• Molecules and Cells
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• v.37 no.10
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• pp.753-758
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• 2014

Sorting nexin 9 (SNX9) is a member of the sorting nexin family of proteins and plays a critical role in clathrinmediated endocytosis. It has a Bin-Amphiphysin-Rvs (BAR) domain which can form a crescent-shaped homodimer structure that induces deformation of the plasma membrane. While other BAR-domain containing proteins such as amphiphysin and endophilin have an amphiphatic helix in front of the BAR domain which plays a critical role in membrane penetration, SNX9 does not. Thus, whether and how SNX9 BAR domain could induce the deformation of the plasma membrane is not clear. The present study identified the internal putative amphiphatic stretch in the $1^{st}$ ${\alpha}$-helix of the SNX9 BAR domain and proved that together with the N-terminal helix ($H_0$) region, this internal putative amphiphatic stretch is critical for inducing membrane tubulation. Therefore, our study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrinmediated endocytosis.

• Steel and Composite Structures
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• v.25 no.4
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• pp.403-413
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• 2017

The fabric braided braking hose that delivers the driver's braking force to brake cylinder undergoes the large deformation cyclic motion according to the steering and bump/rebound motions of vehicle. The cyclic large deformation of braking hose may give rise to two critical problems: the interference with other adjacent vehicle parts and the micro cracking stemming from the fatigue damage accumulation. Hence, both the hose deformation and the fatigue damage become the critical issue in the design of braking hose. In this context, this paper introduces a multi-objective optimization method for minimizing the both quantities. The total length of hose and the helix angles of fabric braided composite layers are chosen for the design variables, and the maximum hose deformation and the critical fatigue life cycle are defined by the individual single objective functions. The trade-off between two single objective functions is made by introducing the weighting factors. The proposed optimization method is validated and the improvement of initial hose design is examined through the benchmark simulation. Furthermore, the dependence of optimum solutions on the weighting factors is also investigated.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.11
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• pp.84-91
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• 2010

Heat treatment with carburized quenching process is widely used for automotive helical gear to improve its surface properties of hardness and strength. However, the gear can be deformed with the process over the allowable tolerance, which possibly makes noise, vibration and heat problems in operation. In this study, deformation of helical gear during heat treatment of carburized quenching was analyzed with a numerical method, incorporating coupled calculations of thermal conduction, carbon diffusion, phase transformation and thermal stresses. With the analysis, the effect of coolant temperature in quenching on the deformation was investigated. The result of the analysis revealed that the higher the coolant temperature became, the more change of helix angle and the more compressive stresses in the surface generated, because of delayed generation of martensite in the part.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.6
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• pp.1523-1532
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• 1990

The objective of this study is to develope an optimized multi-facet drill (MFD). The principal factors that affect drilling performance are its geometry and the cutting conditions. In particular, the helix angle in the total twist angle of the twist drill, affects much morgen influence on the dynamic and static stiffness and on determining the characteristics of the chip disposal capacity of the drill. In this study, considering the helix angle as a major parameter, the model was developed. From this model, the deformation of transverse direction was simulated with the bending forces applied. The performance of a drill largely depends upon drilling forces. Comprehensive models for predicating the drilling thrust and torque are developed for the different drill geometries. The effects of MFD geometric parameters on thrust and torque are also deduced from the prediction models, from which an optimal drill geometry is found with the emphasis on minimum drilling forces.

• Journal of Information Display
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• v.1 no.1
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• pp.20-24
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• 2000

We propose on a novel vertical configuration (VC) for a helix-deformed ferroelectric liquid crystal (HDFLC) display that has fast response, high contrast, analog gray scale capability, and wide-viewing characteristics. In contrast to a conventional HDFLC in a planar geometry, smectic layers arrange themselves parallel to the substrates, and thus, extremely uniform alignment of molecules in large area is naturally achieved in our new configuration without additional processes such as the rubbing and/or electric field treatment. Moreover, with a proper design of electrode patterns on the same substrate, multidomain switching is easily realized without employing any complex process of alignment. Our new VC-HDFLC is expected to provide a viable technology to produce a next-generation large area LCD suitable for processing the dynamic image at a video-rate.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.11
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• pp.1752-1759
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• 2004

Reinforced braid layer (RBL) in automobile power steering hose plays an important role in power steering system. When the working oil is applied to the power steering hose, RBL suppresses rubber hose deformation from internal pressure and heat expansion. RBL is woven textile composites having a double-row structure of nylon cords twisted with the specific helix angle. In this paper, effective material properties of RBL are estimated using a detailed 3-D finite element model considering its complicated geometry. Numerical experiments based on a superposition method are carried out to simulate uniaxial tensile loading condition.

• Molecules and Cells
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• v.21 no.3
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• pp.428-435
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• 2006

Specific interaction of the epsin N-terminal homology(ENTH) domain with the plasma membrane appears to bridge other related proteins to the specific regions of the membrane that are invaginated to form endocytic vesicles. An additional $\alpha$-helix, referred to as helix 0 (H0), is formed in the presence of the soluble ligand inositol-1,4,5-trisphosphate [$Ins(1,4,5)P_3$] at the N terminus of the ENTH domain (amino acid residues 3-15). The ENTH domain alone and full-length epsin cause tubulation of liposomes made of brain lipids. Thus, it is believed that H0 is membrane-inserted when it is coordinated with the phospholipid phosphatidylinositol-4,5-bisphosphate [$PtdIns(4,5)P_2$], resulting in membrane deformation as well as recruitment of accessory factors to the membrane. However, formation of H0 in a real biological membrane has not been demonstrated. In the present study, the membrane structure of H0 was determined by measurement of electron paramagnetic resonance (EPR) nitroxide accessibility. H0 was located at the phosphate head-group region of the membrane. Moreover, EPR line-shape analysis indicated that no pre-formed H0-like structure were present on normal acidic membranes. $PtdIns(4,5)P_2$ was necessary and sufficient for interaction of the H0 region with the membrane. H0 was stable only in the membrane. In conclusion, the H0 region of the ENTH domain has an intrinsic ability to form H0 in a $PtdIns(4,5)P_2$-containing membrane, perhaps functioning as a sensor of membrane patches enriched with $PtdIns(4,5)P_2$ that will initiate curvature to form endocytic vesicles.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.59-62
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• 2003

The precision cold forging of helical gear for steering pinion has been studied. Because of the large helix angle, there are many difficult problems to control the material flow and part dimension. The die shape was proposed to improve the flow of workpiece. In order to improve the dimensional accuracy of forged part, a FE analysis was performed. The proposed die shape drives to flow amicably workpiece. The applied load was reduced up to 10 percent, compared to the conventional-shaped-die. The elastic deformation of die has been investigated quantitatively by the 3-dimensional FE analysis. The die-land has been expanded up to $10{\mu}m$ on loading stage, based on the FEM results. Therefore, the elastic deformation amounts should be taken into consideration to improve the dimensional accuracy of forged helical gear.

• Steel and Composite Structures
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• v.21 no.3
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• pp.605-628
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• 2016

The energy absorption characteristics of diamond core sandwich cylindrical columns under axial crushing process depend greatly on the amount of material which participates in the plastic deformation. Both the single-objective and multi-objective optimizations are performed for columns under axial crushing load with core thickness and helix pitch of the honeycomb core as design variables. Models are optimized by multi-objective particle swarm optimization (MOPSO) algorithm to achieve maximum specific energy absorption (SEA) capacity and minimum peak crushing force (PCF). Results show that optimization improves the energy absorption characteristics with constrained and unconstrained peak crashing load. Also, it is concluded that the aluminum tube has a better energy absorption capability rather than steel tube at a certain peak crushing force. The results justify that the interaction effects between the honeycomb and column walls greatly improve the energy absorption efficiency. A ranking technique for order preference (TOPSIS) is then used to sort the non-dominated solutions by the preference of decision makers. That is, a multi-criteria decision which consists of MOPSO and TOPSIS is presented to find out a compromise solution for decision makers. Furthermore, local and global sensitivity analyses are performed to assess the effect of design variable values on the SEA and PCF functions in design domain. Based on the sensitivity analysis results, it is concluded that for both models, the helix pitch of the honeycomb core has greater effect on the sensitivity of SEA, while, the core thickness has greater effect on the sensitivity of PCF.

• Journal of the Korean Society of Industry Convergence
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• v.4 no.3
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• pp.257-261
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• 2001

이 연구는 밀링가공시 체터진동을 억제하기 위하여 부등각 앤드밀(나선각이 서로 다른 앤드밀)을 사용하여 절삭가공을 수행 한 후, 그 가공특성을 고찰한 것으로 가공표면의 기하학적 오차를 일반적으로 사용하는 등각 엔드밀에 의한 값과 실험에 의해 비교 검토한 결과, 두 엔드밀 모두 가공표면의 기하학적 오차는 유사함 나타내고 있으나, 부등각 엔드밀의 절대오차는 등각 엔드밀 보다 더 적은 경향을 나타내고 있다. 이들의 오차는 상향절삭보다 하야절삭 가공했을 때가 더 큰 것으로 나타났다. 더구나, 등각 엔드밀과 부등각 엔드밀과의 절대오차가 다르게 나타난 것은 밀링가공시 사용한 절삭날 인선에 의하여 완전히 의존되어지며, 또한 다른 나선각에 의해 기인된 각각의 절삭날에 대한 절삭날당 이송비의 변화에 의한 원인이라는 것을 명백히 알 수 있었다.