• 환경위생공학
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• 제3권1호
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• pp.75-85
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• 1988

An atomic absorption spectrophotometry analysis study of zinc, cadimium, lead, copper and mercury in human scalp hair samples of 699 subjects in 3 urban and 4 rural communities gave mean values of 170.33/187.00 ppm, 0.18/0.22 ppm, 8.43/8.62 ppm, 9.81/10.24 ppm and 2.13/1.20 ppm for male and female, respectively. The concentration did not differ significantly regardless ages. However, female was higher than male in overall concentration except that of mercury. The percentile methods was partially applied for a reference values of metals in Korean scalp hair to provide more appropriate data for further comparisons.

• Applied Microscopy
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• 제27권3호
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• pp.321-332
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• 1997

The dermal papilla is known to playa major role in influencing the form and dynamics of the hair follicle, which probably involves regulatory substances crossing the basal lamina. But little is known about the junctions between the dermal papilla and the surrounding epithelial cells of the hair bulb, or between the connective tissue and the epithelial cells on the outside of the hair follicle. This study was performed to identify the ultrastructural differences between dermoepidermal junction of the skin and connective tissue-epithelial junctions on the outside of the hair follicle and around the dermal papilla of normal anagen hair follicles in the human fetal scalp skin. Electron microscopic findings of dermoepidermal junction in scalp skin showed that basal lamina was very irregular and undulated, and it contained many attachment plaques of hemidesmosomes with sub-basal dense plates, tonofilaments, and anchoring filaments. Also invaginations of plasma membrane of basal keratinocytes were seen. There were clear differences both on the outside of the follicle and around the dermal papilla as compared with similar junction in the skin. In particular, neither hemidesmosomes nor tonofilaments, as seen in dermoepidermal junction, were observed in the dermal papilla. Also attachment plaque, sub-basal dense plate and anchoring filaments were not observed at the junction on the outside of the follicle and the dermal papilla. There were some differences between connective tissue-epithelial junctions on the outside of the hair follicle and around the dermal papilla, ie, smoothness of basal lamina and orthogonal arrangement of collagen fibers were seen in the outside of hair follicle, but not in the dermal papilla. These results indicate that the mechanical connection between the hair follicle and the connective tissue component is much weaker than that between the corresponding components in skin, and it reflects the dynamic processes during the anagen phase of the hair follicle compared to the relatively permanent state of the epidermis.

• 한국미생물·생명공학회지
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• 제49권4호
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• pp.528-533
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• 2021

The microalga, Tetrathelmis tetrathele, is used in the development of products for the aquaculture, food, and nutraceutical industries. In the present study, we investigated whether the T. tetrathele ethanolic extract (TTE), which has anti-inflammatory properties, can confer protection against alopecia and improve scalp health, influence the proliferation of human keratinocytes, HaCaT cells, and human hair follicle dermal papilla cells (HFDPC), or inhibit 5α-reductase activity. We found that TTE inhibited the production of the inflammatory mediator, nitric oxide (NO), and prostaglandin E₂ (PGE₂) without cytotoxicity in LPS-stimulated RAW 264.7 cells. In addition, TTE encouraged the proliferation of HaCaT cells and HFDPC. Our results showed that TTE had anti-inflammatory activities, proliferated HaCaT cells and HFDPC, and inhibited 5α-reductase activity. Therefore, we suggest that T. tetrathele could be a potent therapeutic agent for alopecia prevention and scalp improvement.

• Environmental Analysis Health and Toxicology
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• 제19권2호
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• pp.153-159
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• 2004

To ascertain the effects of hair dyeing application on oxidative stress in human, a mixture of permanent black colored hair dye with the same amount of oxidant containing 6% hydrogen peroxide was used. A hair dyeing with contacting the scalp (conventional dyeing) and a hair dyeing with 3 to 4mm away from the scalp (alternative dyeing) were applied to each 15 young healthy women. Blood was taken from the brachial vein at two sampling times, just before and 6 hours alter the hair dyeing, and antioxidant enzyme activities and antioxidant contents were measured in red blood cells. After dyeing, malondialdehyde(MDA) contents for conventional dyeing group was shown to a tendence of more increased than alternative dyeing group. After dyeing, reduced glutathione (GSH) contents for conventional dyeing group was shown to a tendence of more decreased than alternative dyeing group. After dyeing, superoxide dismutase (SOD) and catalase (CAT) activities were significantly decreased in conventional dyeing group (p < 0.01), however, SOD and CAT activities were not significantly decreased in alternative dyeing group. After dyeing, there was no significant decrease in glutathione peroxidase (GPX) activity both for conventional dyeing group and alternative dyeing group. Therefore, after dyeing, the degree of oxidative stress in red blood cells for alternative dyeing group was appeared to be lower than conventional dyeing group.

• 반도체디스플레이기술학회지
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• 제14권4호
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• pp.1-7
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• 2015

People are always pursuing the aesthetic feeling relentlessly. But some people have such problems with their hairs like alopecia, cancer chemotherapy, burns, and scalp injury. So the synthetic hair has played a very important role to make up for these deficiencies. But long term use can lead to adverse reactions or uncomfortable feeling. This is primarily caused by its properties differ with human hair. In particular, nanotribological characterizations (roughness, friction force and adhesive force) of synthetic hair surface are dissatisfy with the needs of normal hairs. This paper presents the experiments on nanotribological characterizations measurements of human hairs (coloring hair, permed hair and common hair) in shampooing condition or without shampooing condition. Using atomic force microscopy (AFM) to find out a range of synthetic hair nanotribological characterizations which can correspond with natural hair. The measurements of nanotribological characterizations focus on surface roughness, friction force and adhesive force, and a new design of AFM probe was used for measuring the nanotribological characterizations.

• 대한화장품학회지
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• 제37권2호
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• pp.161-169
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• 2011

본 연구에서는 발모 소재 개발을 위하여 한방복합처방단의 효소처리에 의한 발모 및 흑모 관련 생리활성을 알아보았다. 효소 처리된 한방 복합 처방단의 자유라디칼 소거활성과 superoxide dismutase 유사활성을 알아보았으며, lipoxygenase 활성 저해효과, $5{\alpha}$-reductase 활성 저해효과 및 멜라닌 생성 촉진효과를 확인하였다. 또한, 인체 피부 일차 자극시험 결과 자극이 없는 저자극으로 나타났다. 이로써, 효소 처리된 한방 복합 처방단은 피부자극 없이 모발제품의 기능성 원료로서 큰 가능성을 가지고 있는 것으로 판단된다.

• 생명과학회지
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• 제28권3호
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• pp.345-350
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• 2018

이번 연구에서 우리는 6종의 미세조류 ; Phaeodacylum tricrnutum (PT), Chaetoceros gracilis (CG), Nanochloris oculata (NO), Pavlova lutheri (PL), Chlorella ellipsoidae (CE), and Scendedemus obliquus (SO)를 이용하여 탈모 예방 및 두피 개선효과를 살펴보았다. DPPH 라디칼 소거능 실험에서는 SO, CG, ST9 순으로 활성이 높은 것으로 나타났다. OH 소거능 실험 결과, CG (6.6~42.1%), ST9 (26.0~44.0%), SO (7.8~44.3%)으로 유의적인 효과를 보였다. 그외에도 세포증식실험에서는, SO가 인간표피세포주인 HaCaT 세포 증식을 촉진시켰으며, CG와 SO가 모유두세포주인 HFDPC 세포 증식을 촉진시키는 것으로 나타났다. 마지막으로 5-alpha reductase 저해능 실험결과, PT, CG, SO가 유의적으로 효소활성을 저해하였다. 따라서, 이번 연구에 사용한 6종의 미세조류들 중, 항산화활성, 세포증식 효과, 5-alpha reductase 저해능을 보인 몇가지 조류들이 탈모예방 및 두피개선을 위한 제품개발에 좋은 원료가 될 가능성이 있음을 제시한다.

• 대한화장품학회지
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• 제35권1호
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• pp.41-46
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• 2009

두피의 이상은 탈모, 비듬, 가려움증 등의 두피 질환으로 이어지며, 아직까지 정확한 원인이 규명되지 않은 상태여서 발병하면 치료가 쉽지 않다. 따라서 두피의 생리적인 항상성을 유지해서 두피를 건강한 상태로 유지하는 것이 두피 질환 예방 및 치료에 가장 효과적인 방법이다. 최근 두피 및 모발용 화장품 분야에서는 한의학적으로 효능이 있다고 알려진 약재들을 원료로 사용하려는 시도가 크게 증가하고 있다. 현재까지 화장품 원료로 사용되는 한약재는 대량생산과 규격화 등의 문제로 뜨거운 물에 우려낸 열수추출물을 제형에 혼합하는 형태로 사용하고 있는데, 이 과정에서 고온에 의한 영양소와 효능성분의 파괴는 불가피하다. 따라서 본 연구에서는 한의학적으로 두피 개선 효과가 있다고 알려져 있는 검은콩, 작약, 녹차 잎을 대상으로 성분파괴를 최소화할 수 있는 저온용출법으로 효능 성분을 추출하고, 이 추출물들의 두피 개선 효능을 평가하였다. 실험 결과, 저온용출물들은 열수 추출물보다 평균 2배 이상 높은 항산화력을 보유하였으며, 모낭 및 모발 강화, 두피 보습, 가려움 방지에 효과적임을 확인하였다. 따라서 검은콩, 작약, 녹차잎의 저온용출물은 두피 트러블을 해결하는 효과적인 두피 개선 원료로 활용될 수 있다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XIII)
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• pp.113-117
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• 2003

모낭은 복잡한 상호작용을 통하여 성장 및 주기가 조절되며 다양한 세포들로 구성진 기관이다. 본 연구에서는 조직공학적 방법을 이용하여 모낭을 구성하는 세포들을 분리 및 배양하였고 세포들의 형태와 증식양상을 관찰할 수 있었고, 기관배양의 방법을 통하여 in vitro에서 첨가물에 대한 모발의 성장 및 주기의 변화를 살펴보았다.

• 대한의생명과학회지
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• 제16권4호
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• pp.323-330
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• 2010

Although copper and zinc are essential metals for human health, excessive level of these metals is toxic. Besides, aluminum is known to induce various adverse health effects including neurological disorders. Therefore, monitoring the human body burden of these metals is important in preventing adverse health effects. In this study, we assessed the exposure to copper, zinc, and aluminum among an adult population residing in Daegu and Kyungbuk areas. Based on data from 171 participants, we found that the geometric mean copper, zinc, and aluminum concentrations in hair were $15.1\;{\mu}g/g$ [95% confidence interval (CI): 13.1~17.5], 76.9 (95% CI: 70.4~84.1), and $1.11\;{\mu}g/g$ (95% CI: 0.81~1.51), respectively. The copper concentrations in hair were significantly related to age, education, and residence area. In addition, zinc concentrations in hair were significantly related to age, whereas higher hair aluminum concentrations were related to alcohol drinking. Correlations between copper and zinc in hair had a significant positive correlation. Our findings suggest that the body burden of copper, zinc, and aluminum varies according to demographic factors, and hair could be used as a valuable biological medium for metal exposure.