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http://dx.doi.org/10.5352/JLS.2018.28.3.345

Comparative Study on the Effects of Six Species of Microalgae Extracts on Hair Loss Prevention and Scalp Improvement  

Jung, Min-Hwa (Department of Hair Design, Daedong College)
Lee, Su-Seon (Sunmarine Biotech Co. Ltd.)
Kim, Hyeon-Ah (Sunmarine Biotech Co. Ltd.)
Hwang, Hye-Jung (Department of Food and Nutrition, Dongbusan College)
Publication Information
Journal of Life Science / v.28, no.3, 2018 , pp. 345-350 More about this Journal
Abstract
This study examines the role of six species of microalgae, including Phaeodacylum tricrnutum (PT), Chaetoceros gracilis (CG), Nanochloris oculata (NO), Pavlova lutheri (PL), Chlorella ellipsoidae (CE), and Scendedemus obliquus (SO), on hair loss prevention and scalp improvement. To determine the effects of microalgae extracts on hair loss prevention and scalp improvement, antioxidant activity, cell proliferation in HaCaT cells and HFDPC cells, and the inhibition level of 5-alpha reductase activity were examined. In the study of antioxidant activity, the $EC_{50}$ values of DPPH anti-radical activities indicated that the SO, CG, and ST9 treatment groups demonstrate significant antioxidant activity. In the study of the hydroxyl radical scavenging activity, CG (6.6~42.1%), ST9 (26.0~44.0%), and SO (7.8~44.3%) demonstrated significant effects. Furthermore, SO promoted the proliferation of HaCaT cells and a human epidermal cell line during a 6-day treatment. In the study of the proliferation of HFDPC cells, a hair follicle dermal papilla cell line, CG, and SO significantly stimulated cell proliferation. Finally, PT, CG, and SO significantly inhibited 5-alpha reductase activity. These results suggest that among the six microalgae used in this study, CG and SO have antioxidant effects, induce cell proliferation, inhibit 5-alpha reductase activity, and can be used for hair loss prevention and scalp improvement.
Keywords
5-alpha reductase; andioxidant; hair loss; microalgae; scalp improvement;
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