• The Korean Journal of Pharmacology
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• v.26 no.2
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• pp.113-120
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• 1990

Influences of trigger calcium on myocardial contraction from several sources were investigated on the frequency reduction-induced changes of contraction in rat left atria driven by electrical field stimulation. Rat atria elicited characteristic three phase-changes according to frequency reduction: the first rapid rise in twitch tension, the second transient fast decrease in tension and the third maintenance of twitch tension at about 200% of resting tension during high frequency. Caffeine treatment enormously suppressed the frequency reduction-induced twitch tension increase. The atrial contraction during high frequency vanished after verapamil treatment. But, during low frequency, atrial contraction revived in the presence of verapamil. Ouabain treatment and sodium depletion in superfusing solution abolished the characteristic second phase with slow frequency. These results suggest that slow calcium channel is an indispensable calcium entry route and calcium release from sarcoplasmic reticulum is an major source for trigger calcium in cardiac contraction. And sodium-calcium exchange has a modulatory roles in the regualtion of trigger calcium according to the changes of intracellular sodium concentration.

• Proceedings of the ESK Conference
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• 1994.04a
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• pp.49-51
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• 1994

The aims of this study were first to determine the influence of vibration displacement amplitude $(200{\mu}m, 300{\mu}m peak-to-peak)$ at selected frequencies (40-200Hz) on a commonly observed but often undesired motor response elicited bylocal vibratory stimulation, the Tonic Vibration Reflex (TVR). Second, to determine the degree of synchronization of motor unit (MU) activity with vibratory stimuli. Vibration was applied to the distal tendons of the hand flexor muscles. Changes in root- mean-square electromyographic (EMG) activity of the finger and wrist flexor muscles were analyzed both as a function of their initial contraction level (0%, 10%, 20% of the maximal voluntarycontraction: MVC) and as a function of the vibration parameters. The results indicate that the TVR increased with the initial muscle contraction up to 10% MVC: The TVR increased with vibration frequency up to 100-150 Hz and decreases beyond; A significant increase of the TVR with vibration displacement amplitude was observed only for the wrist flexor muscle; MU synchronization at vibration frequency (VF) was found more often in the low frequency range $(f{\leq}100 Hz)$ and tended todecrease beyond; In the high frequency range $(f{\geq}120 Hz)$, MU activity at subharmonic frequency was predominant; The "cut-off" frequency of the synchronization with VF was neither affected by the vibration displacement amplitude nor initial muscle contraction level. The surface EMG turned out to be a useful means to analyze MU synchronization since it is noninvasive, and it can be easily used for analysis of different muscle contraction levels, while single MU technique might have some difficulties at high muscle contraction levels. Furthermore, these results indicate that high frequencyvibration (f>150 Hz) tends to induce less muscle/tendon stress and MU synchronization. Such remarks are of importance for the design of hand-held vibrating tools.ing tools.

• Journal of Ginseng Research
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• v.29 no.3
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• pp.119-125
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• 2005

The previous reports demonstrated that ginseng saponins, active ingredient of Panax ginseng, inhibited blood vessel contraction induced by various hormones or high $K^+$. Recently, we demonstrated that 20(R)- and 20(S)-ginsenoside $Rg_3$. regulate ion channel activities with differential manners. The aim of this study was to examine whether ginsenoside $Rg_3$ isomers also show differential effects on swine coronary artery contractionresponses induced by high $K^+$, serotonin (5-HT) or acetylcholine. Treatment of 20(S)- but not 20(R)-ginsenoside $Rg_3$ caused a concentration-dependent relaxation of coronary artery contracted by 25mM KCI. 20(S)- and 20(R)-ginsenoside $Rg_3$ induced significant relaxations of coronary artery contraction induced by 5-HT $(3{\mu}M)$ in the presence of endothelium with concentration-dependent manner and, also in the absence of endothelium only 20(S)-ginsenoside $Rg_3$ induced a strong Inhibition of coronary artery contraction induced by 5-HT in a concentration-dependent manner. 20(S)-ginsenoside $Rg_3$ caused relaxation of coronary artery in the absence and presence of endothelium. In contrast, treatment of 20(S)- and 20(R)-ginsenoside $Rg_3\;(100{\mu}M)$ did not show significant inhibition of coronary artery contraction induced by acetylcholine $(0.01\;to\;30{\mu}M)$ in the presence of endothelium, whereas both isomers caused significant inhibition of coronary artery contraction induced by acetylcholine $(0.01\;to\;30{\mu}M)$ in the absence of endothelium in a concentration-dependent manner. These findings indicate that 20(S)-or 20(R)-ginsenoside $Rg_3$ exhibits differential relaxation eff3cts of swine coronary artery contractions caused by high $K^+$, acetylcholine, and 5-HT treatment and that this differential vasorelaxing effects of ginsenoside $Rg_3$ isomers also might be dependent on endothelium.

• Korea-Australia Rheology Journal
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• v.17 no.3
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• pp.99-110
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• 2005

This work presents results of finite element analysis of isothermal incompressible creeping viscoelastic flows with the tensor-logarithmic formulation of the Leonov model especially for the planar geometry with singular comers in the domain. In the case of 4:1 contraction flow, for all 5 meshes we have obtained solutions over the Deborah number of 100, even though there exists slight decrease of convergence limit as the mesh becomes finer. From this analysis, singular behavior of the comer vortex has been clearly seen and proper interpolation of variables in terms of the logarithmic transformation is demonstrated. Solutions of 4:1:4 contraction/expansion flow are also presented, where there exists 2 singular comers. 5 different types spatial resolutions are also employed, in which convergent solutions are obtained over the Deborah number of 10. Although the convergence limit is rather low in comparison with the result of the contraction flow, the results presented herein seem to be the only numerical outcome available for this flow type. As the flow rate increases, the upstream vortex increases, but the downstream vortex decreases in their size. In addition, peculiar deflection of the streamlines near the exit comer has been found. When the spatial resolution is fine enough and the Deborah number is high, small lip vortex just before the exit comer has been observed. It seems to occur due to abrupt expansion of the elastic liquid through the constriction exit that accompanies sudden relaxation of elastic deformation.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1994.04a
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• pp.394-398
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• 1994

The aim of the present study was to determine the influence of vibration frequency and muscle contraction level at constant vibration displacement amplitudes on a commonly observed motor response elicited by local vibratory stimulation, i.e., the Tonic Vibration Reflex (TVR). Vibration was applied to the distal tendons of the hand flexor muscles. Changes in activity of the hand flexor and extensor muscles were analyzed as a function of the vibration frequency (40-200 Hz), displacement amplitude(200.mu.m and 300.mu.m peak-to-peak), and the initial contraction level of the flexor muscles (0%, 10%, and 20% of the maximal voluntary contraction: MVC). The main results indicate that the TVR increases with vibration frequency up to 100-150 Hz and decreases beyond, and the TVR attains its maximum at 10% MVC. It appears that high frequency vibration tends to induce less muscle/tendon stress. Such a result is of particular importance for the design of handheld vibrating tools.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.2 no.3
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• pp.25-35
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• 2004

The purpose of this study was compared to MTICs(maximal tolerated isometric contraction), decrement and recovery. For this, using isokinetic exercise analysis device(Biodex Medical Systems Inc., Biodex System 3PRO, USA), low rate(20 Hz) and high rate(100 Hz) NMES(neuromuscular electrical stimulation) were applied to the quadriceps muscles of fifteen patients with spastic hemiplegia caused by lesions in the central nervous system. The results were as follows: 1. It was shown to fast decrement in the middle of phase at low rate NMES and to slow decrement of MTIC response at high rate NMES(p<.01). 2. It was shown to fast recovery at high rate NMES and to slow recovery at low rate NMES in recovery tendency of MTIC(p<.01). These conclusions suggest that NMES of high rate caused to slow fatigue and fast recovery different from low rate NMES.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.4
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• pp.287-297
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• 2001

Contraction of smooth muscle is initiated by an increase in cytosolic $Ca^{2+}$ leading to activation of $Ca^{2+}$/ calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms mediating contraction differ depending on the region. The involvement of these different mechanisms varies depending on the source of $Ca^{2+}$ and the kinetic of $Ca^{2+}$ mobilization. $Ca^{2+}$ mobilizing agonists stimulate different phospholipases $(PLC-{\beta},\;PLD\;and\;PLA_2)$ to generate one or more $Ca^{2+}$ mobilizing messengers $(IP_3\;and\;AA),$ and diacylglycerol (DAG), an activator of protein kinase C (PKC). The relative contributions of $PLC-{\beta},\;PLA_2$ and PLD to generate second messengers vary greatly between cells and types of contraction. In smooth muscle cell derived form the circular muscle layer of the intestine, preferential hydrolysis of $PIP_2$ and generation of $IP_3$ and $IP_3-dependent\;Ca^{2+}$ release initiate the contraction. In smooth muscle cells derived from longitudinal muscle layer of the intestine, preferential hydrolysis of PC by PLA2, generation of AA and AA-mediated $Ca^{2+}$ influx, cADP ribose formation and $Ca^{2+}-induced\;Ca^{2+}$ release initiate the contraction. Sustained contraction, however, in both cell types is mediated by $Ca^{2+}-independent$ mechanism involving activation of $PKC-{\varepsilon}$ by DAG derived form PLD. A functional linkage between $G_{13},$ RhoA, ROCK, $PKC-{\varepsilon},$ CPI-17 and MLC phosphorylation in sustained contraction has been implicated. Contraction of normal esophageal circular muscle (ESO) in response to acetylcholine (ACh) is linked to $M_2$ muscarinic receptors activating at least three intracellular phospholipases, i.e. phosphatidylcholine-specific phospholipase C (PC-PLC), phospholipase D (PLD) and the high molecular weight (85 kDa) cytosolic phospholipase $A_2\;(cPLA_2)$ to induce phosphatidylcholine (PC) metabolism, production of diacylglycerol (DAG) and arachidonic acid (AA), resulting in activation of a protein kinase C (PKC)-dependent pathway. In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic $M_3$ receptors, linked to pertussis toxin-insensitive GTP-binding proteins of the $G_{q/11}$ type. They activate phospholipase C, which hydrolyzes phosphatidylinositol bisphosphate $(PIP_2),$ producing inositol 1, 4, 5-trisphosphate $(IP_3)$ and DAG. $IP_3$ causes release of intracellular $Ca^{2+}$ and formation of a $Ca^{2+}$-calmodulin complex, resulting in activation of myosin light chain kinase and contraction through a calmodulin-dependent pathway.

• Journal of the korean academy of Pediatric Dentistry
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• v.33 no.2
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• pp.233-243
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• 2006

The aim of this study was to investigate the relationship between the C-factor and shrinkage strain values of composite resin and examine the strain values in different incremental filling techniques. Experiment consisted two aims. First, we compared with strain value in two different C-factors(3.7 and 1.0). Second, we examined the strain values in three different filling techniques. The results of the present study can be summarized as follows : 1. High C-factor groups showed higher contraction stress values than low C-factor groups at 900 sec after polymerization. 2. Hybrid resin showed higher contraction stress values than flowable resin in high C-factor cavities. But contraction stress was not revealed significant difference between hybrid resin and flowable resin in low C-factor cavities (P>0.05). 3. Bulk felling with hybrid resin(Group 1) showed high contraction stress and lining with flowable resin followed hybrid resin (Group 5) showed lower contraction stress. 4. Contraction stress were increased during 900 sec after polymerization in high C-factor groups but decreased gradually after 900 sec. 5. Low C-factor groups showed tight marginal seal between resin and cavity wall but high C-factor groups showed gaps formed between resin and cavity wall in part. On the basis above results, layering techniques in high C-factor cavity showed advantages in reducing contraction stress and gap formation between cavity wall and resin restoration.

• Journal of Environmental Science International
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• v.22 no.3
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• pp.291-301
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• 2013

Sediment from the upstream channel has been deposited near the Nakdong River Estuary Barrage (NREB) due to the mild slope and decreased velocity. The annual mechanical dredging to ensure the flood capacity has been performed to remove the deposited sediment. However, the dredging method is not considered as an effective countermeasure due to high cost and long time to operate. Therefore, many methods for sedimentation reduction have been proposed for NREB. Especially, the channel contraction method to mitigate sedimentation problem by changing the channel geometry from 2 km to 3 km upstream of NREB has been recently suggested as an effective countermeasure. However, there is the possibility that the channel contraction method induces flood level increase compared to original condition. Therefore, it is necessary to investigate quantitatively the flood level changes in the upstream and downstream section due to the channel contraction method for NREB. In this study, water level changes by 10% channel contraction of whole width has been evaluated using the HEC-RAS model and simulated with and without channel contraction for various flood discharge. As a result, water level in the section where the channel was contracted was decreased by 0.02 m and flood level at the upstream of channel contracted was increased up to 0.015 m for the 500-year flood.

• PNF and Movement
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• v.17 no.3
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• pp.487-497
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• 2019

Purpose: This tutorial review investigated the effect of prior fatigue and passive stretches on eccentric contraction-induced muscle injuries, as well as the underlying mechanisms of eccentric contraction-related injuries. Methods: Contraction-induced muscle damage is the most common disabling problem in sports and routines. The mechanisms underlying the pathology and prevention of muscle damage lessened by prior fatigue or stretches are critical in assessing musculoskeletal injuries. Even though there are treatments to reduce eccentric contraction-induced muscle injuries, fatigue negatively influences them. Therefore, we reviewed previous studies on eccentric contraction-induced muscle injuries with prior treatments using the MEDLINE and PubMed databases. Results: Prior passive stretching had a preventative and therapeutic effect, but prior lengthening contractions did not. On the other hand, prior isometric contractions involving relatively small forces may not provide a sufficient stimulus to induce protection. As a result, high force isometric contractions may be necessary. The studies supported the positive effects of prior fatigue, concluding that it was a factor in determining the amount of damage caused by eccentric exercise. This was due to a reduction in force and increased temperature. Studies that did not support the positive effects of prior fatigue concluded that a shift in optimal length to a longer length and reduced energy absorption during lengthening are evidence that fatigue is not related to muscle injuries induced by lengthening. Conclusion: The variability of the experiment models, conditions, muscles, and treatment methods make it necessary to interpret the conditions of previous studies carefully and draw conclusions without making direct comparisons. Thus, additional studies should be carefully conducted to investigate the positive effect of fatigue on lengthening.