• Biomolecules & Therapeutics
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• 제6권2호
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• pp.119-129
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• 1998

The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was inves-tigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 mg/kg b.wt. in $CCl_4$-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 mg/kg b.wt. in $CCl_4$-induced chronic liver disease, 30 mg/tg b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.

• 대한의생명과학회지
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• 제10권1호
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• pp.35-42
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• 2004

Liver and serum $\beta$-D-mannosidase activities were determined in ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD) to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. Liver $\beta$-D-mannosidase activity and its Vmax value in CBD ligated rats with chronic ethanol intoxication were found to be significantly decreased than that in CBD ligation alone. However, the difference of Km value on above hepatic enzyme was not found between the experimental groups. On the other hand, serum $\beta$-D-mannosidase activity in CBD ligated rats with chronic ethanol intoxication was increased more than that in CBD ligation alone. These results indicate that the biosynthesis of the hepatic $\beta$-D-mannosidase decreases and the serum $\beta$-D-mannosidase activity increases in cholestasis combined with chronic ehtanol intoxication, reflecting damage of aggravated hapatocytic membrane. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.

• 대한한의학방제학회지
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• 제12권2호
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• pp.109-117
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• 2004

This study was carried out to investigate the liver protective effects of extracts from Persicae Semen (WT-003, WT-005, WT-006). The acute hepatic injury was induced by intraperitoneal injection of alpha-naphtylisothiocyanate (75 mg/kg, p.o.) and treated with WT-006 (100 mg/kg/day, 200 mg/kg/day, 400 mg/kg/day). The experimental hepatic fibrosis was induced by bile duct ligation／scission(BDL/S), duration of 4 weeks and treated with WT-003, WT-005 or WT-006 (200 mg/kg/days for 4 week). In acute liver injury, WT-006 (200 or 400 mg/kg) lowered serum alanine transferase(ALT) and aspartate transferase(AST) significantly. In fibrotic rats, WT-006 treatment inhibited the hydroxyproline deposition in liver and lowered serum AST, ALT and ALP, significantly. These results suggest WT-006 extract, which does not contain amygdalin, from Persicae Semen have liver protective and antifibrotic effects in rats.

• 한국동물위생학회지
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• 제38권4호
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• pp.227-232
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• 2015

This study was conducted to investigate the prevalence of fascioliasis in slaughtered cattle in Kangwon (Wonju, Hoengseong, Hongcheon, Cheorwon, Pyeongchang) province and Daejeon from October to December in 2014. From the total 10,780 examined cattle, 0.54% (58/10,780) were found to be positive for fascioliasis by postmortem macroscopic inspection. The Fasciola spp. infection rates were higher in the most Daejeon (1.83%, 41/2,240), followed by Hoengseong (0.40%, 15/3,714) and Hongcheon (0.22%, 2/901). It was not infected in the other regions. The outward appearances of Fasciola spp. infected livers looked almost normal and the worms were all parasitize in the main hepatic duct.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권2호
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• pp.121-124
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• 2014

Omega (${\omega}$)-3 polyunsaturated fatty acids appear to be effective in preventing and treating parenteral nutrition-associated liver disease, and several mechanisms were proposed for this observation. An 8-week-old male infant with cholestasis and acholic stool was diagnosed non-syndromic intrahepatic interlobular bile duct paucity by open-wedge liver biopsy. Initially he was treated with usual supportive medical therapy, including ursodeoxycholic acid. However, the clinical status and laboratory tests did not improve. Omega (${\omega}$)-3 polyunsaturated fatty acids (initially intravenous administration and oral administration later), were started and his liver function, including aminotransferase level and bilirubin levels normalized, and the ivory stool color turned green. We report the possible effectiveness of ${\omega}$-3 polyunsaturated fatty acids as a potent choleretic agent for non-syndromic intrahepatic interlobular bile duct paucity, a very rare structural pediatric hepatic disease.

• 대한방사선기술학회지:방사선기술과학
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• 제31권2호
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• pp.149-159
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• 2008

목 적: 지금까지의 경복부 초음파를 이용한 간외담관에 대한 검사는 주로 담낭과 간외 담도, 즉 총수담관(CBD)만을 확인하는 수준의 검사가 전부인 것처럼 여겨져 왔다. 그러나 저자들은 임상에서의 다양한 경험을 바탕으로 간외담도의 비정상 확장에 대해 분석할 수 있고, 담도질환 유무 및 관련성을 평가하는데 필요한 기술적 접근 방법에 대한 새로운 이론적 토대를 마련하였다. 이 새로운 이론을 기본으로 신뢰성 있는 검사 성적을 얻기 위하여 일정기간 교육 후 scanning 훈련을 시켜 그 효과를 평가함으로서 담관질환 검사의 새로운 기준을 정립코자 한다. 대상 및 방법: 초음파 교육생 30명을 대상으로 간외담관에 대한 새로운 이론에 근거하여 기술적 접근 방법에 대한 교육을 전수한 후 학생 1인당 3시간(30분${\times}$6회)을 배당하여 scanning 훈련을 집중였다. 교육 방법은 강사와 학생 1:1 방식으로 하였다. Scanning 훈련 후 평가 기준으로 모든 학생에게 5분 내에 간외담관 중에서 좌우 담관으로부터 (1) 담낭관 합류부(간외담관 및 담낭관), (2) 췌장 상부담관, (3) 췌두부내 담관, (4) 유두부내 공통관 등 네 분절을 명확하게 구분된 개념으로 scan하게 한 후 정확도를 평가하였다. 결 과: 기존의 교육과 훈련 방식은 간외담관에 대한 경복부 초음파검사의 신뢰도가 매우 낮고, 췌장 상부 담관에만 국한적으로 영상화할 수 있었다. 그러나 새로운 이론에 근거한 교육과 훈련을 마친 후 성적의 평가는 모든 학생(30명)이 (1) 담낭관 합류부(간외담관 및 담낭관), (2) 췌장 상부담관까지 객관성 있게 접근하였다. 24명의 학생이 (3) 췌두부내 담관 말단까지 접근하였으며, 1명의 학생만이 (4) 유두부내 공통관까지 영상화할 수 있었다. 결 론: 간내외 담관의 평가는 간내인성, 담관성 그리고 병태생리학적 다면 평가가 이뤄져야 하지만, 경복부초음파검사에 의해 간외담관을 유두부내 공통관까지 객관적이고 신뢰성 있게 영상화시킬 수 있다면 단순 감별진단 목적으로 시행하는 ERCP같은 환자에게 고통이 수반된 침습적인 검사를 대폭 줄일 수 있을 것이다. 따라서 저자들이 제시한 새로운 검사방법으로 간외 담관에 대한 기술적 접근 방법을 scanning 훈련하여 임상에 적용하게 된다면 초음파의 객관적인 신뢰도를 높일 수 있을 것으로 생각된다.

• Journal of Yeungnam Medical Science
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• 제7권1호
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• pp.165-171
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• 1990

영남대학교 의과대학 외과학교실에서는 1989년 11월에 한국에서 발병한 간흡충병의 여섯번째 증례로, 특히 간내 담관에 발생한 첫 증례를 우측 간엽 절제술 및 담낭 적출술로 좋은 결과를 얻었으며, 간내 담관에 발생한 경우에는 간암과의 구별이 요구되어야 한다는 점을 상기 시키면서 증례보고와 더불어 문헌적 고찰을 하였다.

• 대한소화기학회지
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• 제72권6호
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• pp.318-321
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• 2018

Primary neuroendocrine tumors originating from the extrahepatic bile duct are rare. Among these tumors, large cell neuroendocrine carcinomas (NECs) are extremely rare. A 59-year-old man was admitted to Sanggye Paik Hospital with jaundice that started 10 days previously. He had a history of laparoscopic cholecystectomy, which he had undergone 12 years previously due to chronic calculous cholecystitis. Laboratory data showed abnormally elevated levels of total bilirubin 15.3 mg/dL (normal 0.2-1.2 mg/dL), AST 200 IU (normal 0-40 IU), ALT 390 IU (normal 0-40 IU), and gamma-glutamyl transferase 1,288 U/L (normal 0-60 U/L). Serum CEA was normal, but CA 19-9 was elevated 5,863 U/mL (normal 0-37 U/mL). Abdominal CT revealed a 4.5 cm sized mass involving the common bile duct and liver hilum and dilatation of both intrahepatic ducts. Percutaneous transhepatic drainage in the left hepatic duct was performed for preoperative biliary drainage. The patient underwent radical common bile duct and Roux-en-Y hepaticojejunostomy for histopathological diagnosis and surgical excision. On histopathological examination, the tumor exhibited large cell NEC (mitotic index >20/10 high-power field, Ki-67 index >20%, CD56 [+], synaptophysin [+], chromogranin [+]). Adjuvant concurrent chemotherapy and radiotherapy were started because the tumor had invaded the proximal resection margin. No recurrence was detected at 10 months by follow-up CT.

• 대한의생명과학회지
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• 제8권4호
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• pp.203-209
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• 2002

Serum $\alpha$-D-mannosidase isozyme activities were measured in rats with ethanol intoxication combined with extrahepatic cholestasis induced by common bile duct ligation for the manifestation of the biochemical background of drinking hazards under the hepatobiliary disease. When chronic ethanol intoxication was combine with extraheparlc cholestasis, the activities of the rat's serum cytosolic, Iysosomal and Golgi $\alpha$-D-mannosidase isozymes increased at a more significant rate than those of the cholestasis alone. However, when acute ethanol intoxication was combined with extrahepatic cholestasis, the activities of the above isozymes were seen in the cholestasis alone. The results suggested that the elevated activities of these isozymes in chronic ethanol intoxication with cholestasis rather than in cholestasis alone were indications of increased hepatic damages, which caused these isozymes to leak into the blood in great quantity. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.

• Advances in pediatric surgery
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• 제14권2호
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• pp.178-182
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• 2008

Forme fruste choledochal cyst (FFCC) is one of the diverse types of choledochal cyst with little or no dilatation of the extrahepatic bile duct (EHBD). It is considered that FFCC has to do with the pancreatobiliary malunion (PBM). In children, 3 to 6 millimeters of EHBD is assumed to be normal. Even though there is no clear-cut definition, FFCC is likely to be associated with bile duct dilatation less than 10 millimeters. Almost all cases have PBMs and symptoms of the pancreatitis or cholangitis. We experienced a case of FFCC in a 4-year-old boy. His EHBD measures 10 mm diameter. He had symptoms of pancreatitis and elevated hepatic transaminases. The pancreatobiliary common channel was 28 millimeters. He underwent EHBD resection and Roux-en-Y hepaticojejunostomy and was discharged with no specific complications.