Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress
![]() |
Im, Heh-In
(Department of Pharmacology, Seoul National University College of Medicine, Neuroscience Research Institute Medical Research Cent)
Nam, Eun-Joo (Department of Pharmacology, Seoul National University College of Medicine, Neuroscience Research Institute Medical Research Cent) Lee, Eun-Sun (Department of Pharmacology, Seoul National University College of Medicine, Neuroscience Research Institute Medical Research Cent) Hwang, Yu-Jin (Department of Pharmacology, Seoul National University College of Medicine, Neuroscience Research Institute Medical Research Cent) Kim, Yong-Sik (Department of Pharmacology, Seoul National University College of Medicine, Neuroscience Research Institute Medical Research Cent) |
1 | Gerlach M, Riederer P. Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J Neural Transm 103: 987-1041,1996 DOI |
2 | Hwang YS, Shin CY, Huh Y, Ryu JH. Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats. Life Sci 71: 2105-2117, 2002 DOI ScienceOn |
3 | Luthman J, Herrera-Marschitz M, Lindqvist E. Unilateral neonatal intracerebroventricular 6-hydroxydopamine administration in rats: I. Effects on spontaneous and drug-induced rotational behavior and on postmortem monoamine levels. Psychopharmacol 116: 443-450, 1994 DOI |
4 | Olanow CW. A radical hypothesis for neurodegeneration. Trends Neurosci 16: 439-444, 1993 DOI ScienceOn |
5 | van Acker SA, van Balen GP, van der Berg DJ, Bast A, van der Vijgh WJ. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem Pharmacol 56: 935-943, 1998 DOI ScienceOn |
6 | Wakabayashi I. Inhibitory effects of baicalein and wogonin on lipopolysaccharide induced nitric oxide production in macrophages. Pharmacol Toxicol 84: 288-291, 1999 DOI ScienceOn |
7 | Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport 12: 3871-3875, 2001 DOI ScienceOn |
8 | Onn SP, Berger TW, Stricker EM, Zigmond MJ. Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: histochemical and neurochemical analysis. Brain Res 376: 8-19. 1986 DOI ScienceOn |
9 | Rebekah JJ, Jonathan TK, Delinda AJ, Jeffrey AJ. Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. Toxicol Sci 87: 176-186, 2005 DOI ScienceOn |
10 | Russel J, Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 56: 359-384, 1998 DOI ScienceOn |
11 | Ruxandra I, Paul M, Patrik B, Gesine P. Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Behav Brain Res 162: 1-10, 2005 DOI ScienceOn |
12 | Cohen G, Heikkila RE. The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biochem 249: 2447- 2452, 1974 |
13 | Li FQ, Wang T, Pei Z, Liu B, Hong JS. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation- mediated degeneration of dopaminergic neurons. J Neural Transm 112: 331-347, 2005 DOI |
14 | Saija A, Salese M, Lanza M, Marzullo D, Bonina F, Castelli F. Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic Biol Med 19: 481-486, 1995 DOI ScienceOn |
15 | Sudheesh S, Sandya C, Sarah Koshy A, Vijayalakshmi NR. Antioxidant activity of flavonoids from Solanum melongena. Phytother Res 13: 393-396, 1999 DOI ScienceOn |
16 | Bensadoun JC, Mirochnitchenko O, Inouye M, Aebischer P, Zum AD. Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice. Eur J Neurosci 10: 3231-3236, 1998 DOI ScienceOn |
17 | Kim MS, Lee JI, Lee WY, Kim SE. Neuroprotective Effect of Ginkgo biloba L. Extract in a rat model of Parkinson's disease. Phytother Res 18: 663-666, 2004 DOI ScienceOn |
18 | Glinka Y, Gassen M, Youdim MB. Mechanism of 6-hydroxydopamine neurotoxicity. J Neural Transm 50(suppl): 55-56, 1997 |
19 | Carmen LS, Gage FH, Shults CW. Partial lesion of the substantianigra: relation between extent of lesion and rotational behavior. Brain Res 553: 275-283, 1991 DOI ScienceOn |
20 | Cai Q, Wei H. Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr Cancer 25: 1-7, 1996 DOI ScienceOn |
21 | Glinka Y, Gassen M, Youdim MB. Nature of inhibition of mitochondrial respiratory complex 1 by 6-hydroxydopamine. J Neurochem 66: 2004-2010, 1996 DOI |
22 | van Acker SA, van der Berg DJ, Tromp MN, Griffioen DH, van Bennekom WP, van der Vijgh WJ, Bast A. Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med 20: 331-342, 1996 DOI ScienceOn |
23 | Lee HH, Yang LL, Wang CC, Hu SY, Chang SF, Lee YH. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Brain Res 986: 103- 113, 2003 DOI |
24 | Levites Y, Weinreb O, Maor G, Youdim MB, Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78: 1073-1082. 2001 DOI ScienceOn |
25 | Lebeau A, Esclaire F, Rostene W, Pelaprat D. Baicalein protects cortical neurons from beta-amyloid (25-35) induced toxicity. Neuroreport 12: 2199-2202, 2001 DOI ScienceOn |
26 | Pietta PG. Flavonoids as antioxidants. J Nat Prod 63: 1035-1042, 2000 DOI ScienceOn |
27 | Im HI, Joo WS, Nam E, Lee ES, Hwang YJ, Kim YS. Baicalein prevents 6-OHDA-induced dopaminergic dysfunction and lipid peroxidation in mice. J Phamacol Sci 98: 185-189, 2005 |
28 | Iancu R, Mohapel P, Brundin P, Paul G. Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Behav Brain Res 162: 1-10, 2005 DOI ScienceOn |
29 | Morel I, Lescoat G, Cogrel P, Sergent O, Pasdeloup N, Brissot P, Cillard P, Cillard J. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem Pharmacol 45: 13-19, 1993 DOI ScienceOn |
30 | Ara J, Przedborski S, Naini AB, Jackson-Lewis V, Trifiletti RR, Horwitz J, Ischiropoulos H. Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Proc Natl Acad Sci 95: 7659-7663, 1998 |
31 | Rice Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB. The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 22: 375-383, 1995 DOI ScienceOn |
32 | Esposito E, Rotilio D, Di Matteo V, Di Giulio C, Cacchio M, Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 23: 719-735, 2002 DOI ScienceOn |
33 | Fisher LJ, Jinnah HA, Kale LC, Higgins GA, Gage FH. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron 6: 371-380, 1991 DOI ScienceOn |
![]() |