• Natural Product Sciences
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• v.10 no.2
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• pp.85-88
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• 2004

One hundred Indonesian plant extracts were screened to investigate their effects on the P-glycoprotein (P-gp) activity in human uterine sarcoma cells, MES-SA/DX5, for the first time. Among others, four samples, Alpinia galanga (BuOH ext.), Sindora sumatrana $(CHCl_3\;ext.)$, Strychnos ligustrina $(CHCl_3\;ext.)$, and Zingiber cassumunar Roxb (hexane ext.), exhibited the most potent inhibition on the P-gp activity. They increased cytotoxic activity of daunomycin up to $IC_{50}$ values of less than $1.41\;{\mu}M$, which is a value with a positive control, verapamil. Other 25 samples showed significant P-gp inhibitory activity with $IC_{50}$ values between 1.4 and $4.0\;{\mu}M$. These prospective samples will be subjected to further laboratory phytochemical investigation to find active principles.

• Proceedings of the KSPS conference
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• 2007.05a
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• pp.240-242
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• 2007

The goal of this paper is to investigate effects of three prosodic factors, such as phrasal accent (accented vs. unaccented), prosodic boundary (IP-initial vs. IP-medial) and coda voicing (e.g., bed vs. bet), on acoustic realization of English vowels (/i, $_I/$, $/{\varepsilon}$, ${\ae}/$) as produced by native (Canadian) and nonnative (Korean) speakers. The speech corpus included 16 minimal pairs (e.g., bet-bat, bet-bed) embedded in a sentence. Results show that phonological contrast between vowels are maximized when they were accented, though the contrast maximization pattern was not the same between the English and Korean speakers. However, domain-initial position do not affect the phonetic manifestation of vowels. Results also show that phonological contrast due to coda voicing is maximized only when the vowels are accented. These results propose that the phonetic realization of vowels is affected by phrasal accent only, and not by the location within prosodic position.

• Speech Sciences
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• v.15 no.2
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• pp.21-30
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• 2008

The current study investigated distributional properties of the Korean Accentual Phrase and their implication to word segmentation. The properties examined were the frequency of various AP tonal patterns, the types of tonal patterns that are imposed upon content words, and the average number and temporal location of content words within the AP. A total of 414 sentences from the Read speech corpus and the Radio corpus were used for the data analysis. The results showed that the 84% of the APs contained one content word, and that almost 90% of the content words are located in AP-initial position. When the AP-initial onset was not an aspirated or tense consonant, the most common AP patterns were LH, LHH, and LHLH (78%), and 88% of the multisyllabic content words start with a rising tone in AP-initial position. When the AP-initial onset was an aspirated or tense consonant, the most common AP patterns were HH, HHLH, and HHL (72%), and 74% of the multisyllabic content words start with a level H tone in AP-initial position. The data further showed that 84.1% of APs end with the final H tone. The findings provide valuable information about the prosodic pattern and structure of Korean APs, and account for the results of a previous study which showed that Korean listeners are sensitive to AP-initial rising and AP-final high tones (Kim, 2007). This is in line with other cross-linguistic research which has revealed the correlation between prosodic probability and speech processing strategy.

• Phonetics and Speech Sciences
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• v.1 no.1
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• pp.33-40
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• 2009

This study examines how young speakers of Seoul Korean produce tri-consonantal clusters /1kt/ and /1pt/ as in palk-ta ('to be bright') and palp-ta ('to step on'). Production data were collected from 20 speakers of Seoul Korean. The results of narrow transcription of the data showed that simplification is not obligatory as some speakers often preserve all three consonants. When simplified, there was a clear asymmetry between /1kt/ and /1pt/. Speakers showed no clear preference for either C1 preservation (C1=/1/) or C2 preservation (C2=/k/ in /1kt/ and /p/ in /1pt/) in production of /1kt/, but in production of /1pt/, strong preference was found for C1-preserved to C2-preserved variant. When compared with production data in Cho (1999), simplification patterns appear to have changed over the past 10 years, in a direction to preserve the first member of the cluster (/1/) more often, especially with /1kt/. There was no substantial between-item variation, indicating that simplification patterns are not lexically specified. Finally, the results suggest that the process of tri-consonantal simplification has not been fully phonologized in the grammar of the language as evident in substantial inter- and intra-speaker variation.

• Korean Journal of Plant Taxonomy
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• v.38 no.2
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• pp.187-196
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• 2008

Two naturalized species, Carduus natans L. and Lepidium latifolium L. were newly reported from Korea. Carduus natans, "Sa-hyang-ung-gung-kwi", was found from Nanjido, Seoul, and Yangsuri and Naejangri, Gyunggi-do. It is distinguished from widely naturalized C. crispus by having large nodding heads (30-60mm in diameter) and acuminate lanceolate involucral bracts. Lepidium latifolium, "Keun-ki-da-dag-naeng-i", was found from Noeul Park, Nanjido, Seoul. It is distinguished from the related species by having tall height (about 1 m), subsessile upper leaves, pinnately lobed lower leaves, and corymbose inflorescence.

• Journal of Microbiology and Biotechnology
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• v.21 no.11
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• pp.1147-1150
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• 2011

Xanthomonas oryzae causes rice bacterial blight, which has been reported as one of the most destructive diseases of rice. Metabolites were identified through cheonggukjang, a traditional Korean fermented soybean product fermented by the Bacillus spp., to control the bacteria. HPLC, MS, and UPLC-Q-TOF-MS analyses were performed to identify metabolites responsible for antimicrobial activity. In this analysis, the m/z values of 253.0498, 283.0600, 269.0455, 992.6287, and 1,006.6436 were identified as daidzein, glycitein, genistein, surfactin B, and surfactin A, respectively. The levels of surfactin B and surfactin A were found to be high at 24 h (4.35 ${\mu}g$/ml) and 36 h (3.43 ${\mu}g$/ml) of fermentation, respectively.

• Korean Journal of Oriental Medicine
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• v.15 no.3
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• pp.45-51
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• 2009

Objectives : The objective of this article is to compare acupuncture treatment of stroke in the medical documents of the Chosun-Korea dynasty. Through such inquisition, the development process of acupuncture of stroke treatment could be found. Methods : We used Cross-comparison analysis of the contents of five medical books, HyangYakZipSungBang (HYZSB), UiRimChwarYo(URCY), DongEuiBoGam(DEBG), ChimGuGyungHumBang(CGGHB) and Saam-Acupuncture(SA) of the Chosun-Korea dynasty. Results & Conclusion : 1. Distinction between Stroke of Viscera and Stroke of Bowel was important. Firts two books divided stroke into three type. But last three books separated into Stroke of Viscera and Stroke of Bowel. 2. They emphasized Symptoms of Five Visceral Disease. They devised Symptoms of Five Visceral Disease for Stroke of Viscera treatment. This method appears very rarely in clinical medicine. 3. They used common important acupoint for treatment of stroke. Most of these acupoints exist at the limbs. 4. They chose acupoints on the opposite side against the symptom.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.79-79
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• 2020

Halophyte is a plant that has evolved to grow well in salty places, and is mainly distributed in coastal wetlands, sand dunes, salt fields, and reclaimed lands in tidal flats and river estuaries. Because it grows in the soil where seawater enters and exits, it is very abound in natural minerals and produces certain metabolites to survive sustainably in the surrounding environment. In this study, anti-inflammatory studies were conducted using 15 kinds of halophyte to secure data on halophytes of infinite value as functional materials. The aim of this study was to select a group of halophytes that regulate iNOS expression, which is involved in the secretion of inflammatory cytokines and nitric oxide production in LPS-induced macrophages. Among the 15 species of halophyte, except for Triglochin maritimum, Suaeda japonica, and Carex pumila, NO production was reduced in 12 species of halophytes, and 7 species of halophyte (Suaeda asparagoides, Artemisia fukudo, Spergularia marina, Aster tripolium, Suaeda australis, Atriplex subcordata, Calystegia soldanella) significantly decreased the expression levels of TNF-α and IL-1β.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.41-59
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• 2007

From the study of prescription on low back pain, the following conclusions are obtained. 1. Among classified cause of low back pain, ShinHur(腎虛) lowback pain and its prescription was most mentioned. 2. Prescriptions such as ChungAWhan(靑娥丸), KookBangAnShinWhan(局方安腎丸) BoSooDan(補髓丹) BaekBaeWhan(百倍丸) DooChungWhan(杜沖丸) JangBonDan(壯本丹) NokKakWhan(鹿角丸) were used in ShinHur(腎虛) type low back pain. 3. Prescription such as TaekRanTang(澤蘭湯) JiRyongSan(地龍散) YoeShinSan(如神散) ShinKookJoo(神麴酒) SoeGuenSan(舒筋散) were used in JwaSumJilBak(閃挫跌撲) type low back pain. 4. Prescription such as ChangChulTang(蒼朮湯) JumTongTang(拈痛湯) ChulBuTang(朮附湯) YiChoChangBaekSan(二炒蒼栢散) were used in SeupYoel(濕熱) type low back pain. 5. Prescription such as ChunGoongYookGaeTang(川芎肉桂湯) GaMiSaMulTang(加味四物湯) PaHoelSanDongTang(破血散疼湯) JiRyongSan(地龍散) were used in UhHoel(瘀血) type low back pain. 6. Prescription such as (蒼術復煎散) (五積散) (摩腰丹) (滲濕湯) were used in HanSeup(寒濕) type low back pain. 7. Prescription such as GaMiYiJinTang(加味二陳湯) GongYeonDan(控涎丹) SaMoolTangHapYiJinTangGaMi(四物湯合二陳湯加味) were used in DamUem(痰飮) type low back pain. 8. Prescription such as OhJukSanGaMi(五積散加味) OhYakSoonGiSanGaMi(烏藥順氣散加味) GaMiYongHoSan(加味龍虎散) SoSokMyoungTang(小續命湯) were used in Poong(風) type low back pain. 9. Prescription such as (四物湯合二陳湯) (仰腰湯) were used in SikJuk(食積) type low back pain and (五積散) (煨腎散) (三花神祐丸) in Seup(濕) type low back pain. 10. Prescription such as ChilKiTang(七氣湯) ChimHyangGangKiTang(沈香降氣湯) ChoKiSan(調氣散) InSamSoonKiSan(人參順氣散) were used in Ki(氣) type low back pain.

• Journal of Life Science
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• v.24 no.8
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• pp.837-842
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• 2014

The purpose of this study was to investigate the effect of Brunfelsia grandiflora ethanol extract (BGEE) on the induction of autophagy via regulation of SIRT1 expression and p53 activation in a human lung fibroblast cell line, IMR 90. BGEE at a concentration of $5{\mu}g/ml$ or more exhibited a cytotoxic effect on IMR 90 cells. For the first time, this study showed that BGEE induces autophagy in normal human lung fibroblasts. BGEE also increased the expression level of beclin-1 at $2.5{\mu}g/ml$ or less and Atg7 at $5{\mu}g/ml$, both of which are known to be involved in the induction of autophagy. In addition, BGEE modulated the expression of other proteins related to autophagy in normal human lung fibroblasts. The expression levels of p53 and p-p53, an active form of p53, were decreased in the presence of BGEE at a noncytotoxic concentration. In contrast, the expression level of SIRT1 was increased in human lung fibroblasts treated with BGEE at a noncytotoxic concentration. Moreover, SA-${\beta}$-Gal staining, an aging marker, was reduced in the normal human lung fibroblasts treated with BGEE. These findings suggest that BGEE promotes the induction of autophagy and antiaging through the modulation of p53 and SIRT1 in human lung fibroblasts.