Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.4.2433

Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Breast Cancer Risk in a Chinese Population  

Luo, Ting (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Chen, Long (Department of Laboratory Medicine, West China Hospital, Sichuan University)
He, Ping (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Hu, Qian-Cheng (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Zhong, Xiao-Rong (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Sun, Yu (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Yang, Yuan-Fu (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Tian, Ting-Lun (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Zheng, Hong (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.4, 2013 , pp. 2433-2437 More about this Journal
Abstract
Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and thereby involved in the development and progression of solid tumours. Associations between three VEGF gene polymorphisms (-634 G/C, +936 C/T, and +1612 G/A) and breast cancer risk have been extensively studied, but the currently available results are inconclusive. Our aim was to investigate associations between three VEGF gene polymorphisms and breast cancer risk in Chinese Han patients. We performed a hospital-based case-control study including 680 female incident breast cancer patients and 680 female age-matched healthy control subjects. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the three VEGF gene polymorphisms. We observed that women carriers of +936 TT genotypes [odds ratio (OR) =0.46, 95% confidence interval (CI) = 0.28, 0.76; P=0.002] or 936 T-allele (OR=0.81, 95% CI= 0.68, 0.98; P=0.03) had a protective effect concerning the disease. Our study suggested that the +1612G/A polymorphism was unlikely to be associated with breast cancer risk. The -634CC genotype was significantly associated with high tumor aggressiveness [large tumor size (OR=2.63, 95% CI=1.15, 6.02; P=0.02) and high histologic grade (OR=1.47, 95% CI= 1.06, 2.03; P=0.02)]. The genotypes were not related with other tumor characteristics such as regional or distant metastasis, stage at diagnosis, or estrogen or progesterone receptor status. Our study revealed that the VEGF -634 G/C and +936 C/T gene polymorphisms may be associated with breast cancer in Chinese Han patients.
Keywords
VEGF; single nucleotide polymorphism; breast cancer risk; Han Chinese;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
연도 인용수 순위
1 Bae SJ, Ahn DH, Hong SP, et al (2008). Gender-specific association between polymorphism of vascular endothelial growth factor (VEGF 936C>T) gene and patients with stomach cancer. Yonsei Med J, 49, 783-91.   DOI   ScienceOn
2 Belinsky GS, Claffey KP, Nambiar PR, et al (2005). Vascular endothelial growth factor and enhanced angiogenesis do not promote metastatic conversion of a newly established azoxymethane-induced colon cancer cell line. Mol Carcinog, 43, 65-74.   DOI   ScienceOn
3 Dassoulas K, Gazouli M, Rizos S, et al (2009). Common polymorphisms in the vascular endothelial growth factor gene and colorectal cancer development, prognosis, and survival. Mol Carcinog, 48, 563-9.   DOI   ScienceOn
4 Eroglu A, Ozturk A, Cam R, et al (2008). Vascular endothelial growth factor gene 936 C/T polymorphism in breast cancer patients. Med Oncol, 25, 54-5.   DOI   ScienceOn
5 Ferrara N (2002). VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer, 2, 795-803.   DOI   ScienceOn
6 Ferrara N, Gerber HP, LeCouter J (2003). The biology of VEGF and its receptors. Nat Med, 9, 669-76.   DOI   ScienceOn
7 Garcia-Closas M, Malats N, Real FX, et al (2007). Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk. PLoS Genet, 3, e29.   DOI   ScienceOn
8 Gu D, Wang M (2011). VEGF 936C>T polymorphism and breast cancer risk: evidence from 5,729 cases and 5,868 controls. Breast Cancer Res Treat, 125, 489-93.   DOI
9 Iordache S, Saftoiu A, Georgescu CV, et al (2010). Vascular endothelial growth factor expression and microvessel density-two useful tools for the assessment of prognosis and survival in gastric cancer patients. J Gastrointestin Liver Dis, 19, 135-9.
10 Jacobs EJ, Feigelson HS, Bain EB, et al (2006). Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort. Breast Cancer Res, 8, R22.   DOI   ScienceOn
11 Jakubowska A, Gronwald J, Menkiszak J, et al (2008). The VEGF_936_C>T 3'UTR polymorphism reduces BRCA1-associated breast cancer risk in Polish women. Cancer Lett, 262, 71-6.   DOI   ScienceOn
12 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
13 Jin B, Jiang F, Ding Z (2011). Revaluation of the association between vascular endothelial growth factor gene 936 C/T polymorphism and breast cancer risk. Breast Cancer Res Treat, 128, 909-12.   DOI   ScienceOn
14 Jin Q, Hemminki K, Enquist K, et al (2005). Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer Res, 11, 3647-53.   DOI   ScienceOn
15 Lee SJ, Lee SY, Jeon HS, et al (2005). Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev, 14, 571-5.   DOI   ScienceOn
16 Kataoka N, Cai Q, Wen W, et al (2006). Population-based casecontrol study of VEGF gene polymorphisms and breast cancer risk among Chinese women. Cancer Epidemiol Biomarkers Prev, 15, 1148-52.   DOI   ScienceOn
17 Krippl P, Langsenlehner U, Renner W, et al (2003). A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk. Int J Cancer, 106, 468-71.   DOI   ScienceOn
18 Langsenlehner U, Wolf G, Langsenlehner T, et al (2008). Genetic polymorphisms in the vascular endothelial growth factor gene and breast cancer risk. The Austrian "tumor of breast tissue: incidence, genetics, and environmental risk factors" study. Breast Cancer Res Treat, 109, 297-304.   DOI
19 Liu L, Hua FZ, Cao JQ, et al (2011). VEGF 936C>T polymorphism and breast cancer risk: evidence needed further clarification. Breast Cancer Res Treat, 127, 569-71.   DOI
20 Lu H, Shu XO, Cui Y, et al (2005). Association of genetic polymorphisms in the VEGF gene with breast cancer survival. Cancer Res, 65, 5015-9.   DOI   ScienceOn
21 Oliveira C, Lourenco GJ, Silva PM, et al (2011). Polymorphisms in the 5'-and 3'-untranslated region of the VEGF gene and sporadic breast cancer risk and clinicopathologic characteristics. Tumour Biol, 32, 295-300.   DOI   ScienceOn
22 Perrone G, Vincenzi B, Santini D, et al (2004). Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinicopathological features in colon cancer. Cancer Lett, 208, 227-34.   DOI   ScienceOn
23 Ronco AL, De Stefani E, Deneo-Pellegrini H (2012a). Risk factors for premenopausal breast cancer: a case-control study in Uruguay. Asian Pac J Cancer Prev, 13, 2879-86.   DOI   ScienceOn
24 Qiu LX, Wang K, Yang S, et al (2011). Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility. Mol Biol Rep, 38, 4491-4.   DOI
25 Renner W, Kotschan S, Hoffmann C, et al (2000). A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res, 37, 443-8.   DOI   ScienceOn
26 Rodrigues P, Furriol J, Tormo E, et al (2012). The singlenucleotide polymorphisms +936 C/T VEGF and-710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population. Breast Cancer Res Treat, 133, 769-78.   DOI   ScienceOn
27 Ronco AL, De Stefani E, Deneo-Pellegrini H, et al (2012b). Diabetes, overweight and risk of postmenopausal breast cancer: a case-control study in Uruguay. Asian Pac J Cancer Prev, 13, 139-46.   DOI   ScienceOn
28 Roy H, Bhardwaj S, Yla-Herttuala S (2006). Biology of vascular endothelial growth factors. FEBS Lett, 580, 2879-87.   DOI   ScienceOn
29 Schneider BP, Wang M, Radovich M, et al (2008). Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol, 26, 4672-8.   DOI   ScienceOn
30 Shamsi U, Khan S, Usman S, et al (2013). A multicenter matched case control study of breast cancer risk factors among women in Karachi, Pakistan. Asian Pac J Cancer Prev, 14, 183-8.   DOI   ScienceOn
31 Wang K, Li X, Zhou C, et al (2013). Socio-economic Factors Influencing Tumor Presentation and Treatment Options in Chinese Breast Cancer Patients. Asian Pac J Cancer Prev, 14, 267-74.   DOI   ScienceOn
32 Stefanou D, Batistatou A, Kamina S, et al (2004). Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in benign prostatic hyperplasia and prostate cancer. In Vivo, 18, 155-60.
33 Sun JW, Li XR, Gao HY, et al (2013). Electromagnetic Field Exposure and Male Breast Cancer Risk: A Meta-analysis of 18 Studies. Asian Pac J Cancer Prev, 14, 523-8.   DOI   ScienceOn
34 Vincenti V, Cassano C, Rocchi M, et al (1996). Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation, 93, 1493-5.   DOI   ScienceOn
35 Wang K, Liu L, Zhu ZM, et al (2011). Five polymorphisms of vascular endothelial growth factor (VEGF) and risk of breast cancer: a meta-analysis involving 16,703 individuals. Cytokine, 56, 167-73.   DOI   ScienceOn
36 Wang K, Peng HL, Li LK (2012). Prognostic value of vascular endothelial growth factor expression in patients with prostate cancer: a systematic review with meta-analysis. Asian Pac J Cancer Prev, 13, 5665-9.   DOI   ScienceOn
37 Watson CJ, Webb NJ, Bottomley MJ, et al (2000). Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine, 12, 1232-5.   DOI   ScienceOn
38 Wehrschuetz M, Schollnast H, Wehrschuetz E, et al (2009). VEGF 936C > T polymorphism and association of BI-RADS score in women with suspected breast cancer. Breast Cancer (Auckl), 3, 77-81.
39 Yang DS, Park KH, Woo OH, et al (2011). Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis. Breast Cancer Res Treat, 125, 849-53.   DOI
40 Zhang YF, Kang HB, Li BL, et al (2012). Positive effects of soy isoflavone food on survival of breast cancer patients in China. Asian Pac J Cancer Prev, 13, 479-82.   DOI   ScienceOn
41 Zhou LP, Luan H, Dong XH, et al (2012a). Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis. Asian Pac J Cancer Prev, 13, 3637-43.   DOI   ScienceOn
42 Zhou P, Huang W, Chu X, et al (2012b). The lymphotoxin-alpha 252A>G polymorphism and breast cancer: a meta-analysis. Asian Pac J Cancer Prev, 13, 1949-52.   DOI   ScienceOn
43 Zhou Y, Li N, Zhuang W, et al (2011). Vascular endothelial growth factor (VEGF) gene polymorphisms and gastric cancer risk in a Chinese Han population. Mol Carcinog, 50, 184-8.   DOI   ScienceOn