• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.1
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• pp.54-63
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• 2010

Baicalin, a flavonoid, was shown to have diverse effects such as anti-inflammatory, anti-cancer, anti-viral, anti-bacterial and others. Recently, we found that the baicalin inhibits adipogenesis through the modulations of anti-adipogenic and pro-adipogenic factors of the adipogenesis pathway. In the present study, we further characterized the molecular mechanism of the anti-adipogenic effect of baicalin using microarray technology. Microarray analyses were conducted to analyze the gene expression profiles during the differentiation time course (0 day, 2 day, 4 day and 7 day) in 3T3-L1 cells with or without baicalin treatment. We identified a total of 3972 genes of which expressions were changed more than 2 fold. These 3972 genes were further analyzed using hierarchical clustering analysis, resulting in 20 clusters. Four clusters among 20 showed clearly up-regulated expression patterns (cluster 8 and cluster 10) or clearly down-regulated expression patterns (cluster 12 and cluster 14) by baicalin treatment for over-all differentiation period. The cluster 8 and cluster 10 included many genes which enhance cell proliferation or inhibit adipogenesis. On the other hand, the cluster 12 and cluster 14 included many genes which are related with proliferation inhibition, cell cycle arrest, cell growth suppression or adipogenesis induction. In conclusion, these data provide detailed information on the molecular mechanism of baicalin-induced inhibition of adipogenesis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1291-1300
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• 2004

Baicalin, a biologically active flavonoid form the roots of Scutallaria baicalensis (Skullcap), have been reported to not only function as anti-oxidants but also cause anticancer effect. We investigated the mechanism of baicalin-induced cytotoxicity and the macro scale gene expression analysis in leukemia cell line, HL-60 cells. Baicalin (10 μM) were used to treat the cells for 6h, 12h, 24h, 48h and 72h. In a human cDNAchip study of 65,000 genes evaluated 6, 12, 24, 48. 72 hours after treated with Baicalin in HL-60 cells. Hierarchical cluster against the genes which showed expression changes by more than two fold. One hundred one genes were grouped into 6 clusters according to their profile of expression by a hierarchical clustering algorithm. For genes differentially expressed in response to baicalin treatment, we tested functional classes based on Gene Ontology (GO) terms. This study provides the most comprehensive available survey of gene expression changes in response to baicalin treatment in HL-60 cell line.

• Journal of Korean Society for Atmospheric Environment
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• v.30 no.5
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• pp.504-509
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• 2014

Twenty-five stations of the urban monitoring network in Seoul were assessed with a focus on surveillance function of the exceedances of 8-hour ozone and 24-hour $PM_{10}$ standards. The two standards were selected because their attainment rates were particularly low. Two hierarchical cluster analyses were performed to group stations with similar atmospheric environments-one using daily highest 8-hour [$O_3+NO_2$], 8-hour $O_3$ concentrations plus corresponding 8-hour $NO_2$ concentrations considering the interconversion of $O_3$ and $NO_2$, and the other using 24-hour $PM_{10}$ concentrations. An index to measure higher concentration and exceedances of the standards was introduced. Within a cluster, sufficiently high score was assigned to the trends station or the station with higher index. Scores for $O_3+NO_2$ and $PM_{10}$ of a given station were added and ranked in the descending order to determine the relative importance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.3B
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• pp.123-134
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• 2008

In this paper, a routing algorithm for wireless sensor networks is proposed to improve the efficiency of energy consumption in sensor nodes. Each sensor node has the value called ‘Flooding Level’ obtained through the initial flooding from a sink node instead of sending beacon messages in multi-hop sensor field. This value can be used for guaranteeing the sensor nodes to connect with a sink node and determining the roles of cluster-head and cluster-gateway node efficiently and simply during the clustering. If different algorithms are added to our protocol, it will work better in the side of energyefficiency. This algorithm is evaluated through analysis and extensive simulations.

• Journal of Korean Society for Atmospheric Environment
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• v.9 no.3
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• pp.207-215
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• 1993

In order to statistically predict $O_3$ levels in Seoul, the study used the TMS (telemeted air monitoring system) data from the Department of Environment, which have monitored at 20 sites in 1989 and 1990. Each data in each site was characterized by 6 major criteria pollutants ($SO_2, TSP, CO, NO_2, THC, and O_3$) and 2 meteorological parameters, such as wind speed and wind direction. To select proper variables and to determine each pollutant's behavior, univariate statistical analyses were extensively studied in the beginning, and then various applied statistical techniques like cluster analysis, regression analysis, and expert system have been intensively examined. For the initial study of high level $O_3$ prediction, the raw data set in each site was separated into 2 group based on 60 ppb $O_3$ level. A hierarchical cluster analysis was applied to classify the group based on 60 ppb $O_3$ into small calsses. Each class in each site has its own pattern. Next, multiple regression for each class was repeatedly applied to determine an $O_3$ prediction submodel and to determine outliers in each class based on a certain level of standardized redisual. Thus, a prediction submodel for each homogeneous class could be obtained. The study was extended to model $O_3$ prediction for both on-time basis and 1-hr after basis. Finally, an expect system was used to build a unified classification rule based on examples of the homogenous classes for all of sites. Thus, a concept of high level $O_3$ prediction model was developed for one of $O_3$ alert systems.

• Journal of Korea Trade
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• v.23 no.4
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• pp.103-114
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• 2019

Purpose - This paper investigates the structure of exports across countries in terms of value added. Exports value added is examined under two categories, domestic and overseas. Using a statistical classification method by distance based on these two value added categories, this paper estimates the similarity of exports value added across countries including Korea. Design/methodology - The model of study is to employ a generalized distance function and then derive the Manhattan and Euclidean distances. The paper also performs cluster analysis using the Partitioning Around Medoids (PAM) and hierarchical methods to classify the 44 sample countries considered in this study. Findings - Our main findings are as follows. The 44 countries can be classified under 5 groups by their domestic and overseas value added in exports. Korea has a sandwich global value chains (GVCs) position between Japan, China, and Taiwan in the East Asian region. Originality/value - Existing papers point out the double counting problem of trade statistics as the intermediate goods trade across borders increases. This paper addresses the double counting problem by using the World Input-Output Table. The paper shows the need to explore the similarity of value added in exports structure across countries and investigate the GVCs position and role of each country.

• Culinary science and hospitality research
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• v.18 no.4
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• pp.47-58
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• 2012

This study, targeting the students of "K" university in Busan City area, was performed to draw the groups by food-related lifestyle types and to identify the correlation between each group's attributes of selecting places to eat out and obesity index. The purpose of the study was achieved by means of the PASW Statistic 18.0(Predictive Analytics Software) which conducted frequency analysis, factor analysis, reliability analysis, t-test, ${\chi}^2$-test, non-hierarchical cluster analysis and ANOVA. It turned out that the male university students were 175.59 cm tall and weigh 69.53 kg on average. And the female university students showed their average height of 162.81 cm and weight of 53.42 kg. When examined by the body mass index(BMI), male students were composed of 1.7% of underweight, 64.6% of normal weight, 19.7% of overweight and 14.0% of obese. As for the female students, 22.9% were classified as underweight, 62.7% as normal weight, 8.5% as overweight and 5.9% as obese. The food-related lifestyle categories were divided into five factors; health seeking type, safety seeking type, mood seeking type, taste seeking type, and western food seeking type. The four attributes of selecting places to eat out included quality of food and service, price reasonableness, accessibility and atmosphere, and experience to have eaten. With regard to food-related lifestyle, the groups were named by cluster 1 [careless diet group], Cluster 2 [health oriented group], and cluster3 [careless healthcare group]. In terms of the correlation between the clusters by food-related lifestyle and their attributes of selecting places to eat out, Cluster 1 had a high mean value in experience to have eaten, Cluster 2 quality of food and service, Cluster 3 accessibility and atmosphere.

• Journal of Korean Society for Geospatial Information Science
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• v.19 no.4
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• pp.139-144
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• 2011

This study proposed a classification method of LIDAR data by using simultaneously the color information (R, G, B) and reflection intensity information (I) obtained from terrestrial LIDAR and by analyzing the association between these data through the use of statistical classification methods. To this end, first, the factors that maximize variance were calculated using the variables, R, G, B, and I, whereby the factor matrix between the principal factor and each variable was calculated. However, although the factor matrix shows basic data by reducing them, it is difficult to know clearly which variables become highly associated by which factors; therefore, Varimax method from orthogonal rotation was used to obtain the factor matrix and then the factor scores were calculated. And, by using a non-hierarchical clustering method, K-mean method, a cluster analysis was performed on the factor scores obtained via K-mean method as factor analysis, and afterwards the classification accuracy of the terrestrial LiDAR data was evaluated.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.10a
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• pp.733-736
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• 2013

The sensor network technology for core technology of ubiquitous computing is in the spotlight recently, the research on sensor network is proceeding actively which is composed many different sensor node. The major traffic patterns of plenty of sensor networks are composed of collecting types of single directional data, which is transmitting packets from several sensor nodes to sink node. One of the important condition for design of sensor node is to extend for network life which is to minimize power-consumption under the limited resources of sensor network. In this paper analysis used routing protocols using the network simulation that was used second level cluster structure to reduce delay and power-consumption of sensor node.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.7
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• pp.1721-1726
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• 2014

The sensor network technology for core technology of ubiquitous computing is in the spotlight recently, the research on sensor network is proceeding actively which is composed many different sensor node. The major traffic patterns of plenty of sensor networks are composed of collecting types of single directional data, which is transmitting packets from several sensor nodes to sink node. One of the important condition for design of sensor node is to extend for network life which is to minimize power-consumption under the limited resources of sensor network. In this paper analysis used routing protocols using the network simulation that was used second level cluster structure to reduce delay and power-consumption of sensor node.