• 대한한방소아과학회지
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• 제23권2호
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• pp.131-144
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• 2009

Objectives : The purpose of this study is to have better data and to make efficient clinical reviews on pre-school children's growth based on two measurements; Body composition for measuring body volume and bone age for potential growth. Methods : The study was conducted with 221 children(118 of boys and 103 of girls) from three kindergartens. Body compositions(soft lean mass, body fat mass, percent body fat) were measured by bioelectrical impedance analysis, bone age was measured by bone density through ultrasonic image of calcaneus. Results and Conclusions : 1. The higher level on weight or BMI, the more averages of soft lean mass, body fat mass, percent body fat. 2. The average bone ages and bone age-chronological age were lower in under 50 percentile's group, but it was higher in upper 50 percentile's group. Also, children with high BMI had older in bone ages and bone age-chronological age. 3. The higher in height percentile based on the bone age; there were more soft lean mass. 4. The averages of bone age and bone age-chronological age were significantly decreased, the more percentiles of height according to bone age were big, they were higher than total average in under 50 percentile's group of height, lower than total average in over 50 percentile's group of height in both boys and girls. 5. The average of MPH were significantly decreased in top percentiles of children's height distribution. Also, in the upper percentiles of height distribution based on bone age were big in only boys. 6. The body compositions(soft lean mass, body fat mass, percent body fat) were related to body volume growth, which can he measured by weight or BMI. The bone age, bone age-chronological age, and MPH were related in terms of hight. The body volume growth was a little hit related with potential growth.

• 대한한방소아과학회지
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• 제32권4호
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• pp.51-62
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• 2018

Objectives The purpose of this study is to analyze the characteristic of pediatric patients who visited oriental medical hospital for growth treatment. Methods The study was conducted with 130 pediatric patients who visited ${\bigcirc}{\bigcirc}$ Korean medicine hospital from January 2016 to August 2017. The patient's data was classified by sex, age, pattern identification and diseases. The classified data was analyzed to find the correlations and characteristics among variables. Results There were 50.8% of boys and 49.2% of girls. 6.2% of the total patients were in 'early childhood', 50.8% were in 'late childhood' and 43.1% were in 'puberty' stage. In terms of pattern identification, 44.6% of the total patients were 'Spleen-lung Qi Deficiency', 53.8% were 'Lung-kidney Yin Deficiency' and 1.5% were 'Weakness of Heart and gallbladder'. 44.3% of the patients had various diseases including rhinitis (77.6% of 120.7%). Height percentile of the children with using the Growth chart of 2017 was lower than using the Growth chart of 2007. Predicted height based on the child's bone-age were higher than the predicted height based on the parental height, although both of the precited factors were correlated to the current child's height. Conclusions This study showed the characteristic of the pediatric patients who visited oriental medical hospital for growth treatment. It helps to determine prognosis and treatment, and to explain treatment measures.

• Annals of Pediatric Endocrinology and Metabolism
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• 제23권4호
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• pp.176-181
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• 2018

Noonan syndrome (NS) is an autosomal dominant disorder that involves multiple organ systems, with short stature as the most common presentation (>70%). Possible mechanisms of short stature in NS include growth hormone (GH) deficiency, neurosecretory dysfunction, and GH resistance. Accordingly, GH therapy has been carried out for NS patients over the last three decades, and multiple studies have reported acceleration of growth velocity (GV) and increase of height standard deviation score (SDS) in both prepubertal and pubertal NS patients upon GH therapy. One year of GH therapy resulted in almost doubling of GV compared with baseline; afterwards, the increase in GV gradually decreased in the following years, showing that the effect of GH therapy wanes over time. After four years of GH therapy, ~70% of NS patients reached normal height considering their age and sex. Early initiation, long duration of GH therapy, and higher height SDS at the onset of puberty were associated with improved final height, whereas gender, dosage of GH, and the clinical severity did not show significant association with final height. Studies have reported no significant adverse events of GH therapy regarding progression of hypertrophic cardiomyopathy, alteration of metabolism, and tumor development. Therefore, GH therapy is effective for improving height and GV of NS patients; nevertheless, concerns on possible malignancy remains, which necessitates continuous monitoring of NS patients receiving GH therapy.

• 대한한방소아과학회지
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• 제28권1호
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• pp.43-51
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• 2014

Objectives The purpose of this study is to find out the relationship between mid parental height (MPH), birth weight, current growth condition of children (height, weight, BMI, body fat percentage, bone age) and final height of the future. Methods The study was conducted with 237 children, who were 12 - 14 years old. They were analyzed to find out the relationship between MPH, birth weight, height, current weight, BMI, body fat percentage, bone age and predicted height. Results 1. As MPH was increased, height and predicted height were also increased. As MPHs in girls were increased, 'bone age - chronological age' were decreased. As MPHs in girls were increased, body fat percentages were decreased. 2. As birth weights were increased, height, weight, BMI and body fat percentages were also increased in boys. 3. As body fat percentage was increased, predicted height was decreased. As 'bone age - chronological age' was increased, predicted height was decreased. As BMI was increased, 'bone age - chronological age' was increased. As body fat percentages in boys were increased, heights were decreased. As body fat percentages in girls were increased, 'bone age - chronological age' were increased. Conclusions MPH, birth weight, current growth condition (height, weight, BMI, body fat percentage, bone age) and predicted height are correlated to each other. There are some differences between boys and girls in these relationships.

• 보건교육건강증진학회지
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• 제12권2호
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• pp.36-47
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• 1995

This research was obtained from analyzing how the physiques of the 3rd grade students of high school for males and females and developed for the last eleven years(from 1983 to 1993). By the physiques and nutritional index of physical growth and development, Relative Body Weight of 36.62 exceeded the standard, on the other hand females showed lower records than the standard. Relative Chest Girth Index belonged to the normal type of males and females in all, in the comparison of the records between 1983 and 1993, males increased in average 0.29 and females in average 0.55. Relative Chest Girth Index of females was greater than that of females. By the results of Relative Sitting Height Index, growth of the lower body for males and females was greater than that of males. In case of Vervaeck Index, males increased in average 2.04 but females increased in average 1, 20 relatively less than males. These phenomena provided for the evidence of the deficient nutrition in females. In the regression models of body height and body weight within a certain period, statistical regression model types which best indicated chronological average changes of body height and body weight, took 3rd Order Polynomial Regression Model rather than linear regression model. In females, statistical regression model types which best is suitable for chronological average change of body height and body weight, took 4th and 2nd Order Polynomial Regression Model respectively. The prediction value of 1995 by estimated polynomial regression model anticipated that body height of 3rd grade year students of high school of males in 1993 went on increasing from 170.87cm to 171.79cm in average 0.92cm growth and that of females from 158.99cm to 160.79cm in average 1.80cm growth. In addition, body weight of males seemed to increase from 62.58kg to 64.52kg in average 1.94kg growth and that of females seemed to increase from 54.05kg to 54.19kg in average 0.14kg growth. Linear Regression Model was suitable for the regression model of body weight for body height. Prediction on increase of an average body weight for body height was that, according to growth of body height 1cm in males, body weight increased 1.41kg averagely and that of females 0.86kg. For that reason, we came to conclusion that body weight increase for body height 1cm in males was greater than that in females on average.

• 대한한방소아과학회지
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• 제35권2호
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• pp.11-20
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• 2021

Objectives The purpose of the study is to evaluate the safety of the Allium Fistulosum extract in children and its effectiveness in height growth. Methods This study is randomized, double-blind, placebo-controlled trial. The participants are children between the 3rd and 25th percentiles in height, and between the ages of 5 and 12 years. They are randomly assigned to treatment group or control group. The treatment group will take 5 g (1 g as Allium Fistulosum extract) for 24 weeks, 1 time a day. The control group will take the 5 g (0 g as Allium Fistulosum extract) of placebo for 24 weeks, 1 time a day. The primary outcome is change in height, and the secondary outcomes are growth rate, height standard deviations, Insulin-like growth factor-1 (IGF-1), Insulin-like growth factor binding protein-3 (IGFBP-3), IGF1-1/IGFBP-3 ratio, growth hormone, bone age, osteocalcin, and Z-score for growth. Results This protocol has been approved by the institutional review board (IRB) of Daejeon Korean Medicine Hospital of Daejeon University (IRB No. DJDSKH-20-BM-15), and registered in the Clinical Research Information Service (CRIS) (Registry No. KCT0005981). Conclusions This study will provide clinical information about the effectiveness and safety of Allium Fistulosum extract in children for their growth.

• The Korean Journal of Ecology
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• 제25권1호
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• pp.29-31
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• 2002

The purpose of this study is to estimate height growth patterns and site index cuties (base index age 50 years) for Japanese red cedar trees(Cryptomeria japonica D. Don) grown in southern regions of Korea. The Chapman-Richards growth function was selected for stand height prediction using on the results of stem analysis data sets. Anamorphic base age invariant site index cuties were presented based on this height prediction equation. The resulting site index prediction equation can provide an indication of the productivity of the site quality based on Japanese red cedar trees plantation ages planted in southern regions of Korea.

• 아시안잔디학회지
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• 제5권2호
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• pp.75-80
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• 1991

The purpose of this experiment was in order to detect the effect of cutting height on the growth and thatch accumulation in Zoysio japonica Cutting height treatments were 2.5, 3.8, 5.1cm and no cutting, respectively. The results were obtained as follows : 1.Cutting treatments great]y affected to the growth of Zoysia japonica and thatch accumulation. 2.The dry weight of Leaf and shoot had the highest at 5.1cm. So 5.1cm treatment was desirable level for the top growth of Zoysia japonica 3.The dry weight of leaf, shoot, root and coverage of control were obtained the higher than cutting treatments. 4.The dry weight of thatch of control were less than cutting treatments, and 5.1cm treatment were more than tow cutting height. 5.Retationships of dry weight of thatch with thatch depth and C/F ratio were positive significant differences at 5% level. 6. Relationship between dry weight of shoot and coverage showed a positive significant difference at 5% level.

• Journal of Preventive Medicine and Public Health
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• 제17권1호
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• pp.145-172
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• 1984

In order to assess the physical growth pattern of Korean Youth, the authors measured the body height, body weight, chestgirth and sitting height of 40967 persons (24832 males and 16135 females) from primary schools, middle and high schools and colleges of metropolitan (urban) and rural areas, and calculated the mene, standard deviation, standard error and coefficient variance of the body weight chestgirth, sitting height and various pertinent index by body height to demonstrate the standard physical growth and development by body height of sex and age. The following conclusions were obtained. 1. Physical growth and development: Rapid growth of physical growth in terms of body height has been observed among males in the age $7{\sim}15$ and among female $7{\sim}13$. Growth in terms of body height turned out to be slower among students of higher age by both sexes. The age of cross over between to sexes is between 10 to 13 years where upon girls out grows boys. Maximum annual growth were upon girls out grows boys. Maximum annual growth were both of 6.16cm from 8 to 9 years old and 12 to 13 years old for boys and 7.2cm from 8 to 9 and 6.1cm from 9 to 10 for girls. This indicates that girls enter a rapidly growing stage 2 years earlier than boys. Meanwhile, prominent improvement in body height of national students over period of ten year was noticed. 2. The distribution status of body height by age: The distribution status of body height by age were as follows; 7 year of age: boys-30cm range of body height from 104.0cm to 133.9cm, girls-27cm from 104.0cm to 130.9cm 8 year of age: boys-30cm from 116.0 to 145.9cm girls-33cm from 113.0 to 145.9cm 9 year of age: boys-30cm from 116.0 to 145.9cm girls-33cm from 113.0 to 145.9cm 10 year of age: boys-39cm from 116.0 to 154.9cm girls-39cm from 119.0 to 157.9cm 11 year of age: boys-45cm from 119.0 to 163.9cm girls-39cm from 122.0 to 160.9cm 12 year of age: boys-45cm from 125.0 to 169.9cm girls-42cm from 125.0 to 166.9cm 13 year of age: boys-45cm from 128.0 to 172.9cm girls-42cm from 128.0 to 169.9cm 14 year of age: boys-48cm from 131.0 to 178.9cm girls-36cm from 134.0 to 169.9cm 15 year of age: boys-42cm from 137.0 to 181.9cm girls-33cm from 137.0 to 169.9cm 16 year of age: boys-39cm from 146.0 to 184.9cm girls-30cm from 143.0 to 172.9cm 17 year of age: boys-39cm from 146.0 to 184.9cm girls-27cm from 143.0 to 169.9cm 18 year of age: boys-36cm from 152.0 to 187.9cm girls-27cm from 146.0 to 172.9cm 19 year of age: boys-30cm from 155.0 to 184.9cm girls-24cm from 146.0 to 169.9cm 20 year of age: boys-24cm from 158.0 to 181.9cm girls-l8cm from 149.0 to 166.9cm 3. Standard values of body weight, chest-girth and sitting height by body height of age were found all age groups from 7 to 20 years old and listed in tables from3-a to 16-a. 4. Standard values of relative body weight, relative chestgirth and relative sitting height by body height of age were found all age groups from 7 to 20 years old and listed in tables from 3-b to 16-b. 5. Standard values of physical and nutritional indices (Rohrer index, Kaup index, Vervaeck index and Pelidisi index) by body height of age were found all age groups from 7 to 20 years old and listed in tables from 3-c to 16-c.

• Clinical and Experimental Pediatrics
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• 제46권8호
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• pp.803-810
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• 2003

목 적 : 특발성과 기질성 성장호르몬 결핍증 환자에서 성장호르몬 치료 후 최종 성인신장과 총신장(SDS) 증가 그리고 이에 영향을 미치는 인자에 대해 알아보고자 하였다. 방 법 : 1990년부터 2000년까지 서울대학병원 소아과에 내원하여 성장호르몬 결핍증으로 진단되어 성장호르몬 치료를 받은 후 최종 성인신장에 도달한 환자를 대상으로 하였다. 특발성 GHD 3명(남 : 여, 11 : 2)과 기질성 GHD 22명(남 : 여, 12 : 10)에게 성장호르몬을 각각 $0.62{\pm}0.15IU/kg/wk$, $0.52{\pm}0.11IU/ kg/wk$ 용량으로 $3.2{\pm}2.4$년 동안 일주일에 3-7회 피하주사하였다. 결 과 : 1) 치료 시작 전 신장표준편차점수는 특발성 GHD 군에서는 $-4.13{\pm}1.28$, 기질성 GHD 군에서는 $-1.66{\pm}1.06$으로 특발성 GHD 군이 의미 있게 작았으며, 특발성 GHD 군에서 골연령 또한 역연령에 비해 $5.2{\pm}2.9$년 정도로 지연되어 있었다. 2) 치료 첫해 성장속도는 특발성 GHD 군에서 $9.69{\pm}3.19cm$, 기질성 GHD 군에서는 $7.87{\pm}3.65cm$이었다. 3) 사춘기 시작시 신장은 특발성 GHD 군에서 $-2.28{\pm}0.95$ SDS, 기질성 GHD 군에서는 $-0.55{\pm}1.25$ SDS이었다. 4) 최종 성인신장은 특발성 GHD 군에서 $-1.44{\pm}0.84$ SDS, 기질성 GHD 군에서는 $0.22{\pm}1.06$ SDS로 두 군 모두에서 치료 시작시 신장 SDS에 비하여 유의하게 증가되었다. 기질성 GHD 군에서 최종 성인신장이 더 컸으며, 두 군 모두에서 최종 성인신장은 사춘기 시작시의 신장과 깊은 연관 관계가 있었다(특발성, r=0.616, P<0.05; 기질성 r=0.830, P<0.001). 5) 총신장(SDS) 증가는 특발성 GHD 군에서 $2.69{\pm}1.36$으로 기질성 GHD 군($1.88{\pm}1.16$)보다 컸으나, 통계적 유의성은 없었다. 총신장(SDS) 증가는 두군 모두에서 성장호르몬 치료 시작시 신장 SDS가 중간부모신장 SDS에 비하여 작을수록 더 컸으며, 특히 기질성 GHD군에서는 치료 시작시 역연령에 비하여 골연령이 어릴수록, 사춘기전 신장(SDS) 증가가 클수록 더 컸다. 결 론: 특발성 GHD 환자에서 기질성 GHD 환자보다 최종 성인신장이 작았다. 성장호르몬에 의한 신장증가 효과는 치료 전 신장이 중간부모신장에 비하여 작을수록 컸으나, 절대적 최종 성인신장은 사춘기 시작 시 신장과 가장 깊은 관련이 있어, 조기진단 후에 적절한 용량의 성장호르몬으로 꾸준히 치료하여 사춘기가 나타나기 전까지 충분한 신장의 증가를 유도하여야만 만족할만한 최종 성인신장을 얻을 수 있을 것으로 생각된다.