• International Journal of Aeronautical and Space Sciences
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• 제11권1호
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• pp.10-18
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• 2010

The purpose of this paper deals with direct multiple-shooting method (DMS) to resolve helicopter maneuver problems of helicopters. The maneuver problem is transformed into nonlinear problems and solved DMS technique. The DMS method is easy in handling constraints and it has large convergence radius compared to other strategies. When parameterized with piecewise constant controls, the problems become most effectively tractable because the search direction is easily estimated by solving the structured Karush-Kuhn-Tucker (KKT) system. However, generally the computation of function, gradients and Hessian matrices has considerably time-consuming for complex system such as helicopter. This study focused on the approximation of the KKT system using the matrix exponential and its integrals. The propose method is validated by solving optimal control problems for the linear system where the KKT system is exactly expressed with the matrix exponential and its integrals. The trajectory tracking problem of various maneuvers like bob up, sidestep near hovering flight speed and hurdle hop, slalom, transient turn, acceleration and deceleration are analyzed to investigate the effects of algorithmic details. The results show the matrix exponential approach to compute gradients and the Hessian matrix is most efficient among the implemented methods when combined with the mixed time integration method for the system dynamics. The analyses with the proposed method show good convergence and capability of tracking the prescribed trajectory. Therefore, it can be used to solve critical areas of helicopter flight dynamic problems.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.658-658
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• 2013

Graphene is an attractive material for various device applications due to great electrical properties and chemical properties. However, lack of band gap is significant hurdle of graphene for future electrical device applications. In the past few years, several methods have been attempted to open and tune a band gap of graphene. For example, researchers try to fabricate graphene nanoribbon (GNR) using various templates or unzip the carbon nanotubes itself. However, these methods generate small driving currents or transconductances because of the large amount of scattering source at edge of GNRs. At 2009, Bai et al. introduced graphene nanomesh (GNM) structures which can open the band gap of large area graphene at room temperature with high current. However, this method is complex and only small area is possible. For practical applications, it needs more simple and large scale process. Herein, we introduce a photosensitive graphene device fabrication using CdSe QD coated nano-porous graphene (NPG). In our experiment, NPG was fabricated by thin film anodic aluminum oxide (AAO) film as an etching mask. First of all, we transfer the AAO on the graphene. And then, we etch the graphene using O2 reactive ion etching (RIE). Finally, we fabricate graphene device thorough photolithography process. We can control the length of NPG neckwidth from AAO pore widening time and RIE etching time. And we can increase size of NPG as large as 2 $cm^2$. Thin CdSe QD layer was deposited by spin coatingprocess. We carried out NPG structure by using field emission scanning electron microscopy (FE-SEM). And device measurements were done by Keithley 4200 SCS with 532 nm laser beam (5 mW) irradiation.

• Preventive Nutrition and Food Science
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• 제12권4호
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• pp.242-250
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• 2007

This study evaluated the storage stability of a variety of sauce products in the Korean market, determined primary quality indices for three typical products, and proposed functional relationships that are useful for determining shelf life at different temperatures. Most of the products examined were found to combine hurdles of low pH, low water activity, and the use of heat processing as methods for producing the required storage stability while maintaining the sensory quality of the products. For a meat extract solution produced for cold noodles (pH=4.3; $a_w=0.98$), the primary quality change determining shelf life was lipid oxidation, determined here by the TBA value. The primary quality index of a soybean paste seasoning mix (pH=4.0; $a_w=0.78$), which had a microbial load of 2.8 log (CFU/g), was a decrease in its pH. The primary quality index for a sandwich spread (pH=4.0; $a_w=0.88$) was changes in its surface color. The temperature dependence of changes in the primary quality indices can be described by the Arrhenius equation, which can estimate the shelf life at any arbitrary limit as a function of temperature. The activation energies for changes in the primary quality indices of the meat extract solution, the soybean paste seasoning, and the sandwich spread were 20.3, 27.2, and 43.5 kJ/mol, respectively.

• Journal of Microbiology
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• 제45권3호
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• pp.187-192
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• 2007

REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome. They are common isolates of the respiratory and gastrointestinal tract of humans but are not associated with severe disease and are therefore considered relatively benign. An intriguing characteristic of reovirus is its innate oncolytic potential, which is linked to the transformed state of the cell. When immortalized cells are transfected in vitro with activated oncogenes such as Ras, Sos, v-erbB, or c-myc, they became susceptible to reovirus infection and subsequent cellular lysis, indicating that oncogene signaling pathways are exploited by reovirus. This observation has led to the use of the virus in clinical trials as an anti-cancer agent against oncogenic tumors. In addition to the exploitation of oncogene signaling, reovirus may further utilize host immune responses to enhance its antitumor activity in vivo due to its innate interferon induction ability. Reovirus is, however, not entirely benign to immunocompromised animal models. Reovirus causes so-called "black feet syndrome" in immunodeficient mice and can also harm neonatal animals. Because cancer patients often undergo immunosuppression due to heavy chemo/radiation-treatments or advanced tumor progression, this pathogenic response may be a hurdle in virus-based anticancer therapies. However, a genetically attenuated reovirus variant derived from persistent reovirus infection of cells in vitro is able to exert potent anti-tumor activity with significantly reduced viral pathogenesis in immunocompromised animals. Importantly, in this instance the attenuated, reovirus maintains its oncolytic potential while significantly reducing viral pathogenesis in vivo.

• 교육시설 논문지
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• 제21권3호
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• pp.3-10
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• 2014

A study of facility securement and space utilization at national universities in Korea was conducted in order to help develop an efficient model for space management at national universities going forward. For the study, 36 national universities were asked to submit answers to a questionnaire on usage of campus facilities in 2013. We then analyzed the results of space management for the 27 universities that participated in the questionnaire in each of the past three years (2011-2013). Lastly, we conducted an awareness test on the space utilization policies and space management for these universities. The results are as follows. First, the aggregate average score for space utilization over the past three years is 74.06. The annual average score increased year-over-year and then decreased; it was 69.44 in 2011, 80.68 in 2012, and 72.05 in 2013. A decline in the sense of responsibility of universities to effectively manage space appears to be a factor in the decrease. Second, with 53% of respondents in agreement, treatment of campus area as private space appears to be the biggest hurdle for efficient space management. As such, a plan to foster a more communal view of campus facility area is required. Third, resistance from constituents to existing guidelines for space allocation on campuses appears to be limited (78.1% of respondents answered the guidelines currently in place were average, satisfactory, or very satisfactory). We believe this result points to a mutual understanding forming amongst constituents regarding guidelines on space allocation on campus.results of satisfaction research: the users are generally satisfied with education and student.

• 한국정보통신학회논문지
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• 제2권2호
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• pp.169-180
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• 1998

본 논문에서는 데스크탑 회의시스템 지원을 위해 메시지 처리 시스템에서 실시간 서비스 프리미티브를 개발한다. 데스크탑 회의시스템은 대표적인 실시간 그룹통신 서비스중의 하나이다. 현대 조직 사회에서는 조직의 작업 대부분이 서로간의 헙동체제로 처리됨에 따라 조직원간의 통신을 효율적으로 지원하기 위해 실시간 그룹통신에 대한 요구가 점차 증가되고 있다. 현재까지 다양한 형태의 실시간 그룹통신 시스템이 개발되었지만 널리 사용되는 시스템은 드문 실정이다. 이러한 실시간 그룹통신 시스템의 확산을 막는 걸림돌은 사용자가 보다 쉽게 접할 수 있는 보편적인 실시간 그룹정보 전송환경의 부재에 기인한다. 분산사무환경에서 정보교환 서비스로 가장 널리 사용되고 있는 메시지 처리 시스템은 표준화된 정보전송 체계를 제공하며 다른 응용 프로토콜과의 연동시 유용하게 이용될 수 있는 특징을 가지고 있다. 따라서 본 논문에서는 실시간 그룹통신지원을 위해 메시지 처리 시스템을 이용하는 방안을 제시하고자 한다. 즉, 메시지 처리 시스템에서 실시간 그룹정보를 효율적으로 관리하고 실시간 전송을 지원하는 서비스 프리미티브를 제안한다.

• 환경영향평가
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• 제20권3호
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• pp.337-348
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• 2011

Urban environmental problem became one of major issues during its urbanization processes. Environmental impacts are assessed during recent urban planning and development. Though the environmental impact assessment considers meteorological impact as a minor component, changes in wind environment during development can largely affect the distribution pattern of air temperature, humidity, and pollutants. Impact assessment of local wind is, therefore, a major element for impact assessment prior to any other meteorological impact assessment. Computational Fluid Dynamics (CFD) models are utilized in various fields such as in wind field assessment during a construction of a new building and in post analysis of a fire event over a mountain. CFD models require specially formatted input data and produce specific output files, which can be analyzed using special programs. CFD's huge requirement in computing power is another hurdle in practical use. In this study, a CFD model and related software processors were automated and integrated as a microscale wind environmental impact assessment system. A supercomputer system was used to reduce the running hours of the model. Input data processor ingests development plans in CAD or GIS formatted files and produces input data files for the CFD model. Output data processor produces various analytical graphs upon user requests. The system was used in assessing the impacts of a new building near an observatory on wind fields and showed the changes by the construction visually and quantitatively. The microscale wind assessment system will evolve, of course, incorporating new improvement of the models and processors. Nevertheless the framework suggested here can be utilized as a basic system for the assessment.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.296-307
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• 2017

In spite of frequent usage of primary human foreskin keratinocytes (HFKs) in the study of skin biology, senescence-induced block-age of in vitro proliferation has been a big hurdle for their effective utilization. In order to overcome this passage limitation, we first isolated ten HFK lines from circumcision patients and successfully immortalized four of them via a retroviral transduction of high-risk human papillomavirus (HPV) E6 and E7 oncogenes. We confirmed expression of a keratinocyte marker protein, keratin 14 and two viral oncoproteins in these immortalized HFKs. We also observed their robust responsiveness to various exogenous stimuli, which was evidenced by increased mRNA expression of epithelial differentiation markers and pro-inflammatory genes in response to three reactive chemicals. In addition, their applicability to cytotoxicity assessment turned out to be comparable to that of HaCaT cells. Finally, we confirmed their differentiation capacity by construction of well-stratified three dimensional skin cultures. These newly established immortalized HFKs will be valuable tools not only for generation of in vitro skin disease models but also for prediction of potential toxicities of various cosmetic chemicals.

• 한국정보과학회논문지:시스템및이론
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• 제28권11호
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• pp.592-600
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• 2001

슈퍼스칼라 프로세서는 성능향상을 위해 명령어 반입폭과 이슈율을 증가시키고 있다. 데이터 종속성은 ILP(Instruction-Level Parallelism)를 향상시키는데 주요 장애요소가 되고 있으며, 최근 여러 논문에서 데이터 종속성을 제거하기 위해서 명령어의 결과값을 예상하는 메커니즘이 연구되었다. 그러나 이러한 예측기들은 예상한 명령어의 실제 결과값으로 예상 테이블을 갱신하기 전에 그 명령어를 다시 예상할 때 부적절(stale)한 데이터를 사용함으로써 예상 실패율이 증가하여 프로세서의 성능을 감소시킨다. 본 논문에서는 부적절 데이터 사용을 줄여 높은 성능을 얻을 수 있는 새로운 하이브리드 예측 메커니즘을 제안한다. 제안된 하이브리드 결과값 예측기는 예상 테이블을 모험적으로 갱신할 수 있기 때문에 부적절 데이터로 인해 잘못 예상되는 명령어의 수를 효과적으로 감소시킨다. 16-이슈폭 슈퍼스칼라 프로세서에서 SPECint95 벤치마크 프로그램에 대해 모험적 갱신을 사용함으로써 모험적 갱신을 사용하지 않은 경우의 평균 예상 정확도 59%에 비해 평균 예상 정확도가 72%에 비해 평균 예상 정확도가 72%로 크게 향상되었다.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2012년도 임시총회 및 하계학술연구발표회
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• pp.121-122
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• 2012

Iron-excess gallium ferrite, $Ga_{0.6}Fe_{1.4}O_3$ (GFO), is known to have room-temperature ferromagnetic phases and potentially exhibit ferroelectricity as well [1]. But, leaky polarization-electric field (PE) hysteresis curves of the GFO thin film are hurdle to prove its spontaneous polarization, in other words, ferroelecticity. One of the reasons that the GFO films have leaky PE hysteresis loop is carrier hopping between $Fe^{2+}$ and $Fe^{3+}$ sites due to oxygen deficiency. We focus on reducing conducting current by substituting divalent cations at $Fe^{2+}$ sites. GFO thin films were grown epitaxially along b-axis normal to $SrRuO_3/SrTiO_3$ (111) substrates by pulsed laser deposition. Current density of the ion-substituted GFO thin films was reduced by $10^3$ or more. Ferroelectric properties of the ion-substituted GFO thin films were measured using macroscopic and microscopic schemes. In particular, local ferroelectric properties of the GFO thin films were exhibited and their remnant polarization and piezoelectric d33 coefficient were obtained.