• IMMUNE NETWORK
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• 제15권1호
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• pp.37-43
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• 2015

It is well established that TGF-${\beta}1$ and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching in spleen B cells. The present study explored the effect of LF on the Ig production by mouse peritoneal B cells. LF, like TGF-${\beta}1$, substantially increased IgA production in peritoneal B1 cells but little in peritoneal B2 cells. In contrast, LF increased IgG2b production in peritoneal B2 cells much more strongly than in peritoneal B1 cells. LF in combination with RA further enhanced the IgA production and, interestingly, this enhancement was restricted to IgA isotype and B1 cells. Similarly, the combination of the two molecules also led to expression of gut homing molecules ${\alpha}4{\beta}7$ and CCR9 on peritoneal B1 cells, but not on peritoneal B2 cells. Thus, these results indicate that LF and RA can contribute to gut IgA response through stimulating IgA isotype switching and expression of gut-homing molecules in peritoneal B1 cells.

• International Journal of Aeronautical and Space Sciences
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• 제18권4호
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• pp.709-718
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• 2017

This paper proposes the guidance laws for an agile turn of air-to-air missiles during the initial boost phase. Optimal solution for the agile turn is obtained based on the optimal control theory with a simplified missile dynamic model. Angle-of-attack command generating methods for completion of agile turn are then proposed from the optimal solution. Collision triangle condition for non-maneuvering target is reviewed and implemented for update of terminal condition for the agile turn. The performance of the proposed method is compared with an existing homing guidance law and the minimum-time optimal solution through simulations under various initial engagement scenarios. Simulation results verify that transition to homing phase after boost phase with the proposed method is more effective than direct usage of the homing guidance law.

• 한국수산과학회지
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• 제41권3호
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• pp.221-227
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• 2008

The black rockfish (Sebastes schlegeli) is an important commercial species in Korean fisheries. We used acoustic telemetry using coded ultrasonic transmitters to track the home ranges and homing routes of the black rockfish that inhabit in the Tongyeong marine ranching area. Twenty-four fish were released at five points. The distance from the capture point (C1) to the released point was 0 (R7), 0.2 (R1), 0.9 (R2), 1.3 (R3) and 1.9 (R4) km. Two of the three fish released at R1 (0.2 km) returned home in under 48hrs. Another was found 0.8km from C1. Two of the five fish released at R2 returned home, but it took over 250 days. None of the ten fish released at R3 and R4 returned home. Three of the ten fish moved 1.1-2.6 km from C1 and were found near a cage or a natural reef. Six fish were released at R7. The younger the fish, the wider was its movement range around the artificial reefs. Fish over 3 years old were likely to move less far.

• 한국항공우주학회지
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• 제35권5호
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• pp.412-418
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• 2007

본 논문에서는 충돌각 구속조건을 갖는 비행체 호밍 제어 유도법칙에 대한 역최적 문제를 제시한다. 편향비례항법 유도법칙의 이득과 LQ 문제에서의 가중치와의 관계를 규명하고, Riccati 방정식으로부터 제어입력이 LQ 최적제어가 되기 위한 영역을 제시한다. 이를 근거로 종말 구속조건을 만족하는 호밍 유도법칙의 제어이득이 최적제어법칙이 되기 위한 범위를 제안한다. 이론적 해석 결과의 타당성은 3-DOF 모의시험을 통하여 확인한다.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2006년도 제27회 추계학술대회논문집
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• pp.247-250
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• 2006

기존 연구를 통해 고체추진제 연소속도 측정을 위한 초음파 측정 시스템 및 연소속도 산정 기법을 개발하였으며, 개발 시스템을 적용하여 composite 추진제의 연소속도를 측정하였다. 본 연구에서는 연소 압력 증가에 따라 연소속도가 비선형적으로 변하는 double base형 고체 추진제 인 N-5와 AA-2 고체추진제의 연소속도를 개발 시스템을 이용하여 측정하였으며, 스트랜드버너법으로 측정된 값과의 비교를 통해 측정결과의 신뢰성을 평가하였다.

• 한국해양공학회지
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• 제23권5호
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• pp.61-70
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• 2009

An AUV (Autonomous Underwater Vehicle) is an unmanned underwater vessel to investigate sea environments and deep sea resource. To be completely autonomous, AUV must have the ability to home and dock to the launcher. In this paper, we consider a class of homing trajectory planning problem for an AUV with kinematic and tactical constraints in horizontal plane. Since the AUV under consideration has underactuated characteristics, trajectory for this kind of AUV must be designed considering the underactuated characteristics. Otherwise, the AUV cannot follow the trajectory. Proposed homing trajectory panning method that called VGM (Virtual Goal Method) based on visibility graph takes the underactated characteristics into consideration. And it guarantees shortest collision free trajectory. For tracking control, we propose a PD controller by simple guidance law. Finally, we validate the trajectory planning algorithm and tracking controller by numerical simulation and ocean engineering basin experiment in KORDI.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권5호
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• pp.1973-1991
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• 2018

Multimedia applications over wireless networks have been evolving to augmented reality or virtual reality services. However, a rich data size compared to conventional multimedia services causes bandwidth bottlenecks over wireless networks, which is one of the main reasons why those applications are not used widely. To overcome this limitation, bandwidth aggregation techniques, which exploit a multi-path transmission, have been considered to maximize link utilization. Currently, most of the conventional researches have been focusing on the user end problems to improve the quality of service (QoS) through optimal load distribution. In this paper, we address the joint pricing and load distribution problem for multi-homing in heterogeneous wireless access networks (ANs), considering the interests of both the users and the service providers. Specifically, we consider profit from resource allocation and cost of power consumption expenditure for operation as an utility of each service provider. Here, users decide how much to request the resource and how to split the resource over heterogeneous wireless ANs to minimize their cost while supporting the required QoS. Then, service providers compete with each other by setting the price to maximize their utilities over user reactions. We study the behaviors of users and service providers by analyzing their hierarchical decision-making process as a multileader-, multifollower Stackelberg game. We show that both the user and service provider strategies are closed form solutions. Finally, we discuss how the proposed scheme is well converged to equilibrium points.

• 전기학회논문지
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• 제68권1호
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• pp.172-181
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• 2019

This paper deals with the problem of generating the energy optimal trajectory which is intended to enhance the target tracking performance of a passive homing missile. Noticing that the essence of passive target tracking is the range estimation problem, the target information gathered by passive measurements can be readily analyzed by introducing the range estimator designed in line-of-sight(LOS) frame. Moreover, for the linear filter structure of the suggested range estimator, the cost function associated with the target information is clearly expressed as a function of the line-of-sight rate. Based on this idea, the optimal missile trajectory maximizing the target information is obtained by solving the saddle point problem for an indefinite quadratic cost which consists of the target information and the energy. It is shown that, different from the previous heuristic approaches, the guidance command producing the optimal passive homing trajectory is produced by the modified proportional navigation guidance law whose navigation constant is determined by the weighting coefficient for target information cost.

• 한국군사과학기술학회지
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• 제27권3호
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• pp.416-427
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• 2024

The wake-homing underwater guided weapon that detects and tracks wake generated during voyage of a surface ship is impossible to avoid with the present acoustic deception torpedo defense system. Therefore, research on bubble-generating wake decoy is necessary to deceive wake-homing underwater guided weapon. Experiments in various environments are required to verify the effective operation method and performance of the wake decoy, but performance verification through underwater experiment is limited. In this paper, we develop a simulator for an torpedo defense system of surface ship, which is applied bubble-generating wake decoy, against acoustic, wake, and hybrid homing underwater guided weapon attack. The simulator includes surface ship model, acoustic decoy(static, mobile) model, bubble-generating wake decoy model, search and motion model of underwater guided weapon and so on. By integrating various models, MATLAB GUI simulator was developed. Through the simulation results for various environmental variables by this simulator, it is judged that effective operation method and performance verification of the bubble-generating wake decoy can be performed.

• 폴리머
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• 제36권5호
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• pp.586-592
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• 2012

산화철($Fe_3O_4$은 세포에 의해 섭취된 후 대사반응에 의해 분비되므로 세포독성을 나타내지 않는다. 따라서 산화철 나노입자는 MRI 촬영을 하기에 앞서 조영제로서 널리 사용되고 있다. 본 연구에서는 통상의 공침법으로 산화철 나노입자를 합성하고 폴리에틸렌글리콜을 스페이서로 하여 혈관내피세포 및 방광암 세포막의 IL-4 리셉터에 특이적으로 반응하는 homing 펩타이드(AP)를 고정화하였다. AP를 고정화한 산화철 나노입자의 크기는 수용액 상에서 약 39 nm이었다. 섬유아세포 및 방광암세포를 이용하여 AP고정화 산화철 나노입자의 uptake를 조사한 결과 섬유아세포에는 선택적 uptake를 발견할 수 없었으나 방광암세포에는 선택적으로 uptake됨을 알 수 있었다. 따라서 AP 고정화 산화철 나노입자는 조기 암진단용 조영제로서 가능성을 지니고 있다고 할 수 있다.