• 동의생리병리학회지
• /
• 제23권3호
• /
• pp.678-684
• /
• 2009

It was reported that Dipsaci Radix has decrease pain effect on the Complex Region Pain Syndrome(CRPS). the CRPS was induced by unilateral loose occlusion in 4 part of the sciatic nerve of the rats. For the fingding significantly change on CRPS rats were divided into 4 different experimental groups. and each groups were induced CRPS. Experimental group I (control group; n=15), experimental group II (100 mg/kg Dipsaci Radix dieted rats; n=15), experimental group III (300 mg/kg Dipsaci Radix dieted rats; n=15), and experimental group IV(500 mg/kg Dipsaci Radix dieted rats; n=15). The study of Dipsaci Radix concentration was that foot withdrawal threshold to the thermal stimuli(Hot plate test), foot withdrawal threshold to the mechanical stimuli(von Frey's filament) and immunohistochemistry staining that were substance P. Hot plate test and von Frey Filament were increase in experimental group II, III, IV than group I, especially group III was most significantly change than group II and IV in post-hoc(Duncan's multiple range). and In immunohistochemistry observation; group I showed increase in the group II, III, IV. especially group III had the minimal level of the substance P expression while the experimental group II, III. These results suggested that the Dipsaci Radix dieted made the decrease of pain in CRPS.

• 대한기계학회논문집
• /
• 제12권5호
• /
• pp.952-958
• /
• 1988

본 연구에서는 폭방향 불균일 냉각에 따른 열응력이 판변형 및 잔류응력의 주 요원인이라는 고려하에 냉각중에 압연판의 온도분포 및 열응력을 예측할 수 있는 수치 해석 모델을 구성하였다. 온도와 응력 계산에 상변태 현상을 고려하였으며, 판변형 은 압축성분 열응력에 의한 좌굴현상으로 고려하여 해석하였다.

• 대한용접접합학회:학술대회논문집
• /
• 대한용접접합학회 2006년도 춘계 학술대회 개요집
• /
• pp.68-70
• /
• 2006

For the aluminum material of the thick-thickness more than 100mm Penetration depth Electron beam welding is effectively applicable with a characteristic of high energy intensity. But Al 6061 alloy has high crack sensitivity due to minor alloys, which are silicon, magnesium, copper etc. With a sample block of 135mm thickness EBW test was performed in vertical position. As tensile strength has $210{\sim}220N/mm^2$ with weld area broken. Bend test shows low ductility with fracture of partly specimens. Chemical contents of alloys show no difference between weld and base metal. Defect in middle weld area figures out typical hot crack due to low melting materials. Micro structure of weld area has some difference compare to HAZ and base metal. As a result of EBW test for Al 6061 alloy, it shows that weld defect could be occurred even though establishing of optimum weld parameter condition.

• Journal of Welding and Joining
• /
• 제31권2호
• /
• pp.49-56
• /
• 2013

We have investigated traits of clad metals in hot-rolled clad steel plates, sensitization and mechanical properties of STS 316 steel plate and carbon steel(A516). Clad steel plates were butt-weld by SAW+SMAW, and with the time of heat treatment as the variable, heat treatment was conducted at $625^{\circ}C$, for 80, 160, 320, 640, 1280 minutes. As a way to evaluate it, sectioned weldments and external surfaces were investigated to reveal the degree of sensitization by mechanical property, etching and those of EPR test, results were compared with it. In short, the purpose of this study is suggesting some considerations in developing on-site techniques to evaluate the sensitization of stainless steels.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.371.1-371.1
• /
• 2002

Triterpenoids. Ursolic acid (1). 23-hydroxyursolic acid (2). and tormentic acid (3) were obtained by the hydrolysis of BuOH fraction of Cussonia bancoensis extract and further chromatographic isolation to test antinociceptive and anti-inflammatory effect of C. bancoensis (Aratiaceae). Compound 1 and 2 exhibited anti-nociceptive effects, which were determined by acetic acid-induced writhing test and hot plate test. However. the effect of tormentic acid was not significant (omitted)

• 한국추진공학회지
• /
• 제7권4호
• /
• pp.63-72
• /
• 2003

배플이 장착된 KSR-III 엔진의 연소장 및 성능을 예측하기 위하여 수치해석을 수행하였다. 수치해석의 검증을 위해 3차원 계산을 수행하여 연소시험과 비교하였으며, 정성적으로 잘 일치하는 것을 볼 수 있었다. 배플이 장착됨에 따라 연소실 전압이 감소하여 특성속도가 감소하는 것을 볼 수 있었고, 이것은 엔진의 성능 감소로 이어지는 것을 알 수 있었다. 또한 분사기 면과 연소실 벽면 및 배플 벽면에 국부적인 고온 영역이 발생하는 것을 볼 수 있었으며, 이것은 분사기 면에 막냉각을 설계하여 장착할 수 있는 기본 자료로 활용되었고 실제 엔진에 적용되었다.

• 소성∙가공
• /
• 제22권5호
• /
• pp.250-257
• /
• 2013

A series of finite element analyses of the rolling process were performed and a neural network algorithm was employed to calculate the amount of ski-effect for an arbitrary thickness of incoming material in the roll gap. Pilot hot plate rolling tests were also conducted to verify the usefulness of the finite element analyzes conducted in this study. In these experiments, plates with thicknesses varying from 25 to 65 mm were tested. In addition, a number of rolling reductions of up to 31% were examined. Finally, a number of circumferential upper and lower rolls were investigated. Experimental validations demonstrated that the neural network algorithm predicted the proper amount of ski when rolling conditions(material thickness, reduction ratio, roll velocity differential) changed arbitrarily.

• 한국식품영양과학회지
• /
• 제31권5호
• /
• pp.910-916
• /
• 2002

생약재의 식품ㆍ생물 산업적 이용증대에 따라 생약재의 안전한 위생화 기술이 요구되고 있다 본 연구에서는 생약재의 위생화 기술로서 방사선 조사기법의 활용 가능성을 검토하기 위하여, 감마선을 조사한 생약재 3종에 대한 유전독성학적 안전성을 평가하고자 하였다. 공시 재료는 오염유기체 완전 구제선량인 10 kGy의 감마선을 조사시킨 황기, 백출 및 승마로 하였으며, 각각의 열수 추출물의 유전독성을 in vitro 시험으로 평가하였다. 유전독성 평가는 Salmonella typhimurium TA98 및 TA100 균주를 이용한 복귀 돌연변이 시험(Ames test)과 Chiilese hamster ovary(CHO) 세포를 이용한 in vitro 소핵 유발 시험으로 시행하였다. 각각의 시험은 59 nix를 첨가한 대사 활성화 시스템과 첨 가하지 않은 비활성화 시스템으로 구분하여 실시하였으며, 시료의 최고 처리 농도는 복귀돌연변이 시험에서는 5mg/plate로, 소핵유발시험에서는 50%의 세포증식 억제를 나타내는 농도(1 mg/mL)로 하였다. 복귀 돌연변이 시험 결과 대사 활성화 및 비활성화의 경우 모두에서 각 시료에 의한 복귀변이 집락수의 증가를 인정할 수 없었으며, 각 용량단계에서 감마선 조사군과 비조사군 간의 차이도 볼 수 없었으므로 음성으로 판정하였다. 소핵 유발시험에서도 음성 대조군 및 감마선 조사군과 비조사군 모두 각 용량 단계에서 세포 내에 생성된 소핵의 빈도가 3% 이하로 나타남에 따라, 시료에 의한 소핵의 유발을 인정할 수 없었으므로 음성으로 판정하였다 따라서 감마선이 조사된 각각의 시료는 직접 및 간접 돌연변이원으로 작용하지 않으며 세포유전 독성을 나타내지 않음을 확인할 수 있었다. 향후, 생체내 유전독성 시험, 만성독성 시험 및 생식독성 시험 등의 추가적인 in vivo실험이 행하여진다면 감마선 조사 생약재의 안전성을 보다 명확히 밝힐 수 있을 것으로 생각된다.

• 한방재활의학과학회지
• /
• 제24권1호
• /
• pp.13-30
• /
• 2014

Objectives This study was designed to investigate the effects of Bambusae caulis in liquamen and Bambusae concretio silicae on blood sugar reduction and improvement of peripheral nerve function in diabetic rat models. Methods Diabetic rat models induced by streptozotocin were divided into five groups. We fed experimental group I of rats basal diet and administered normal saline (3 ml, 1 time/1 day) for 6 weeks. We fed experimental group II of rats basal diet and administered Bambusae caulis in liquamen (100 mg/kg, 1 time/1 day) for 6 weeks. We fed experimental group III, IV, V of rats basal diet and administered Bambusae concretio silicae (100 mg/kg, 200 mg/kg, 400 mg/kg once a day) for 6 weeks. We investigated weight and glucose level of rats, and carried out touch test, hot plate test, sensory & motor nerve conduction velocity test and immunohistochemical study after 48 hours, 2 weeks, 4 weeks and 6 weeks. Results 1. The weight of all experimental group was gradually decreased. And glucose level was significantly decreased in the experimental group II, III, IV, V as compared with experimental group I. Especially experimental group II, IV, V were significantly decreased as compared with experimental group III. 2. In the quantitative analysis by touch test and hot plate test, mechanical pain threshold and heat pain threshold were significantly decreased in the other experimental groups as compared with experimental group I. Especially experimental group II, IV, V were significantly decreased as compared with experimental group III. 3. In the sensory and motor nerve conduction velocity test, sensory and motor nerve conduction velocity were significantly increased in the other experimental groups as compared with experimental group I. Especially experimental group II, IV, V were significantly increased as compared with experimental group III. 4. In the substance P immunohistochemical study, experimental group II, IV, V showed strong immune response in spinal cord. Conclusions Bambusae caulis in liquamen and Bambusae concretio silicae were probably useful to treat patients with diabetic peripheral neuropathy.

• Biomolecules & Therapeutics
• /
• 제10권4호
• /
• pp.258-267
• /
• 2002

In this study the general pharmacological profiles of AS6 on the central nervous system, cardiovascular and the other organs were investigated. The dosages given were 0, 250, 500 and 1000 mg/kg and drugs were orally administered. The animals used for this study were mice, rats and guinea pigs. Significant increases (p<0.01) in the charcoal transport capacity were observed at the high dose of 1000 mg/kg and significant increases in retardation of pain threshold were observed in the test using acetic acid in all dosed animals. However, AS6 showed no noticeable effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced sleep time, body temperature, analgesic activity in the test using hot plate method and anticonvulsant activity. Furthermore no noticeable effects were observed in cardiovascular functions in the isolated rat heart, contraction and relaxation of the smooth muscle in the isolated guinea ileum, gastric secretion and renal function.