• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4993-4998
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• 2012

Vanillic acid, a vegetable phenolic compound, is a strong antioxidant. The aim of the present study was to determine its effects on mitomycin C-induced DNA damage in human blood lymphocyte cultures in vitro, both alone and in combination with mitomycin C (MMC). The cytokinesis block micronucleus test and alkaline comet assay were used to determine genotoxic damage and anti-genotoxic effects of vanillic acid at the DNA and chromosome levels. MMC induced genotoxicity at a dose of $0.25{\mu}g/ml$. Vanillic acid ($1{\mu}g/ml$) significantly reduced both the rates of DNA damaged cells and the frequency of micronucleated cells. A high dose of vanillic acid ($2{\mu}g/ml$) itself had genotoxic effects on DNA. In addition, both test systems showed similar results when tested with the negative control, consisting of dimethyl sulfoxide (DMSO) in combination with vanillic acid ($1{\mu}g/ml$)+MMC. In conclusion, vanillic acid could prevent oxidative damage to DNA and chromosomes when used at an appropriately low dose.

• Journal of Korea Multimedia Society
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• v.20 no.7
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• pp.1038-1045
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• 2017

The increase in frequency and scale of natural disasters is the typical negative examples of the global climate change and the change of the human living environment. The damage caused by natural disasters in particular including human and physical damage is directly linked to the safety and properties of citizens. Besides, damage occurs directly or indirectly to the SOC facility, and the damaged SOC facility violates the citizens' safety rights. Therefore, a plan to provide prompt and effective risk map information by linking a 3D disaster information display system, which handles the information of the damage that may occur to SOC facilities at the time of disasters, with an on-site assistance application is suggested in this study. The prompt provision of risk map information is defined as a dynamic expression technology in this study. It also processes and compresses the system to display disaster information, a spreading system that can utilize on-site information, and a module developed to organically link with the DB system that builds information and relationships. Based on the module, the effective disaster information compression plan will be prepared, and the prompt information transmission system will be secured.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.6
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• pp.57-68
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• 2009

Recently, damage scale of human-induced disaster is sharply increased but its occurrences and damages are so uncertain that it is hard to construct a resonable response & mitigation plan for infrastructures. Therefore, the needs for a advanced risk management technique based on a probabilistic and stochastic risk evaluation theory is increased. In this study, these evaluation methods were investigated and a advanced disaster risk evaluation method, which is based on the probabilistic or stochastic risk assessment theory and also is a quantitative evaluation technique, was suggested. With this method, the safety changes as the result of fire damage management for recent 40 years was analyzed. And the result was compared with that of Japan. Through the consilience of the traditional risk assessment method and this method, a stochastical estimation technique for the uncertainty of future disaster's damage could support a cost-effective information for a resonable decision making on disaster mitigation.

• Journal of the Korean Society of Hazard Mitigation
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• v.5 no.4 s.19
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• pp.71-78
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• 2005

The principal basic concepts of aseismic design minimize damage of human-life and have little probability during life of structures. For detailed understanding of the design, the best reasonable countermeasure can be possible equally the smallest damage of human-life and economic loss. As a result, it can be achieved by notion of not structure-centered but city-centered, the notion is actualized by development of a macro-level evaluation. A seismic damage between city and country is different. And the larger the city then, the greater the loss by rather collateral hazards than collapse of structures. Hence, the macro-evaluation of an earthquake disaster is suitable for an old city where is center of political and economic activity, and is concentration of population and infrastructure. This study aims to develop comprehensive earthquake desaster risk index, and assesses relative earthquake risk of six zones in Seoul metropolitan area.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.6
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• pp.309-315
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• 2006

The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was induced by stereotaxically injecting 6-OHDA into the right striatum. Baicalein was administered intraperitoneally 30 min before and 90 min after lesion induction. Animals received a further daily injection of baicalein for 3 consecutive days. Two weeks after 6-OHDA injection, contralateral rotational asymmetry was observed by apomorphine challenge in lesioned mice. Tyrosine hydroxylase (TH) immunohistochemistry revealed a significant loss of terminals in lesioned striatum and the reduction of the numbers of TH-positive cell in the ipsilateral substantia nigra (SN). In addition, the levels of dopamine (DA) and DA metabolites were reduced and lipid peroxidation was increased in lesioned striatum. However, baicalein treatment reduced apomorphine-induced rotational behavior in 6-OHDA-lesioned mice, and increased TH immunoreactivity in the striatum and SN, and DA levels in lesioned striatum. Lipid peroxidation induced by 6-OHDA was also inhibited by baicalein treatment. Furthermore, when SH-SY5Y human neuroblastoma cells were treated with baicalein, 6-OHDA-induced cytotoxicity and reactive oxygen species (ROS) production were significantly reduced. These results indicate that baicalein effectively protects 6-OHDA-induced neuronal damage through antioxidant action.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.176-176
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• 2001

Endocrine disruptors have been implicated in carcinogenesis in animal studies, but carcinogenetic effects on human remain controversial. In order to examine the genotoxicity of two common endocrine disruptors, Bisphenol A and Diethylstilbestrol, cytogenetic endpoints including chromosome aberration(CA), sister chromatid exchange (SCE), micronuclei (MN) analyses and DNA damage by single cell gel electrophoresis (SCGE) were assayed.(omitted)

• Proceedings of the KSR Conference
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• 2004.10a
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• pp.1419-1424
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• 2004

Railway safety is based on a risk analysis and safety assessment for the whole railway system as human, train, electric, signaling, operation, maintenance and etc. Therefore in this study, after investigating the accidents happened in electric railway on Choongang line for 5 years, from '97 to '01, a Data-Base was made through a cause and result analysis. In consideration of economic loss and human resources damage, a risk assessment for electric railway was also performed.

• Journal of Sport and Applied Science
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• v.5 no.2
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• pp.31-38
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• 2021

Purpose: A new form of sports human rights platform is needed for policy-related officials, athletes, leaders, and parents to easily share information on sports human rights and to promote communication between the sports community and the outside. Research design, data, and methodology: Participants were collected from athletes (n=3,007) who were registered in Korean Sport & Olympic Committee. Participants were asked to respond the survey items measuring their experiences of human right violations in sport. Descriptive analysis, t-test, and ANOVA were used to analyze data. Results: The platform should include information on prevention and safety of human rights violations during sports activities, procedures and methods for reporting damage, countermeasures, leader education programs, human rights protection guidelines, roles and supervision of sports organizations and institutions, and related statues. It can form a community as well as exchange information in the Internet space through the operation of bulletin boards by professional athletes, student athletes, parents, and leaders, and plays a role in crisis counseling or information provision. Given the reality that players can be blocked from the outside world, information communication channels on SNS can be a useful means of protecting and improving players' human rights. Conclusions: Therefore, it is necessary to provide a foundation for creating related platforms so that sports human rights sites or SNS can be operated voluntarily. Implications and future directions were discussed.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.135-143
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• 2014

Human body fluid and humor include not only sweat, joint fluid but also every fluids, for example, blood, essence, kidney essence and marrow. Historically, in the oriental medicine, there are a lot of efforts in order to preserve fluid and humor. In "Treatise on Cold Damage and Miscellaneous Disease (傷寒雜病論)", when treating cold damage, preservation of fluid and humor is put first. I tried to find out the relation about fluid and humor and pain treatment in "Treatise on Cold Damage and Miscellaneous Disease". So, I investigated sentences related to pains in "Treatise on Cold Damage and Miscellaneous Disease" "greater yang disease part" and commentaries of several chinese medical doctors. And I divide pain treatments into four categories. (fluid and humor sufficiency-exterior pattern, fluid and humor sufficiency-interior pattern, fluid and humor deficiency-exterior pattern, fluid and humor deficiency-interior pattern) At first, when treating pains of cold damage, there are many considerations about deficiency and sufficiency of fluid and humor through pulse condition and symptoms. Second, in pain-cases of fluid and humor sufficiency, purge methods is chosen. And in pain-cases of fluid and humor deficiency, tonifying methods is chosen. Finally, one of the main objects of "Treatise on Cold Damage and Miscellaneous Disease" is preservation and supply of fluid and humor.

• The Journal of the Korea Contents Association
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• v.17 no.4
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• pp.267-274
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• 2017

The natural disasters such as typhoon, earthquake, flood, heavy rain, drought, sweltering heat, wind wave, tsunami and so on, are difficult to estimate the scale of damage and spot. Also, these disasters were being damaged to human life. However, if based on the disaster statistics the past damage cases are analyzed and the estimated damages can be calculated, the initial damage action can be taken immediately and based on the estimated damage scale the damage can be mitigated. In the present study, therefore, we proposed the functions of wind wave damage estimation for the southern coast. The functions are developed based on Disaster Report('91~'14) for wind wave and typhoon disaster statistics, regional characteristics and observed sea weather.