Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.423.2-424
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- 2002
In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice
- Kim, Byong-Moon (Research Laboratories, Dong-A Pharmaceutical Co., Ltd.) ;
- Lee, Dong-Sop (Department of Life Science,Pohang University of Science and Technolog) ;
- Kim, Chae-Young (Department of Life Science,Pohang University of Science and Technolog) ;
- Son, Mi-Won (Department of Life Science,Pohang University of Science and Technolog) ;
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Sung, Young-Chul
(Department of Life Science,Pohang University of Science and Technolog)
;
- Kim, Won-Bae (Department of Life Science,Pohang University of Science and Technology)
- Published : 2002.10.01
Abstract
The present study evaluates the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. PCR analysis after i.v. injection in mice showed that plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min post-injection. Plasmid DNA concentration also rapidly declined at the injection site after i.m. injection. with less than 1 % of the initial concentration remaining at 90 min post-injection. (omitted)
Keywords