction of NOx and soot. Two-color method is used to measure flame temperature and KL value, which is approximately proportional to the soot consentration along the optical path. Laser induced scattering method was used to measure distribution of soot at two dimensional area. Also, it is compared exhaust characteristics of NOx and soot with results of optical measurement.

• Magazine of the Korean Society of Agricultural Engineers
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• v.44 no.4
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• pp.62-74
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• 2002

The purpose of this study is to find the variation of sedimentation patterns before Saemangeum reclamation. Residual flow before Saemangeum reclamation was calculated diagnostically from the observed water temperature and salinity data in May 1992 by the Marine Development Institute of Kunsan National University and wind data which were obtained from spring 1969 through winter 1977 by the Gunsan Meteorological Observatory. Three dimensional movements of injected particles due to currents, turbulence and sinking velocity are tracked by the Euler-Lagrange method. Calculated sedimentation patterns of riverine materials are highly similar to the observed ones. When suspended sediments with the size of soil grain of 60 ${\mu}m$ are injected from the Mangyeong River, their dispersion range of sediment is about 25km for 24 hours after the injection, while about 35km for 72 hours after the injection. When suspended sediments with the size of soil grain of 200 ${\mu}m$ are injected, their dispersion range of sediment is about 18km for 24 hours after the injection, while about 21km for 72 hours after the injection.

• The Korean Journal of Nuclear Medicine
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• v.3 no.2
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• pp.29-31
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• 1969

The author observed the uptake rate of $^{131}I$ by the thyroid gland, and disappearing rate of the $^{131}I$ at the site of the intradermal injection of 0.1ml of 5mCi of $^{131}I$ in normal physiologic saline on 20 patients with hyperthyroidism and on 15 patients with hypothyroidism who visited the Radioisotpe department of the Pusan National University Hospital during the period from January 1967 to Aug. 1968, and during the same period 15 normal persons were examined by the same methods and found. The results were as follows: (1) The disappearance rate of $^{131}I$ at the injected site was highest in the cases of hyperthyrodism. The next highest results were obtained in the normal cases. The lowest results were obtained in the cases of hypothyroidism. (2) The uptake rate of the thyroid gland after intradermal injection of the $^{131}I$ was highest in the cases of hyperthyroidism and the next highest results were obtained in the cases of nomal findings. The lowest results were obtained in the cases of hypothyroidism. (3) In conclusion, the intradermal method of injecting $^{131}I$ by the author is a useful way of testing the function of the thyroid gland.

• Natural Product Sciences
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• v.11 no.4
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• pp.199-206
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• 2005

Investigation of M. peregrina aerial parts revealed the isolation and identification of 4-flavonoidal compounds, quercetin, quercetin-3-0-rutinoside (rutin), chrysoeriol-7-0-rhamnoside 6,8,3',5'-tetramethoxy apigenin. The compounds were identified by TLC, PC, MS, and $H^1-NMR$. The fatty acids and unsaponifiable matter were studied. The $LD_{50}$ for M. peregrina was 113.4 mg/100g b.wt. Repeated intraperitoneal injection of 1/20 and 1/10 $LD_{50}$ (5.67 mg and 11.34 mg/100g b.wt.) of defatted alcoholic of M. peregrina for 30 days induced significant decrease in serum glucose, liver enzymes and lipid components. M. peregrina administered i.p., 30min prior to carrageenan at the above doses significantly inhibited the rat paw oedema response, In acute pain models, namely, the acetic acid-induced writing and hot-plate assay, M. peregrina exhibited marked analgesic properties. In addition, M. peregrina administered at time of indomethacin injection inhibited the development of gastric lesions in rats.

• Journal of ILASS-Korea
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• v.2 no.3
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• pp.25-31
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• 1997

This experiment was undertaken to investigate the spray characteristics of the conventional injection system and the ultrasonic energy added injection system. Test fuels include light oil and mixed light-BC oil. The mixed light-BC oil was injected at the normal temperature$(20^{\circ}C)$ and the high temperature$(95{\pm}2^{\circ}C)$ and injection pressure was $120kg/cm^2$. Sauter mean diameter was measured under the variation of the spray distance. To measure the droplet size, we used the Malvern system 2600C. Droplet size distribution was analyzed from the result data of Malvern system. It is also found that the condition of the ultrasonic energy added injection and high temperature injection generates the smaller droplets than that of the conventional injection.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.7
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• pp.69-76
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• 1995

A new device structure has been developed for p-i-n switches. In this structure, the phosphorus-diffused n$^{+}$ layter adjacent to the boron-doped anode is used to short the p$^{+}$ anode-channel(i-region). This change in the anode electrode structure results in a significant improvement in the threshold voltage-to-holding voltage($V_{Th}/V_{h}$) ratio, which is due to the suppression of the hold injection from the anode by the n$^{+}$ layer. The shorted anode p-i-n devices of a 100 .mu.m channel length show an extremely high threshold voltage in the 250~300 V range and a low holding voltage in the 5~9 V range. These features of the device are expected to acdelerate their practical application to power switching circuits.

• Korean Journal of Head & Neck Oncology
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• v.17 no.2
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• pp.174-178
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• 2001

Background and Objective: Percutaneous ethanol injection therapy has been used in the treatment of the benign thyroid diseases. Although the reported side-effects of the therapy was mild and transient, some side-effects including local or radiating pain are troublesome to the patients. Radioactive iodine-131($Ra-^{131}I$) also has been effectively and safely used for management of the benign thyroid diseases. So we developed the percutaneous intranodular injection therapy of $Ra-^{131}I$ as an alternative of percutaneous ethanol injection therapy. Materials and Methods: From December 1998 to October 1999, we treated 29 outpatients (25 women and 4 men, mean age: $47{\pm}12$ years). Inclusion criteria were follows; age >30 years, cytologically benign, with normal thyroid function, cold nodule on thyroid scintigram, solid or mixed natured nodules in sonographical evaluation. Nodular volume was estimated by sonography according to the ellipsoid formula. $Ra-^{131}I$(0.1mCi/ml) was administered in a single dose injection. Follow-up studies every 3 months consisted of full history, thyroid function test, and sonography. We determined the therapeutic response is effective if the volume reduction of the nodule occurred above 30%. Results: After at least 3 months follow-up, 11 patients showed effective response, 12 patients showed minimal or unchanged response and 6 patients showed progression. Although side-effects such as injection pain, febrile reaction, and hormonal changes were absent, an infectious complication in injection site was developed from 1 case. Conclusion: Although we need a more prolonged follow-up to evaluate the delayed sequelae, we can suggest that percutaneous intranodular injection therapy of $Ra-^{131}I$ may be an attractive non-surgical treatment in selected cases of benign thyroid nodules.