• The Journal of Korean Medicine
• /
• v.36 no.1
• /
• pp.61-74
• /
• 2015

Objectives: The main purpose of this study is to find a solution for modernized classification of herbal medicinal preparations in dual medical systems. Through this study, we expect to provide a reasonable foundation of herbal medicine for public health. Methods: We studied legal or technical terms of herbal medicinal preparations from the past regulations, and through this procedure, we could suggest clear definitions of terms for herbal medicinal preparations. We also investigated documents for approval of herbal medicinal preparation from US, EU(European union), The People's Republic of China, Japan, so that we can refer to them to revise regulation for appropriate use of herbal preparations. Results: In Korea pharmaceutical affairs act, any basis of 'Crude drugs' does not exist. But in some subordinary notifications, the way that they use the 'Natural product medicine' is used as a means of limiting basic rights of doctor or pharmacist of Korean medicine compared to doctor or pharmacist. At the same time, in subordinary notifications, provisions are vague and not enough for scientific evidence of Korean medicine. Thus, we re-categorized herbal medicinal preparations into new drugs, drugs made from herbal medicinal preparations and suggested requirements for drug approval. Conclusions: Instead of using the term 'Crude drug preparations', and we should use term 'Herbal medicinal preparations' in related act and notification. And also we suggest to amend subordinary regulations and documents for approval of herbal medicinal preparations. Through this, we can make herbal medicinal preparations be more industrialized.

• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.315-316
• /
• 2012

• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.207-208
• /
• 2012

• 대한한약학회:학술대회논문집
• /
• 2007.11a
• /
• pp.183-184
• /
• 2007

• The Journal of Korean Medicine
• /
• v.40 no.2
• /
• pp.94-105
• /
• 2019

Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel. Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.

• Herbal Formula Science
• /
• v.21 no.2
• /
• pp.29-43
• /
• 2013

Objectives : The aim of this study is reviewing the past legal definition and regulations, to provide basis for the future desirable direction of Korean herbal pharmaceutical industry and national herbal drug policies. Methods : We reviewed how concept of herbal medicinal preparation has been utilized and changed along with various national laws and regulations. And this study also reviewed problems related herbal medicinal preparation policies. Results : Since 1990s, especially inauguration of Korea Food & Drug Administration (KFDA) at 1998, the concept of crude drug preparation has constantly expanded and distorted the scope of herbal medicinal preparations. This resulted in decline of herbal medicinal preparation industry. Conclusions : It means policies related herbal medicinal preparation which was driven steadily during this decade have lost their consistency. Also, it restricted the various medical options which can guarantee people's health rights.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.5
• /
• pp.1541-1542
• /
• 2013

• 한국약용작물학회:학술대회논문집
• /
• 2012.05a
• /
• pp.273-274
• /
• 2012

• The Journal of Korean Medical History
• /
• v.27 no.2
• /
• pp.11-37
• /
• 2014

Objectives : The purpose of this study was to analyze and identify the problems of the changes in regulations that are relevant to approval, notification, and review of herbal medicinal preparations and crude drug preparations. Methods : I collected the regulations of approval, notification, and review of medicinal products mostly from official gazettes, analyzed enactment and amendments regarding herbal medicinal preparations and crude drug preparations, and studied it from the view point of Korean medicine field. Results : Regulations in regards to approval, notification, and review of herbal medicinal preparations and crude drug preparations were first established in 1978. Herbal drugs started to be categorized as crude drug preparations in 1981 and the regulatory outlines were completed in 1999. From 2008 to 2012, the regulatory standards that let crude drug preparations be new drugs from natural products were established. Through those procedures, the followings became crude drug preparations: 1) wholly new prescriptions that are not recorded in Korean Medical Classics, 2) prescriptions that are recorded in Korean Medical classics but prepared with new standard, composition and efficacy, 3) prescriptions that are recorded in Korean Medical classics but prepared with new formulation, and 4) herbal drugs. In case of herbal medicinal preparations, however, only regulations that are related to 1) drugs prepared with new compositions that are not recorded in Korean Medical Classics, 2) drugs with same prescription and same formulation, and 3) drugs with new formulation were arranged. Conclusions : Actual circumstances on crude drug-oriented regulations regarding approval, notification and review and future forms of prescription and drug administration in Korean Medical Institutions can be expected due to expansion in range of herbal medicinal preparations and shrink in that of on-site preparations. Reasonable improvement in efficient usage of modernized herbal medicinal preparations in Korean medical institutions and prospective cooperation from related pharmaceutical industry are needed.

• Journal of Information Processing Systems
• /
• v.13 no.5
• /
• pp.1103-1125
• /
• 2017

This paper aims to extract an ObjectProperty-UsageMethod relation, in particular the HerbalMedicinalProperty-UsageMethod relation of the herb-plant object, as a semantic relation between two related sets, a herbal-medicinal-property concept set and a usage-method concept set from several web documents. This HerbalMedicinalProperty-UsageMethod relation benefits people by providing an alternative treatment/solution knowledge to health problems. The research includes three main problems: how to determine EDU (where EDU is an elementary discourse unit or a simple sentence/clause) with a medicinal-property/usage-method concept; how to determine the usage-method boundary; and how to determine the HerbalMedicinalProperty-UsageMethod relation between the two related sets. We propose using N-Word-Co on the verb phrase with the medicinal-property/usage-method concept to solve the first and second problems where the N-Word-Co size is determined by the learning of maximum entropy, support vector machine, and naïve Bayes. We also apply naïve Bayes to solve the third problem of determining the HerbalMedicinalProperty-UsageMethod relation with N-Word-Co elements as features. The research results can provide high precision in the HerbalMedicinalProperty-UsageMethod relation extraction.