• 제목/요약/키워드: high risk population

검색결과 842건 처리시간 0.025초

Genetic diversity analysis of Thai indigenous pig population using microsatellite markers

  • Charoensook, Rangsun;Gatphayak, Kesinee;Brenig, Bertram;Knorr, Christoph
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제32권10호
    • /
    • pp.1491-1500
    • /
    • 2019
  • Objective: European pigs have been imported to improve the economically important traits of Thai pigs by crossbreeding and was finally completely replaced. Currently Thai indigenous pigs are particularly kept in a small population. Therefore, indigenous pigs risk losing their genetic diversity and identity. Thus, this study was conducted to perform large-scale genetic diversity and phylogenetic analyses on the many pig breeds available in Thailand. Methods: Genetic diversity and phylogenetics analyses of 222 pigs belonging to Thai native pigs (TNP), Thai wild boars (TWB), European commercial pigs, commercial crossbred pigs, and Chinese indigenous pigs were investigated by genotyping using 26 microsatellite markers. Results: The results showed that Thai pig populations had a high genetic diversity with mean total and effective ($N_e$) number of alleles of 14.59 and 3.71, respectively, and expected heterozygosity ($H_e$) across loci (0.710). The polymorphic information content per locus ranged between 0.651 and 0.914 leading to an average value above all loci of 0.789, and private alleles were found in six populations. The higher $H_e$ compared to observed heterozygosity ($H_o$) in TNP, TWB, and the commercial pigs indicated some inbreeding within a population. The Nei's genetic distance, mean $F_{ST}$ estimates, neighbour-joining tree of populations and individual, as well as multidimensional analysis indicated close genetic relationship between Thai indigenous pigs and some Chinese pigs, and they are distinctly different from European pigs. Conclusion: Our study reveals a close genetic relationship between TNP and Chinese pigs. The genetic introgression from European breeds is found in some TNP populations, and signs of genetic erosion are shown. Private alleles found in this study should be taken into consideration for the breeding program. The genetic information from this study will be a benefit for both conservation and utilization of Thai pig genetic resources.

폐광지역 산업도시의 도시축소양상과 도시공간정책방안에 관한 연구 -석탄산업합리화조치에 따른 폐광지역 축소도시에 대한 사례 연구 (A Study on the Urban Spatial Policy for the Industrial Cities in Abandoned Mining Area Through the Analysis of the Actual Condition of Urban Shrinkage - A Case Study on Shrinking Cities in Abandoned Mining area by the Coal Industry Rationalization Policy)

  • 지은희;한동규;정찬구;강준모
    • 대한토목학회논문집
    • /
    • 제42권1호
    • /
    • pp.135-144
    • /
    • 2022
  • 이 논문은 폐광지역진흥지구가 지정된 4개의 사례도시를 대상으로 최근 20년간 도시축소 유형을 분석하고 도시축소 실태분석을 통해 향후 도시공간정책의 방향을 제시하고자 하였다. 최근 20년간의 1년 단위 도시축소유형 분석결과, 사례도시 모두 고착형 축소도시로 분석되었으며 최근 40년간 정점인구 대비 30 % 이상의 인구감소를 나타냈다. 공간구조적으로는 인구감소에도 불구하고 시가화면적과 비도시지역의 지구단위계획구역 지정면적은 매년 증가하고 있으며, 비도시지역의 개발행위허가 및 건축허가도 증가추세에 있어 도시공간의 효율적 관리와 운영이 필요하다. 향후 소멸 고위험단계에 있는 군급 도시에 대한 연구와 도시축소 유형의 세분화 및 유형별 실태분석을 위한 다양한 지표의 개발이 요구된다.

Occupational Characteristics and Health Status of Vietnamese Male Migrant Workers in the Republic of Korea

  • Ohwi Kwon;Ji-Hun Song;Jeong-Ok Kong;Seong-Won Ma;Young Shin Lee;Joonho Ahn
    • Safety and Health at Work
    • /
    • 제14권3호
    • /
    • pp.267-271
    • /
    • 2023
  • Background: The objective of this study is to identify the working conditions and health status of Vietnamese male migrant workers in Republic of Korea, in comparison to the Korean general population. Methods: We conducted our survey through the Migrant People Center, and we received completed questionnaires from 87 male Vietnamese migrant workers. The questionnaire employed was identical to those used in the Korean Working Conditions Survey and the 2020 Korea National Health and Nutrition Examination Survey. The collected data from the Vietnamese migrant workers was then compared with the Korean reference population using indirect age-standardization. Results: Vietnamese male workers demonstrated a higher prevalence of health problems including hearing problems (age-standardized prevalence ratio (aSPR) 13.22, 95% confidence interval [CI]: 8.07-20.4), skin problems (aSPR 13.49, 95% CI: 8.07-20.4), and low back pain (aSPR 8.40, 95% CI: 6.50-10.69). Elevated exposure to workplace hazards such as chemicals (aSPR 2.36, 95% CI: 1.51-3.51), organic solvents (aSPR 2.22, 95% CI: 1.44-3.28), handling of heavy objects (aSPR 1.67, 95% CI: 1.24-2.21), and high temperatures (aSPR 1.96, 95% CI: 1.46-2.57) was observed among them. Additionally, they faced a higher risk of no personal protective equipment (aSPR 2.53, 95% CI: 1.26-4.52) and a greater prevalence of unmet medical needs (aSPR 7.14, 95% CI: 4.74-10.32). Conclusion: Our findings highlight the elevated workplace hazards, health problems, and unmet medical needs among Vietnamese male workers compared to the Korean reference population. These findings underscores the urgency for enhanced scrutiny over working conditions and protective equipment provision, coupled with efforts to improve healthcare accessibility and worker education.

한국특산 복사앵도나무(Prunus choreiana H. T. Im)의 분포특성, 개체군구조 및 결실동태 (Distributional Characteristics, Population Structures and Fruition Dynamics of Korean Endemic plant, Prunus choreiana H. T. Im)

  • 김영철;채현희;손성원
    • 한국환경생태학회지
    • /
    • 제36권2호
    • /
    • pp.177-201
    • /
    • 2022
  • 생물다양성보전 당사국 총회에서 지구식물보전전략의 채택에 따라 각각의 목표 달성을 위한 활동이 활발하게 진행되고 있다. GSPC-2020의 목표 2와 7의 달성을 위한 보전생태학적인 연구의 필요성이 높아지고 있다. GSPC-2020의 목표 달성을 위해 우선순위를 가지는 종은 희귀식물과 특산식물이다. 특히 특정한 지역에 제한적인 분포를 나타내는 특산식물은 멸종위협 또한 높다고 평가된다. 이러한 필요성에 따라 본 연구에서는 한국특산식물인 복사앵도나무를 대상으로 먼저 분포현황을 평가하였다. 다음으로 생육지의 식생환경을 조사하였고 각 개체군의 구조를 평가하였다. 또한 열매의 생산성을 평가하였고 열매의 생산에 있어서 화분매개곤충의 영향을 평가하였다. 이와 더불어 생산한 꽃의 수에 따른 열매의 결실 비율을 평가하였다. 마지막으로 연간생장특성을 관찰하였다. 복사앵도나무의 분포지는 특정한 식생유형을 나타내지 않았다. 모든 분포지는 한반도 중부에 위치한 강원도의 석회암지대에 위치하였고 교목과 아교목의 피복도가 높지 않거나 존재하지 않는 공간을 점유하였다. 개체군의 구조는 열매를 생산할 수 있는 성숙단계에 속하는 개체의 비율이 높았고 유묘와 어린단계의 개체 비율이 낮았다. 열매의 생산에는 화분매개곤충에 의한 수분이 필요하였고 각 개체의 활력이 영향을 미치는 것으로 나타났다. 다량의 꽃을 생산하지만 관찰되는 열매는 최대 20%, 평균적으로는 2~6%에 불과하였다. 이러한 개화특성은 열매의 생산에 화분매개곤충이 필요하지만 개화기에 해당하는 3월 중순에서 4월 초순은 화분매개곤충의 종류가 적고 활동 또한 활발하지 않음에 따라 다량의 꽃을 이용한 곤충의 유인이 필요하기 때문으로 판단되었다. 복사앵도나무 분포지에서 종자에 의한 재정착은 드물게 관찰되었다. 그럼에도 불구하고 오랜 수명을 소유하고 있고 주기적으로 다량의 열매를 생산하는 특성에 따라 개체군의 지속은 가능할 것으로 예상되었다. 다만 복사앵도나무는 경쟁관계에 있는 교목 및 아교목에 의한 울폐도가 증가할 경우 생장의 저해 및 소멸에 이를 것으로 예상됨에 따라 현재와 같이 분포지의 식생환경이 변화할 경우 장기적으로 개체수의 감소와 분포지의 축소가 예상되었다. 본 연구의 결과는 IUCN의 국가 적색목록평가의 기초 정보가 될 수 있음은 물론 GSPC-2020의 달성에 필요한 중요한 자료가 될 것으로 판단되었다.

Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Breast Cancer Risk in a Chinese Population

  • Luo, Ting;Chen, Long;He, Ping;Hu, Qian-Cheng;Zhong, Xiao-Rong;Sun, Yu;Yang, Yuan-Fu;Tian, Ting-Lun;Zheng, Hong
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제14권4호
    • /
    • pp.2433-2437
    • /
    • 2013
  • Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and thereby involved in the development and progression of solid tumours. Associations between three VEGF gene polymorphisms (-634 G/C, +936 C/T, and +1612 G/A) and breast cancer risk have been extensively studied, but the currently available results are inconclusive. Our aim was to investigate associations between three VEGF gene polymorphisms and breast cancer risk in Chinese Han patients. We performed a hospital-based case-control study including 680 female incident breast cancer patients and 680 female age-matched healthy control subjects. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the three VEGF gene polymorphisms. We observed that women carriers of +936 TT genotypes [odds ratio (OR) =0.46, 95% confidence interval (CI) = 0.28, 0.76; P=0.002] or 936 T-allele (OR=0.81, 95% CI= 0.68, 0.98; P=0.03) had a protective effect concerning the disease. Our study suggested that the +1612G/A polymorphism was unlikely to be associated with breast cancer risk. The -634CC genotype was significantly associated with high tumor aggressiveness [large tumor size (OR=2.63, 95% CI=1.15, 6.02; P=0.02) and high histologic grade (OR=1.47, 95% CI= 1.06, 2.03; P=0.02)]. The genotypes were not related with other tumor characteristics such as regional or distant metastasis, stage at diagnosis, or estrogen or progesterone receptor status. Our study revealed that the VEGF -634 G/C and +936 C/T gene polymorphisms may be associated with breast cancer in Chinese Han patients.

Competitor density and food concentration: an empirical approach to elucidate the mechanism of seasonal succession of two coexisting Bosmina

  • Mano, Hiroyuki;Sakamoto, Masaki
    • Journal of Ecology and Environment
    • /
    • 제36권4호
    • /
    • pp.267-271
    • /
    • 2013
  • To examine the density effect and food concentration in the competitive output of two Bosmina species, the population growths of Bosmina fatalis were investigated by manipulating the density of B. longirostris and the concentration of algae. The B. fatalis density did not increase in conditions with abundant B. longirostris regardless of the food concentrations. The B. fatalis increased only at low densities of B. longirostris with high food concentrations. Based on the current results, a possible mechanism underlying the seasonal shift from B. longirostris to B. fatalis in Japanese eutrophic lakes will be explored below.

한국인의 건강행태 유형에 관한 연구 (Health Behavior Patterns of Korean)

  • 이순영;김선우;박주원
    • Journal of Preventive Medicine and Public Health
    • /
    • 제30권1호
    • /
    • pp.181-193
    • /
    • 1997
  • The purpose of this study was to identify population subgroups with similar patterns of diet quality, physical activity, alcohol consumption and cigarette smoking of Korean. The cluster analysis was conducted using the data from Korea National Health Survey(KNHS) in 1995, which consisted of 5,805 persons. We identified six health behavior typologies : 32.9% of the sample had a good diet but sedentary activity level(good diet lifestyle), 7.2% had high activity level but less diet quality(fitness lifestyle). Individuals in the passive lifestyle cluster(39.1%) had no active health promoting activities but tended to avoid risk taking health behavior such as cigarette smoking and alcohol drinking. 1.1% of the sample were in a drinking cluster, 17.2% in a smoking cluster and 2.5% had a hedonic lifestyle characterized by heavy drinking and smoking. The other characteristics of these lifestyle clusters could be presented by demographic and socioeconomic factors.

  • PDF

AGD(통합치과전문임상의)교육 프로그램 질 보장 방안 (Quality Assurance Strategy for AGO Program in Korea)

  • 신제원
    • 대한치과의사협회지
    • /
    • 제48권11호
    • /
    • pp.790-796
    • /
    • 2010
  • Currently, KDA adopted new post-graduated program; advanced education general dentistry(AGD) for 3 years preparation. The AGO program provides the resident the opportunity to deliver the highest quality of comprehensive dental care to the broadest range of the population with a knowledge, comfort, and ease in treating the high risk patient. The purpose of this article is to study the assurance systems of AGO programs in USA and Japan and to suggest a piece of advice whether we choose the way of AGO program assurance system in Korea.

지역사회 주민의 시력장애 이환율 및 영양소 섭취수준 (Prevalence of Refractive Error and Nutrient Intake Status in a Community Study)

  • 최혜정;진가헌;김영옥
    • 한국식품영양학회지
    • /
    • 제13권5호
    • /
    • pp.425-433
    • /
    • 2000
  • This study was conducted to estimate the prevalence of ametropias such as myopia and hyperopia from the community based population study. Another purpose of this study was to determine the association between ametropia and nutrient intake. The study subjects was 492 residents over 20 years of age residing in Kuri City. Ametropia was tested based on re(rector error using auto referactor. Nutrient intake was estimated from the dietary survey using 24 hour recall method. As a result of data analysis, the prevalence of myopia was 57% and that of hyperopia was 11%. Such a high rate of ametropia prevalence may suggest the increasing risk of eye health in a Korean society. Nutrient intake of myopia group was 5∼15% higher than that of normal group in most of the nutrients. Whereas intake of most nutrient except calcium, retinal, fiber for the hyperopia group was lower than that of normal group. The result may suggest that inbalance of nutrient intake has been related with ametropia.

  • PDF

Significant fibrosis after radiation therapy in a patient with Marfan syndrome

  • Suarez, Eva M.;Knackstedt, Rebecca J.;Jenrette, Joseph M.
    • Radiation Oncology Journal
    • /
    • 제32권3호
    • /
    • pp.208-212
    • /
    • 2014
  • Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-${\beta}1$) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient's TGF-${\beta}1$ level during and after treatment. Despite maintaining stable levels of plasma TGF-${\beta}1$, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.