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http://dx.doi.org/10.13048/jkm.19020

Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell  

Choi, Susanna (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kwon, Oh-Bin (New Drug Development Center, Daegu Gyeonbuk Medical Innovation Foundation)
Lee, SION (New Drug Development Center, Daegu Gyeonbuk Medical Innovation Foundation)
Seo, Chang-Seob (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Shin, Hyeun-Kyoo (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
The Journal of Korean Medicine / v.40, no.2, 2019 , pp. 94-105 More about this Journal
Abstract
Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel. Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.
Keywords
Medicinal herbal formulas; Korea traditional medicine; cardiac safety; cardiotoxicity; hERG potassium channel;
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Times Cited By KSCI : 3  (Citation Analysis)
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