Purpose: The purpose of this study was to investigate the relationship among health behavior, obesity and QOL, and to identify factors affecting QOL of University Students in rural area, to provide the basic data for health promoting program in order to improve the QOL. Methods: The subjects of this study were 991 university students. The collected data was analyzed using descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson correlation coefficient and Stepwise multiple regression with SAS. Results: In the degree of the obesity were 13.4% of the underweight group, 48.9% of the normal weight group, and 37.6% of the overweight group. The average item score for the QOL was 3.19; the highest score on the subscale was physical domains(M=3.25) with the lowest environmental domains. In the degree of health behavior performance were 15.3% of regular health check, 27.5% of exercise, 45.1% of no-smoking, 32.4% of no-drinking alcohol, 53.1% of sleeping 7-hour, 49.7% of weight care, 56.1% of stress management, and 44.4% of breakfast. The score of QOL was statistically significant difference according to age, occupation of father, the number of brothers, total income, level of life, perceived health status, and admission of hospital. The score of QOL correlated positively with health behavior(r=.2521, p<.0001), and the scores of health behavior correlated positively with obesity(r=.0915, p=.0039). Stepwise multiple regression analysis for QOL revealed that the most powerful predictor was level of life. Stress management, perceived health status, sleeping 7-hour, regular health check, admission of hospital, total income, and weight care explained 13.2% of the variance. Conclusions: Therefore, it is necessary to develop health behavior promotion program in order to enhance the quality of life of university students. Future studies need to be pursued to find significant influencing factors for QOL of university students.