A Study on the Hepatoprotective effect of PS-1 from Artemisia iwayomogi

한인전 추출물의 간장보호 작용에 관한 연구

  • 이순복 (성균관대학교 약학대학) ;
  • 조태순 (성균관대학교 약학대학) ;
  • 윤기욱 (성균관대학교 약학대학) ;
  • 이종찬 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 심성보 (코오롱그룹 중앙연구소)
  • Published : 1998.06.01


The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was inves-tigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 mg/kg b.wt. in $CCl_4$-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 mg/kg b.wt. in $CCl_4$-induced chronic liver disease, 30 mg/tg b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.