• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.543-548
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• 2000

After Vanherweghem J-L reported the rapidly progressive interstitial renal fibrosis that developed in patients taking the slimming preparation compounded with chinese Herb in Belgium 1993. Chinese Herb Nephropathy(CHN) has become known as a new renal disease, CHN is described as the decrease of urinary renal enzyme, neutral endopeptidase(NEP). N-acetyl-${\beta}$-Dglucosaminidase(NAG). increase of urinary low molecular protein, ${\alpha}$1-microglobulin, ${\beta}$2-microglobulin. clara cell protein(CC16), retinol-binding protein(RBP) in clinical findings, and the proximal tubular atrophy, interstitial fibrosis. urothelial atrophy. glomerular sclerosis in histology, Because CHN was caused by Chinese herb contained in slimming preparation, western medical doctors have thought that all Herb medicine might have caused renal disease and prohibit the taking of any Herb medicine, However. CHN was actually caused by the aristolochic acid contained in some Herb medicines. Aristolochia manshuriensis, Aristolochia fang chi, which is the substitutions of Akebia quinata, Stephania tetrandra has being used in clinical. Aristolochia manshuriensis. Aristolochia fang chi were different with Akebia quinata. Stephania tetrandra in botany, and it have not been classified with medicines in Oriental medicine, That is, the aristolochic acid, not Herb medicines. causes CHN, So, Chinese Herb Nephropathy should be changed to Aristolochic acid Nephropathy.

• Food Science and Preservation
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• v.13 no.2
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• pp.241-245
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• 2006

The biofunctional properties of traditional Doenjang supplemented with the extract of herb medicines (refer as DHM) were examined DHM divided to four groups, I, II, III and IV according to herb medicines were added. Nitrite scavenging-activities from all 4 groups of DHMs were significantly higher than that of control. Also hydrogen donating-activities from all 4 groups of DHMs were slightly higher than that of control. Antibacterial activities against pathogenic bacteria such as Streptococcus mutant and Salmonella enteritidis and fibrinolytic activity of all DHMs on fibrin plate were higher than those of control. On the other those of groups III and IV were higher in sensory score, biofunctional and antimicrobial activities than those of group I, II and control. Therefore, the usage of extract of Korean herb medicines instead of water to make Doenjang will effective in development of traditional soybean Doenjang with the biofunctional properties.

• Food Science and Preservation
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• v.9 no.2
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• pp.168-173
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• 2002

Growth characteristics and crude protein content of soybean sprouts cultivated with extracts of some Korean herb medicines for 4 days were investigated. Extracts of Korean herb medicines were utilized and adjusted to 100 ppm, 200 ppm, 300 ppm and 400 ppm as culturing water of soybean sprouts. Of Korean herb medicines tested, extract of Panax ginseng was most effective to increase of weight and length of soybean sprouts, followed by Glycyrrhiza glabra. Extracts of Angelica gigas and Cnidium officinale were similar with that of control group. Extract of Coptidis japonica inhibited the growth of soybean sprout. Optimal concentrations of extracts of Glycyrrhiza glabra and Panax ginseng for growth of soybean sprout were 100 ppm and 200 ppm, respectively. Weight of soybean sprout cultivated with extract of Panax ginseng (PGE) was increased to 7.2%(wet basis) as compared with that of control group. Length of soybean sprouts cultivated with 200 ppm of PGE was accelerated to 32% and increased to 50% in soybean sprout cultivated for 3 days. Crude protein contents of soybean sprout cultivated with extract of Angelica gigas or Panax ginseng was slightly increased according to cultivation period. In Cnidium officinale group, crude protein contents was increased at a 300∼400 ppm concentration and 4 days of cultivation.

• The Journal of Internal Korean Medicine
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• v.21 no.2
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• pp.291-297
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• 2000

Objective : In order to find antiviral compounds against Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect(CPE) inhibition assay was introduced. Methods : Fourteen purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Results : Cytotoxic concentration (CC) of the $H_2O$ extracts of Hyongbangpaedoksan against HSV-1 and HSV-2 was 181.12. This is high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of herbal medicine play a major role in improvement of antiviral activity at the first infective cell. But antiviral effect was unable to figure out for selective index(Sl)=CC50/EC50. The other herbal medicines were unable to showed potent anti-HSV activity. Conclusions : The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

• Korean Journal of Medicinal Crop Science
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• v.12 no.1
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• pp.53-59
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• 2004

Finding a means to discriminate the commercial herb medicines when they were dried and sliced is a very important and imminent project in Korea. To differentiate plant origins and the commercial herb medicines of Atractylodes japonica and A. macrocephala, two discriminative methods using anatomical characteristics and SCAR marker were applied. It was possible to discriminate plant origins and the commercial herb medicines between A. japonica and A. macrocephala by anatomical characteristics: development of periderm, layer of stone cell, distribution of laticiferous vessels, development of xylem fiber in xylem ray, contained quantity of clustered crystals and others. While, two SCAR markers were developed from RAPD clones: SAjR2 (600 bp) from AjR2 and SAmR1 (1,200 bp) from AmR1. These two markers were enough for discrimination plant origins and the commercial herb medicines between A. japonica and A. macrocephala. The result of application of anatomical characteristics and SCAR markers to investigate current status in domestic herb market, Daegu and Kumsan herb market, it was identified to be current herb medicines of A japonica.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.3
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• pp.34-55
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• 2012

Objective : The purpose of this study is to survey the experimental studies for Herbal Medicines of Anti-allergic Effects by reviewing oriental medicine journals. Methods : We collected 48 research papers on Oriental herbal medicines (prescriptions, herbs and aqua-acupunctures) of Anti-allergic effects in the internet site OASIS using the keyword 'Antiallergy'. Then we analyzed them according to published journals, years, and research methods, etc. Results : 48 papers in relation to Oriental herbal medicines of anti-allergic effects have been published in many kinds of journals and shows a tendency to increase every year. There are 23 cases of using herb simplexes, 21 cases of herb-combined prescription, and 4 cases of aqua-acupuncture. Conclusions : This result will provide useful information of field of Oriental herbal medicine for the development of anti-allergic related herb simplexes and herb combined prescriptions. In the future, we have to perform more studies such as clinical trial and research papers on combined medication of the oriental and the western medicines for anti-allergic effects.

• Korean Journal of Medicinal Crop Science
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• v.18 no.5
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• pp.338-344
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• 2010

Our paper shows the results of 302 samples of herb medicines about fungal contamination at Yakyeang markets in Seoul. The sample medicines were treated VICAM pretreatment and analysed by post column derivatisation procedure(PHRED-HPLC) with a fluorescence detector. Aflatoxin B1 was founded from 50.3% of samples, aflatoxin B2 was 39.7%, aflatoxin G1 was 21.2% and aflatoxin G2 was 23.5%. The detected ranges of aflatoxin B1, B2, G1 and G2 were from 0.1 to $57.2\;{\mu}g/kg$, 0.1 to $42.6\;{\mu}g/kg$, 0.1 to $23.5\;{\mu}g/kg$ and 0.1 to $9.5\;{\mu}g/kg$ respectively. Among total samples, 26 samples contained aflatoxin B1 violated the regulation (less than 10 ug/kg) for aflatoxin B1 of KFDA. From the result, we could presumed that more than a half of samples were contaminated by aflatoxins. Therefore, it seems to be necessary that the new safety giudeline will be established aflatoxin B2, G1 and G2 from herb medicines as aflatoxin B1.

• Journal of Aquaculture
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• v.22 no.1
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• pp.112-117
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• 2009

This study were conducted to investigate the effects of several additives in experimental diets on the growth, feed utilization and body composition of juvenile and grower rockfish. Three replicates of juveniles (3.6 g/fish) and two replicates growers (166 g/fish) were fed the experimental diets containing herb medicines mixture, Artemisia asiatica and Epimedium koreanum for 8 weeks. Dietary supplementation with herb medicines mixture had no beneficial effects on growth and feed utilization of juvenile fish. Weight gain, daily feed intake, condition factor and hepatosomatic index of grower fish fed the diet were not affected by dietary additive (P>0.05). Peed efficiency and protein efficiency ratio of grower fish fed the diet containing herb medicines mixture were significantly higher than those of fish fed the control diet (P<0.05), but not significantly different from fish fed the diet containing A. asiatica and E. koreanum (P>0.05). Proximate analysis of whole body, muscle, viscera and liver in the juvenile and grower were not affected by dietary additives (P>0.05). The results of this study suggest that feed efficiency and protein efficiency ratio of grower rockfish may improved by herb medicines mixture supplementation in the diet.

• Korean Journal of Plant Resources
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• v.3 no.2
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• pp.107-114
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• 1990

In view of the results to have measured metallic elements which is included in 45 sorts of herb medicines and surveyed their distribution, 8 kinds ofmetals including Co, Ge, Ga, TL, Cd, As, 8i, Pb, are never or little includedin almost herb medicines . Other twenty-five sorts of elements (Mo, Sc, Be, V,Ni, Sn, Se, Ba, Cr, Sb, Si, Ti, B, Li, Mg, Ca, Cr, Mn, Fe, Cu, Zn, p, Al, Na,K) are more or Less included in all herb Bedicines ana Na, Ca, p and K aremetals that are included in Large quentities in comrarison with others . Patri-uiae Radix Contains 7 kinds of metal lic elements more than other herb medicinesdoes .

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2008.05a
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• pp.423-425
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• 2008

In this paper, We have designed and manufactured a photochemical reaction lamp type ozonizer system which was applied to keep quality of herb medicines during storage. We used photochemical reaction lamp in a storage system, and investigated the sterilization characteristic. Also, we made research an ingredient and quality characteristic of herb medicines according to ozone storage.