Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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Study on the Effect of CSDDT on Hyperlipidemia

정신도담탕(精神導痰湯)이 식이성(食餌性) 고지혈증(高脂血症) 동물(動物) 병태(病態)에 미치는 영향(影響)

  • Lee, Won-Gu (Dept. of internal Medicine, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Lee, Yong-Gu (Dept. of internal Medicine, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Namgung, Uk (Dept. of Neurophysiology, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Kim, Dong-Hee (Dept. of Pathology, Collage of Oriental Medicine, Daejeon Univ.)
  • 이원구 (대전대학교 한의과대학부속한방병원 내과학교실) ;
  • 이용구 (대전대학교 한의과대학부속한방병원 내과학교실) ;
  • 남궁욱 (대전대학교 신경생리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Accepted : 2004.10.14
  • Published : 2004.12.30
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Abstract

As a long-term goal for the development of new prescriptions for hyperlipidemia, Cheungsimdodamtang(CSDDT) was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. CSDDT-treated animal group showed only a 4.5% body weight increase compared to normal animal group whereas hyper- lipidemia-induced control group increased body weight by 13.6% compared to normal animals. 2. CSDDT-induced animal group showed a significant decrease in cholesterol levels beginning one week after CSDDT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 6. SGOT and SGPT levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 7. HDL-cholesterol levels were significantly increased in CSDDT -treated animal group compared to the hypeiIipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in CSDDT-treated animal group compared to the hyperlipidemia-induced control group.

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