• Title/Summary/Keyword: high Tg

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Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet

  • Kim, Min-Ji;Kim, Yang-Ha
    • Nutrition Research and Practice
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    • v.4 no.3
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    • pp.191-195
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    • 2010
  • There is an increasing interest in curcumin (Curcuma longa L.) as a cardiovascular disease (CVD) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (LDL-cholesterol) level. The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level. Male Sprague-Dawley rats were fed a 45% high fat diet or same diet supplemented with curcumin (0.1% wt/wt) for 8 weeks. The curcumin diet significantly decreased serum triglyceride (TG) by 27%, total cholesterol (TC) by 33.8%, and LDL-cholesterol by 56%, respectively as compared to control group. The curcumin-supplemented diet also significantly lowered the atherogenic index (AI) by 48% as compared to control group. Hepatic TG level was significantly reduced by 41% in rats fed with curcumin-supplemented diet in comparison with control group (P < 0.05). Conversely, the curcumin diet significantly increased fecal TG and TC. The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P < 0.05). These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin.

Sex differences in Risk of Cardiovascular Disease, Depression and Self-Care Activities in Type 2 Diabetes with Metabolic Syndrome (대사증후군을 동반하는 당뇨병 환자의 심혈관 위험도, 우울과 자가 관리활동 - 성별비교 -)

  • Kim, Chun-Ja
    • Korean Journal of Adult Nursing
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    • v.20 no.1
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    • pp.33-43
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    • 2008
  • Purpose: This study was to investigate the sex differences in risk of cardiovascular disease(CVD), depression and self-care activities in type 2 diabetes with metabolic syndrome. Methods: The descriptive correlational design was conducted using a convenient sample. One hundred and twenty-nine diabetic patients with metabolic syndrome were recruited in a university hospital. The data were analyzed using descriptive statistics, the Pearson correlation coefficient, Students' t-test, one way ANOVA, and stepwise multiple regression with SPSS/WIN 12.0. Results: The risk of CVD in diabetic patients with metabolic syndrome indicated a significantly negative correlation to self-care activities and age, and positive correlation to waist_C, SBP, DBP and TG. The metabolic syndrome is associated with an approximate 1.7-fold increase in the relative risk in CVD in diabetic women. The main significant predictors influencing CVD risk of diabetes with metabolic syndrome were age, waist_C, SBP and TG, which explained about 29.7%. Conclusion: These results indicate that patients with diabetes with metabolic syndrome with a high degree of waist_C, SBP and TG are likely to be high in risk of CVD.

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Study on combustion and emission characteristics of chars from low-temperature and fast pyrolysis of coals with TG-MS

  • Liu, Lei;Gong, Zhiqiang;Wang, Zhenbo;Zhang, Haoteng
    • Environmental Engineering Research
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    • v.25 no.4
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    • pp.522-528
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    • 2020
  • To achieve the clean and efficient utilization of low-rank coal, the combustion and pollutant emission characteristics of chars from low-temperature and fast pyrolysis in a horizontal tube furnace were investigated in a TG-MS analyzer. According to the results, the combustion characteristic of chars was poorer than its parent coals. The temperature range of gaseous product release had a good agreement with that of TGA weight loss. Gaseous products of samples with high content of volatile were released earlier. The NO and NO2 emissions of chars were lower than their parent coals. Coals of high rank (anthracite and sub-bituminous) released more NO and NO2 than low rank coals of lignite, so were chars from coals of different ranks. SO2 emissions of char samples were lower than parent coals and did not show obvious relationship with coal ranks.

Properties of Stretchable Electrode Pattern Printed on Urethane Film (우레탄 필름에 인쇄된 신축 가능한 전극 패턴의 특성)

  • Nam, Su-Yong;Kwon, Bo-Seok;Nam, Hyun-Jin;Nam, Ki-Woo;Park, Hyo-Zun
    • Journal of Power System Engineering
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    • v.22 no.1
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    • pp.64-71
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    • 2018
  • Currently, functional patterns are formed by screen printing on stretchable films, and they are applied to wearable and stretchable devices. In this study, three types of silver paste were prepared using three polyester binders with different Tg and molecular weights in order to impart elasticity to the conductive pattern itself. Rheological properties and DSC measurements were performed for each silver paste. Then, each silver paste was screen printing and cured by an IR dryer to evaluate adhesive strength, pencil hardness, resistance and surface shape change according to strain. As a result, it was found that the silver paste using a binder with a low Tg and a high molecular weight has the smallest resistance change depending on the strain. Namely, it was found that it is most preferable to use a binder with a low Tg and a high molecular weight as the stretchable electrode.

Hypoglycemic and Hypolipidemic Effects of Crude Saponin Fractions from Panax ginseng and Gynostemma pentaphyllum (인삼 및 틀의 초 saponin분획의 항당뇨 및 항고지혈 효과)

  • 장윤정;김중권;이명수;함인혜;김기호;김홍진
    • YAKHAK HOEJI
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    • v.45 no.5
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    • pp.545-556
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    • 2001
  • Crude saponin fractions were isolated using non-ionic resin chromatography from Ginseng Radix Alba (PG) and Gynostemmae Herba+ (GP). These saponin fractions were orally administered to strep- tozotocin (STZ)-induced diabetic rats for 2 weeks and to high-fat diet-induced obese rats for 4 weeks. Treatment with either PG saponin or GP saponin at a dose of 1 mg/kg significantly decreased the plasma glucose level to that of glibenclamide treated or normal groups. The increased plasma triglyceride (TG) level in diabetic rats was decreased by 50% with PG or GP saponin treatment. Combined administration of PG and GP saponins with different ratios (total dose of 1 mg/kg) also had the similar effects on the blood glucose and TG levels with that of PG or GP alone. Treatments with GP (1 mg/kg) or GP (0.5 mg/kg) and PG (0.5 mg/kg) together significantly suppressed the rise in TG levels induced by high-fat diet whereas slightly suppressed the rise in the total cholesterol level. The body weight gain was also decreased both in the two saponin treated groups. These results demonstrate that either alone or mixture of PG and GP have similar degree of effects on hyperglycemia and hyperlipidemia.

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Systematic Literature Review and Meta-Analysis on the Effect of Exercise Intervention Programs on Blood Lipids in Obese Adolescents in Korea according to Sex (국내 비만 청소년을 대상으로 실시한 운동 중재 프로그램의 혈중지질 효과에 대한 체계적 문헌고찰과 메타분석: 성별 차이 분석)

  • Kim, Juri;Lee, Mikyoung
    • Journal of the Korean Society of School Health
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    • v.34 no.2
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    • pp.87-97
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    • 2021
  • Purpose: The authors used a meta-analysis approach to investigate the effects of exercise on gender-specific triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) in obese adolescents. Methods: This study is a systematic review and meta-analysis study to confirm the effect of exercise intervention according to gender for obese adolescents. PICO were obese a adolescents, exercise intervention, comparative intervention (control and general group),TG and HDL-C. Results: The group of obese male adolescents showed a statistically significant decrease of 51.72 in TG (n=175, MD=-51.72; 95% CI -52.44 to -51.00).There was a statistically significant increase of 4.44 in HDL-C (n=175, MD=4.44; 95% CI 3.79 to 5.10) in the group of obese male adolescents. Conclusion: Triglyceride and high-density lipoprotein cholesterol were analyzed to determine the effect of exercise interventions in obese adolescents according to gender differences. The results of this study can be used as basic data for the design of future exercise intervention studies, subjects, exercise methods, and intervention periods.

Microstructure Characteristics of Concrete Exposed to High Temperature (고온에 노출된 콘크리트 미세조직의 특성)

  • 태순호;이병곤
    • Fire Science and Engineering
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    • v.12 no.4
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    • pp.31-40
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    • 1998
  • Very often, whether accidentally or intentionally set fire, according as building are elevated, varied or complicated day by day. It is of primary importance that we have a treatment of fire damaged structure. In general, strength and elasticity modulus of heated concrete are reduced. Product background of cement, sand and coarse aggregate differ from country to country, so that thermal behaviour of concrete make a difference in high temperature. To cope with demand, this paper is a study on relation to microstructure and strength reduction. In consequence of experiments, concrete exposed to high temperature are estimating the reduction of mechanical properties in comparison with microstructure characteristics which are abtained from the SEM/EDX, XRD and DSC-TG analysis of heated specimens under various temperature.

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Effect of Fermented Milk on the Blood Cholesterol Level of Korean (한국인에서 유산균 발효유의 섭취가 혈중 콜레스테롤에 미치는 영향)

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    • Journal of Food Hygiene and Safety
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    • v.12 no.1
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    • pp.83-95
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    • 1997
  • This study showed the effect of fermented milk on the cholesterol level of Korean. 130 persons among the teachers of elementary, middle and high schools, professors and graduate school students were divided into two groups according to their cholesterol level and provided with fermented milk 300 $m\ell$ dairly from Sep.25 to No. V3. They were given blood test at 20 days and 40 days after drinking fermented milk, and surveyed about their ordinary life style and the change of fecal condition. Cholesterol, LDL and the ratio of LDL and HDL in blood were significantly decreased in both high cholesterol group and normal group while HDL cholesterol was notably increased. TG showed slightly tendency of decrease in normal group while no changed in high group. There is no significant change in cholesterol level after drinking fermented milk among groups which are divided by factors of dringking, smoking, caffeine, B.M.I. and family history. The research also showed that drinking fermented milk improved the fecal frequency and fecal condition.

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Effects of Allium victorials Extract on Lowing Lipid, Anti-oxidation and Concentration of Inflammatory Mediators in Rats Fed High Oxidized Fat (산마늘추출물이 과산화지질급여 비만쥐의 지질강하, 항산화효과 및 염증매개물질의 생산에 미치는 영향)

  • Lee, Eun
    • Korean Journal of Plant Resources
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    • v.26 no.2
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    • pp.227-233
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    • 2013
  • This study was carried out to effects of Allium victorials extract on lowering lipid, anti-oxidation and concentration of inflammatory mediators in rats fed high oxidized fat. Concentration of free fatty acid(FFA), triglyceride(TG), total cholesterol and LDL-cholesterol in plasma decreased in the Allium victorials extract groups and plasma HDL-cholesterol concentration revealed a tendency to increase in Allium victorials extract groups. Concentration of total cholesterol and TG in liver showed a tendency to decrease in Allium victorials extract groups. Concentration of thiobarbituric acid(TBARS) in plasma and liver showed a lower values in Allium victorials extract groups than that of control group. Activities of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) in liver showed a tendency to increase in Allium victorials extract groups. Concentration of nitrogen oxide(NO), ceruloplasmin and ${\alpha}1$-acid glycoprotein in plasma showed a lower values in Allium victorials extract groups than that of control group. These results indicate that the Allium victorials extract have an functional material for lowering lipid, anti-oxidation and anti-inflammatory effect.

Diverse Fatty Acids of Triacylglyrerols in Fucus serratus(Phaeophyta) Caused by Seasonal changes (계절 변화에 따른 Fucus serratus ( 갈조식물 ) 에서의 Triacylglycerol 지방산의 다양성)

  • Kim, Mi-Kyung;Jean Paul Dubacq
    • The Korean Journal of Ecology
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    • v.19 no.1
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    • pp.21-29
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    • 1996
  • Variation in triacylglycerols(TGs) and fatty acids in Fucus serratus was analyzed for a period of one year. TGs were more concentrated during the summer(2.8mg/g dw)and autumn(2.6mg/g dw) than during the spring (0,7mg/g dw)and winter (0.5mg/g dw). The dominant fatty acides in total liqid were palmitic acid ($C_{16:0}$, 24.1%), oleic acid (($C_{18:1}$, 22.4%) and arachidonic acid (($C_{20:4}$, 14.4%) but the dominant ones in TG were $C_{16:0}$(22.8%), $C_{18:1}$(36.4%) and $C_{18:2}$(linoleic acid, 16.4%). The levels of $C_16$ fatty acids were high in winter while $C_18$ in summer and autumn. The polyunsaturated fatty acids (UFAs) were more abundant in the $C_20$ series, while the UFAs of the $C_16$ were low. Especially, the amount of arachidonic acid ($C_{20:4}$, 14.4% of total fatty acids (TFA) was more abundant than that of eicosapentaenoic acid ($C_{20:5}$, 10.4% of TFA). The amount of $C_{20:4}$ and $C_{20:5}$,in TG was 9.2% and 4.8%, respectively. These UFAs in total lipid were thus higher than TG. Therefore, the synthesis of TG and fatty acid was stimulated by the alternation of emersion and submersion of thalli from sea water and eco-physiological conditions during summer: high temperature and light, and low concentration of nitrogen.

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