• 동의생리병리학회지
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• 제22권5호
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• pp.1283-1292
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• 2008

This study was designed to investigate the hyperlipidemia-healing effect of water extract from Iksukangjiryung, it was performed on the hyperlipidemia of rats induced by Triton WR-1339 and high cholesterol diet. We prepared two types of hyperlipidemia model in rats induced by Triton WR-1339 and high cholesterol diet. The amount of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, lipid peroxide, glutathione and the activity of superoxide dismutase(SOD) were measured. The water extract from Iksukangjiryung showed significant decreasing effects on total cholesterol, LDL- cholesterol, triglyceride, lipid peroxide in the both model. And it showed significant increasing effects on the activity of SOD in both model and amount of glutathione in Triton WR-1339 model. These results suggest that water extract from Iksukangjiryung has healing efficacy on hyperlipidemia induced by Triton WR-1339 and high cholesterol diet.

• 대한예방한의학회지
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• 제7권2호
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• pp.107-119
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• 2003

In order to study the preventive effects of hyperlipidemia depending on endogenous and exogenous methods of induction, after observing what happens when Nokyongdaebotang, a strengthening up treatment is orally administrated into the ways that cause hyperlipidemia either by the exogenous hyperlipidemia condition model method, which is the way where you orally administrate the cholesterol that was dissolved in olive oil, or the endogenous hyperlipidemia model method, where it uses the injecting the Triton WR-1339 vein method, or to the already inducted white rats, the following conclusions could be drawn. 1. The endogenous induction method, cholesterol diet, helps preventing Total Cholesterol, TG, and LDL-Cholesterol, Free Fatty Acid, Phospholipid's augmentation within the blood in the white rats that is being induced or just inducted with hyperlipidemia 2. The exogenous induction method, Triton WR injection, helps preventing Total Cholesterol, TG, and LDL-Cholesterol, Free Fatty Acid, Phospholipid's augmentation within the blood in the white rats that is being induced or just inducted with hyperlipidemia 3. The HDL-Cholesterol did not increase in regard. This is considered to be because when the geological features the HDL-Cholesterol increases proportionally. In deference to the above results, Nokyongdaebotang, which strengthens the vitality, showed that it helps prevent white rats that is being induced or just inducted with hyperlipidemia no matter whether it is endogenous or exogenous.

• 혜화의학회지
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• 제13권2호
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• pp.109-122
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• 2004

As a long-term goal for the development of new prescriptions for hyperlipidemia, Cheungsimdodamtang(CSDDT) was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. CSDDT-treated animal group showed only a 4.5% body weight increase compared to normal animal group whereas hyper- lipidemia-induced control group increased body weight by 13.6% compared to normal animals. 2. CSDDT-induced animal group showed a significant decrease in cholesterol levels beginning one week after CSDDT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 6. SGOT and SGPT levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 7. HDL-cholesterol levels were significantly increased in CSDDT -treated animal group compared to the hypeiIipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in CSDDT-treated animal group compared to the hyperlipidemia-induced control group.

• 혜화의학회지
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• 제11권1호
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• pp.85-90
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• 2002

From June 1th to December 31th 2001, the study was carried out 285 person who came to the Daejon oriental hospital for the examination of CVA. The result was as follows : 1. Hyperlipidemia patient is 41%, 50's is the highest. 2. In the case of Hyperlipidemia patient, Taeyum type is 49%, Soyang type is 36% and Soyum type is 15%. but in the Control group Taeyum type is 36%, Soyang type is 44% and Soyum type is 20%. 3. In the case of Abnormal EKG, Hyperlipidemia group is 34%, Control group is 32%. 4. In the case of Liver disease, Hyperlipidemia group is 17%, Control group is 9%. 5. In the case of Diabet mellitus, Hyperlipidemia group is 30%, Control group is 7%. 6. In the case of Hypertension, Hyperlipidemia group is 50%, Control group is 42%.

• 대한한방내과학회지
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• 제21권4호
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• pp.549-554
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• 2000

Purpose : Intravascular Laser Irradiation on Blood(ILlB) therapy has been usedto various circulatory diseases recently. In this study, we sought to find out the effects of ILIB on hyperlipidemia . Material and Methods : In this study of 163 patients with hyperlipidemia , we observed change of total cholesterol and triglyceride in serum after ILIB therapy. Results and Conclusion : In patients with hyperlipidemia , total cholesterol mean values decreased from $240.04{\pm}56.23$mg/dL to $214.90{\pm}45.84$mg/dL and triglyceride mean values decreased from $304.98{\pm}134.37$mg/dL to $244.05{\pm}120.46$mg/dL, after ILIB thetapy. We evaluated that ILIB therapy reduced total cholesterol and triglyceride (p<0.001) in patients with hyperlipidemia and IUB therapy is more effective to patients with hyperlipidemia than normal(p<0.001).

• 대한한방내과학회지
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• 제29권2호
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• pp.432-442
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• 2008

Objective : Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia. Methods : We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups. Results : SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol). Conclusion : These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.

• 대한한의학회지
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• 제18권2호
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• pp.245-266
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• 1997

In order to study the effects of Guibitanggamibang on blood pressure and hyperlipidemia, experimental study were performed on hypertension in normal and SHR rats, and on hyperlipidemia induced by Triton WR-1339 in normal rats. Also the level of total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, phospholipid and transaminase(GOT, GPT) were measured. The results are summarized as follows: 1. After Guibitanggamibang was given to normal rats, the results showed that inhibitory effects on blood pressure and heart beat were not statistically significant. 2. After Guibitanggamibang was given to SHR rats, the results showed that inhibitory effects on blood pressure were statistically significant. 3. In the model of hyperlipidemia induced by 2% cholesterol food, Guibitanggarrubang had significantly-decreasing effects on total cholesterol, triglyceride, HDL-cholesterol, LDL-choleste rol, Transaminase(GOT, GPT) level in serum. 4. In the model of hyperlipidemia induced by Triton WR-1339, Guibitanggamibang had significantly-decreasing effects on total cholesterol, triglyceride, LDL-cholesterol, phospholipid, Transaminase(GOT, GPT) level in serum. 5. In the model of hyperlipidemia induced by Triton WR-1339, Guibitanggamibang had no significant effects on HDL-cholesterol level in serum. These results show that Guibitanggamibang(歸脾湯加味方) has significant inhibitory effects on blood pressure and hyperlipidemia and that it could be clinically applied for hypertension and hyperlipidemia.

• 산업융합연구
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• 제22권1호
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• pp.163-168
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• 2024

본 연구는 중년기성인의 고지혈증 관리 요인을 확인하기 위하여 시도되었으며, 연구방법은 한국의료패널조사 2018년도 자료를 분석한 이차분석연구이다. 연구 대상자는 40세 이상 65세 미만의 성인 중 고지혈증진단을 받은 622명을 대상으로 분석하였다. 연구결과 교육수준과 고지혈증관리 유무가 관련성이 있으며(𝒳²=7.285, p=.026), 대상자가 주관적으로 느끼는 건강상태와 고지혈증관리 유무가 서로 관련성이 있는 것으로 조사되었다(𝒳²=7.295, p=.026). 중년기는 신체적인 노화과정이 본격적으로 일어나는 시기로 만성질환에 이환될 가능성이 높으며, 고지혈증은 만성질환을 유발하는 초기 질환이다. 이에 적극적인 건강관리가 필요하며 특히 대상자의 교육수준과 건강상태에 맞는 고지혈증관리를 위한 차별화된 프로그램 개발이 요구된다.

• 대한한의학회지
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• 제25권2호
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• pp.22-32
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• 2004

Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

• 대한한의학회지
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• 제33권2호
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• pp.11-24
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• 2012

Objectives: This study was designed to evaluate lipid-lowering and antioxidant effects of Artemisia capillaris(A. capillaris) using a model of hyperlipidemic rats induced by poloxamer-407. Methods: Rats were previously treated by A. capillaris water extract, and intraperitoneally injected by poloxamer-407 to induce hyperlipidemia. Parameters of serum lipid and oxidative stress biomarkers were determined. Results: 1. A. capillaris ameliorated the elevation of serum total cholesterol, triglyceride, LDL-cholesterol and MDA level. 2. A. capillaris ameliorated the reduction of serum TAC and SOD activities. 3. A. capillaris ameliorated the reduction of serum GSH and GSH-reductase level. Conclusions: According to these results, A. capillaris can be used to treat hyperlipidemia or as basis for making new drugs for treating hyperlipidemia in the future.