• 한국임상수의학회지
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• 제23권2호
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• pp.149-152
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• 2006

The canine thyroglobulin autoantibody assay is to be used for the diagnosis of autoimmune thyroid disease in dogs. Antithyroglobulin antibodies are present in about 50 percent of hypothyroid dogs. In this report, the sera of the five canine patients ($P1{\sim}P5$) referred to the Veterinary Medical Teaching Hospital in Seoul National University were assessed by T4, TSH and thyroglobulin autoantibody (TgAA). P1 was diagnosed as severe hypothyroidism since he showed very high TSH levels with low T4 values. P2 and P3 born with a genetic predisposition were assessed as normal in thyroid function. P4 was normal, but needed follow-up examination for TgAA assay. P5 showed the positive result in TgAA assay, so it was diagnosed as autoimmune thyroiditis. As the cases above show, not only T4 and TSH, but also TgAA assay to be considered for more accurate assessment of the status of the thyroid.

• 대한본초학회지
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• 제36권6호
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• pp.39-46
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• 2021

Objectives : AMP-activated protein kinase (AMPK) is a key metabolic regulator that reduces lipogenesis. AMPK is mainly activated via phosphorylation of liver kinase B (LKB) 1 under energy stress. Here, we highlighted the anti-obesity effect and underlying mechanism of Coix lacryma-jobi var. mayuen Stapf sprout water extract (CSW) sprout extract in connection with the LKB1/AMPK signaling pathway. Methods : C57BL/6 mice (20~25 g) fed HFD to induce obesity and at the same time administered CSW 100 mg/kg (CSWL; (CSWL; CSW low concentration) or CSW 200 mg/kg (CSWH; CSW high concentration) or Garcinia extract (Garcinia) 200 mg/kg orally for 6 weeks. Body weight and food intake were measured at the same time each day. After 6 weeks of CSW administration, liver tissue and serum were obtained through an autopsy. After the end of the experiment, biochemical analysis (triglycerides (TG), total cholesterol (TC), HDL-cholesterol, and LDL-cholesterol) was performed on the serum. And then, protein levels related to TG and TC synthesis were measured through western blot analysis in liver tissue. Results : As a result, serum TG, TC, and LDL-cholesterol levels were significantly increased in the control group and significantly decreased in the CSW administration group. On the other hand, the HDL-cholesterol level was increased in the CSW-administered group. And as a result of Western blot analysis, CSW significantly increased the phosphorylation of LKB1 & AMPK, and remarkably decreased the expression of factors related to TG and TC synthesis. Conclusions : Our findings suggest that CSW influences the TG and TC synthesis to positively affect HFD-induced obesity in C57BL/6 mice.

• 운동영양학회지
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• 제14권2호
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• pp.63-68
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• 2010

This study evaluated the effects of high pressured red ginseng(HRG) and ginseng berry(GB) supplementation on lipid profiles and run to exercise time in SD rats. Five weeks-old male rats were randomly assigned into six groups, ie. control group(AC: n = 8), exercise group(AE: n = 7), general extracted red ginseng group(C: n = 8), HRG group(high density D: n = 8, low density E: n = 7), and HRG + GB group(F: n = 7). The AC and AE groups had a supplementation of AIN-93G, and AE group performed 40 min treadmill exercise five times per week for five weeks. E, C, D, and F groups had a supplementation composed of general extracted red ginseng(GRG), HRG(250 mpk and 500 mpk), and HRG(250 mpk) + GB(167 mpk) in the AIN-93G. Main results of the study were as follow 1) the duration of running time to exhaustion was higher in exercise group compared to other groups. HRG had no effect on run to exhaustion time, but, GRG and HRG + GB showed longer run time than control groups. 2) Blood TC, TG, HDL-C and liver TG showed no difference between groups, but, liver TC showed lower level in the HRG groups than other groups. It was concluded that the 5 weeks of supplementation of HRG extract would have positive effects on liver cholesterol, and GRG and HRG + GB have a positive effect on exercise performance tested run to exhaustion time, but, we can not find a positive effect of supplementation of HRG on exercise performance.

• 한국임상약학회지
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• 제3권2호
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• pp.157-162
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• 1993

The present study was designed to examine the effect of tested preparation, WY-91 (consisting of ginseng extract, ganoderma extract and Royal jelly) on alcohol-induced unusual metabolism(such as blood glucose(BG), triBlyceride(TG), and blood urea nitrogen(BUN) level in blood) and nrperinlental liver injury($CCl_4$ and high fat diet) in mice. WY-91 lowered the level of blood glucose (BG),triglyceride(TG) and blood urea nitrogen(BUN) induced by alcohol in a dose-dependent manner. This preparation could protect hepatic function from a damages caused by high fat diet and $CCl_4$ administration(p.o.).

• 생약학회지
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• 제40권3호
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• pp.244-250
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• 2009

Anti-hyperlipidemic effect of Sophorae Fructus in male Spague-Dawley rats induced by high-rich diet were studied. Oral administration of Sophorae Fructus extract significantly decreased serum total cholesterol (TC), LDL-cholesterol, triglyceride (TG), GOT and GPT levels, and incresed serum HDL-cholesterol level and also decreased the level of liver TC, TG, GOT and GPT. These results suggest that Sophorae Fructus extract is effective for the hyperlipidemia.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2017년도 춘계 학술논문 발표대회
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• pp.160-161
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• 2017

In In this study, we measured the relative density and the compressive strength in order to select the appropriate W/B for the ultra-high strength concrete development. If W/B is lowered than the W/B of highest relative density, it was confirmed that the strength is lowered. However, if water is increased than the W/B, the relative density is decreased compressive strength was similar. The selection of the W/B of the lower than the highest relative density is not appropriate. Appropriate W/B is selected to be more than the maximum relative density of W/B. This was confirmed for TG-DTA.

• 한국식생활문화학회지
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• 제16권5호
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• pp.416-422
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• 2001

This study was conducted to investigate the effects of corn peptide(CP) on lipid metabolism. Sprague-Dawley(S.D) male rats were assigned to three dietary groups {control diet(CD), high fat diet (HFD) & high fat com peptide diet(FCD)} and fed 4 weeks to examine the effects of CP. There were no significantly different in cholesterol concentrations in the liver among the groups. However, triglyceride(TG) concentrations of the FCD & CD significantly lower than the HFD. Fecal excretion of neutral steroids & bile acids of the FCD significantly higher than the CD & HFD. Serum total cholesterol TG & LDL-cholesterol concentrations of the FCD & CD significantly lower than the HFD. These results suggest the improvement of lipid composition in serum by CP might be inhibit of lipid absorption in intestine & increment of neutral steroids & bile acids excretion in feces.

• Journal of electromagnetic engineering and science
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• 제18권1호
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• pp.20-28
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• 2018

The time synchronization of each sub-unit of a pulsed generator is important to generate an output high-power radio frequency (RF) signal. To obtain the time synchronization between an input RF signal fed by an external source and an electron beam produced by an electric pulse generator, the influence of different charging voltages on a delay and a rise time of the output pulse waveform in the electric pulse generator should be carefully considered. This paper aims to study the timing characteristics of the delay and the rise time as a function of different charging voltages with a peak value of less than -35 kV in the high-voltage pulse generator, including a trigger generator (TG) and a pulse-forming line (PFL). The simulation has been carried out to estimate characteristics in the time domain, in addition to their output high-voltage amplitude. Experimental results compared with those obtained by simulation indicate that the delay of the output pulses of the TG and PFL, which are made by controlling the external triggering signal with respect to different charging voltages, is getting longer as the charging voltage is increasing, and their rise times are inversely proportional to the amplitude of the charging voltage.

• Journal of Korean Biological Nursing Science
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• 제19권2호
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• pp.107-112
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• 2017

Purpose: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. Methods: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. Results: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. Conclusion: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.

• 한국식품위생안전성학회지
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• 제29권4호
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• pp.370-375
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• 2014

Cladosiphon okamuranus is edible brown algae cultured commercially and massively at Okinawa coast. Dietary fiber occupying most of C. okamuranus isn't digested and absorbed by digestive enzymes of human. But it is known to prevent and treat constipation as metabolic disease. This study was to investigate the effects of dietary fiber extracted from C. okamuranus on the damage of liver and the blood cholesterol level in the high fat diet-fed rats. The effects were measured by the levels of aspartate aminotransferase (ALT), alanine aminotransferase (AST), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) in sera. The levels of ALT, AST, TC, TG and LDL were significantly reduced in the C. okamuranus-treated group compared with the high fat diet group. But HDL level was markedly increased. The results showed that the dietary fiber extracts from C. okamuranus have the inhibitive effects of cholesterol biosynthesis in the high fat diet-fed rats.